AlphaFold3 for Noncanonical Cyclic Peptide Modeling: Hierarchical Benchmarking Reveals Accuracy and Practical Guidelines.

Despite the revolutionary impact of AlphaFold3 on structural biology, this model's capability in predicting noncanonical cyclic peptides remains unexplored. Given the clinical significance of cyclic peptides containing unnatural residues as a therapeutic modality, we present the first systematic evaluation of AlphaFold3 for this class of molecules. To facilitate benchmarking, we developed an automated input pipeline to streamline AlphaFold3 predictions for cyclic peptides.

Study on the water stability and safety mechanism of warm mixed recycled SBS modified asphalt mixture.

The warm-mix recycled asphalt mixture (RAM), which integrates the warm-mix technique with recycling technology, offers significant energy savings and promotes the effective use of waste materials, delivering both environmental and economic benefits. Therefore, this study selected Evotherm surface-active additive to investigate its impact on the properties of recycled asphalt binder and its corresponding mixture, compared and analyzed the differences between road properties of hot-mix RAM and warm-mix RAM, focusing on the water stability of warm-mix RAM and the safety mechanism of warm-mix additive. The results revealed that while Evotherm did not significantly alter the penetration, softening point, or ductility of recycled SBSMA, it enhanced the surface energy and aggregate adhesion.

E7 peptide and magnesium oxide-functionalized coaxial fibre membranes enhance the recruitment of bone marrow mesenchymal stem cells and promote bone regeneration.

Background: The repair of bone defects remains a significant clinical challenge. Although magnesium (Mg)-based biomimetic scaffolds are widely utilized for bone defect repair, the release of Mg²⁺ ions often leads to an alkaline microenvironment, thereby adversely affecting bone regeneration. Regenerative medicine strategies that leverage the recruitment of endogenous bone marrow mesenchymal stem cells (BMSCs) offer a novel approach to treating bone defects.

Study on Stability and Applicability of Calcium Carbide Slag-Dealkalized Red Mud and Solid Waste Composite Materials in Road Materials.

The storage of highly alkaline red mud (RM) consumes land and threatens the environment, making its reuse crucial. The study used calcium carbide slag to dealkalize it, and analyzed the changes in mineral particles in RM using a CT scan. It then evaluated the stabilization effects of different materials and explored the mechanism of RM solidification through analysis of micro-mechanisms.

Circadian rest-activity rhythms and multimorbidity and mortality risks among menopausal women: a trajectory analysis of a UK Biobank cohort.

Background: Menopausal women undergo substantial physiological changes that can impact their overall health.

Objectives: We examined relationships between circadian rest-activity rhythms (CRARs) and multimorbidity progression in this population.

Methods: We used UK Biobank data, involving 10,138 participants, who were initially free of chronic conditions.

Sustainable Materials and Structures Used in Pavement Engineering.

Sustainable materials and structures have become widely used in asphalt pavements to mitigate the resource crisis and achieve carbon neutrality [...

Strength Properties and Microscopic Experimental Study of Modified Sawdust Based on Solid Waste Synergistic Utilization.

Sawdust is the cutting tailings produced during stone processing, which is difficult to deal with and has a huge stock. Therefore, it is particularly important to enhance the comprehensive utilization of sawdust. The aim of this study was to synergistically utilize sawdust with other industrial wastes (fly ash, silt, and red mud), add cement as a curing agent to prepare modified sawdust, and analyze its performance through an unconfined compressive strength test, dry and wet cycle tests, and SEM.

Hazard evaluation of goaf based on DBO algorithm coupled with BP neural network.

China is rich in mineral resources, and problems of goaf formed in the process of resource exploitation are serious obstacle to the development of China's economic, so it is of great significance for the assessment and management of goafs. This paper introduces emerging dung beetle optimizer (DBO) algorithm and establishes DBO-BP (back-propagation) model, at the same time, it is compared with a series of heuristic algorithms coupled with BP neural network models: PSO (particle swarm optimization) - BP model, WOA (whale optimization algorithm) - BP model, and SSA (sparrow search algorithm) - BP model. Then they are applied to evaluate the hazard of goafs, the result shows that the DBO-BP model gets the highest train set accuracy, which is at least 2.

Clinicopathological Characteristics and Outcome of Cytophagic Histiocytic Panniculitis: A Single-Center, Retrospective Study.

Background: Cytophagic histiocytic panniculitis (CHP) is a rare panniculitis associated with systemic features characterized by the infiltration of subcutaneous adipose tissue by benign-appearing T lymphocytes and phagocytic histiocytes, mimicking hemophagocytic lymphohistiocytosis (HLH) and subcutaneous panniculitis-like T-cell lymphoma (SPTCL).

Purpose: To establish the clinicopathological features and response to treatment of CHP and evaluate the prognosis of patients and guide therapy based on the current state of knowledge.

Material And Methods: Clinical, laboratory, histopathological, and outcome data of 12 patients with CHP were retrospectively collected between 2009 and 2022.

Effect of Sasobit/Waste Cooking Oil Composite on the Physical, Rheological, and Aging Properties of Styrene-Butadiene Rubber (SBR)-Modified Bitumen Binders.

The modifying effects of polymer on bitumen low-temperature performance are substantially compromised by the thermal breakdown of styrene-butadiene rubber (SBR) polymer during bitumen mixture production operations. The efficacy of the utilization of Sasobit/waste cooking oil (Sasobit/WCO) as a warm-mix additive has been demonstrated in mitigating the adverse consequences of thermal aging on SBR-modified bitumen binder (SB) while preserving the binder's original performance characteristics. However, few studies have been conducted to further investigate the rheological properties and aging resistance of SB modified with Sasobit/WCO compounds.

Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling.

Psoriasis is a chronic inflammatory skin disease that affects millions of people worldwide. Sulforaphane (SFN) has been shown to have anti-inflammatory and antioxidant properties. In this study, we investigated the effects of SFN on a mouse model of psoriasis induced by imiquimod (IMQ) and its underlying molecular mechanism.

Comprehensive Analysis on Prognostic Signature Based on T Cell-Mediated Tumor Killing Related Genes in Gastric Cancer.

Although immunotherapy is a valuable treatment for gastric cancer (GC), identifying the patients who would benefit most from this approach presents a challenge. In this study, GC patients were divided into two subtypes by consensus clustering according to T cell-mediated tumor killing related genes (TTKRGs), and there were significant differences in tumor-infiltrating immune cells, signaling pathways, and gene expression of immunomodulators and inhibitory immune checkpoints between the two subtypes. Then, we developed an individualized signature based on TTKRGs, and its clinical and predictive value in GC patients for chemotherapeutic and immunotherapeutic responses was assessed.

SSAGCN: Social Soft Attention Graph Convolution Network for Pedestrian Trajectory Prediction.

Pedestrian trajectory prediction is an important technique of autonomous driving. In order to accurately predict the reasonable future trajectory of pedestrians, it is inevitable to consider social interactions among pedestrians and the influence of surrounding scene simultaneously, which can fully represent the complex behavior information and ensure the rationality of predicted trajectories obeyed realistic rules. In this article, we propose one new prediction model named social soft attention graph convolution network (SSAGCN), which aims to simultaneously handle social interactions among pedestrians and scene interactions between pedestrians and environments.

The Synergistic Effect of Polyphosphates Acid and Different Compounds of Waste Cooking Oil on Conventional and Rheological Properties of Modified Bitumen.

In order to conserve non-renewable natural resources, waste cooking oil (WCO) in bitumen can help lower CO emissions and advance the environmental economy. In this study, three different components of WCO were isolated and then, together with polyphosphoric acid (PPA), used separately as bitumen modifiers to determine the suitability of various substances in WCO with PPA. Conventional tests, including penetration, softening point temperature, and ductility, and the dynamic shear rheology (DSR) test, including temperature sweep and frequency sweep, were used to evaluate the influence of WCO/PPA on the traditional performance and rheological properties at high and low temperatures.

The therapeutic role of Jingchuan tablet on ischaemic cerebral stroke via the HIF-1α/EPO/VEGFA signalling pathway.

Context: Jingchuan tablet (JCT) is a Chinese medicine prescription for treating ischaemic cerebral stroke (ICS). However, its relevant mechanisms remain unclear.

Objective: To unravel the intrinsic mechanisms of JCT anti-ICS.

Acupuncture Combined with Traditional Chinese Medicine and Drug Therapy for the Treatment of Cerebral Infarction (Phlegm-Blood Stasis Syndrome) and Carotid Atherosclerotic Plaque: A Preliminary Randomized Controlled Study.

Carotid atherosclerotic plaque (CAP) is one of the leading causes of cerebral infarction. Western medicine usually uses lipid-lowering drugs to stabilize plaques. Currently, studies reporting on drugs that can reduce plaques are lacking.

[The allozyme analysis of the genetic differentiation in self-inbred early generations of Lilium formolongi Hort].

The genetic diversity and differentiation of Lilium formolongi Hort. lines in self-inbred early generations were studied by allozyme electrophoresis. The results showed that mean allele number/locus, percentage of polymorphic loci, average observed heterozygosity and average expected heterozygosity were decreased with the increment of self-inbred generations.