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The significance of acquiring motor skills for daily activities and professional tasks is universally acknowledged. Two experiments were conducted to explore the impact of Self-Performed Task (SPT) and Experimenter-Performed Task (EPT) during both encoding and retrieval on the memory of dynamic sequential actions presented in videos. The first experiment, involving 48 participants, determined that SPT-encoding was more effective than EPT-encoding. The second experiment, with 60 participants, revealed a significant interaction between the encoding mode and the recognition mode. Notably, when with EPT-encoding, there was a significant difference in memory precision between the two recognition methods, with the EPT-recognition yielding better memory outcomes than the SPT-recognition. However, there was no significant difference in memory performance between the two recognition methods under the SPT-encoding conditions. Collectively, the findings of these experiments confirm the persistence of the enactment effect in the memory of dynamic and continuous actions, with some results also offering empirical support for both the two-component hypothesis and action encoding theory.
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http://dx.doi.org/10.1007/s00426-025-02151-y | DOI Listing |
Front Immunol
September 2025
Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
NSG-SGM3 humanized mouse models are well-suited for studying human immune physiology but are technically challenging and expensive. We previously characterized a simplified NSG-SGM3 mouse, engrafted with human donor CD34 hematopoietic stem cells without receiving prior bone marrow ablation or human secondary lymphoid tissue implantation, that still retains human mast cell- and basophil-dependent passive anaphylaxis responses. Its capacities for human antibody production and human B cell maturation, however, remain unknown.
View Article and Find Full Text PDFFront Hum Neurosci
August 2025
Baptist Medical Center, Department of Behavioral Health, Jacksonville, FL, United States.
Introduction: This study investigates four subdomains of executive functioning-initiation, cognitive inhibition, mental shifting, and working memory-using task-based functional magnetic resonance imaging (fMRI) data and graph analysis.
Methods: We used healthy adults' functional magnetic resonance imaging (fMRI) data to construct brain connectomes and network graphs for each task and analyzed global and node-level graph metrics.
Results: The bilateral precuneus and right medial prefrontal cortex emerged as pivotal hubs and influencers, emphasizing their crucial regulatory role in all four subdomains of executive function.
Neuropsychiatr Dis Treat
September 2025
Medical College, Tibet University, Lhasa, Tibet, People's Republic of China.
Background: Tripterygium glycoside (TG) has been reported to have the effect of ameliorating Alzheimer's disease (AD)-like symptoms in mice model. However, the underlying mechanism is largely unknown. This study aimed to investigate the potential mechanism of TG against AD by integrating metabolomics, 16s rRNA sequencing, network pharmacology, molecular docking, and molecular dynamics simulation.
View Article and Find Full Text PDFPsychophysiology
September 2025
Shandong Provincial Key Laboratory of Brain Science and Mental Health, Faculty of Psychology, Shandong Normal University, Jinan, China.
"Metacontrol" refers to the ability to achieve an adaptive balance between more persistent and more flexible cognitive-control styles. Recent evidence from tasks focusing on the regulation of response conflict and of switching between tasks suggests a consistent relationship between aperiodic EEG activity and task conditions that are likely to elicit a more persistent versus more flexible control style. Here we investigated whether this relationship between metacontrol and aperiodic activity can also be demonstrated for working memory (WM).
View Article and Find Full Text PDFJ Neurosci
September 2025
Center for Studies in Behavioural Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada, H4B 1R6
Adaptive behavior depends on a dynamic balance between acquisition and extinction memories. Male and female rodents differ in extinction learning rates, suggestion potential sex-based differences in this balance. In males, deletion of extinction-recruited neurons in the central nucleus (CN) of the amygdala impairs extinction retrieval, shifting behavior toward acquisition (Lay et al.
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