The long non-coding RNA RSDR protects against acute kidney injury in mice by interacting with hnRNPK to regulate DHODH-mediated ferroptosis.

Acute kidney injury (AKI) is a serious clinical condition whose underlying mechanisms remain unclear. Here we identify a long non-coding RNA, RSDR, as a critical regulator of renal protection in AKI. RSDR interacts with the RNA-binding protein hnRNPK, forming a positive feedback loop that enhances the transcription of DHODH, a key ferroptosis-suppressing gene.

Macrophage Response to Avirulent and Virulent Mycobacterium tuberculosis and Anti-TB Effects of Exosome Treatment.

Tuberculosis (TB) returned as the leading cause of death from a single infectious agent in 2023. Human-macrophages and their secreted exosomes play important roles in combating invading Mycobacterium tuberculosis (Mtb). However, panoramic analysis of the underlying immune mechanism for infected macrophages, package mechanism and anti-TB effect of Mtb treated exosomes remain understood.

Regulation of metal valence states for enhancing second harmonic generation performance of chiral tin halides.

Chiral metal halide perovskites (MHPs) possess an inherent noncentrosymmetric structure, offering a promising platform for the development of second-order nonlinear optical (NLO) materials. Recent research has emphasized the influence of metal valence states on the physical and chemical properties of perovskites. In this work, a series of novel chiral tin-based MHPs were constructed by adjusting the metal valence states, thereby tuning the second-order NLO performance.

Spatiotemporal Evolution of the Prevalence of Depressive Symptoms Among Older Adults - China, 2013-2020.

What Is Already Known About This Topic?: Depression among older adults represents a critical public health challenge in China. While previous research has documented spatial heterogeneity in the prevalence of depressive symptoms among elderly populations across China, the comprehensive spatiotemporal patterns remain inadequately characterized.

What Is Added By This Report?: This study provides the first comprehensive city-level analysis of elderly depressive symptom prevalence in China from 2013 to 2020.

Genetic factors driving the outbreak among children post-COVID-19 in China: a whole genome analysis.

Background: is a leading cause of community-acquired pneumonia in children. Post-COVID-19, a significant resurgence of infections has been observed in China, but whole-genome analyses on the genetic mechanisms driving this resurgence remain limited.

Methods: We performed whole-genome sequencing on 169 isolates from Beijing and Baoding, collected before and after COVID-19.

The role of individual and regional environment factors on levels of a cardiovascular risk predictor in middle-aged and older Chinese adults.

Background: Cardiovascular disease (CVD) remains the leading cause of death in China and worldwide. However, a large proportion of CVD can be prevented by regulating the levels of cardiovascular risk predictors. Despite the contribution of well-established factors to changes in cardiovascular risk predictors, the role of the regional environment and its combined effects with individual factors, which could affect health outcomes, remain unclear.

Inverted Chiroptical Properties of Hybrid Metal Halides Through Reversible Chiral Induction Driven by External and Internal Chirality Transfer.

Chiral organic-inorganic hybrid metal halides (OIHMHs) are commonly constructed by introducing pairs of enantiomorphic chiral precursors through a single chirality transfer pathway, which may limit the regulation of chiral structural diversity and chiroptoelectronic properties. Herein, we propose a new strategy for achieving reversible chiral induction of OIHMHs with inverted chiroptical properties through external and internal chirality transfer pathways, by utilizing a single chiral reagent R-/S-α-methylbenzylamine (R-/S-MBA). Specifically, R-MBA can externally induce chiral enrichment of M-DMA(BiInSb)Cl (M-DMA(Bi-In-Sb)Cl, DMA = dimethylammonium cation) without integrating into structure.

Gut microbiota's role in the enhancement of type 2 diabetes treatment by a traditional Chinese herbal formula compared to metformin.

Type 2 diabetes mellitus (T2DM) is a rapidly increasing metabolic disorder that poses a significant threat to global public health. Recent evidence suggests that targeting the gut microbiota through dietary and pharmaceutical interventions can effectively manage T2DM. In this study, we developed a novel Chinese herbal formula, CCM, specifically for T2DM, composed of , , and .

Association between long-term ambient air pollution exposure and the incidence of breast cancer: A meta-analysis based on updated evidence.

Background: Air pollution is a significant risk factor for breast cancer. However, epidemiological studies have yielded inconsistent results. Previous systematic reviews and meta-analyses have identified an association between nitrogen dioxide (NO) exposure and the incidence of breast cancer, yet no consistent association has been observed for particulate matter (PM).

Chiral Bimetallic Cuprous-Lead Hybrid Iodide Single Crystals toward Occurrence of Second Harmonic Generation.

Hybrid bimetallic halides with two different optical activities have exhibited excellent optical properties, which demonstrates great potential in the optoelectronic fields. To develop hybrid cuprous-lead bimetallic halides with unique non-centrosymmetric structures, we introduced the chiral cations /-2-CHN (CHN = methylpiperazinium) into inorganic frameworks containing two different heterometallic cuprous and lead cations, respectively, and successfully obtained the novel chiral hybrid bimetallic halides of (/-2-CHN)CuPbI single crystals by the hydrothermal method. Bimetallic anionic [CuPbI] framework structures were constructed from two different [PbI] and two different [CuI] twisted polyhedra, and band gap calculations were demonstrated.

BMAL1 alleviates sepsis-induced AKI by inhibiting ferroptosis.

Background: The role of BMAL1 in various diseases remains unclear, particularly its impact on sepsis-induced acute kidney injury (AKI). This study aims to investigate the role of BMAL1 in sepsis-induced AKI and its potential effects on cell ferroptosis. Initially, we assessed BMAL1 expression levels in mice treated with sepsis-induced AKI (via LPS injection) and in LPS-stimulated renal tubular epithelial cells.

MTA2 knockdown suppresses human osteosarcoma metastasis by inhibiting uPA expression.

The relationship between metastasis-associated protein 2 (MTA2) overexpression and tumor growth and metastasis has been extensively studied in a variety of tumor cells but not in human osteosarcoma cells. This study aims to elucidate the clinical significance, underlying molecular mechanisms, and biological functions of MTA2 in human osteosarcoma and . Our results show that MTA2 was elevated in osteosarcoma cell lines and osteosarcoma tissues and was associated with tumor stage and overall survival of osteosarcoma patients.

Cholesterol Metabolism and Urinary System Tumors.

Cancers of the urinary system account for 13.1% of new cancer cases and 7.9% of cancer-related deaths.

Distribution of scoliosis in 2.22 million adolescents in mainland China: A population-wide analysis.

Background: The characteristics of scoliosis afflicting school children and adolescents in mainland China are still unclear. Therefore, we conducted a systematic review to estimate scoliosis's prevalence and characterise its distribution in China.

Methods: We screened PubMed, Scopus, WanFang, China National Knowledge Infrastructure, National Science and Technology Library, and WeiPu databases for mainland China articles published between 1 January 1980 and 31 October 2022.

NPRL2 is required for proliferation of oncogenic Ras-transformed bronchial epithelial cells.

Nitrogen permease regulator-like 2 (NPRL2/TUSC4) is known to exert both tumor-suppressing and oncogenic effects in different types of cancers, suggesting that its actions are context dependent. Here, we delineated the molecular and functional effects of NPRL2 in malignantly transformed bronchial epithelial cells. To do so, we depleted NPRL2 in oncogenic HRas-transduced and malignantly transformed human bronchial epithelial (BEAS2B), Ras-AI-T2 cells.

Exosomes on the development and progression of renal fibrosis.

Renal fibrosis is a prevalent pathological alteration that occurs throughout the progression of primary and secondary renal disorders towards end-stage renal disease. As a complex and irreversible pathophysiological phenomenon, it includes a sequence of intricate regulatory processes at the molecular and cellular levels. Exosomes are a distinct category of extracellular vesicles that play a crucial role in facilitating intercellular communication.

Asiatic acid inhibits osteosarcoma cell migration and invasion via the AKT/Sp1/MMP1 axis.

Osteosarcoma is a malignant bone tumor affecting adolescents and children. No effective treatment is currently available. Asiatic acid (AA), a triterpenoid compound found in Centella asiatica, possesses anti-tumor, anti-inflammatory, and anti-oxidant properties in various types of tumor cells.

Comprehensive analysis indicated that NDE1 is a potential biomarker for pan-cancer and promotes bladder cancer progression.

Background: The nuclear distribution E homologue 1 (NDE1) is a crucial dynein binding partner. The NDE1 protein has the potential to disrupt the normal functioning of centrosomes, leading to a compromised ability to generate spindles and ensure precise separation of chromosomes during cell division. The potential consequences of this phenomenon include genomic instability, malignant transformation and the proliferation of neoplastic growths.

Copper-cobalt dual-site on N-doped carbon nanotube with dual-promoted synergy for glucose electrochemical detection.

Doping specific active sites and accelerating the decisive step of glucose catalysis to construct highly active glucose sensing electrochemical catalysts remains a major challenge for glucose sensing. Herein, we report the detailed design of Cu-Co dual active site N-doped carbon nanotube (CuCo-NCNTs) obtained by electrodeposition modification, programmed warming and calcination for electrochemical glucose detection. In the CuCo-NCNTs material system, Cu serves as the main active site for glucose sensing.

PRMT5 and CDK4/6 inhibition result in distinctive patterns of alternative splicing in melanoma.

Drugs targeting cyclin-dependent kinases 4 and 6 (CDK4/6) are promising new treatments for melanoma and other solid malignancies. In studies on CDK4/6 inhibitor resistance, protein arginine methyltransferase 5 (PRMT5) regulation of alternative splicing was shown to be an important downstream component of the CDK4/6 pathway. However, the full effects of inhibition of CDK4/6 on splicing events in melanoma and the extent to which they are dependent on PRMT5 has not been established.

Proteomic analyses of smear-positive/negative tuberculosis patients uncover differential antigen-presenting cell activation and lipid metabolism.

Background: Tuberculosis (TB) remains a major global health concern, ranking as the second most lethal infectious disease following COVID-19. Smear-Negative Pulmonary Tuberculosis (SNPT) and Smear-Positive Pulmonary Tuberculosis (SPPT) are two common types of pulmonary tuberculosis characterized by distinct bacterial loads. To date, the precise molecular mechanisms underlying the differences between SNPT and SPPT patients remain unclear.