Metal(loid) Source Apportionment and Spatial Drivers in Irrigated Terrace Soils in a Typical Pb-Zn Mining Area.

Metal(loid) contamination levels and the factors governing metal(loid) accumulation patterns in terraced agricultural systems were studied using 1250 surface (0-20 cm depth) soil samples. The average concentrations of Cr, Ni, Cu, As, Cd, Pb, and Zn were 132, 62.3, 140, 42.

Evaluation of the Effects of Chitin and Chitosan on Pseudo-Allergic Reaction by Inhibiting MRGPRX2 Activation.

Chitin and chitosan, characterized by their extensive applications, abundant availability, and low cost, have been demonstrated to modulate immune responses. Mast cells (MCs) are important innate immune cells, and few studies on the regulation of MCs by chitin and chitosan were conducted. The key receptor Mas-related G protein-coupled receptor X2 (MRGPRX2), highly expressed in MCs, is involved in drug pseudo-allergic responses and several chronic diseases by mediating MC activation.

Silver-Catalyzed Difluorocarbene Activation Enables Multicomponent Synthesis of δ,γ-Unsaturated β-Hydroxynitriles.

Herein, we report an efficient and general one-pot multicomponent strategy, innovatively developed for the construction of δ,γ-unsaturated β-hydroxy nitrile scaffolds. Using readily available aldehydes and ketones as starting materials and TMSCFBr as a difluorocarbene precursor, the transformation proceeds via tandem Aldol condensation, a difluorocarbene electrophilic reaction, and hydrolysis. Mechanistic studies revealed that the difluorocarbene activates the oxygen atom of the α,β-unsaturated carbonyl group through electrophilic orientation, significantly enhancing the electrophilicity of the carbonyl carbon, thereby driving the reaction to proceed with high selectivity via a 1,2-addition pathway.

Cellular and Molecular Architecture of Renin-Angiotensin System Signaling in the PVN Under Cardiometabolic Stress.

The hypothalamic paraventricular nucleus (PVN) integrates neuroendocrine and autonomic signals that regulate blood pressure and metabolism. Although the renin-angiotensin system (RAS) is implicated in neurogenic hypertension and obesity, cell-type-specific expression and regulation of its components within the PVN remain poorly understood. Here, we employed single-nucleus RNA sequencing (snRNA-seq) to profile the transcriptomic landscape of the PVN in male mice under baseline conditions and in models of DOCA-salt-induced hypertension and high-fat diet (HFD)-induced obesity.

LINC00114 promotes colorectal cancer metastasis by targeting HNRNPA1 to regulate glutamine metabolism reprogramming and angiogenesis.

Colorectal cancer (CRC) is a common type of gastrointestinal malignancy, and it has a close connection with long noncoding RNAs (lncRNAs). This study aims to examine the involvement of long noncoding RNA LINC00114, which targets heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) in regulating glutamine metabolism and angiogenesis in the metastasis of colorectal cancer (CRC). LINC00114 and HNRNPA1 levels are measured in CRC tissues and cells to determine their expression levels.

Proportion and related factors of depression and anxiety for patients with pulmonary nodules in China: a outpatient-based cross-sectional study.

Investigating the proportion of depression and anxiety in patients with pulmonary nodules (PNs) and exploring the factors influencing them may help to optimize PNs management protocols and guide clinical decision-making. This study employed a cross-sectional design and included 260 patients attending the hospital's outpatient clinic. The assessment of depression and anxiety in patients with PNs was conducted using the Hamilton Depression Scale (HAMD) and the Hamilton Anxiety Scale (HAMA), respectively.

Identification and validation of prognostic genes associated with mitochondrial nuclear genes in gastric cancer.

Mitochondrial-related nuclear genes (MNGs) have shown great importance in cancer diagnosis and prognosis, but their role in gastric cancer (GC) remains unclear. GC-related transcriptome data from the gene expression omnibus and cancer genome atlas databases were analyzed to identify differentially expressed MNGs. A prognostic risk model was constructed through univariate Cox and least absolute shrinkage and selection operator regression, validated by Kaplan-Meier (K-M) survival curve and receiver operating characteristic curve.

L009 peptide as a novel antiangiogenic agent for corneal neovascularization via regulation of the TNFSF15-VEGF axis.

Corneal neovascularization (CNV) is a leading cause of vision impairment, with existing therapeutic options offering limited efficacy. This study presents L009, a novel antiangiogenic agent derived from the Kringle 5 domain of human plasminogen, specifically a heptapeptide, designed to treat CNV. In preclinical models, L009 demonstrated substantial efficacy by markedly inhibiting endothelial cell proliferation and migration, reducing vascular permeability, and maintaining ocular safety.

The Effectiveness of Nurse-Led Multidimensional Digital Cardiac Rehabilitation in Patients With Unstable Angina Undergoing Percutaneous Coronary Intervention: Emulated Target Trial.

Background: Cardiac rehabilitation (CR) interventions for patients with coronary heart disease are increasingly adopted. However, research on the integration of digital health technologies into CR for patients with unstable angina (UA) undergoing percutaneous coronary intervention (PCI) remains limited.

Objective: This study assessed the effectiveness of a multidimensional digital CR program for patients with UA undergoing PCI.

Visceral, Neural, and Immunotoxicity of Per- and Polyfluoroalkyl Substances: A Mini Review.

Per- and polyfluoroalkyl substances (PFASs) have gained significant attention due to their widespread distribution in the environment and potential adverse health effects. While ingestion, especially through contaminated drinking water, is considered the primary route of human exposure, recent research suggests that other pathways, such as inhalation and dermal absorption, also play a significant role. This review provides a concise overview of the toxicological impacts of both legacy and emerging PFASs, such as GenX and perfluorobutane sulfonic acid (PFBS), with a particular focus on their effects on the liver, kidneys, and immune and nervous systems, based on findings from recent in vivo, in vitro, and epidemiological studies.

Application of three-dimensional fluorescence spectral characterization and chemometrics in the analysis of traceability of Paeoniae Radix Rubra.

Natural products are treasure troves of resources that the environment has given upon humans and are directly linked to human health and well-being. Extracting natural products from medicinal plants is the material basis for treating various diseases but the natural product content of the same medicinal plant can vary due to environmental conditions, which may exert an influence on the therapeutic outcome. Since the existing identification methods for the origin of medicinal plants are cumbersome, it is necessary to find a easy, quick, and accurate way to trace the origins of medicinal plants and ensures the quality of natural products.

Hospital acquired drug resistant pathogens infections in patients with viral respiratory tract infections: a retrospective study.

Background: Viral respiratory infections (VRTIs) caused by influenza (Flu) and COVID-19 pose significant global health challenges. Clinical outcomes are further exacerbated by infections with hospital acquired drug resistant pathogens (DRPs).

Methods: A retrospective analysis was conducted on the data of 1,051 hospitalized patients with VRTIs from 2018 to 2024 at Beijing Ditan Hospital.

Correlation between saltiness-enhancement and fluorescence intensity of Maillard reaction intermediates from corn peptides and taste stability during subsequent thermal reaction.

Protein hydrolysates are considered as suitable reactants for the Maillard reaction due to their desirable taste characteristic and highly reactivity. However, the complexity of Maillard reaction systems involving protein hydrolysates makes it challenging to predict and control peptide taste stability. This study employed fluorescence intensity (FI) as an indicator of Maillard reaction degree to investigate its correlation with the saltiness-enhancing (SE) effect of peptides.

The FTR dual-loop architecture based on SID-NLMS can achieve a threshold of 0.0001°/s and an ARW of 0.006°/√h for MEMS QMG.

With the introduction of technologies such as structural optimization and error correction, the performance of the MEMS quad-mass gyroscope (QMG) has significantly improved, while noise has gradually become a critical factor limiting its performance. For ease of analysis, this paper categorizes noise into two types: noise at the signal detection end and noise at the excitation end. Firstly, a closed-loop noise model for QMG is established, and the effects of these two types of noise on the dynamic and static performance of QMG are investigated.

Injectable HMME-Loading Emulsion Hydrogel for Ultrasound-Triggered Release and Enhanced Sonodynamic Immunotherapy.

Immune checkpoint blockade (ICB) therapies, such as targeting programmed death-1 (PD-1) and programmed cell death protein ligand-1 (PD-L1), are often ineffective in low-immunogenic tumors, limiting their widespread use. In this study, an emulsion hydrogel is developed to encapsulate the sonosensitizer hematoporphyrin monomethyl ether (HMME), aimed at enhancing sonodynamic immunotherapy for low-immunogenic cancers. The water-in-oil emulsion hydrogel, characterized by its shear-thinning rheological properties, demonstrates excellent ultrasound (US)-triggered and lipase-triggered release, followed by sustained release.

Effects of Underwater Noise Exposure on Early Development in Zebrafish.

Anthropogenic noise pollution is a significant global environmental issue that adversely affects the behavior, physiology, and auditory functions of aquatic species. However, studies on the effects of underwater noise on early developmental stages of fish remain scarce, particularly regarding the differential impacts of daytime versus nighttime noise exposure. In this study, zebrafish () embryos were exposed to control group (no additional noise), daytime noise (100-1000 Hz, 130 dB, from 08:00 to 20:00) or nighttime noise (100-1000 Hz, 130 dB, from 20:00 to 08:00) for 5 days, and their embryonic development and oxidative stress levels were analyzed.

A robust strategy for thermoformable cellulosic composite bioplastics hydrogen bond substitution.

Cellulose represents a promising renewable resource for the development of sustainable alternatives to petroleum-derived plastics, owing to its exceptional biodegradability and renewability. However, the extensive hydrogen-bonding network and ordered crystalline structure of cellulose limit its solubility and thermo-processability, posing significant challenges for large-scale production of recyclable high-performance bioplastics. In this study, we propose a robust strategy for cellulosic composite bioplastic by controlling the disruption and reformation of hydrogen bonds in ethyl cellulose (EC) nanocomposites incorporating rheologically tunable graphene (Rt-G), which can dynamically dissociate hydrogen bonds within the EC matrix.

Conversion of Glucose-Glycine Amadori Compound to 2-Furfural Induced by Glyoxal.

2-Furfural is a potential genotoxic compound that could be generated through the Maillard reaction. Clarification of reaction pathways affecting the 2-furfural formation shows great significance. 2-Furfural formation from the glucose-glycine Amadori compound (AC) was found to be greatly influenced by the intermediate glyoxal.

Discriminant research on edible oil components by oblique-incidence reflectivity difference.

Edible oil plays an important role in people's diet. Due to economic and nutritional benefits, it is necessary to analyze the components in edible oils, which can ensure consumer rights. In this study, edible oil components were identified by oblique-incidence reflectivity difference (OIRD) which included linoleic acid, oleic acid, alpha linolenic acid.

Pharmacokinetics, Safety, and Tolerability of (R)-Ketamine Hydrochloride Injection, a Novel Rapid-Acting Antidepressant, in Healthy Chinese Subjects.

: (R)-ketamine hydrochloride injection is a novel, rapid-acting antidepressant for the treatment of treatment-resistant depression. The aim of this study was to assess the pharmacokinetics, safety, and tolerability of (R)-ketamine hydrochloride injection in healthy Chinese subjects following ascending single intravenous doses ranging from 10.0 mg to 180 mg.

Targeting CX3CR1 Signaling Dynamics: A Critical Determinant in the Temporal Regulation of Post-Stroke Neurorepair.

Ischemic stroke ranks among the top global causes of disability and mortality, with a highly dynamic pathological process. Post-stroke neuroinflammation, mediated by microglia, demonstrates a dual role in both injury and repair. The CX3CR1/CX3CL1 signaling axis, highly expressed in microglia, acts as a key regulator.

Novel loop structure of human IgG1 Fc fused CD38 targeted bispecific antibodies and their anti-tumor effect in acute myeloid leukemia.

Background: Acute myeloid leukemia (AML) still lacks an ideal immunotherapy target. CD38 serves as a potential therapeutic target for AML. Classical bispecific antibody (BsAb) requires continuous infusion due to small molecular size and short half-life.