A novel intelligent portable photoelectrochemical sensor based on CuCoO@ZnInS nanocomposites and smartphone for the sensitive detection of dopamine.

In this study, a portable photoelectrochemical diagnostic platform based on CuCoO@ZnInS nanocomposites and a smartphone was developed to detect dopamine (DA). CuCoO@ZnInS heterojunction was prepared by a simple one-pot method, and it was found that CuCoO@ZnInS showed significant photoelectrochemical (PEC) activity. DA acts as an electron donor and interacts with the composites.

Synthesis, anti-tumor evaluation, and mechanistic investigation of 3-indolylpyrazole phenoxyacetamide derivatives against chronic myeloid leukemia cells.

Both indole and phenol structures are important active components of drug structure. In this study, a series of novel 3-indole pyrazole derivatives incorporating phenolic moieties were rationally designed and synthesized through molecular hybridization strategy. A comprehensive evaluation of antitumor activity demonstrated that these target compounds exhibited remarkable cytotoxicity across four distinct cancer cell lines.

Investigation of the DNA Methylation-Modified 8-17 DNAzyme Functions via Sensitive Catalytic Hairpin Self-Assembly Reaction.

8-17 DNAzyme is a well-known versatile nucleic acid tool for achieving a specific cleavage function, and thus, investigation of 8-17 DNAzyme functions can prove to be of great significance. The conventional epigenetic modification on DNAzyme may pave a new way for the study of catalytic properties. Herein, the most abundant and best characterized modifications 5-methylcytosine (5mC) and -methyladenosine (m6A) are introduced into the central catalytic core and stem sequence of 8-17 DNAzyme to evaluate the cleavage activity.

Fluorescence detection of phenylethylamine based on Cucurbit[7]uril supramolecular assemblies.

Background: Phenethylamine (PEA) is a novel psychoactive substance that can cause agitation and hallucinations, posing a threat to human health. In this study, a N1@Q[7] supramolecular assembly with a robust fluorescent probe effect was prepared through the supramolecular self-assembly of cucurbit[7]uril (Q[7]) and a bromophenylpyridine derivative (N1).

Results: In this supramolecular assembly, the isoquinoline moiety of N1 entered the cavity of Q[7], while the 4,4-bromophenylpyridyl moiety remained outside, forming a 1:1 inclusion complex.

Design, synthesis and evaluation of antibacterial activity and mechanism of novel 1-H-indole-3-pyrazolamide derivatives.

Background: Xanthomonas oryzae pv. oryzae (Xoo) is widely acknowledged as a highly destructive bacterial pathogen responsible for bacterial leaf blight (BLB), leading to substantial yield and economic losses in rice cultivation. This study involved the synthesis of 21 novel structural derivatives of 1-H-indole-3-pyrazole-mercaptoacetamide, followed by the assessment of their antibacterial properties.

Synthesis and antitumor activity of a novel class of covalent inhibitors of EGFR with 2-indolone backbone.

The percentage of people with lung cancer remains high. Given that the majority of NSCLC patients are currently on third-generation clinical agents, the search for a class of highly effective and low-toxicity inhibitors is critical. Hence, in the present study, 24 compounds were synthesized by scaffold hopping with 2-indolone as the parent nucleus.

Label-Free and Sequence-Independent Isothermal Amplification Strategy for the Simultaneous Detection of Genomic 5-Methylcytosine and 5-Hydroxymethylcytosine.

5-Methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are crucial epigenetic modifications in eukaryotic genomic DNA that regulate gene expression and are associated with the occurrence of various cancers. Here, we combined bisulfite conversion with 4-acetamido-2,2,6,6-tetramethyl-1-oxopiperridinium tetrafluoroborate (ACTBF, TCI) oxidation to develop a label-free and sequence-independent isothermal amplification (BTIA) assay for a genome-wide 5mC and 5hmC analysis. The BTIA strategy can distinguish 5mC and 5hmC signatures from other bases with high sensitivity and good specificity, avoiding sophisticated chemical modifications and expensive protein labeling.

16S rRNA sequencing-based evaluation of the protective effects of key gut microbiota on inhaled allergen-induced allergic rhinitis.

Introduction: Allergic rhinitis (AR) is a common respiratory disorder influenced by various factors in its pathogenesis. Recent studies have begun to emphasize the significant role of gut microbiota in immune modulation and its potential association with the development of AR. This research aims to characterize the gut microbiota of patients with AR who are sensitized via inhalation, utilizing 16S rRNA sequencing to shed light on the pathogenesis of AR and identify potential therapeutic targets.

Design, synthesis, and in vitro antitumor evaluation of novel benzimidazole acylhydrazone derivatives.

This study focuses on the design, synthesis, and evaluation of benzimidazole derivatives for their anti-tumor activity against A549 and PC-3 cells. Initial screening using the MTT assay identified compound 5m as the most potent inhibitor of A549 cells with an IC of 7.19 μM, which was superior to the positive agents 5-Fluorouracil and Gefitinib.

Synthesis, anticancer evaluation, preliminary mechanism study of novel 1, 2, 3-triazole-piperlongumine derivatives.

Piperlongumine, a natural product from traditional Chinese medicine, shows promising antitumor effects but suffers from high toxicity. In this study, X and Q series Piperlongumine derivatives containing 1, 2, 3-triazole were designed and synthesized using the principle of molecular hybridization. The antitumor activity of these target compounds was evaluated, revealing significant activity compared to piperlongumine across four cancer cell lines.

Chiral Bimetallic Cuprous-Lead Hybrid Iodide Single Crystals toward Occurrence of Second Harmonic Generation.

Hybrid bimetallic halides with two different optical activities have exhibited excellent optical properties, which demonstrates great potential in the optoelectronic fields. To develop hybrid cuprous-lead bimetallic halides with unique non-centrosymmetric structures, we introduced the chiral cations /-2-CHN (CHN = methylpiperazinium) into inorganic frameworks containing two different heterometallic cuprous and lead cations, respectively, and successfully obtained the novel chiral hybrid bimetallic halides of (/-2-CHN)CuPbI single crystals by the hydrothermal method. Bimetallic anionic [CuPbI] framework structures were constructed from two different [PbI] and two different [CuI] twisted polyhedra, and band gap calculations were demonstrated.

Continous-wave and passively Q-switched laser at 1.36 µm of a Nd-doped phosphate fiber with a Yb-doped inner cladding.

All-fiber continuous-wave (CW) and passively Q-switched lasers at 1.36 µm (F→ I) by a Nd-doped double cladding phosphate fiber are demonstrated for the first time, to the best of our knowledge. To suppress the competitive 0.

Design, Synthesis and Biological Activity Evaluation of β-Carboline Derivatives Containing Nitrogen Heterocycles.

A series of β-carboline derivatives containing nitrogen heterocycles were designed and synthesized. All compounds were screened for their antitumor activity against four human tumor cell lines (A549, K562, PC-3, T47D). Notably, compound -(4-(morpholinomethyl)phenyl)-2-((5-(1-(3,4,5-trimethoxyphenyl)-9-pyrido[3,4-b]indol-3-yl)-1,3,4-oxadiazol-2-yl)thio)acetamide () exhibited significant inhibitory activity against PC-3 cells with an IC value of 9.

Photoelectrochemical sensor for nitrite determination based on the etching of BiOCl/ZnCdS.

A rapid photoelectrochemical (PEC) sensor was constructed for nitrite detection in food based on the one-step chemical etching strategy of BiOCl/ZnCdS (BOC/ZCS) nanocomposites by nitrite. BOC/ZCS heterojunction was prepared by a simple coprecipitation method, and it was found that BOC/ZCS showed significant photoelectrochemical (PEC) activity. The results of this study confirmed that the decrease in the photocurrent of the sensor was linked to the etching of ZCS by nitrite under acidic conditions.

Synthesis of novel 4-substituted isatin Schiff base derivatives as potential autophagy inducers and evaluation of their antitumour activity.

Induction of autophagic death in cancer cells is one of the promising strategies for the development of anti-cancer therapeutics. In the present study, we designed and synthesized a series of isatin Schiff base derivatives containing thioether structures. After discovering the highly active target compound H13 (IC = 4.

A Novel Tryptanthrin Derivative D6 Induces Apoptosis and DNA Damage in Non-small-cell Lung Cancer Cells Through Regulating the EGFR Pathway.

Background: Non-small-cell lung cancer is a prevalent malignancy associated with significant morbidity and mortality rates. Tryptanthrin and its derivatives have exhibited potent antitumor activity.

Objective: This study aims to investigate the inhibitory effect of a novel synthesized tryptanthrin derivative D6 on proliferation and the possible mechanism of human non-small cell lung cancer cell lines (A549) .

Single-frequency DBR lasing by integrating FBGs into germanium-free photosensitive highly Yb-doped silica fibers.

Monolithic distributed Bragg reflector (DBR) cavity which directly integrates fiber Bragg gratings (FBGs) into the photosensitive RE-doped fibers is a promising configuration in constructing compact and efficient single frequency fiber lasers (SFFLs). Yet, the doping level of rare-earth (RE) ions has generally to be sacrificed in the classical Ge-photosensitized RE-doped silica fibers because of the dramatic refractive index increase caused by the introduction of Ge. Here, we demonstrate an approach to realize the trade-off between photosensitivity and RE doping concentration.

Nonlinear Optical Effects of Hybrid Antimony(III) Halides Induced by Stereoactive 5s Lone Pairs and Trimethylammonium Cations.

Organic-inorganic hybrid metal halides have unique optical and electronic properties, which are advantageous in the study of nonlinear optical materials. To investigate the effect of stereoactive lone pair electrons and the induction of organic cations on the structure of hybrid antimony(III) halides on nonlinear optics, we synthesize two noncentrosymmetric hybrid antimony(III)-based halide single crystals (TMA)SbX (TMA = NH(CH), X = Cl, Br) by a room-temperature slow evaporation method, and their single-crystal structures, phase transition, X-ray photoelectron spectroscopy, and energy-band structure calculations are studied. More importantly, second-harmonic generation results of (TMA)SbX (X = Cl, Br) are about 0.

Design, synthesis, antibacterial evaluation of isopropylamine linked with different substituted phenol and piperazine novel derivatives.

Background: Xanthomonas oryzae pv. oryzae (Xoo) is often considered one of the most destructive bacterial pathogens causing bacterial leaf blight (BLB), resulting in significant yield and cost losses in rice. In this study, a series of novel derivatives containing the isopropanolamine moiety linked to various substituted phenols and piperazines were designed, synthesized and screened.

Theoretical and experimental investigation of Al ion-suppressed phase-separation structures in rare-earth-doped high-phosphorus silica glasses.

Rare-earth-doped silica-based composite glasses (Re-SCGs) are widely used as high-quality laser gain media in defense, aerospace, energy, power, and medical applications. The variable regional chemical environments of Re-SCGs can induce new photoluminescence properties of rare-earth ions but can cause the selective aggregation of rare-earth ions, limiting the application of Re-SCGs in the field of high-power lasers. Here, topological engineering is proposed to adjust the degree of cross-linking of phase-separation network chains in Re-SCGs.

Discovery of tryptanthrin analogues bearing F and piperazine moieties as novel phytopathogenic antibacterial and antiviral agents.

Background: Plant bacterial infections and plant viruses seriously affect the yield and quality of crops. Based on the various activities of tryptanthrin, a series of tryptanthrin analogues bearing F and piperazine moieties were designed, synthesized, and evaluated for their biological activities against three plant bacteria and tobacco mosaic virus (TMV).

Results: Bioassay results indicated that compounds 6a-6l displayed excellent antibacterial activities in vitro and 6a-6c and 6g exhibited better antiviral activities against TMV than commercial ribavirin.

Thermal/Water-Induced Phase Transformation and Photoluminescence of Hybrid Manganese(II)-Based Chloride Single Crystals.

Mn(II)-based hybrid halides have attracted great attention from the optoelectronic fields due to their nontoxicity, special luminescent properties, and structural diversity. Here, two novel organic-inorganic hybrid Mn(II)-based halide single crystals (1-mpip)MnCl·3HO and (1-mpip)MnCl (1-mpip = 1-methylpiperazinium, CHN) were grown by a slow evaporation method in ambient atmosphere. Interestingly, (1-mpip)MnCl single crystals exhibit the green emission with a PL peak at 522 nm and photoluminescence quantum yields (PLQYs) of ≈5.