Unveiling key aroma compounds formation during the roasting process of Yunnan Arabica coffee using molecular sensory science approaches.

Yunnan coffee is praised for the sweet caramel aroma and slightly sour taste, but its key flavor compounds and aroma formation mechanisms remain unclear. In this study, the dynamic changes of coffee aroma, amino acids, free fatty acids, free sugars, chlorogenic acids and caffeine at different roasting degrees were investigated by SAFE-GC-MS and HPLC. Roasted coffees exhibited richer flavor profiles, especially caramel, nutty and roasted flavors, while the grassy, cereal and beany flavors of green beans (GB) were significantly diminished.

High-Performance Micro-LED Displays via Etching-Damage-Free Pixelation Strategy for Multifunctional Integrated Applications.

As Micro-LED sizes shrink, luminescence efficiency drops significantly due to sidewall damage from plasma etching. This study introduces a precision-selective ion implantation (PSII) strategy to boost external quantum efficiency (EQE) and brightness of Micro-LED at high current density, vital for applications like augmented reality (AR) and optical communication, instead of relying on sidewall passivation for low current density efficiency. PSII's effects is systematically evaluated on electrical isolation and photoelectric properties.

Deep learning-based histomorphological subtyping and risk stratification of small cell lung cancer from hematoxylin and eosin-stained whole slide images.

Background: Accurate subtyping and risk stratification are imperative for prognostication and clinical decision-making in small cell lung cancer (SCLC). However, traditional molecular subtyping is resource-intensive and challenging to translate into clinical practice.

Methods: A total of 517 SCLC patients and their corresponding hematoxylin and eosin (H&E)-stained whole slide images (WSIs) from three independent medical institutions were analyzed.

Fatty acid β-oxidation enhances immune regulatory function of double-negative T cells through pSTAT4-OX40 signaling pathway.

Background: Double-negative T (DNT) cells (CD3+CD4-CD8-NK1.1-) demonstrate immunoregulatory functions in maintaining hepatic immune homeostasis. This study investigates how energy metabolism impacts DNT cell survival and immunoregulatory functions, exploring potential therapeutic applications for autoimmune hepatitis.

Cobalt Polypyridyl-Enabled Highly Regioselective α-Heteroarylation of N,O-Containing Aliphatics Through Photoelectrocatalysis.

The regioselective functionalization of C─H bonds at positions with nearly identical chemical environments remains a pivotal challenge in synthetic chemistry. While conventional hydrogen atom transfer (HAT) strategies dominate current methodologies, their limitations in selectivity drive the pursuit of alternative mechanisms. Here, we report a photoelectrochemically cooperative catalytic system mediated by a polypyridyl cobalt catalyst, enabling highly regioselective α-heteroarylation of ethers, alcohols, and amides.

The role of CBFβ::MYH11 fusion gene in acute lysis pneumopathy: A dual impact on risk and prognosis.

Acute lysis pneumopathy (ALP) is a rare but fatal complication that can occur during induction chemotherapy for newly diagnosed acute myeloid leukaemia (AML). Currently, there is a paucity of large case reports detailing high-risk and poor prognostic factors associated with its occurrence. To provide evidence-based guidance on ALP, we conducted a retrospective analysis of 608 patients with newly diagnosed AML (non-M3), among whom 20 developed ALP during hydroxycarbamide (hydroxyurea) therapy and/or induction chemotherapy, resulting in an overall incidence rate of 3.

An ultra-wide-field fundus image dataset for intelligent diagnosis of intraocular tumors.

Retinal fundus photographs are now widely used in developing artificial intelligence (AI) systems for the detection of various fundus diseases. However, the application of AI algorithms in intraocular tumors remains limited due to the scarcity of large, publicly available, and diverse multi-disease fundus image datasets. Ultra-wide-field (UWF) fundus images, with a broad imaging range, offer unique advantages for early detection of intraocular tumors.

The Trajectory of Reflux and its Associating Factors in Patients After Esophagectomy Based on Salivary Pepsin-Testing: A Prospective Longitudinal Study.

Background: Post-esophagectomy reflux remains a significant clinical challenge. This study pioneered the use of salivary pepsin-testing (SPT) as an objective biomarker to explore the reflux, addressing limitations of subjective symptom scoring in esophagectomy outcomes research.

Methods: Consecutive patients (age 18-75 years) with histologically confirmed esophageal carcinoma who underwent esophagectomy were prospectively enrolled to explore the trajectory and associating factors of reflux after surgery.

Study on the water stability and safety mechanism of warm mixed recycled SBS modified asphalt mixture.

The warm-mix recycled asphalt mixture (RAM), which integrates the warm-mix technique with recycling technology, offers significant energy savings and promotes the effective use of waste materials, delivering both environmental and economic benefits. Therefore, this study selected Evotherm surface-active additive to investigate its impact on the properties of recycled asphalt binder and its corresponding mixture, compared and analyzed the differences between road properties of hot-mix RAM and warm-mix RAM, focusing on the water stability of warm-mix RAM and the safety mechanism of warm-mix additive. The results revealed that while Evotherm did not significantly alter the penetration, softening point, or ductility of recycled SBSMA, it enhanced the surface energy and aggregate adhesion.

Visualization of enantiorecognition by excited-state conformation modulation.

Chiral purity is crucial in life sciences, emphasizing the importance of precise enantiomeric identification and the development of analytical techniques. Here, we design functional dyes with visual chiral recognition capabilities by introducing recognition units 2-amino-1,2-diphenylethanol into vibration-induced emission molecules. The unambiguous differentiation in luminescent colors upon binding to enantiomers facilitates the efficient recognition of enantiomers and the analysis of enantiomeric excess.

Two new compounds from the green walnut husks of .

Two new compounds () and thirteen known tetrahydroaphcosterones () were isolated from the green walnut husks of , with structures elucidated via spectroscopic analyses. Cytotoxicity screening against BGC-823, A-549, and HepG-2 cancer cell lines revealed that compound inhibited A-549 with the IC value of (54.94 ± 1.

Current status and influencing factors of blue carbon in seagrass beds: An extensive survey and comprehensive analysis in the Yellow and Bohai Seas, China.

Seagrass beds constitute a unique blue carbon ecosystem that mitigates climate change by capturing and sequestering CO over extended periods. Despite being recognized as potent carbon sinks, there is still limited information on the quantification, regional variability, and drivers influencing their blue carbon stocks. In this study, we established 108 sampling sites to estimate organic carbon (C), sediment accumulation rates (SARs), and carbon accumulation rates (CARs) across 13 seagrass beds located in the Yellow and Bohai Seas of China.

Surface Field Effect-Enhanced Cu-Doped WO Nanowires for Fast Response HS Sensors.

Accurately detecting hydrogen sulfide in the environment and monitoring its pollution sources are crucial for pollution assessment and personal safety. However, rapid detection is a challenge due to the influence of carrier behavior and surface adsorption states. In this paper, Cu-doped WO nanowires were synthesized by the solvothermal method.

The Structural Regulation of Electrocatalyst Nanomaterials via Electrochemical Tuning.

The global energy crisis has intensified the demand for advanced electrocatalysts to facilitate critical key reactions in emerging energy technologies, such as fuel cells, water electrolysis, and metal-air batteries. Emerging from foundational research in metal-ion batteries, the metal ion electrochemical tuning (MET) methodology demonstrates exceptional precision in regulating reversible intercalation/deintercalation processes, distinguishing itself from other electrocatalyst preparation techniques. This innovative approach overcomes the inherent limitations of conventional methodologies, which primarily implement static compositional modifications while lacking the capability for dynamic performance optimization.

Evaluating treatment options for symptomatic uterine fibroids: a systematic review and meta-analysis of effectiveness, recovery, and long-term outcomes (MARIE WP1).

Background: Uterine fibroids can significantly impair the quality of life of women. While most fibroids remain asymptomatic, 25% of women diagnosed with uterine fibroids require medical intervention.

Methods: A systematic review and meta-analysis protocol was developed and published in PROSPERO (CRD42022346251) to explore surgical treatment outcomes linked to uterine fibroids.

A functionally tunable magnetic nanochains platform for N-glycoproteomic analysis of extracellular vesicles from ultratrace biofluids.

Extracellular vesicles (EVs) carry complex glycoproteins critical mediators of disease progression and hold great potential for liquid biopsy applications. However, their low abundance presents significant analytical challenges. This study develop a versatile platform for EV N-glycoproteomic analysis (EVGpro), which enables tandem EV capture, EV protein digestion, and enrichment of N-glycopeptides.

A comparative study of the clinical characteristics of esophageal-pulmonary fistula in children.

Objectives: Esophageal-pulmonary fistula (EPF) is a rare complication after esophageal surgery, especially following esophageal atresia/tracheoesophageal fistula (EA/TEF) repair in neonates. Its clinical characteristics remain unclear, and the etiology is still under investigation. This study aims to describe the clinical features of EPF by comparing it with traditional recurrent TEF (rTEF) after EA repair.

STRaM: A genetic framework for improved cell product provenance for research and clinical translations.

Multiple assessment checks are required to handle the increasingly complex engineered-cell and cell-line provenance. To manage the biosafety and efficacy demands, we developed a bioinformatic pipeline for de novo profiling of short tandem repeats and mutations (STRaM) to identify and track homologous edited/engineered cells. The core technology of STRaM comprises an error-sensing bioinformatic pipeline with 3 analysis modules (STR analysis, STR flanking analysis and EMS analysis) for profiling, and an integrated assessment system with three indices for the respective reporting of identity, purity and genetic modifications of tested cells.

Unveiling causal relationship between white matter tracts and psychiatric disorders.

White matter tracts (WMTs), which mediate information transmission in the brain, are closely associated with the pathogenesis of psychiatric disorders, yet the causality of their associations remain unclear. Thus, we employed two-sample bidirectional Mendelian randomization to explore the causality between WMTs and 10 psychiatric disorders. We found that one standard deviation changes of WMTs metrics modified risks for 8 psychiatric disorders by 2·2% to 71·4%.

Association between fibrinogen levels and mortality following cardiopulmonary resuscitation: a retrospective cohort study.

Background: Cardiac arrest (CA) is a critical condition that would cause high mortality. Fibrinogen, as a macromolecular protein involved in both inflammatory response and coagulation regulation, was reported to be associated with a series of life-threatening conditions. The aim of this study is to investigate the association between fibrinogen level and prognosis of patients after cardiac arrest.

Analysis of Mechanical Properties of Crumb Rubber Tires Mixed with Silty Sand of Various Sizes and Percentages.

Every year, a billion tires are discarded worldwide, with only a small percentage being recycled. This leads to significant environmental hazards, such as fire risks and improper disposal. Silty sand also presents technical challenges due to its poor shear strength, susceptibility to erosion, and low permeability.

Enhancing the performance of high-power DUV-LEDs with sloped sidewall by introducing N-electrode holes and interrupted mesa.

This study introduces innovative structural enhancements in deep ultraviolet LEDs (DUV-LEDs) to optimize Performance. By implementing a 46.9° sloped mesa sidewall, we have designed what we believe to be two novel structures: an n-electrode hole structure that extends the active region and an interrupted mesa structure that significantly enlarges the sidewall area.