Phytochemical Profiling, Antioxidant Capacity, and α-Amylase/α-Glucosidase Inhibitory Effects of 29 Faba Bean ( L.) Varieties from China.

Faba bean ( L.), a nutrient-rich legume beneficial to human health, is valued for its high L-3,4-dihydroxyphenylalanine (L-DOPA) and phenolic content. This study investigated phytochemical diversity and bioactivity across 29 Chinese faba bean varieties.

Study on regional disparities and influencing factors of public health service supply in China from the perspective of fairness.

Background: The public health service supply level is an essential factor affecting public health, and fairness is vital in distributing public health services. The spatiotemporal differences in public health services have attracted academic attention. However, few studies have systematically analyzed regional disparities and their influencing factors from a fair perspective.

Network Pharmacology and Experimental Validation Identify Paeoniflorin as a Novel SRC-Targeted Therapy for Castration-Resistant Prostate Cancer.

Despite advances in prostate cancer treatment, castration-resistant prostate cancer (CRPC) remains clinically challenging due to inherent therapy resistance and a lack of durable alternatives. Although traditional Chinese medicine offers untapped potential, the therapeutic role of paeoniflorin (Pae), a bioactive compound derived from Paeonia lactiflora, in prostate cancer has yet to be investigated. Using an integrative approach (network pharmacology, molecular docking, and experimental validation), we identified Pae key targets, constructed protein-protein interaction networks, and performed GO/KEGG pathway analyses.

Study on the Influence of Aging Temperature on the Microstructure and Properties of Ti-38644 Metastable β-Type Titanium Alloy.

This article investigates the precipitation behavior of the phases in metastable β-type titanium alloys (Ti-38644) and their significant impact on the mechanical properties. By manipulating various solid solution aging parameters, the morphology, quantity, and distribution of the αs phase can be optimized. After one hour of solid solution treatment at 760 °C, the alloy is predominantly composed of the β phase, with a higher concentration of aluminum at the grain boundaries compared to the interior of the grains.

GLM7 - A Novel Composite Glycolipid Index Derived from Routine Health Indicators for Enhanced Diagnosis and Prediction of Multimorbidity.

Routine health examinations for healthy adults typically involve measurements such as height, weight, blood biochemistry, complete blood count, and urinalysis. However, the current scope of physical examinations has expanded to include numerous tests, some of which have questionable insight into underlying pathology. In this study, we analyzed 26,289 samples from the NHANES (National Health and Nutrition Examination Survey) database, along with 49 included indicators, to systematically explore the correlation between conventional indicators and various diseases.

Psychological crisis and emergency response in public health emergencies: a case study of the Mpox epidemic.

Background: The frequent occurrence of social infectious diseases not only threatens the lives and health of the public but also brings about a more serious psychological crisis for the public. Understanding the public's psychological reactions during public health emergencies is crucial to developing an effective crisis management strategy.

Methods: This study focuses on the monkeypox epidemic and uses Python to crawl the topic data on monkeypox on Weibo.

Investigation of an Injectable Concentrated Growth Factor Gel for Pulp Tissue Regeneration.

Cell homing and stem cell transplantation offers promising approaches for pulp regeneration. This study investigated the efficacy of an injectable concentrated growth factor gel for dental pulp regeneration in beagles. Six groups of beagle teeth were studied: Blank control group, CGF group, Collagen sponge group, CGF + Collagen sponge group, Dental pulp stem cells group, CGF + Dental pulp stem cells group.

Bibliometric Analysis of Exosome Research in Spinal Cord Injury (2000-May 2024). Trends, Collaborations, and Emerging Insights.

Purpose: Exosomes have emerged as promising therapeutic agents for spinal cord injury (SCI). The present study was conducted to provide a systematic bibliometric analysis of research trends related to SCI and exosomes.

Patients And Methods: Publications on exosomes in SCI were identified from the Web of Science Core Collection using specific search criteria.

Regulation of metal valence states for enhancing second harmonic generation performance of chiral tin halides.

Chiral metal halide perovskites (MHPs) possess an inherent noncentrosymmetric structure, offering a promising platform for the development of second-order nonlinear optical (NLO) materials. Recent research has emphasized the influence of metal valence states on the physical and chemical properties of perovskites. In this work, a series of novel chiral tin-based MHPs were constructed by adjusting the metal valence states, thereby tuning the second-order NLO performance.

Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease.

The immunological synapse (IS) serves as the fundamental architectural framework for direct interactions and secretory crosstalk between immune cells, as well as between immune cells and other cells. Its dysregulation is thought to be a key underlying cause of immune evasion or inflammation observed in various diseases, including tumors and infections. Numerous recent studies have addressed key signaling mechanisms and reported novel targets related to IS, further broadening our understanding of its function and regulatory factors.

E7 peptide and magnesium oxide-functionalized coaxial fibre membranes enhance the recruitment of bone marrow mesenchymal stem cells and promote bone regeneration.

Background: The repair of bone defects remains a significant clinical challenge. Although magnesium (Mg)-based biomimetic scaffolds are widely utilized for bone defect repair, the release of Mg²⁺ ions often leads to an alkaline microenvironment, thereby adversely affecting bone regeneration. Regenerative medicine strategies that leverage the recruitment of endogenous bone marrow mesenchymal stem cells (BMSCs) offer a novel approach to treating bone defects.

Modeling urban land surface dynamics using Arizona single-layer urban canopy model in Python (ASLUM-Py).

Urban ecosystems are increasingly challenged by numerous environmental issues in the face of global climate change. The efficacy of sustainable urban planning strategies depends largely on the capability of resolving urban land surface dynamics. In this study, we developed a state-of-the-art urban land surface model, viz.

The role of mitochondrial dysfunction in diabetes-associated cognitive dysfunction: A bibliometric analysis.

BackgroundDiabetes, a prevalent chronic disorder, is frequently complicated by diabetes-associated cognitive dysfunction (DACD). The impact of diabetes on specific cerebral regions accelerates the progression from mild cognitive impairment to Alzheimer's disease. Research has indicated that mitochondrial dysfunction is a pivotal factor in DACD, yet its underlying mechanisms remain elusive.

Integrated Omics and Multi-Cohort Analyses Identify an Enhancer Variant Linking Ferroptosis to Precision Therapy in Prostate Cancer.

Prostate cancer is the most prevalent cancer among men worldwide and exhibits significant genetic heritability. In this study, we performed an integrative analysis combining chromatin accessibility profiling, transcriptomics, and two-stage case-control studies, alongside an unbiased phenome-wide exploration in the FinnGen cohort. This comprehensive approach identified the enhancer-associated single-nucleotide polymorphism rs7077830 at chromosome 10q11 as a critical modulator of prostate cancer susceptibility.

Machine learning differentiation of abdominal IgA vasculitis without purpura from appendicitis.

Background: Abdominal IgA vasculitis without purpura (IgAVNP) shares clinical manifestations with acute uncomplicated appendicitis (AUA), and traditional diagnostic methods have limitations. Therefore, more accurate diagnostic tools are needed for differentiation.

Methods: A retrospective analysis was conducted on 702 children aged 2-14 years who were diagnosed between 2011 and 2020.

Research progress on mesenchymal stem cell‑derived exosomes in the treatment of osteoporosis induced by knee osteoarthritis (Review).

Knee osteoarthritis (KOA) and osteoporosis (OP) are closely related, age‑related, degenerative orthopedic conditions. Elderly patients with OP frequently develop concurrent KOA, with high co‑occurrence rates. Studies indicate that OP significantly increases KOA risk and that these conditions mutually exacerbate each other.

Effects of exercise on body fat percentage and cardiorespiratory fitness in sedentary adults: a systematic review and network meta-analysis.

Background: Sedentary behavior is increasingly prevalent worldwide and associated with numerous health concerns including obesity and cardiovascular diseases. This study aimed to evaluate the comparative effectiveness of various exercise interventions on body fat percentage and cardiorespiratory fitness in sedentary adults.

Methods: A systematic review and network meta-analysis of randomized controlled trials was conducted.

GC vitamin D-binding protein gene functional genetic variants and gestational diabetes mellitus risk and prediction.

Gestational diabetes mellitus (GDM) is a pregnancy-complicated disease that poses risks to maternal and infant health. However, its etiology has not yet been elucidated. This study investigated the associations between functional genetic variants of the GC vitamin D-binding protein (GC) gene and the risk of GDM.

Chop Deficiency Exacerbates Cyclophosphamide-Induced Overactive Bladder via Impaired Macrophage Apoptosis.

Objective: Overactive bladder, a storage syndrome characterized by urinary urgency, frequency, and nocturia with or without urgency urinary incontinence, severely affects the quality of life of patients. The aim of this study was to investigate the role and mechanism of the C/EBP homologous protein in the overactive bladder.

Methods: An overactive bladder mouse model was established via the intraperitoneal injection of cyclophosphamide in wild-type and Chop-deficient mice.

Antioxidant Intervention Against Microplastic Hazards.

Microplastic pollution (<5 mm) poses a serious threat to the environment and human health, inducing cellular stress damage in organisms (especially through oxidative stress). The damage results from excessive reactive oxygen species and impaired defense mechanisms, affecting energy production, organelles, and triggering inflammation. Antioxidants (such as vitamin C, curcumin, and quercetin) reduce stress markers and inflammation by neutralizing harmful molecules, activating protective pathways, and regulating autophagy, providing potential protection.

Microbial strategies on polyhydroxyalkanoates production from food waste to support the circular bioeconomy.

The effective utilization of food waste is beneficial for valuable chemicals production, green development, ecological protection and circular bioeconomy. Biological manufacturing is deemed to be more conducive than chemical processing for the development of circular economy. The food waste bioconversion exhibits great potential to generate polyhydroxyalkanoates and reduce pollution.

Robust Polyp Detection and Diagnosis through Compositional Prompt-Guided Diffusion Models.

Colorectal cancer (CRC) is a significant global health concern, and early detection through screening plays a critical role in reducing mortality. While deep learning models have shown promise in improving polyp detection, classification, and segmentation, their generalization across diverse clinical environments, particularly with out-of-distribution (OOD) data, remains a challenge. Multi-center datasets like PolypGen have been developed to address these issues, but their collection is costly and time-consuming.

A Fully-Integrated 0.068-mm Implantable Pressure Sensing Device with Wireless Energy Harvesting and Data Telemetry.

This paper reports a fully-integrated sub-0.1 mm wireless pressure sensing device for implantable applications. The miniature device integrates a customized system-on-a-chip (SoC) and an off-the-shelf half-bridge piezoresistive pressure transducer, eliminating off-chip passive components.

Analysis of the effects of MIPPO under the anterolateral approach on stress indicators and ankle joint function in patients with open fracture of tibia and fibula.

Background: To compare clinical application value of minimally invasive percutaneous plate osteosynthesis (MIPPO) through anterolateral approach and conventional posterolateral approach, and conduct retrospective analysis of MIPPO surgical methods through different approaches in patients with open tibial and fibular fractures (OTFF), to supply reference for clinical operations.

Methods: A retrospective analysis was implemented on 84 patients with distal OTFF divided into groups according to different approaches for MIPPO surgery. Patients who received MIPPO treatment through anterolateral approach were in observation group ( = 42), and patients who received MIPPO treatment through conventional posterolateral approach were in the control group ( = 42).

DAPK3-Ablation Regulates the AMPK/mTOR-GPX4 Signaling Pathway to Affect Biological Functions of Staphylococcus aureus-Treated Bone Marrow Mesenchymal Stem Cells and Potentially Ameliorate Osteomyelitis.

Staphylococcus aureus (SA)-caused osteomyelitis (OM) is inflammation-related refractory disease that seriously degrades the life quality of human beings. Unfortunately, up until now, the molecular mechanisms of OM progression have not been fully delineated, which hampered the development of treatment strategies for this disease. The present study aimed to resolve this issue and a novel DAPK3/AMPK/mTOR-GPX4 signal pathway was significantly linked to the development of OM.