Connectivity-based localization and mapping of central epilepsy semiology.

Objective: Semiology-based preoperative anatomical hypotheses are necessary, yet comprehensive reports on the semiology and its correlation with central subregions in central epilepsy has still lacked. We wished to identify semiologic subgroups and their correlations with central subregions.

Methods: We retrospectively included 21 patients with central epilepsy identified by stereoelectroencephalography (sEEG).

In Situ Electrochemical Oxidation for High-Energy-Density Aqueous Batteries: Mechanisms, Materials, and Prospects.

To advance the commercial utilization of aqueous electrochemical devices for grid-scale energy storage, it is crucial to address the current limitations related to energy density and cycle stability. Indeed, the lack of high-performance cathodes is still an obstructive issue, not to mention the limited capacities related to the monotonic cation intercalation/deintercalation mechanism. Fortunately, conversion chemistries with redox reactions bring a new dimension, where materials with multiple valence states facilitate multi-electron redox reactions, offering the potential for high-energy-density storage.

Identifying Hub Genes Associated with Sex Disparities in Prolactinomas.

Male patients with prolactinomas exhibit greater invasiveness, resistance to dopamine agonists, making treatment more challenging. This study aims to explore the potential different genes contributing to sex disparities in prolactinomas. Weighted gene co-expression network analysis and differential expressed genes analysis were performed to identify sex-related hub genes.

The link between systemic inflammation and mental disorders: a study on CLR, depression, and anxiety in a US cohort.

Background: Depression and anxiety are significant global health concerns, with systemic inflammation playing a critical role in their pathophysiology. Recent studies have highlighted the C-reactive protein to lymphocyte ratio (CLR) as a potential biomarker of inflammation that may be associated with these mental health conditions. However, the relationship between CLR and depression and anxiety, especially within a diverse population, remains underexplored.

Proportions and trends of global adolescent knowledge and attitudes toward tobacco smoking from 1999 to 2019.

Objective: We aimed to assess the recent levels of knowledge and attitudes toward tobacco smoking among adolescents aged 12-16 years in 2010-2019, and to examine trends from 1999 to 2019.

Methods: We used the most recent data from 145 countries/territories (hereafter "countries") that conducted at least one Global Youth Tobacco Survey (GYTS) between 2010 and 2019 to assess the current levels of knowledge and attitudes toward tobacco smoking among adolescents aged 12-16 years. And 112 countries that conducted at least three GYTS surveys from 1999 to 2019 were used to assess the trends among adolescents aged 12-16 years over time.

Mechanically Adaptive Cathode-Electrolyte Interphase via Dynamic Covalent Chemistry for Long-Life Ni-Rich Lithium Batteries.

High-nickel LiNiCoMnO (NCM83) cathodes suffer from interfacial instability resulting from cathode-electrolyte reactions and anisotropic mechanical strain within secondary particles. Herein, we present a mechanically adaptive cathode-electrolyte interphase (CEI) engineered via a dynamic covalent network that features a supramolecular ion-conducting polyurethane ureido-pyrimidinone (SPU-UPy) elastomer. The dynamic network integrates cooperative hydrogen bonds and disulfide bonds and imparts exceptional mechanical resilience and autonomous self-healing capabilities that allow it to accommodate volume fluctuations without compromising structural integrity.

Effects of harvest maturity coupled with various drying methods on the quality and aroma composition of gray jujube powder.

This study aimed to explore the impact of different harvest maturity stages (white, semi-ripe, and fully ripe) and various drying methods [freeze drying (FD), freeze drying followed by heat pump drying, and FD followed by far-infrared drying (FD-FID)] on the quality and aroma profile of gray jujube powder. The results demonstrated that both the harvest maturity stage and drying methods significantly ( < 0.05) influenced the physical properties, chemical composition, and aroma profile of gray jujube powder.

Epidemiological characteristics of influenza after COVID-19 pandemic in Zhejiang province, China.

Background: To analyse the epidemiological characteristics and variation trend of influenza in Zhejiang Province from 2018 to 2023, so as to provide reference for the prevention and control of influenza after COVID-19 pandemic.

Methods: Throat swab samples of influenza-like illness (ILI) cases from 16 local sentinel hospitals were collected every week, and real-time reverse transcription-polymerase chain reaction (RT-PCR) was used to detect and identify the specific types of influenza viruses. Descriptive epidemiological method was used to analyse the surveillance data from sentinel hospitals and network laboratories.

Effect of V content on high temperature oxidation resistance of S30403 austenitic stainless steel.

In this study, the high-temperature oxidation resistance of six variants of S30403 austenitic stainless steel, differing in V content, was investigated at 700 and 800 °C under air atmosphere using the static discontinuous oxidation weight gain method. The results demonstrate that V exhibits a negative impact on the high-temperature oxidation resistance of austenitic stainless steel at 700 and 800 °C. As the V content in the steel rises, the oxidation rate also tends to elevate, with the highest values recorded at 0.

Immunochromatographic assay for rapid detection of SIGLEC15 to evaluate its therapeutic potential in cervical cancer.

SIGLEC15 is a novel immunosuppressive transmembrane protein promotes cancer development. However, the role of SIGLEC15 in cervical cancer remains poorly understood until now. In this study, we identified that the expression of SIGLEC15 was significantly increased in cervical cancer cells and tissues, and it was closely related to the metastasis of cervical cancer (70.

Calpain-2 facilitates infection of the intracellular bacteria Listeria monocytogenes and invasion intestinal immune barrier by impairing nitric oxide homeostasis.

Introduction: The ubiquitously expressed enzymes, calpain-1 and -2 (CAPN1 and 2) play important roles in a wide variety of physiological and pathological processes including infection and immune responses. CAPN2 is of particular interest due to its role in regulating intracellular bacterial infection and invasion, but the underlying mechanisms remain to be elucidated.

Objectives: In this study, we focused on intestinal CAPN2 involved in infection by the intracellular bacteria Listeria monocytogenes (L.

MDCK cell line expressing H9N2 avian influenza virus NS1 protein promotes replication of the NS1 gene truncation virus.

H9N2 subtype avian influenza virus (AIV) remains a major threat to poultry industry. Our previously developed live-attenuated vaccine candidate rTX-NS1-128(mut) demonstrated promising immunogenicity, but its truncated NS1 gene reduced replication in MDCK cells relative to the parental rTX strain. In this study, we engineered an MDCK derived cell line (2G8D5) to enhance replication of interferon-sensitive AIV candidates.

Accelerometer-derived "weekend warrior" physical activity pattern and cardiovascular disease in individuals with hypertension: a prospective cohort study.

Background: Extensive evidence has demonstrated that physical activity (PA), particularly moderate-to-vigorous intensity PA (MVPA), has protective effects on cardiovascular disease (CVD) in individuals with hypertension. However, the relative effects of different PA patterns in this high-risk population remain unclear. We aimed to evaluate the associations of three PA patterns ("weekend warrior" (WW), regularly active, and inactive) with incident CVD in individuals with hypertension.

Advances in bone organoids research and future perspectives.

Skeletal diseases pose a significant threat to both physical and mental health, emerging as a critical global issue. A thorough understanding of bone physiology and the development of effective clinical interventions necessitate robust research methodologies. Recently, organoids have gained widespread attention as three-dimensionalmodels capable of recapitulating complexenvironments, addressing key limitations of traditional two-dimensional cell cultures and animal models.

An unrecognized mechanism of self-protection in degenerating neurons mediated by astrocytic YAP through Wnts/β-catenin/EAAT2 signaling in C9orf72-poly-GA mice.

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive loss of motor neurons in the central nervous system (CNS). Non-neuronal cells, particularly astrocytes, have been recognized as pivotal contributors to ALS onset and progression. However, the underlying mechanisms of interactions between astrocytes and motor neurons during ALS remain unclear.

Human fecal microbiota transplantation attenuates high dietary oxalate-induced renal calcium oxalate crystal depositions in rats via repairing related gut barrier damage.

Unlabelled: High dietary oxalate (HDOx) diet is a key factor in kidney stone formation, with gut microbiota playing a significant role. Although several studies have indicated that fecal microbiota transplantation from healthy animals can effectively reduce renal calcium oxalate (CaOx) depositions in rats, the gut microbiota composition between human and animal still remains different. This study aims to explore the effect and underlying mechanisms of healthy human-source fecal microbiota transplantation (hFMT) on CaOx crystal depositions, providing new evidence for its potential clinical application in hyperoxaluria and kidney stone treatment.

The mild cognitive impairment window for optimal Alzheimer's disease intervention.

The FDA approval of disease-modifying Alzheimer's disease therapies marks a major shift in treatment but exposes a critical challenge: identifying patients during the mild cognitive impairment (MCI) stage when intervention is most effective. Despite early biological changes, most diagnoses occur after significant decline. Drawing from over 180 stakeholder interviews conducted through the NSF I-Corps program reveal major detection gaps across primary care, specialty access, and available tools.

Cross-species single-cell transcriptomic atlas of retinal photoreceptors reveals molecular signatures underlying color vision adaptation.

The retina exhibits conserved structural and functional features across species, yet the evolutionary mechanisms underlying color vision remain unclear. Here, we employ a single-cell prediction (scPred) model to construct a cross-species single-cell retinal atlas from 24 species. We identify conserved retinal cell types and expression patterns, with photoreceptor cells, especially rods, showing evolutionary shifts.

extracellular vesicle-driven oxygen-releasing photothermal hydrogel reprograms macrophages and promotes angiogenesis to accelerate diabetic wound healing.

Chronic wound healing remains clinically challenging due to insufficient angiogenesis coupled with persistent inflammatory microenvironments. Macrophage M2 polarization plays a pivotal role in resolving inflammation and promoting angiogenesis. Capitalizing on scalability and translational advantages, extracellular vesicles derived from (-EVs) were employed to activate this mechanism.

The role of cyclic di-GMP in biomaterial-associated infections caused by commensal Escherichia coli.

Biofilms are protective structures that bacteria use to evade the immune system and resist antibiotics, leading to complications in medical treatments, especially with implanted devices. The molecule cyclic di-GMP (c-di-GMP) is crucial for biofilm formation in Escherichia coli (E. coli).

Deciphering Closed-Pore Formation and Size-Dependent Sodium Cluster Filling Behavior for Nanopore-Confined Derived Hard Carbon Anodes.

The low-voltage plateau capacity (LVPC) of hard carbon (HC) anodes for sodium-ion batteries originates from sodium cluster filling within closed pores, and closed-pore engineering of activated carbon (AC) via nanopore-confined pyrolysis is a feasible strategy to produce HC anodes with high LVPC. However, the formation mechanism of closed pores and their size-dependent effects on sodium cluster filling behavior remain poorly understood. Herein, pitch-confined pyrolysis is utilized within the nanopores of AC to transform its open pores into closed pores, with pitch dose regulating closed-pore size.

Global covariation of forest age transitions with the net carbon balance.

Forest age transitions are critical in shaping the global carbon balance, yet their influence on carbon stocks and fluxes remains poorly quantified. Here we analyse global forest age dynamics from 2010 to 2020 using the Global Age Mapping Integration v2.0 dataset, alongside satellite-derived aboveground carbon (AGC) and atmospheric inversion-derived net CO flux data.

Automated diagnostic method for sleep apnea and hypopnea using overnight airflow and oxygen saturation.

Polysomnography (PSG) is the gold standard for diagnosing obstructive sleep apnea-hypopnea syndrome (OSAHS), but it relies heavily on manual scoring by experienced clinicians, which is time-consuming and costly. This study presents an automated method for detecting sleep apnea and hypopnea events using overnight airflow and blood oxygen saturation signals. Apnea episodes are identified through local range (LR) analysis of airflow, while rapid oxygen desaturation supports hypopnea detection.