Seasonal Spatial Distribution Patterns and Climate Scenario Predictions of : A Key Shrimp Species Depressing Jellyfish Blooms in the East China Sea Region.

is an ecologically important shrimp species that plays a vital role in depressing jellyfish blooms in the southern Yellow and East China Seas of China. However, information on its distribution pattern and migration route related to environmental variables is fragmented. We conducted independent trawling surveys of between 2018 and 2019.

Seasonal Spatial Distribution Patterns of the Sand Crab (De Haan 1833) in the Southern Yellow and East China Seas and Predictions from Various Climate Scenarios.

In the past two decades, little information has been updated to understand the resource status of the crab species in the East China Sea Region. In this study, we conducted surveys in 2018 and 2019 to identify the seasonal spatial distribution patterns of the economically important sand crab (De Haan 1833) in the southern Yellow and East China Seas. In the study area, the largest biomass of crabs was observed in the fishing grounds of Dasha and the Yangtze River mouth, and the second largest biomass was detected in the Jiangwai-Zhouwai area.

Ligand-mediated structural modulation and membrane stabilization of LPA1 receptor: Insights from molecular dynamics simulations.

Lysophosphatidic acid (LPA) is an important bioactive signaling molecule that activates six distinct G protein-coupled receptors (GPCRs), among which the LPA1 subtype possesses high therapeutic target potential due to its critical roles in malignant tumors, pulmonary fibrosis, inflammation, and neuropathic pain. Recent studies have shown that the small molecule ONO-0740556 can effectively disrupt the overall structure of LPA1 in solution; however, its effects in a native membrane environment remain unclear. According to the Traditional Chinese Medicine Systems Pharmacology Database (TCMS), Dan Shen(Salvia miltiorrhiza) exhibits anti-inflammatory and anti-pulmonary fibrosis properties, and its natural compound cryptoxanthin may serve as a novel LPA1 inhibitor.

A population-based nomogram for prognostic assessment in advanced lung cancer following progression with immune checkpoint inhibitor.

Background: The complexity of immunoresistance patterns in advanced lung cancer (LC) and the uniqueness of its efficacy response (e.g., pseudoprogression and hyperprogression) make it difficult to standardize treatment regimens after progression.

Towards Walkable and Safe Areas: DRL-Based Redirected Walking Leveraging Spatial Walkability Entropy.

Redirected walking (RDW) expands the virtually reachable areas within confined physical spaces by real-walking locomotion. However, existing RDW controllers struggle with extracting spatial features, hindering the improvement for physical obstacle avoidance. To overcome this, we propose a novel spatial walkability-aware redirection controller utilizing deep reinforcement learning (DRL), which learns to enhance obstacle avoidance capability by leveraging comprehensive spatial features.

Energy-landscape analysis of brain network dynamics in a multi-center Alzheimer's disease and mild cognitive impairment cohort.

Convergent dynamic functional connectivity studies have demonstrated their potential as a hallmark for capturing the impairments in brain function associated with Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, understanding whole-brain dynamics patterns remains limited, hampering the understanding of cognitive impairment and symptomatology for AD and MCI. An energy-landscape analysis was conducted to investigate brain dynamics across seven large-scale networks in 516 normal controls (NC), 404 AD patients, and 441 MCI participants from a multi-center cohort.

Rare Primary Diffuse Large B-Cell Lymphoma Confined to Bone Marrow: Features and Prognosis.

Background: Primary bone marrow diffuse large B-cell lymphoma (PBM-DLBCL) represents an uncommon yet clinically aggressive hematologic malignancy. Despite its significant clinical impact, this entity lacks standardized diagnostic criteria in current WHO classifications.

Methods: We performed a retrospective analysis of 55 PBM-DLBCL cases from our institutional database and published literature (2001-2022) to characterize disease features and identify prognostic factors, with particular focus on assessing how different treatment regimens influence therapeutic efficacy and long-term outcomes.

Elucidating microbial succession dynamics and flavor metabolite formation in korean style spicy cabbage fermentation: Integration of flavoromics, amplicon sequencing, and metagenomics.

Korean style spicy cabbage (KSC) is a prominent fermented vegetable consumed globally. Nevertheless, microbial succession dynamics, interactions, and flavor-core microbiome correlations lack comprehensive understanding. Metabolomics revealed eight taste-active compounds and sixteen aroma-active compounds as key flavor determinants throughout fermentation.

pH-Dependent β-Strand Alignment of the Alzheimer's Amyloid-β (16-22) Peptide.

The extracellular amyloid plaques of amyloid-β (Aβ) peptides formed in the human brain are an important pathological hallmark of Alzheimer's disease. There is evidence that pH affects the morphologies of fibrils and the kinetics of amyloid fibril formation. However, the underlying molecular mechanism is not well understood.

Design, synthesis and structure-activity relationship studies of novel macrocyclic 2,4-diaminopyrimidines as HPK1 inhibitors.

Hematopoietic progenitor kinase 1 (HPK1) functions as a key negative regulator of T cell receptor signaling and has been considered a potential target for cancer immunotherapy. Despite great progress in developing HPK1 inhibitors, no small-molecule inhibitors have been approved for cancer treatment to date. Herein, we describe the design and synthesis of a novel series of macrocyclic 2,4-diaminopyrimidine derivatives as HPK1 inhibitors.

B7-H3 and c-MET in advanced prostate cancer: exploring possibilities of novel bi-specific drug development.

Purpose: Prostate cancer (PCa) is a serious malignancy worldwide with the fifth highest mortality rate among tumors in males, and there are unmet clinical needs for PCa treatment. In this work, we aim to explore the expression and overlap between B7 Homolog 3 protein (B7-H3) and cell-surface receptor c-mesenchymal-epithelial transition factor (c-MET), to provide insight on B7-H3 and c-MET bi-specific ADC drugs development for advanced PCa.

Patients And Methods: In this retrospective cross-sectional study, formalin-fixed paraffin-embedded (FFPE) samples were analyzed from 135 male patients with advanced PCa at Hubei Cancer Hospital between 2019 and 2023.

JMC14: a novel dual PI3Kδ/CSF1R inhibitor with potent antitumor activity in hematological and solid tumors.

PI3Kδ, predominantly expressed in immune cells and markedly dysregulated in B-cell malignancies, emerges as a promising and well-validated therapeutic target in hematologic cancers. Meanwhile, CSF1R regulates the formation and polarization of tumor-associated macrophages (TAMs), facilitating immune suppression and tumor progression in various solid tumors. Although targeting PI3Kδ or CSF1R has shown promise, the clinical application is often constrained by off-target effects, toxicity, and limited efficacy, particularly in solid malignancies.

Novel Cyano-Artemisinin Dimer ZQJ29 Targets PARP1 to Induce Ferroptosis in Pancreatic Cancer Treatment.

Pancreatic cancer remains one of the most lethal malignancies in the digestive system, with limited available drugs and a need for improved efficacy. This unmet clinical need highlights the urgency to discover novel, highly efficient small-molecule compounds. Herein, a novel cyano-containing artemisinin dimer derivative, ZQJ29, is synthesized through structural modifications of artemisinin.

The current status and prospects of gut microbiota combined with PD-1/PD-L1 inhibitors in the treatment of colorectal cancer: a review.

Background: Colorectal cancer (CRC) is a common malignant tumor. Immune checkpoint inhibitors (ICIs), particularly those targeting programmed cell death protein 1(PD-1) and programmed cell death ligand 1(PD-L1), have shown promising potential in the treatment of CRC. Specific gut microbiota can modulate the efficacy of ICIs through immune or metabolic pathways.

Short sleep duration and daytime outdoor activities effects on adolescents mental health: A stress susceptibility-recovery model analysis.

Background: Mental health disorders are a growing public health challenge globally. This study aimed to utilize the Stress Susceptibility-Recovery Model to identify the relationship between sleep duration, daytime outdoor activities, and major mental health outcomes among adolescents.

Methods: Data from the Yunnan Students' Common Disease Survey was analyzed.

Spatiotemporal analysis of the burden of lower respiratory infections in the older adult population due to air pollution: trends from 1990 to 2021 and predictions for the next 30 years.

Background: Lower respiratory infections (LRI), caused by various pathogens, have significant impacts on global health. Air pollution is a major environmental factor in the development of LRI, and with ongoing urbanization and industrialization, it has become a critical public health concern. The older adult population, with declining immune function and physiological capabilities, exhibits reduced resistance to air pollution, making them a high-risk group for LRI.

Analysis of the quality and bacterial composition of spicy cabbage between Liaoning and Yanbian in northeastern China based on flavoromics and amplicon sequencing.

Background: Chinese spicy cabbage (CSC) is a famous traditional fermented vegetable widely consumed in northeast China. However, the differences in characteristics between Liaoning spicy cabbage (LNSC) and Yanbian spicy cabbage (YBSC), as well as the correlation between flavor attributes and microbiota remain unclear. This study clearly delineated the characteristics and correlations of ingredients, aroma characteristics and microbial communities between LNSC and YBSC.

Magnesium Silicate Honeycomb Structure on Attapulgite Clay Composite by Self-Template Method for Adsorption of Methylene Blue.

A series of porous silica materials coated with honeycomb-like magnesium silicate were prepared under hydrothermal conditions, using natural one-dimensional porous attapulgite as the template and a silicon source with different Mg/Si ratios, by adjusting the amount of MgCl⋅6HO and the attapulgite precursor and regulating pH. The influence of the Mg/Si ratios was carefully investigated on morphology, pore structure, and related adsorption actions toward methylene blue. The Langmuir isotherm and pseudo-second-order kinetic models were used to explain the adsorption behavior of methylene blue.

Preoperative inflammatory markers and tumor markers in predicting lymphatic metastasis and postoperative complications in colorectal cancer: a retrospective study.

Objective: To analyze the impact of preoperative inflammatory markers and tumor markers on lymphatic metastasis and postoperative complications in colorectal cancer patients, and explore their predictive value for these outcomes. Furthermore, based on the preoperative inflammatory and tumor marker indicators with significant effects, predictive models for the risk of lymphatic metastasis and the incidence of postoperative complications will be constructed.

Methods: This study retrospectively analyzed the clinical data of CRC patients who underwent surgical treatment at Shanxi Bethune Hospital between January 2021 and June 2024.

Identification of CircRNAs that promote cancer and their potential contribution to hepatocellular carcinoma (HCC) pathogenesis.

The critical involvement of circRNAs in tumour progression and development is becoming increasingly evident. This study aimed to identify novel cancer-promoting circRNAs and explore their potential contribution to the pathogenesis of hepatocellular carcinoma (HCC). Expression profiles of circRNAs, miRNAs, and mRNAs associated with HCC were predicted through interaction analysis using data from the GEO and TCGA databases.

Reaction Coordinates Are Optimal Channels of Energy Flow.

Reaction coordinates (RCs) are the few essential coordinates of a protein that control its functional processes, such as allostery, enzymatic reaction, and conformational change. They are critical for understanding protein function and provide optimal enhanced sampling of protein conformational changes and states. Since the pioneering work in the late 1990s, identifying the correct and objectively provable RCs has been a central topic in molecular biophysics and chemical physics.

Design, Synthesis, and biological evaluation of 7H-Pyrrolo[2,3-d]pyrimidines as potent HPK1 kinase inhibitors.

Hematopoietic progenitor kinase 1 (HPK1) has emerged as a promising target for cancer immunotherapy due to its critical role as a negative regulator of T cell receptor (TCR) signaling. Despite this potential, no HPK1 inhibitors have been approved for cancer treatment, underscoring the need for structurally novel inhibitors. Herein, we describe the design, synthesis and biological evaluation of a series of potent HPK1 inhibitors based on our previously identified hit 9.

Transport and action of sesame protein-derived ACE inhibitory peptides ITAPHW and IRPNGL.

Vascular endothelial dysfunction is an important pathogenic factor in hypertension, in which angiotensin-converting enzyme (ACE) plays an important role. Peptides that bind to ACE may attenuate vascular endothelial dysfunction by altering the structure of ACE. This study demonstrated that ITAPHW and IRPNGL were resistant to simulated gastrointestinal fluid and were transported across the Caco-2 monolayer via the intercellular space, with ITAPHW showing a high apparent permeability coefficient of (1.

Enhanced sampling of protein conformational changes via true reaction coordinates from energy relaxation.

The bottleneck in enhanced sampling lies in finding collective variables that effectively accelerate protein conformational changes; true reaction coordinates that accurately predict the committor are the well-recognized optimal choice. However, identifying them requires unbiased natural reactive trajectories, which, paradoxically, require effective enhanced sampling. Using the generalized work functional method, we uncover that true reaction coordinates control both conformational changes and energy relaxation, enabling us to compute them from energy relaxation simulations.

FBXW7 metabolic reprogramming inhibits the development of colon cancer by down-regulating the activity of arginine/mToR pathways.

FBXW7 is a tumor suppressor gene that regulates metabolism and is associated with the onset and progression of colorectal cancer (CRC)), however, the precise mechanism whereby FBXW7 participates in the metabolic reprogramming of CRC remains unclear. Here, the research aims to reveal the association between the expression of FBXW7 and clinical variables and to investigate the molecular mechanism by which FBXW7 plays a critical role in the development of CRC. The clinical importance of FBXW7 in CRC was determined by immunohistochemistry.