Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Phenethylamine (PEA) is a novel psychoactive substance that can cause agitation and hallucinations, posing a threat to human health. In this study, a N1@Q[7] supramolecular assembly with a robust fluorescent probe effect was prepared through the supramolecular self-assembly of cucurbit[7]uril (Q[7]) and a bromophenylpyridine derivative (N1).
Results: In this supramolecular assembly, the isoquinoline moiety of N1 entered the cavity of Q[7], while the 4,4-bromophenylpyridyl moiety remained outside, forming a 1:1 inclusion complex. It was found that the addition of other amines did not significantly affect the fluorescence of the assembly, but the addition of PEA caused a notable decrease in fluorescence intensity and a red shift. N1@Q[7] demonstrated sensitive specificity and high selectivity to PEA. The principle is that PEA molecules, N1 molecules, and Q[7] form a synergistic ternary system. Based on this, the detection of PEA in real urine samples by N1@Q[7] was simulated.
Signiffcance And Novelty: The probe exhibited high selectivity in the presence of major components of real urine and enabled visual detection of PEA through fluorescence color change at different concentrations. This study provides a new fluorescent probe method for the detection of drugs and their metabolites.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.aca.2025.344126 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Research progress on calixarene/pillararene-based controlled drug release systems.
Beilstein J Org Chem
September 2025
School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang 421001, China.
Intelligent controlled-release drug delivery systems that are responsive to various external stimuli have garnered significant interest from researchers and have broad applications in the biomedical field. Aromatic macrocycles, including calixarenes and pillararenes, are considered ideal candidates for the construction of supramolecular drug delivery systems because of their simple synthesis, ease of modification, electron-rich and hydrophobic cavities, and highly selective molecular recognition. In recent years, numerous supramolecular drug delivery systems utilizing aromatic macrocycles have been developed.
View Article and Find Full Text PDFCalcification of the elastic component: the impact on the cardiovascular system.
Front Cardiovasc Med
August 2025
Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
In the cardiovascular system, elastic fibres exert a fundamental role providing the long-range elasticity required for physiological functions. Elastic fibres are complex in composition and structure containing, in addition to elastin, a wide range of matrix components, such as microfibrillar proteins, calcium-binding proteins and glycosaminoglycans. Changes in composition and/or structure can affect the biomechanics of the tissue as well as the intrinsic affinity of elastin for Ca ions.
View Article and Find Full Text PDFHarnessing Radical-Based Dynamic Covalent Chemistry and Supramolecular Synthon for Directional Self-Assembly.
J Am Chem Soc
September 2025
State Key Laboratory of Petroleum Molecular & Process Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.
The discovery of new weak supramolecular interactions and supramolecular synthons is essential for directing self-assembly processes with enhanced precision, diversity, and functionality in complex molecular architectures. Here, we report the controlled self-assembly of diverse supramolecular architectures by a new directional bonding approach through the integration of radical-based dynamic covalent chemistry and supramolecular synthons. A novel macrocyclic synthon, , with a linear direction is constructed via radical-based dynamic covalent bonds from the phenothiazine building block substituted with two dicyanomethyl radicals.
View Article and Find Full Text PDFHarnessing Dynamic Heteroleptic Complexation for Self-Assembly of Robust Nested Metallo-Supramolecular Cages.
J Am Chem Soc
September 2025
Department of Chemistry, National Taiwan University, Taipei 106319, Taiwan.
The exclusive formation of artificial multicomponent assemblies remains a significant challenge, in contrast to the well-established organization observed in natural systems, due to intrinsic entropic constraints. To overcome this limitation, recent efforts have been focused on developing precision self-assembly strategies for the rational construction of such architectures. Here, we construct an ideal complementary pair of 2,2':6',2″-terpyridine (tpy)-based ligands by fine-tuning the substituent bulkiness, which enables the quantitative formation of robust nested cages through efficient dynamic heteroleptic complexation with multivalent coordination.
View Article and Find Full Text PDFConcentration-Dependent Nanosheet and Nanotube Networks: Ice-Water Interface Control for Antifreeze Application.
ACS Appl Mater Interfaces
September 2025
Department of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea.
Cyclic peptides (CPs) are versatile building blocks whose conformational constraints foster ordered supramolecular architectures with potential in biomedicine, nanoelectronics, and catalysis. Herein, we report the development of biomimetic antifreeze materials by conjugating CPs bearing ice-binding residues to 4-arm polyethylene glycol (PEG) via click chemistry. The concentration-dependent self-assembly of these CP-PEG conjugates induces programmable morphological transitions, forming nanotube networks above the critical aggregation concentration (CAC) and two-dimensional nanosheet networks near the CAC.
View Article and Find Full Text PDF