Assessing the industrial pollution risk potential to farmland soil environment based on spatialization: A single-year study in China.

Industrial activities are major contributors to farmland soil pollution, posing considerable risk potential to the soil environment. A quantitative and spatial assessment of the industrial pollution-related risk potential will provide critical insights into their characteristics, supporting methodological advancements and practical applications in soil environmental management. This study develops a systematic evaluation framework to assess the risk potential of industrial pollution to the farmland soil environment.

β-Asaronol, the Neuroactive Component of : Mitigating Seizures with Minimal Developmental Risk in Dravet Syndrome.

Developmental epileptic encephalopathies (DEEs), including Dravet syndrome (DS), require antiseizure medications (ASMs) that balance efficacy with developmental safety. There is an urgent clinical need for novel therapeutic agents that combine potent anticonvulsant activity with developmental safety. β-Asarone, an active constituent of plants, has demonstrated antiepileptic potential, but its toxicities severely limit clinical application.

Hydrogel adhesives with a hydrodynamically induced liquid-solid transition for annular fissure sealing and inflammation modulation following microdiscectomy.

Background: Intervertebral disc (IVD) herniation is a major cause of low back pain and disability, with microdiscectomy being the standard surgical treatment. However, microdiscectomy fails to address annulus fibrosus (AF) defects, increasing the risk of recurrent herniation. Current therapeutic strategies for this condition remain limited in efficacy.

Efficacy of Acupuncture Therapy in Treating Non-Motor Symptoms of Parkinson's Disease: A Systematic Review and Network Meta-Analysis.

Purpose: Recently, research on the management of Parkinson's disease (PD), particularly non-motor symptoms (NMS), has been increasingly reported. This systematic review and network meta-analysis (NMA) aimed to evaluate the efficacy of acupuncture interventions for NMS in PD patients to identify the most effective strategy.

Methods: Randomized controlled trials (RCTs) on acupuncture for NMS in PD were retrieved up to July 31, 2024, across eight databases: PubMed, Embase (OVID), Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, VIP Database, and Wanfang Database.

Design optimization of mutual dissolution layer and diffusion interface layer in planar heterojunction near-infrared organic phototransistors for ultrahigh photosensitivity.

The interfacial mutual solubility can result in a random distribution of donor and acceptor materials during the spin-coating step in the fabrication of planar heterojunction (PHJ) near-infrared (NIR) organic phototransistors. In this case, deep trap states are induced by acceptors, accelerating electron-hole recombination, ultimately impairing the photoresponsivity of the phototransistor. To solve this issue, a controllable mutual dissolution layer (formed by co-solvent treatment) combined with a diffusion interface layer (formed by the solvent vapor annealing (SVA) method) was introduced to achieve a more ordered arrangement of donors and acceptors, thereby enhancing the electrical performance of PHJ-based NIR phototransistors.

Metabolic Inhibitor Loaded Metal-Phenolic Nanocapsules Enable Synergistic Cancer Therapy through Cuproptosis and Immunometabolic Reprogramming.

Abnormal glycolysis and glutamine metabolism not only sustain tumor growth but also reprogram the tumor microenvironment (TME). However, due to compensatory mechanisms and low tumor immunogenicity, targeting a single metabolic pathway is often insufficient for effective cancer therapy. We here developed dual-starvation therapeutic metal-phenolic nanocapsules (CG@Cap) by encapsulating a glutamine metabolism inhibitor with a zeolitic imidazolate framework-8 and adsorbing glucose oxidase on the surface, followed by coordination-driven assembly with tannic acid and copper ions.

Polarization of Tumor Cells and Tumor-Associated Macrophages: Molecular Mechanisms and Therapeutic Targets.

Tumor-associated macrophages (TAMs) are prominent constituents of solid tumors, and their prevalence is often associated with poor clinical outcomes. These highly adaptable immune cells undergo dynamic functional changes within the immunosuppressive tumor microenvironment (TME), engaging in reciprocal interactions with malignant cells. This bidirectional communication facilitates concurrent phenotypic transformation: tumor cells shift toward invasive mesenchymal states, whereas TAMs develop immunosuppressive, pro-tumorigenic traits.

[Immune function regulation and tumor-suppressive effects of Shenqi Erpi Granules on S_(180) tumor-bearing mice].

This study aims to establish the S_(180) tumor-bearing mice model, and to investigate the influence of Shenqi Erpi Granules(SQEPG) on immune function, as well as the drug's tumor-suppressive effect and mechanism. SPF grade KM mice(half male and half female) were randomly divided into 6 groups: a control group, a model group, a cyclophosphamide group(50 mg·kg~(-1)), as well as SQEPG groups in low-, medium-, and high-dose(5.25, 10.

RNA binding protein SERBP1 is indispensable for oocyte development and maturation in mice.

RNA-binding proteins (RBPs) are critical regulators of post-transcriptional gene expression and RNA processing during mammalian oocyte development. SERPINE1 mRNA-binding protein 1 (SERBP1), a conserved RNA-binding protein (RBP), exhibits prominent expression in the female reproductive system and throughout oogenesis. Conditional deletion of Serbp1 using oocyte-specific Zp3⁠/⁠Gdf9⁠-Cre drivers resulted in arrested oocyte growth, female infertility, and failure of blastocyst formation from two-cell embryos.

Prognostic role of Ki-67 in colorectal carcinoma: Development and evaluation of machine learning prediction models.

Background: Ki-67 is a routine test item in clinical pathology departments. However, its prognostic value requires further investigation, especially in the context of research using machine learning (ML), which remains relatively underdeveloped.

Aim: To investigate the prognostic value of Ki-67 in cases of colorectal carcinoma (CRC) and explore the potential application of ML algorithms to predict the Ki-67 index.

Proposal of (Artamonova and Krassilnikov 1960) Pridham 1970 (Approved Lists 1980) as a later heterotypic synonym of (Rossi Doria 1891) Waksman 1953 (Approved Lists 1980) and an emended description of .

The taxonomic relationship between and was re-evaluated using comparative genome analysis. The 16S rRNA gene sequence analysis indicated that the type strains of and shared 100% sequence similarity. Phylogenetic trees based on 16S rRNA gene sequences indicated that JCM 4387 was clustered together with CGMCC 4.

NMOD: A Multi-Dimensional Omics Database for Disease Resistance Research in Nicotiana.

High-throughput sequencing has generated extensive omics data for Nicotiana species, a key model genus in the Solanaceae family. However, fragmented data and limited cross-species integration in current databases hinder the identification of disease-resistant genes and germplasm innovation. To address these challenges, we developed Nicotiana Multi-Dimensional Omics Database (http://biodb.

AXL and MERTK facilitate tissue repair in severe acute pancreatitis via a CCR5-dependent neutrophil and macrophage crosstalk.

Severe acute pancreatitis (SAP) is a potentially life-threatening inflammatory disorder of the exocrine pancreas, characterized by massive cell death, which drives the progression and resolution of the disease. However, little is known about the key regulators in the tissue microenvironment that mediate tissue damage and repair. In this study, we discovered that AXL and MERTK in macrophages are responsible for tissue repair and pancreatic inflammation following SAP.

Seed phenotype and maturity groups as determinants of protein, oil, and fatty acid composition patterns in diverse soybean germplasm.

Soybean seed physical characteristics are crucial for quality assessment, but the link between these characteristics and biochemical composition across different maturity groups (MGs) remains unclear. This study examined the relationships between seed physical characteristics (color and weight) and biochemical constituents, including oil content (OC), protein content (PC), and fatty acid (FA) composition in 191 diverse soybean accessions across eight MGs (0-VII) at three locations over two years. The results indicated that black-seeded accessions demonstrated a notably higher average of PC (47.

Global 1-km habitat distribution for endangered species and its spatial changes under future warming scenarios.

Implementing biodiversity and climate actions for endangered terrestrial vertebrates is hampered by a lack of high-precision habitat maps. Therefore, we developed a dataset by linking the suitable land-use types and elevation ranges of each endangered terrestrial vertebrates and mapping these factors onto our recently developed global land use and land cover maps, we generated the distribution of global 1-km habitat suitability ranges distributions from 2020 to 2100 under varied climate warming scenarios for endangered terrestrial vertebrates (2,571 amphibians, 617 birds, 1,280 mammals, and 1,456 reptiles) and obtained the spatial evolution maps as compared to 2020 baseline. Validation of the 2020 data with actual observation data suggested that the AOH maps for 94% of amphibians, 94% of birds, 95% of mammals, and 91% of reptiles exhibited higher densities of observation points within the AOH compared to a uniform random distribution within the IUCN maps, indicating better-than-chance spatial alignment.

Analysis of m7G-related signatures in the tumor immune microenvironment and identification of clinical prognostic regulators in ovarian cancer.

Ovarian cancer (OV) is the most lethal gynecological malignancy in the world. At present, the effect of m7G modification-related genes on the development of ovarian cancer remains unclear. We performed consensus clustering of ovarian cancer samples based on the expression of 24 m7G modification-related genes, and obtained 2 subtypes.

Pressure effects on lithium anode/nickel-manganese-cobalt oxide cathode pouch cells through fixture design.

Applying external pressure to a pouch cell results in improved performance, implicating systems-level design of batteries. Here, different formats and amounts of external pressure to Li-LiNiMnCoO (Li-NMC811) pouch cells were studied under lean electrolyte conditions. Due to the more uniform lithium plating/stripping, a constant gap fixture that retains the distance of the frame during cycling performed greater than a constant pressure fixture that retains applied pressure to the cell.

Stability Evaluation Method and Application of Puff-by-Puff Release of Aerosol Constituents in Heated Tobacco Materials and Products.

Puff-by-puff release stability is critical for heated tobacco product (HTP) quality and user experience, yet existing methods lack dynamic puff-by-puff evaluation. Here, we develop a novel stability index (SI) using the "modulus of the sum vector of two evaluation dimensions" algorithm to quantify puff-by-puff release consistency and interpuff variability. In addition, the algorithm has been validated through practical product applications.

Blueberry Anthocyanins Ameliorate Obesity-Induced Dysfunction of Lipid Metabolism and Gut Microbiota by Inhibiting TLR4 Pathway.

Blueberry anthocyanins demonstrate promising anti-obesity potential, however, their mechanism remains underexplored. This investigation revealed Toll-like receptor 4 (TLR4), an immune receptor recently found to involve in insulin resistance, as a critical mediator of these effects. Male wild-type (WT) and TLR4 gene knockout (TLR4) mice were used to establish obesity model and investigate the anti-obesity effects of blueberry anthocyanin extracts (BAE) based on TLR4.

Influencing factors of flexion contracture among patients with knee osteoarthritis: a multi-center retrospective cross-sectional study.

Knee osteoarthritis (KOA) is a chronic disease with a high prevalence and disability rate. Alterations in lower limb alignment and reduction in lower limb muscle strength are important factors in the progression of KOA. Although pain is the main reason for KOA patients to seek medical treatment, the presence or absence of joint deformity is one of the crucial factors influencing the prognosis and recurrence of the disease.

Combined detection of foodborne pathogens in irrigation water in Jiangsu, China.

Numerous foodborne disease outbreaks have been attributed to the consumption of fresh produce contaminated with foodborne pathogens. Contaminated irrigation water is a well-established source of bacterial and viral contamination during primary production and is frequently responsible for the contamination of fresh produce. However, efficient methods for the simultaneous detection of bacterial and viral pathogens present in irrigation water are still scarce.

Bicarbonate-integrated transarterial chemoembolization (TACE) in real-world hepatocellular carcinoma.

The objective response rate of conventional transarterial chemoembolization (TACE) for locoregional control of hepatocellular carcinoma (HCC) is approximately 50%. We previously developed bicarbonate-integrated TACE, termed TILA-TACE, which demonstrated 100% effectiveness for locoregional control of unresectable HCC. This study aimed to validate its efficacy, selectivity, and safety in real-world clinical practice (ChiCTR-ONC-17013416).

Image-Text-Image Knowledge Transfer for Lifelong Person Re-Identification with Hybrid Clothing States.

With the continuous expansion of intelligent surveillance networks, lifelong person re-identification (LReID) has received widespread attention, pursuing the need of self-evolution across different domains. However, existing LReID studies accumulate knowledge with the assumption that people would not change their clothes. In this paper, we propose a more practical task, namely lifelong person re-identification with hybrid clothing states (LReID-Hybrid), which takes a series of cloth-changing and same-cloth domains into account during lifelong learning.

Radioactive Iodine Therapy for Pediatric Graves' Hyperthyroidism.

BACKGROUND The aim of this study was to determine the remission rate and factors influencing radioactive iodine (RAI) therapy in pediatric patients with Graves' hyperthyroidism (GH) who received treatment for the first time. MATERIAL AND METHODS This retrospective study analyzed a total of 44 pediatric patients with GH who received their first RAI therapy in the nuclear treatment ward of Linyi People's Hospital from December 2018 to December 2023. Follow-up was conducted for 6 months after treatment, and based on treatment outcomes, the patients were divided into the remission group and the failure group.