Crosstalk between heterogeneous cancer-associated fibroblast subpopulations and the immune system in breast cancer: key players and promising therapeutic targets.

The tumor microenvironment (TME) of breast cancer is a complex ecosystem, in which cancer-associated fibroblasts (CAFs), as the most abundant stromal cell type, meticulously construct an ecological niche that supports tumor growth through mechanisms including extracellular matrix (ECM) remodeling, secretion of bioactive factors, and interactions with neighboring cells. High-resolution technologies, including single-cell sequencing and spatial transcriptomics, have revealed the high heterogeneity, functional diversity, and spatial distribution within the CAF population. Significant differences exist in the interactions between distinct CAF subpopulations and immune cells.

Prognostic value of laboratory biomarkers for mortality risk stratification in thrombotic thrombocytopenic purpura.

This study aimed to explore the relationship between laboratory indicators and short-term mortality risk in patients with thrombotic thrombocytopenic purpura (TTP) and to construct a risk stratification model. We retrospectively analyzed the clinical data of 106 patients with TTP admitted to Tongji Hospital between June 2016 and February 2025. Patients were grouped by 28-day survival: death (n = 45) and survival (n = 61).

PHPT1 acts as an inhibitor in high-altitude pulmonary hypertension via negative TRPV5 signaling regulation.

Background: Low barometric pressure hypoxia at high altitudes triggers vascular remodeling, resulting in high-altitude pulmonary hypertension (HAPH). The key step is the transformation of pulmonary artery smooth muscle cells (PASMCs) from a contractile to synthetic phenotype. Protein kinases and phosphatases contribute to phenotype transformation by altering phosphorylated protein expression.

A cross-sectional and bioinformatics-based analysis: perirenal fat thickness as a superior predictor of kidney stone disease.

Background: Kidney stone disease (KSD) is a growing global health concern, with obesity (OB) as a major risk factor linked to metabolic dysfunction and chronic inflammation. Although the common method for evaluating OB is body mass index (BMI), it is not specific enough when it comes to reflecting visceral fat. The perirenal fat thickness (PFT) might present better predictive capabilities.

A 40-year bibliometric analysis of global research on neoadjuvant chemotherapy for oral cancer (1985-2024).

Background: Neoadjuvant chemotherapy (NAC) has become a critical component in the treatment of oral cancer, enhancing tumor resectability and improving patient survival. This study aimed to perform a bibliometric analysis to systematically explore global research trends, key contributors, and emerging hotspots in NAC for oral cancer.

Methods: Publications from 1985 to 2024 were retrieved from the Web of Science Core Collection.

Evaluating the effects of liraglutide, empagliflozin and linagliptin on mild cognitive impairment remission in patients with type 2 diabetes (LIGHT-MCI): study protocol for a multicentre, randomised controlled trial with an extension phase.

Introduction: Diabetes is a significant modifiable risk factor for cognitive dysfunction. There are currently no effective treatments that delay or reverse the progression of cognitive dysfunction. Accumulating evidence demonstrates that specific antidiabetes medications hold promise in improving cognitive function.

HDAC2 enhances the antimicrobial activity of neutrophils by promoting the formation of neutrophil extracellular traps (NETs) in sepsis.

Introduction: Sepsis is characterized as a life-threatening organ dysfunction resulting from a dysregulated host response to infection, representing a critical clinical syndrome. Uncontrolled infection and inflammation are two main characteristics of sepsis. Neutrophil extracellular traps (NETs) is a major mechanism by which neutrophils resist pathogens invasion, but the mechanism of the NETs formation remain completely unclear.

I-YOLOv11n: A Lightweight and Efficient Small Target Detection Framework for UAV Aerial Images.

UAV small target detection in urban security, disaster monitoring, agricultural inspection, and other fields faces the challenge of increasing accuracy and real-time requirements. However, existing detection algorithms still have weak small target representation ability, extensive computational resource overhead, and poor deployment adaptability. Therefore, this paper proposes a lightweight algorithm, I-YOLOv11n, based on YOLOv11n, which is systematically improved in terms of both feature enhancement and structure compression.

Does enactment truly boost action memory? Investigating action memory through dynamic action videos.

The significance of acquiring motor skills for daily activities and professional tasks is universally acknowledged. Two experiments were conducted to explore the impact of Self-Performed Task (SPT) and Experimenter-Performed Task (EPT) during both encoding and retrieval on the memory of dynamic sequential actions presented in videos. The first experiment, involving 48 participants, determined that SPT-encoding was more effective than EPT-encoding.

Identification of M2 macrophage-related biomarkers for a predictive model of interstitial fibrosis and tubular atrophy after kidney transplantation by machine learning algorithms.

Background: Interstitial fibrosis and tubular atrophy (IFTA) represent significant histopathological manifestations contributing to long-term kidney allograft failure after transplantation. Identifying M2 macrophage (Mφ2)-related biomarkers could enhance early diagnosis and prognosis prediction, improving patient outcomes. This study aimed to explore Mφ2-related biomarkers for IFTA via bioinformatics and machine learning approaches.

Development and Validation of a Prognostic Risk Model for Severe Fever With Thrombocytopenia Syndrome Patients.

Few prediction models exist for the prognosis of patients with severe fever with thrombocytopenia syndrome (SFTS). This study analyzed the risk factors for poor prognosis in patients with SFTS and established a prognostic risk prediction model based on these factors. A total of 194 patients with SFTS admitted to Tongji Hospital from April 1, 2023, to July 18, 2024, were enrolled.

MXene-Integrated Printed Piezoresistive Flexible Sensors: A Breakthrough in Real-Time Monitoring for Medical and Smart Applications.

As an emerging 2D transition metal carbide material with metal-like conductivity, MXene exhibits significant potential in the development of piezoresistive sensors. Nevertheless, achieving favorable combined properties in MXene-based pressure sensors remains challenging. This research explores a method for the assisted deposition of Ag nanoparticles between the layers of waffle-structured MXene by template-directed growth strategy, preparing the chocolate-inlaid Ag@waffle-structured MXene (WSM-A8).

The global burden of disease attributable to suboptimal fruit and vegetable intake, 1990-2021: a systematic analysis of the global burden of disease study.

Background: Suboptimal fruit and vegetable intake remains a significant global public health concern. This study aimed to estimate the global intake and the disease burden attributable to suboptimal fruit and vegetable intake.

Methods: In this Global Burden of Disease (GBD) Study 2021, we evaluated the number, age-standardized rates (ASRs), and estimated annual percentage changes (EAPCs) in deaths and disability-adjusted life years (DALYs) attributable to suboptimal fruit and vegetable intake among adults aged over 25 years, across 21 regions and 204 countries and territories, from 1990 to 2021.

Towards Walkable and Safe Areas: DRL-Based Redirected Walking Leveraging Spatial Walkability Entropy.

Redirected walking (RDW) expands the virtually reachable areas within confined physical spaces by real-walking locomotion. However, existing RDW controllers struggle with extracting spatial features, hindering the improvement for physical obstacle avoidance. To overcome this, we propose a novel spatial walkability-aware redirection controller utilizing deep reinforcement learning (DRL), which learns to enhance obstacle avoidance capability by leveraging comprehensive spatial features.

Facet Engineering-Modulated Electrochemiluminescence of Reticular Crystalline Nanoemitters.

Electrochemiluminescence (ECL) as a light-emitting process involves the interfacial charge transfer between the electrochemically generated emitter's intermediate and the coreactant/emitter, critically governed by the emitter's electronic structure and exposed surface state. However, the relationship between the emitter's exposed surface state and ECL performance remains unexplored. Herein, a series of metal-organic framework (MOF) emitters is synthesized via controlled crystal growth, achieving selective exposure of (001), (100), and (110) facets characterized by micro-electron diffraction (MicroED) on nanoplate, nanoblock, and nanorod-shaped MOFs, respectively.

Clinical Observation of Myocardial Contractility Modulation Device in Patients with Chronic Heart Failure.

Heart failure (HF) is one of the most common cardiovascular diseases in the 21st century, affecting more than 25 million individuals worldwide. According to estimates, 8.9 million cases have been reported in China alone.

First application of a 6.3 Fr flexible ureteroscope in the treatment of bilateral staghorn calculi: A case report.

Rationale: Staghorn calculi are a challenging type of kidney stone traditionally treated with percutaneous nephrolithotomy (PCNL) or multiple endoscopic procedures. However, these methods are often associated with a higher risk of postoperative complications and prolonged recovery periods. Recent advancements in flexible ureteroscopy (fURS) technology have offered the potential for improving the management of kidney stones, but its application in treating complex staghorn stones remains limited due to technical and anatomical challenges.

Regulatory mechanism of microplastics on arsenic bioavailability in a subtropical estuary, China.

The increasingly prominent microplastics (MPs) pollution may affect the dynamics of arsenic (As) in estuarine sediments, but the effect of MPs on the bioavailable arsenic (bio-As) and its regulatory mechanism are still unclear. In this study Min River estuary, a typical subtropical estuary, was selected, and DGT technology was used to explore the pattern of change, composition characteristics and regulatory mechanism of bio-As in sediment under the influence of MPs (type: polylactic acid (PLA) and polyethylene terephthalate (PET); dose: 1 % and 5 %) through incubation experiments. The results showed that (1) the low-dose PET significantly increased the concentration of bio-As, (2) during the incubation experiment, the effect of MPs on the composition of the bio-As was phased.

Photoresponsive Multifunctional Nanoplatform Based on ADSC-Exos Coated BPQDs Demonstrates Effective Antibacterial Properties and Induces Macrophage Polarization for Infected Wound Healing.

Bacterial infections and the disturbance of immune microenvironment contribute to chronic non-healing wounds. Macrophage polarization and phenotypic transition play a critical role in modulating the immune microenvironment of wounds. To address these intertwined challenges of bacterial burden and immune dysregulation, an innovative multifunctional therapeutic nanoplatform is developed that integrates black phosphorus quantum dots (BPQDs) into exosomes derived from adipose stem cells (BPQDs@EXOs).

Sulfonium Salt-Mediated Difunctionalization of Alkynes for Access to -Alkenyl Phosphorothioates and Selenophosphates.

In this work, we present a practical and efficient one-pot sulfonium salt-mediated difunctionalization reaction of alkynes. This method facilitates the diverse synthesis of various alkenyl phosphorthioates and selenophosphates in acceptable yields. Importantly, the reaction is completely regio- and stereoselective, producing absolutely -configured alkenylated phosphorothioates and selenophosphates with a broad substrate scope and high functional group tolerance.

Handgrip strength is associated with cognitive function in patients with head injury with loss of consciousness: results from the NHANES 2011-2014.

Background: We evaluated the relationship between handgrip strength (HGS) and cognitive function in patients with head injury with loss of consciousness (HIC) using National Health and Nutrition Examination Survey (NHANES) data.

Methods: Utilizing the 2011-2014 NHANES database, we screened participants who completed the HIC questionnaire and extracted relevant variables. Key variable was the sum of maximum bilateral HGS.

Electrocatalytic CO Reduction to Chemicals and Fuels: From Single-Atom to Dual-Atom.

In recent years, single-atom catalysts (SACs) have emerged as a prominent research focus in electrochemical CO reduction reactions (CORR), owing to their exceptional atomic utilization efficiency and superior catalytic performance. Nevertheless, their practical implementation may be constrained by inherently low metal loading and the presence of linear relationships imposed by their structurally simplistic active sites. Atomic-level engineering of active sites represents a transformative strategy to overcome the intrinsic limitations of SACs.

High-resolution Performance of Leaning Pillar[6]arene Functionalized with Imidazolium Ionic Liquids for Gas Chromatography.

Leaning pillar[6]arene (LP6A) is an expanded version of pillar[6]arene (P6A), possessing not only the nanometer-sized cavity of P6A but also a unique desymmetrized leaning tower-like structure, which offers better structural flexibility and cavity adaptability. Here we report the first example of the utilization of imidazolium ionic liquid (IMIL) functionalized LP6A (LP6A-C10-IM-C8[NTf]) as a stationary phase in capillary gas chromatography (GC). The LP6A-C10-IM-C8[NTf] capillary column was prepared by the static coating method, showing medium polarity (average polarity 155) and high column efficiency (3758 plates/m).

All-component-active metal-organic frameworks for tailored chemoradiotherapy of self-defensive tumors.

Radiotherapy is a widely used clinical treatment for locoregional cancers, but it still faces radiation resistance arising from abundant glutathione (GSH) and DNA damage repair (DDR). To overcome these self-defense pathways, various radiosensitizers have often been integrated with pharmaceutical agents, forming hybridized carriers for combination therapy. Herein, an all-component-active metal-organic framework (aaMOF), composed of chemotherapeutic thioguanine as a linker and copper iodide as nodes, is rationally designed for tailored chemoradiotherapy against tumor self-defense pathways.