Efficacy and safety of cold snare polypectomy for outpatient treatment of sessile polyps smaller than 10mm.

Background: Screening colonoscopy plays a critical role in reducing colorectal cancer incidence by identifying and removing polyps. Simple and safe treatment is the most common request of both doctors and patients. Cold snare polypectomy (CSP) is increasingly favored for polyps < 10 mm, yet concerns remain regarding residual tissue.

Electrostatic correlation free energy for finite polymer chains.

Electrostatic correlation free energy (ECF) is the basis for modeling the thermodynamic behavior of polyelectrolyte solutions. In the past, it has mainly been estimated using the Edwards approximation, valid for infinite chains. Here, we show that the leading contribution due to finite molecular size is of order , regardless of the fractal dimension , where is proportional to molecular weight.

COL10A1 fibroblasts promote colorectal cancer metastasis and M2 macrophage polarization with pan-cancer relevance.

Background: Colorectal cancer (CRC) is a common gastrointestinal cancer with poor response to therapy and high metastatic risk. Cancer-associated fibroblasts (CAFs) support tumor progression, but their functional heterogeneity remains poorly understood.

Methods: We integrated multi-omics data from 10,164 samples, including single-cell, bulk, spatial transcriptomics, and proteomics, to identify and characterize CAF subpopulations.

A comparison of repeated low-level red light and low-dose atropine for myopia control: A two-year retrospective study.

Purpose: To compare the long-term efficacy between repeated low-level red light (RLRL) therapy and low-dose atropine (LDA) eye drops for myopia control.

Methods: Treatment naïve myopic children receiving RLRL or LDA therapy were retrospectively included. The spherical equivalent (SE) and axial length (AL) were evaluated at baseline and 6-, 12-, and 24-month follow-up.

A multidimensional epidemiological perspective on frailty dynamics and prevention.

Frailty, characterized by reduced resilience and increased vulnerability, is a growing public health concern in aging populations. It is increasingly recognized as a dynamic and potentially reversible condition, with transitions between non-frail, pre-frail, and frail states. Recent research has advanced our understanding of frailty through improved multidimensional assessment instruments, trajectories and transitions, and recognition of key risk factors.

Video Segmentation of Wire + Arc Additive Manufacturing (WAAM) Using Visual Large Model.

Process control and quality assurance of wire + arc additive manufacturing (WAAM) and automated welding rely heavily on in-process monitoring videos to quantify variables such as melt pool geometry, location and size of droplet transfer, arc characteristics, etc. To enable feedback control based upon this information, an automatic and robust segmentation method for monitoring of videos and images is required. However, video segmentation in WAAM and welding is challenging due to constantly fluctuating arc brightness, which varies with deposition and welding configurations.

The antitumor effects of lupenone on colon cancer and its mechanistic insights.

Background: Lupenone, a natural constituent derived from medicinal plants and fruits, is classified as a lupane-type triterpenoid and is known for its diverse biological activities, including anti-diabetic, anti-cancer, and anti-inflammatory effects. However, the specific impact of lupenone on colon cancer has not been fully elucidated.

Purpose: The purpose of this research was to explore the anti-cancer effects of lupenone monotherapy and in combination with chemotherapy agents in colon cancer.

Predicting Thoracolumbar Vertebral Osteoporotic Fractures: Value Assessment of Chest CT-Based Machine Learning.

Rationale And Objectives: To assess the value of a chest CT-based machine learning model in predicting osteoporotic vertebral fractures (OVFs) of the thoracolumbar vertebral bodies.

Materials And Methods: We monitored 8910 patients aged ≥50 who underwent chest CT (2021-2024), identifying 54 incident OVFs cases. Using propensity score matching, 108 controls were selected.

Liquid-liquid phase separation: an emerging perspective on the tumorigenesis, progression, and treatment of tumors.

Research in the field of Liquid-liquid phase separation (LLPS) breaks through the classical theory of gene mutation in the mechanism of tumorigenesis and provides a new perspective for comprehending tumors from a network regulation standpoint. Although there have been some reviews discussing the relationship between LLPS and tumors, they often focus on elaborating isolated mechanisms. In the face of complex and diverse disease characteristics, it is necessary to summarize the correlation between LLPS and tumors through a linked and holistic approach to reveal the deep-rooted relationships among tumor disease mechanisms.

Association between serum osmolality and chronic kidney disease prevalence: Evidence from NHANES 1999-2018.

Background: Chronic kidney disease (CKD) is a significant global public health issue, and early identification of risk factors is critical for prevention and intervention. In recent years, serum osmolality has attracted attention as a potential biomarker; however, its association with CKD remains insufficiently understood.

Methods: This study analyzed data from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2018, including 49,008 participants.

Stem cell-based therapeutic strategies for liver aging.

Aging is characterized by a gradual deterioration of the physiological integrity of cells, tissues, and organs, resulting in a decrease in the body's physiological functions and an acceleration of the onset of age-related diseases, ultimately leading to death. The aging of the liver, which is a critical metabolic organ, is closely linked to various chronic liver diseases, such as hepatitis, liver fibrosis, and cirrhosis, and it exacerbates their prognosis and is a primary risk factor for their development at all stages. Therefore, a comprehensive understanding of the causes, mechanisms, and potential therapeutic targets associated with liver aging holds significant clinical importance for delaying or potentially reversing liver aging and for treating chronic liver diseases.

Fine mapping and characterization of Fusarium wilt ( f. sp. ) resistance gene in wax gourd ( Cogn.).

Fusarium wilt (FW), caused by the plant fungus , causes severe economic losses in wax gourd ( Cogn.). Developing disease-resistant varieties is an effective measure.

Compatibility Issues in Organics Electrode and Effective Prelithiation-Enabled SiC/Polyimide Full Cells.

Organic electrode materials are a continuous research hotspot due to their diverse redox mechanisms, flexible application, and well-documented advantages in electrochemical performance. However, the reliable counter electrode is always the biggest obstacle in the way of their practical application, and the compatibility preference of organics adds more difficulty in the full cell fabrication. These issues are mostly obscured in experimental studies where highly excessive metal anode is usually employed.

Knockdown of OPTN modulates miRNA-125b-5p expression via NF-κB pathways in amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease characterized by severe dysfunction in upper and lower motor neurons. Previous studies have reported that the optineurin gene (OPTN) downregulation is one of the causative genetic factors for ALS, leading to the dysfunction of optineurin (OPTN), a multifunctional protein implicated in several cellular processes. Herein, we found that conditional knockout of the Optn gene in mouse microglia leads to activation of microglia.

Resting-State Functional MRI Reveals Altered Seed-Based Connectivity in Diabetic Osteoporosis Patients.

Background: Diabetic osteoporosis (DOP) can cause abnormal brain neural activity, but its mechanism is still unclear. This study aims to further explore the abnormal functional connectivity between different brain regions based on the team's previous research.

Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data were obtained from 14 participants diagnosed with type 2 diabetes mellitus (T2DM) and osteoporosis.

Multifunctional interface engineering enables efficient and stable inverted organic photovoltaics.

Compared to conventional (p-i-n) organic photovoltaics (OPVs), inverted (n-i-p) OPVs hold promise for future commercial applications due to their advantages in printing process compatibility and environment robustness. The current bottleneck lies in the efficiency and light stability, which is closely related to the defects and the photocatalytic reactivity of metal oxides transport layer. This comment summarizes the recent progress on inverted OPV and outlines potential solutions to surmount the hurdles before the technology can be put into production.

Study on the correlation between abnormal bone metabolism and cognitive impairment in type 2 diabetes mellitus.

Introduction: Type 2 diabetes mellitus (T2DM) is often accompanied by bone metabolic disorders and cognitive impairment, forming an interactive network through metabolic derangements, oxidative stress, and inflammatory responses. Hyperglycemia and insulin resistance disrupt bone remodeling leading to osteoporosis while simultaneously impairing cognition via blood-brain barrier damage and neuroinflammation. Osteogenic factors like osteocalcin may bidirectionally regulate glucose metabolism and brain function, suggesting that "bone-brain axis" dysregulation could be a potential mechanism underlying cognitive impairment in T2DM.

Computational analysis of DEHP's oncogenic role in colorectal cancer.

Background: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality globally, with many patients diagnosed at advanced stages. Current treatments, including surgery, chemotherapy, and targeted therapies, face limitations due to tumor metastasis and chemoresistance. Di-(2-ethylhexyl) phthalate (DEHP), a widely-used plasticizer, has been linked to various cancers, including CRC, through mechanisms such as metabolic reprogramming and inflammation.

Induction of feline fetal fibroblasts into pluripotent stem cells using cat-derived reprogramming factors.

There are few studies on the establishment of induced pluripotent stem cells (iPSCs) in cats. Although induction using heterologous reprogramming factors delivered via viral vectors has been reported, its safety and reprogramming efficiency still require improvement. In addition, the reprogramming mechanism needs further elucidation.

Association of multi-metal exposure with hyperuricemia in middle-aged and older adults: A cross-sectional study in rural Guangxi, China.

Background: Hyperuricemia constitutes a significant global public health concern, particularly among the elderly, and is associated with environmental factors such as metal exposure. In China, the predominant focus of existing research has been on urban populations, which leaves the relationship between hyperuricemia and ecological exposures in rural populations inadequately explored. This study investigates the association between hyperuricemia and exposure to multiple metals among elderly residents in rural China.

Air Pollution Control Mitigates Frailty Progression: Evidence from Two Cohorts of Older Adults and DNA Methylation Insights.

Frailty is an underappreciated but modifiable clinical syndrome, but little about how air quality improvements could influence frailty progression is known. Here, we utilized two Chinese cohorts with repeated follow-up visits to address this knowledge gap and explored the underlying DNA methylation mechanisms. We first conducted a multistate modeling analysis in the Chinese Longitudinal Healthy Longevity Study (CLHLS), a nationwide cohort with 21,654 older adults who had participated in at least two survey waves.

[Grounded theory, scientific connotation, and clinical application of aromatic immunity in traditional Chinese medicine].

Aromatic immunity in traditional Chinese medicine(TCM) is the medical knowledge accumulated in the process of people's struggling with diseases. It plays an important role in plague prevention, disease treatment, health preservation, and rehabilitation, and has profound TCM basic theoretical support and abundant modern scientific evidence. With the in-depth promotion of the Healthy China initiative and the succession of health needs in the post-COVID-19 era, how to practice the health concept of aromatic immunity in TCM and develop its health service resources with high quality has become an important proposition to be discussed urgently.

Advances in BRAF mutated colorectal cancer-could deoxycholic acid be the culprit?

BRAF mutated colorectal cancer (CRC) often demonstrates distinct molecular profiles characterized by a high methylator phenotype with two different microsatellite statuses (MSI and MSS) and corresponding methylation spectra. Prognostic disparities between these two different BRAF mutated CRC arise from divergent carcinogenic pathways, with BRAF-mutated MSS CRC exhibiting particularly unfavorable clinical outcomes. The underlying mechanism of these phenomena stems from epigenetic heterogeneity in methylation landscapes.