Effects of nitrogen forms on growth and soil bacterial diversity of Cinnamomum camphora ct. citral seedlings.

The scarcity of natural citral has spurred interest in its alternative sources such as the essential oil-rich branches and leaves of citral balsam fir. This study assessed the impact of nitrate, ammonium, and amide nitrogen forms at varying concentrations on the growth, development, and soil bacterial diversity of 1-year-old Cinnamomum camphora ct. citral seedlings.

Transcriptomic features of immune inflammation and neural plasticity associated with early neurological improvement in acute ischemic stroke patients with large vessel occlusion.

Background: Acute ischemic stroke (AIS) caused by large vessel occlusion (LVO) is a leading cause of disability and mortality worldwide. Although endovascular thrombectomy (EVT) has significantly improved outcomes, many patients do not achieve early neurological improvement (ENI) despite timely reperfusion. This study aims to investigate the peripheral blood mRNA molecular characteristics and underlying mechanisms associated with ENI after EVT in AIS-LVO patients, to inform individualized treatment and optimize prognosis.

Immunochromatographic assay for rapid detection of SIGLEC15 to evaluate its therapeutic potential in cervical cancer.

SIGLEC15 is a novel immunosuppressive transmembrane protein promotes cancer development. However, the role of SIGLEC15 in cervical cancer remains poorly understood until now. In this study, we identified that the expression of SIGLEC15 was significantly increased in cervical cancer cells and tissues, and it was closely related to the metastasis of cervical cancer (70.

NSUN2-tRNA-axis-regulated codon-biased translation drives triple-negative breast cancer glycolysis and progression.

Background: Epitranscriptomic data indicate that aberrant tRNA modifications in malignant diseases can promote tumor growth by facilitating oncogene translation. NSUN2, a 5-methylcytosine (m5C) methyltransferase of tRNA, is elevated in an array of solid cancers, including triple-negative breast cancer (TNBC). However, it remains unclear how NSUN2 drives aggressive behavior and if NSUN2 could be an effective therapeutic target for TNBC.

Hydrogen Storage in Magnesium Hydride at Room Temperature Enabled by Graphene-Stabilized Multivalent Niobium Oxides.

Reversible hydrogen storage in magnesium hydride (MgH) remains hindered by intrinsic, complicated kinetic barriers associated with both hydrogen release and uptake, particularly under mild conditions. In this work, graphene-confined, low-crystallinity niobium oxide nanoparticles are developed to optimize the kinetic barriers across all stages of hydrogen absorption and desorption in MgH. This is realized by the synergistic effect of in situ-generated stable multivalent niobium oxide (NbO) and the electronically modulating graphene.

Bimetallic phenolic network nanoparticles mitigate ischemic stroke by alleviating neuroinflammation and promoting vascular normalization.

Ischemic stroke (IS) is a serious cerebrovascular disease. Due to its complex pathophysiological mechanisms and the limitation of drug delivery by the blood-brain barrier (BBB), current treatments for IS still struggle to achieve ideal outcomes. In this study, a multifunctional bimetallic phenolic network nanoparticle (Sr/Mn@Rh) formed via simple metal-phenolic coordination-driven self-assembly of Mn²⁺, Sr²⁺, and rutin hydrate (Rh) was developed for IS therapy.

Histone ZmH2B regulates resistance to the Southern corn leaf blight pathogen Bipolaris maydis in maize.

Background: H2B histones play crucial roles in plant responses to biotic stress. However, to date, most research on H2B histones has focused on their roles in post-translational modification, and studies specifically investigating the intrinsic properties of these histones remain relatively limited. Here we identified the ZmH2B in maize () and investigated its role in the response of maize to infection by the Southern corn leaf blight pathogen .

Biomarker profile of a Chinese ALS cohort: A comprehensive clinical-biomarkers-imaging analysis.

Background: Amyotrophic lateral sclerosis (ALS) is a fatal central nervous system neurodegenerative disease, but the relationships among genetic mutations, plasma biomarkers, glymphatic system and clinical variables remain unclear.

Methods: This study retrospectively collected data from April 2015 to November 2024 from the Department of Neurology of First Affiliated Hospital, Fujian Medical University, China. ALS patients (including genetic ALS (gALS) and sporadic ALS (sALS)), Alzheimer's disease (AD) patients, and healthy controls (HC) were included.

Impact of COVID-19 on live birth and perinatal outcomes following subsequent frozen-thawed embryo transfer.

Purpose: To evaluate whether prior SARS-CoV-2 infection adversely affects live birth and perinatal outcomes following subsequent frozen-thawed embryo transfer (FET) and to further investigate whether the time interval between infection and embryo transfer influences pregnancy outcomes.

Methods: In this retrospective cohort study, women who tested positive for SARS-CoV-2 before FET were designated as the infected group (n = 1081), while asymptomatic and test-negative women were included as controls (n = 865). The infected group was further subdivided into four subgroups according to the time interval from infection to FET: ≤ 30, 31-60, 61-90, and ≥ 91 days.

Photoswitching-Modulated Interfacial Electron Transfer in Single-Atom Co-TiO for Enhanced Pollutant Mineralization in Persulfate-Based AOPs.

Precise modulation of interfacial electron transfer in heterogeneous catalysts is crucial for efficient degradation of persistent organic pollutants in persulfate-based advanced oxidation processes. In this work, we introduced a photoswitching strategy that in situ regulates electron transfer in single-atom Co-TiO catalysts, optimizing the production of reactive oxidative species during peroxymonosulfate (PMS) activation, thereby improving pollutant mineralization efficiency. Theoretical calculations revealed that the formation of high-valent Co-oxo species during PMS activation was thermodynamically favorable.

Robust transfer learning for individualized treatment rules in the presence of missing data.

Individualized treatment rule (ITR) is a stepping stone to precision medicine. To ensure validity, ITRs are ideally derived from randomized trial data, but the use cases of ITRs extend beyond these trial populations. Transferring knowledge from experimental data to real-world data is of interest, while experimental data with selective inclusion criteria reflect a population distribution that may differ from the real-world target.

BLIMP-1 and CEACAM1 cooperatively regulate human Treg homeostasis and function to control xenogeneic GVHD.

Regulatory T cells (Tregs) are essential for peripheral tolerance and depend on TCR and IL-2R signaling for their homeostasis and function. In mice, IL-2-dependent BLIMP-1 contributes to Treg homeostasis. BLIMP-1 is a major transcriptional hub in human Tregs, but its mechanisms of action remain undefined.

A study on the construction of a nurse refresher training system in traditional Chinese medicine hospitals using the Delphi method.

Background: This study aims to develop a standardized advanced training system for nursing staff in traditional Chinese medicine (TCM) hospitals and verify its effectiveness.

Methods: Based on literature review, training demand research, and semi-structured interviews, this study established a draft training system for TCM nursing staff. 12 experts refined the system through two rounds of correspondence using the Delphi method.

Towards Walkable and Safe Areas: DRL-Based Redirected Walking Leveraging Spatial Walkability Entropy.

Redirected walking (RDW) expands the virtually reachable areas within confined physical spaces by real-walking locomotion. However, existing RDW controllers struggle with extracting spatial features, hindering the improvement for physical obstacle avoidance. To overcome this, we propose a novel spatial walkability-aware redirection controller utilizing deep reinforcement learning (DRL), which learns to enhance obstacle avoidance capability by leveraging comprehensive spatial features.

Influence of metabolism-related comorbidities and insulin resistance on new onset of chronic kidney disease in a health check-up population: a two-stage retrospective cohort study.

Introduction: Limited research has focused on the prospective influence of insulin resistance (IR) on new-onset chronic kidney disease (CKD) in healthy screening populations. Therefore, we aimed to investigate how IR, assessed via the estimated glucose disposal rate (eGDR), and metabolism-related comorbidities influence new-onset CKD.

Research Design And Methods: This two-stage retrospective cohort study (cross-sectional and longitudinal analyses) used data from health check-up participants at the Chinese People's Liberation Army General Hospital (2009-2021).

SBDH-Reader: a large language model-powered method for extracting social and behavioral determinants of health from clinical notes.

Objective: Social and behavioral determinants of health (SBDH) are increasingly recognized as essential for prognostication and informing targeted interventions. Clinical notes often contain details about SBDH in unstructured format. Conventional extraction methods for these data tend to be labor intensive, inaccurate, and/or unscalable.

Neural Network-Based Dynamic Prediction for Interval-Censored Data With Time-Varying Covariates: Application to Alzheimer's Disease.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder accounting for a significant proportion of global dementia cases. Given the lack of effective treatments, there is growing interest in dynamic prediction methods for timely interventions. Notably, many at-risk individuals with periodic clinic visits provide dynamic cognitive and functional scores.

Genetic characteristics and risk factors of extended-spectrum β-lactamase-producing in Chinese intensive care unit: a prospective molecular epidemiology study.

In this 4-month-long prospective observational study, we explored the colonization rate of extended-spectrum β-lactamase-producing (ESBL-EC) in the patient and ward environment of an intensive care unit (ICU). Additionally, we evaluated the risk factors for colonization and analyzed genomic characteristics and modes of transmission of isolates. Clinical samples were collected from patients and the environment to isolate and screen strains.

Impact of Nurses' Knowledge, Self-Efficacy and Clinical Reasoning Competency on Difficulties in Caring for Patients With Delirium in the Intensive Care Unit: A Cross-Sectional Study.

Aim: To examine the impact of critical care nurses' delirium knowledge, self-efficacy and clinical reasoning competency on delirium care difficulties based on the information-motivation-behavioural (IMB) skills model from a behavioural perspective.

Design: Cross-sectional study.

Methods: A total of 440 critical care nurses from five hospitals in China were selected using convenience sampling and invited to complete an online questionnaire for measurement.

A Bioequivalence Study of Recombinant Human Follicle-Stimulating Hormone Injection Versus Recombinant Human Follitropin For Injection in Healthy Chinese Adult Women.

Background And Objective: This study aimed to evaluate the bioequivalence of a novel prefilled recombinant human follicle-stimulating hormone (rh-FSH) injection (GenSci008) compared with the existing rh-FSH for injection (Jinfollin) in healthy Chinese adult women.

Methods: This open-label, randomized, single-center, two-period, two-sequence crossover study involved 24 healthy female volunteers who received single subcutaneous doses of both formulations, separated by a 10-day washout period. Participants underwent pituitary down-regulation using Diphereline to minimize endogenous FSH levels.

Transcranial Optogenetic Stimulation Promotes Corticospinal Tract Axon Regeneration to Repair Spinal Cord Injury by Activating the JAK2/STAT3 Pathway.

Objective: Regeneration of corticospinal tract (CST) axons after spinal cord injury (SCI) is a key element in rebuilding neuronal connections to restore voluntary motor function. However, it remains challenging owing to limited effective interventions. This study adopted a modified transcranial optogenetic technique to stimulate CST axon regeneration into the injury site of completely transected SCI and explore the underlying molecular mechanisms.

Resilience and Affiliate Stigma Among Parents of Children with Autism Spectrum Disorder: The Mediating Role of Life Satisfaction and the Moderating Role of Ostracism.

Purpose: Parents of children with autism spectrum disorder (ASD) often encounter multifaceted challenges when addressing their children's special needs. While existing studies have examined the relationship between parental resilience and mental health in this population, the underlying mechanisms governing this association remain poorly understood. The present study aims to investigate the association between parental resilience and affiliate stigma, examine the mediating role of life satisfaction in this relationship, and assess the moderating effect of ostracism on these pathways.

A strategy to prepare robust enzyme@covalent organic framework microcapsules: a new platform for biosensing.

Enzyme biosensors, despite their high specificity and sensitivity, are constrained by the inherent fragility of enzymes. Despite being considered ideal for enzyme protection by in-situ covalent organic frameworks (COFs) immobilization, the harsh conditions of COFs synthesis often lead to enzyme inactivation. Herein, a strategy was developed to prepare robust enzyme@COFs microcapsules (enzyme@MC) by the interfacial assembly of hydrophobic COFs spheres to form stable Pickering emulsions, followed by COFs regrowth to reinforce the microcapsules.

A computational-based new treatment strategy with three-armed RCT on Mycoplasma pneumoniae pneumonia in children.

Mycoplasma pneumoniae pneumonia (MPP) is a common type of pneumonia among school-aged children and adolescents. Jinzhen Oral Liquid (JZOL) and Azithromycin (AZ) are commonly used treatments in traditional Chinese medicine (TCM) and Western medicine, respectively. There are several clinical and basic research reports on their solo effect against MPP, enabling their combined treatment to become possible.