Association of eating duration less than 8 h with all-cause, cardiovascular, and cancer mortality.

Aims: To assess the association between eating duration less than 8 h and all-cause and cause-specific mortality.

Methods: Adult participants who reported usual intake from two valid 24-h dietary recalls were included from the National Health and Nutrition Examination Survey in 2003-2018 (n = 19,831). Mortality status as of December 2019 was obtained through linkage to the National Death Index.

Unveiling postpartum PTSD: predicting risk factors using decision trees and logistic regression in Chinese women.

Background: While traditional logistic regression emphasizes main effects with limited capacity for interaction detection, emerging decision trees excel in uncovering complex associations. However, no studies have yet integrated both approaches to investigate postpartum posttraumatic stress disorder (PP-PTSD). This study aims to explore the factors associated with postpartum posttraumatic stress disorder (PP-PTSD) in Chinese women using decision tree and logistic regression models, while also comparing the predictive performance of both approaches.

Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice.

Food-specific immunoglobulin E (IgE) triggers life-threatening anaphylaxis; however, for unclear reasons, some people with food-specific IgE are asymptomatic upon allergen consumption. We studied strains of mice with different sensitivities to anaphylaxis when orally challenged with allergen to identify possible causes. In resistant C57BL/6 mice, intestinal goblet cells transported less food allergen than did anaphylaxis-susceptible strains, even before allergic sensitization.

Clinical Validation of the Venus HPV Full-Genotyping Assay for Cervical Cancer Screening in the VALGENT-4 Framework.

The Venus HPV assay (VenusHPV) is a real-time PCR-based human papillomavirus (HPV) test that is widely used in China but lacks extensive clinical validation. The VALidation of HPV GENotyping Tests (VALGENT) framework is an established protocol for evaluating HPV genotyping assays against a standard comparator test. This study aimed to assess the clinical accuracy and reproducibility of the VenusHPV assay following international validation criteria.

Effect of admission blood glucose on early mortality in patients with pontine hemorrhage.

Elevated admission blood glucose (ABG) is increasingly recognized as a prognostic marker in intracerebral hemorrhage, but its specific role in pontine hemorrhage (PH) remains underexplored. This retrospective study analyzed data from 247 PH patients admitted to two tertiary hospitals between 2012 and 2016 to evaluate the association between ABG and 30-day mortality. Receiver operating characteristic analysis identified 8.

PI3K-dependent GAB1/Erk phosphorylation renders head and neck squamous cell carcinoma sensitive to PI3Kα inhibitors.

The hyperactivation of the PI3K pathway in head and neck squamous cell carcinoma (HNSCC) suggests that targeting PI3K is a potential therapeutic strategy. CYH33 is a novel PI3Kα-selective inhibitor discovered by our group, which is currently undergoing a phase I clinical trial (NCT03544905) for the treatment of advanced solid tumors including HNSCC. However, there is an urgent need to elucidate its mechanism of action and improve its efficacy against HNSCC.

Epigenetic Signatures of Type 2 Diabetes Remission and Substantial Weight Loss: The Role of DNA Methylation in Response to Low-Calorie Diet Intervention.

Objectives: Low-calorie diet (LCD) interventions can lead to remission of type 2 diabetes (T2D), but the underlying mechanisms are not well understood. As a diet-sensitive regulator of gene expression, DNA methylation may reveal pathways underlying remission. However, whether individuals with different responses to LCD-induced T2D remission and weight loss exhibit distinct DNA methylation patterns remains unclear.

JMC14: a novel dual PI3Kδ/CSF1R inhibitor with potent antitumor activity in hematological and solid tumors.

PI3Kδ, predominantly expressed in immune cells and markedly dysregulated in B-cell malignancies, emerges as a promising and well-validated therapeutic target in hematologic cancers. Meanwhile, CSF1R regulates the formation and polarization of tumor-associated macrophages (TAMs), facilitating immune suppression and tumor progression in various solid tumors. Although targeting PI3Kδ or CSF1R has shown promise, the clinical application is often constrained by off-target effects, toxicity, and limited efficacy, particularly in solid malignancies.

All-electrospun polylactic acid/chitosan beaded porous nanofibers based single-electrode triboelectric nanogenerator for self-powered electronic skin.

Integrating outstanding electrical responsiveness and multiple practical functions, the self-powering electronic skin (e-skin) on the basis of single-electrode triboelectric nanogenerators (STENGs) shows remarkable competitiveness in next-generation energy, sensing and human-computer interaction applications. To fulfill the sensitivity, breathability, comfort and safety of STENG-based e-skin, the structural designs and material selections of its friction layer are crucial. In this study, a highly sensitive and breathable all-PLA/CS nanofiber STENG (PC-STENG) based e-skin with antimicrobial properties and good biocompatibility was prepared in large quantities by using spherical section free surface electrospinning (SSFSE) technique.

Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID.

Background: The symptomatic and immune responses to COVID-19 vaccination of people with Long COVID are poorly characterized.

Methods: In this prospective study, we evaluated changes in symptoms and immune responses after COVID-19 vaccination in 16 vaccine-naïve individuals with Long COVID. Surveys were administered before vaccination and at 2, 6, and 12 weeks after receiving the first vaccine dose of the primary series.

Self-Supporting Sn-Based Carbon Nanofiber Anodes for High-Performance Lithium-Ion Batteries.

Due to its high theoretical specific capacity, abundant resources, accessibility and environmental friendliness, Sn has been considered as a promising alternative to lithium-ion batteries (LIBs) anodes. However, Sn anodes still face great challenges such as huge volume change and low conductivity. Herein, a self-supporting Sn-based carbon nanofiber anode for high-performance LIBs was prepared.

The Application Status of Radiomics-Based Machine Learning in Intrahepatic Cholangiocarcinoma: Systematic Review and Meta-Analysis.

Background: Over the past few years, radiomics for the detection of intrahepatic cholangiocarcinoma (ICC) has been extensively studied. However, systematic evidence is lacking in the use of radiomics in this domain, which hinders its further development.

Objective: To address this gap, our study delved into the status quo and application value of radiomics in ICC and aimed to offer evidence-based support to promote its systematic application in this field.

Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria.

The caseinolytic protease complex ClpP1P2 is crucial for protein homeostasis in mycobacteria and stress response and virulence of the pathogens. Its role as a potential drug target for combating tuberculosis (TB) has just begun to be substantiated in drug discovery research. We conducted a biochemical screening targeting the ClpP1P2 using a library of compounds phenotypically active against (Mtb).

Enhanced expression of glycolysis regulators KmGcr1p and KmGcr2p in Kluyveromyces marxianus: An efficient strategy for high-temperature ethanol production from inulin.

Bioethanol production from non-food biomass has emerged as a sustainable alternative to satisfy future energy demands. Kluyveromyces marxianus stands out as a potential consolidated bioprocessing (CBP) strain for high-temperature ethanol production from inulin. Nevertheless, enhancing its fermentation efficiency remains crucial.

Specific modes of exercise to improve rotator cuff-related shoulder pain: systematic review and meta-analysis.

Objective: To investigate the effect of specific modes of exercise on rotator cuff-related shoulder pain (RCRSP) patients, aiming to provide a theoretical reference for conservative treatment and exercise prescription.

Methods: Data sources included PubMed/MEDLINE, Web of Science, ScienceDirect, and CNKI, covering studies from database inception to June 2024. Study selection followed pre-set inclusion/exclusion criteria.

Transitional Shock in Newly Graduated Registered Nurses From the Perspective of Self-Depletion and Impact on Cognitive Decision-Making: A Phenomenological Study.

Newly graduated registered nurses face more challenges than their experienced counterparts, as they not only confront the high pressures of an increasingly complex medical environment but also need to quickly adapt to their jobs and role transitions. The emotional burden arising at this stage is referred to as transitional shock. Self-depletion, as proposed by Baumeister, refers to the process by which individuals exhaust their internal psychological control resources when facing challenges, subsequently affecting cognition and emotion.

PbrBGAL6 promotes pollen tube growth by influencing apical pectin level in Pyrus bretschneideri.

Background: β-galactosidase (BGAL), which is an important cell wall-degrading enzyme, participates in various biological processes, but its effects on pollen tube growth (PTG) remain unclear.

Results: We identified 12 PbrBGAL genes (named PbrBGAL1-12) in the pear (Pyrus bretschneideri) genome. PbrBGAL members, containing three conserved domains and two enzyme active sites, were grouped into six subclasses.

Instant Gaussian Splatting Generation for High-Quality and Real-Time Facial Asset Rendering.

Traditional and AI-driven modeling techniques enable high-fidelity 3D asset generation from scans, videos, or text prompts. However, editing and rendering these assets often involves a trade-off between quality and speed. In this paper, we propose GauFace, a novel Gaussian Splatting representation, tailored for efficient rendering of facial mesh with textures.

[Determination of 30 bile acids in the bile of and using ultra-high performance liquid chromatography-triple quadrupole mass spectrometry].

Bile acids (BAs), the primary components of bile, play significant roles in sugar, lipid, and cholesterol metabolism. Normal BA metabolism maintains a dynamic equilibrium by regulating gut microbiota to effectively protect the liver and intestines, thereby sustaining overall health. Conversely, abnormal BA metabolism can cause intestinal tissue and liver damage, disruption of enterohepatic circulation homeostasis, dysbiosis of gut microbiota, and gastrointestinal and hepatic diseases.

Effect of Fentanyl on Remimazolam-Induced Sedation in Female Patients Undergoing Hysteroscopic Surgery: A Randomized Controlled Trial.

Purpose: Previous studies have reported the recommended dosage of remimazolam alone for achieving loss of consciousness (LoC). However, the effect of analgesics on the dosage of remimazolam for successful sedation remains unclear. This study evaluated the impact of fentanyl on the effective dose of remimazolam-induced sedation in female patients undergoing elective hysteroscopic surgery.

NiCu-layered double hydroxide-modified CuO nanorods for enhanced non-enzymatic glucose sensing.

A flexible non-enzymatic glucose sensor with high sensitivity (NiCu-LDH/CuO/NCC) was prepared by growing NiCu-layered double hydroxide (NiCu-LDH)-modified CuO nanorods on N-doped carbon cloth (NCC) using hydrothermal method and electrodeposition. The NCC provided abundant attachment sites and good electrical conductivity for CuO nanorods, and the hierarchical nanostructures (NiCu-LDH/CuO) had large specific surface area and highly catalytic active sites, which facilitated the electrooxidation of glucose. The effect of the ratio of Ni to Cu on the electrocatalytic performance of NiCu-LDH/CuO/NCC was evaluated.

Formation Mechanism and Motion Characteristics of Multiple Jets in Spherical Section Free Surface Electrospinning.

In this study, during the efficient preparation of nanofibers using a spherical section free surface electrospinning (SSFSE) device with different sphere radii, the formation mechanism and motion characteristics of multiple jets were thoroughly investigated through the numerical simulation method. The mechanical model of multiple jets was established, and the key role of electric field intensity in the formation and motion of jets was defined; in addition, the relationship between the jet initial velocity and the electric field intensity distribution on the solution surface was established. On this basis, a magnetohydrodynamic model was introduced, and a turbulence model as well as a volume of fluid model were combined to numerically simulate the jet motion during the SSFSE process.

LIGHt-based rapid detection of starch in tobacco leaves by smartphone sensing.

A rapid and efficient detection method to detect the total starch in tobacco leaves using smartphone-based anthrone-sulfuric acid colorimetry is established under the framework of the low-cost, immediate, general-purpose, and high-throughput (LIGHt) smartphone-based colorimetry. The LIGHt smartphone colorimetry resulted average relative error of 5.74%, with a relative standard deviation (RSD) ranging from 2.

Design, Synthesis, and Pharmacological Evaluation of Quinazoline and Quinoline Derivatives as Potent ENPP1 Inhibitors for Cancer Immunotherapy.

ENPP1, a transmembrane glycoprotein overexpressed in various cancers, has become a promising target for tumor immunotherapy. Several ENPP1 inhibitors have been reported, but only a few have been validated . Herein, based on the reported inhibitors and , we carried out a structural optimization by designing a variety of 8-methoxyquinazoline and its equivalent 8-methoxy-3-cyano-quinoline derivatives featuring bridged- or spirobicycles as the linker.

Path analysis to identify factors associated with health behavior in patients with stroke: Evidence from a cross-sectional and correlational survey.

Objective: To explore the relationship between environmental and personal factors and health behavior in patients with stroke through pathway analysis.

Methods: A path analysis was performed to consider the relationships between social support, healthcare payment, residence, self-regulatory fatigue (SRF), and health literacy (HL) and health behavior.

Results: Social support and residence were directly and indirectly associated with health behavior through the SRF and/or HL.