Molecular Motor Matrix-Based Augment Heat Dissipation Strategy Affording Ultrahigh-PCE J-Aggregates for Potentiate Cancer Photothermal Immunotherapy.

The photothermal conversion efficiency (PCE) stands as a pivotal determinant in the therapeutic efficacy of photothermal nanoagents (PTNAs) within the context of photothermal therapy (PTT). The dearth of universal strategies to greatly enhance PCE has markedly curtailed the practical deployment of PTNAs. Now this problem is addressed by proposing a universal approach founded on molecular rotors and J-aggregates, "highly efficient molecular motor matrix", to greatly elevate the PCE of traditional PTNAs.

Real-World Analysis of Potential Drug-Drug Interactions with Nirmatrelvir/Ritonavir Based on the Hospital Prescription Analysis (HPA) Database in 9 Cities of China.

Purpose: To determine the real-world patterns and extent of potential drug-drug interactions (DDIs) related to nirmatrelvir/ritonavir (NMVr) in China.

Patients And Methods: Data on NMVr-treated patients from over 160 hospitals across 9 Chinese cities from January 2022 to December 2023 were extracted from the Hospital Prescription Analysis (HPA) database, which was established in Beijing in 1997 to promote rational medication use in China. Grade C, D and X DDIs from the Lexicomp database were defined as clinically significant and analyzed in this study.

Global 1-km habitat distribution for endangered species and its spatial changes under future warming scenarios.

Implementing biodiversity and climate actions for endangered terrestrial vertebrates is hampered by a lack of high-precision habitat maps. Therefore, we developed a dataset by linking the suitable land-use types and elevation ranges of each endangered terrestrial vertebrates and mapping these factors onto our recently developed global land use and land cover maps, we generated the distribution of global 1-km habitat suitability ranges distributions from 2020 to 2100 under varied climate warming scenarios for endangered terrestrial vertebrates (2,571 amphibians, 617 birds, 1,280 mammals, and 1,456 reptiles) and obtained the spatial evolution maps as compared to 2020 baseline. Validation of the 2020 data with actual observation data suggested that the AOH maps for 94% of amphibians, 94% of birds, 95% of mammals, and 91% of reptiles exhibited higher densities of observation points within the AOH compared to a uniform random distribution within the IUCN maps, indicating better-than-chance spatial alignment.

Impact of land use change on carbon metabolism in Hunan Province: An ecological network analysis approach.

Rapid urbanization alters land use patterns and, in turn, regional carbon metabolism. Focusing on Hunan Province, China (2000-2020), we combined high-resolution land-use inventories with ecological network analysis to quantify carbon emissions, carbon sequestration, and the interactions among major land categories. Emissions rose markedly over two decades, driven mainly by expanding transportation and industrial zones.

Markers of left atrial cardiopathy and cognitive function trajectories in adults aged ≥45 years without atrial fibrillation: a population-based study.

Introduction: The study aims to investigate associations between markers of atrial cardiopathy and cognitive function trajectories in adults without prior AF.

Methods: The study included 4,486 participants from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. Markers of atrial cardiopathy included atrial premature complexes and N-Terminal pro-Brain Natriuretic Peptide (NT pro-BNP).

Multimodal targeting of metastatic renal cell carcinoma via CD70-directed allogeneic CAR-NKT cells.

Renal cell carcinoma (RCC) represents about 90% of kidney cancers, with 30%-40% of patients developing metastatic disease despite current treatments. Conventional chimeric antigen receptor (CAR)-T therapy targeting CD70 shows promise but faces challenges due to its autologous, personalized nature. Here, we develop allogeneic CD70-directed CAR-engineered invariant natural killer T (CAR70-NKT) cells from hematopoietic stem and progenitor cells using a clinically guided culture method.

Activation of local and systemic calcium and stomatal closure responses by flg22 is regulated by eATP receptor DORN1.

Perception of pathogen-associated molecular patterns (PAMPs) by plants can trigger local and systemic responses in plants. DORN1 (Does not Respond to Nucleotides 1, the lectin receptor kinase I.9) is known as the receptor of extracellular ATP (eATP) of plants and plays important roles in the regulation of the responses of plants to environmental stimulation.

The bone marrow mesenchymal stem cells derived migrasomes induced by Titania nanotubes surface serve as chemotaxis effect for osteogenesis.

The regulatory role of migrasomes (Migs) has attracted growing attentions recently. However, most of the reports only focus on the influence of donor cells on Migs contents, regarding the substrate information. In the present study, the bone marrow mesenchymal stem cells (BMSCs) derived Migs were investigated on titania micropits/nanotubes (MNT) under different anodization voltages.

Electrochemical Detection of Fluoride Ions Enhanced by 3-Aminophenylboronic Acid Manipulated MIL-100(Fe)/g-CN Nanocomposite.

The traditional analysis methods for fluoride ions, including potentiometric titration and chromatography, suffer from issues such as complex analysis processes, high costs, and long duration. Here, a typical nanocomposite, consisting of an iron metal-organic framework (MIL-100(Fe)) with surface defects and graphitic carbon nitride (g-CN), has been successfully developed through regulation by 3-aminophenylboric acid, specifically for the fabrication of fluoride ion sensors. The electrochemical behavior of fluoride ions was investigated using the modified electrode via differential pulse voltammetry.

Novel insights into genetic associations and drug targets of mitochondria-associated proteins with major depressive disorder.

Background: A growing number of observational studies have found that mitochondrial pathomechanisms are associated with major depressive disorder (MDD), but little is known about the causal direction of this association. This study aimed to explore the potential causal relationship between mitochondria-associated proteins and the risk of MDD.

Methods: We used summary data from a genome-wide association study (GWAS) of 66 mitochondria-associated proteins in 3301 individuals of European descent, as well as a large GWAS on MDD, which involved 294,322 cases and 741,438 controls.

Drug repurposing: isosorbide mononitrate enhances tumor accumulation to augment sonodynamic therapy for hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) remains a leading cause of cancer death worldwide. Sonodynamic therapy (SDT) offers a non-invasive, deep-penetrating approach by using ultrasound to activate sonosensitizers and generate cytotoxic reactive oxygen species (ROS). Yet poor intratumoral delivery and low ROS quantum yields of existing agents have stalled clinical translation.

Afterglow-driven tablet quality assessment: non-destructive detection via maltodextrin-based room temperature phosphorescence.

This study explores a non-destructive detection method utilizing the afterglow effect of maltodextrin (MD) for tablet quality detection. Firstly, Fourier transform infrared spectroscopy analysis revealed MD's phosphorescence mechanisms. Then, MD tablets were prepared for hardness response, disintegration testing, and hygroscopicity testing.

Accuracy of robot-assisted dental implant surgery and its clinical influencing factors: a retrospective case series of 100 patients.

Background: This retrospective study aimed to investigate the accuracy of robot-assisted implant surgery and identify the factors influencing it.

Methods: Patients with single or multiple missing teeth were enrolled in the robot-assisted implant surgery. The patients underwent cone-beam computed tomography (CBCT) using a marker.

Morphology vs. toxicity: How temperature reshapes Microcystis' adaptive strategies in a warming world?

Global warming and eutrophication have synergistically intensified cyanobacterial blooms, with Microcystis posing significant ecological and health risks due to microcystin (MC) production. This study investigated how temperature gradients (10 °C, 25 °C, 35 °C, 40 °C) modulate physiological, morphological, and molecular adaptive strategies in M. aeruginosa, focusing on metabolic trade-offs between morphological plasticity and toxin production.

A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma.

CD147 has emerged as a promising tumor-specific therapeutic target. Identifying small-molecule inhibitors that promote its proteolysis represents a critical step toward advancing clinical translation, while elucidating its mechanisms of action could further accelerate this process. In this study, we identify dracorhodin perchlorate (DP) as a potent CD147 inhibitor that induces autophagy-dependent degradation.

Potential circadian rhythm-related pathogenic genes in coronary artery disease: a Mendelian randomization study.

Purpose: Coronary artery disease (CAD) is a leading cause of cardiovascular morbidity and mortality worldwide. Recent studies suggest disruptions in circadian rhythms may contribute to CAD, but the underlying mechanisms remain unclear. This study employs summary-data-based Mendelian randomization to explore the roles of circadian rhythm genes in CAD and their clinical implications.

Discovery of Osivelotor (GBT021601): A Potent, Next-Generation Sickle Hemoglobin Polymerization Inhibitor.

This report details the discovery path of GBT021601 (osivelotor) (), a novel, small molecule, sickle hemoglobin (HbS) polymerization inhibitor. Following a streamlined testing funnel with cassette dosing in rat pharmacokinetic (PK) studies, we identified this next-generation HbS polymerization inhibitor, which had improved PK properties compared with the first-in-class drug, voxelotor (). GBT021601 has ∼4.

Conductive polymers in smart wound healing: From bioelectric stimulation to regenerative therapies.

Wound healing, particularly in particularly after surgical operations and especially cardiothoracic surgeries, presents a significant global healthcare burden due to prolonged recovery time, recurrent infections, and limited effectiveness of the conventional therapies. The recent advancements in biomaterials have positioned conductive polymers (CPs) as promising components in the design of next-generation wound care technologies. CPs, such as polypyrrole (PPy), polyaniline (PANI) and poly (3,4-ethylenedioxythiophene) (PEDOT), possess unique electrical, chemical and biological properties, making them ideal for integration into multifunctional and responsive wound dressings.

Enhanced Near-Infrared-Excitable Organic Afterglow Nanoparticles for Deep-Tissue Multimodal Imaging via Singlet Oxygen-Mediated Energy Transfer.

Afterglow imaging offers exceptional signal-to-background ratios (SBRs) by circumventing real-time excitation and autofluorescence, yet conventional systems rely on visible-light excitation, limiting tissue penetration and signal intensity. Here, we report near-infrared-excitable organic afterglow nanoparticles (NOANPs) that leverage singlet oxygen (O)-mediated energy transfer to achieve prolonged, high-intensity emission with minimal photobleaching. The nanoparticles integrate a near-infrared-photoactive sensitizer (NAM-0), which generates abundant O under 808-nm laser excitation, and a triplenet-anthracene derivative (TD) as the afterglow substrate, which converts O into sustained luminescence.

Dynamic Co(II)/Co(III) Cycle Driven by Outer- and Inner-Sphere Electron Transfer for Sustained Peroxymonosulfate Activation.

In the realm of transition metal (M) activated peroxymonosulfate (PMS), sluggish reduction kinetics of M often lead to the rapid deactivation of catalytic centers, posing a significant challenge for commercialization of homogeneous advanced oxidation processes (AOPs). We report a pioneering elucidation of a distinct Co(II)/Co(III) cycling mechanism within electrochemically enhanced PMS-AOPs, utilizing Co(II) as a model catalyst. Remarkably, this cycling process predominantly unfolds in the anodic region, rather than the cathodic, revealing a novel aspect of electrochemical modulation.

Emerging roles of tsRNAs in programmed cell death and disease therapeutics: challenges, opportunities, and future directions.

Programmed cell death (PCD), which includes various forms such as apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis, plays a pivotal role in disease pathogenesis and progression. tRNA-derived small RNAs (tsRNAs) have emerged as crucial regulators of these processes, influencing cellular fate and disease outcomes. Research has revealed diverse expression profiles of tsRNAs across various diseases, emphasizing their roles in modulating PCD pathways and their potential value in diagnosis and treatment.

Overcoming ovarian cancer resistance and evasion to CAR-T cell therapy by harnessing allogeneic CAR-NKT cells.

Background: Ovarian cancer (OC) poses a significant challenge for conventional chimeric antigen receptor-engineered T (CAR-T) cell therapy, due to frequent recurrence linked to tumor heterogeneity, platinum resistance, immune evasion, and an immunosuppressive tumor microenvironment (TME).

Methods: Here, we analyze primary OC patient samples and identify a unique opportunity for allogeneic CAR-NKT (CAR-NKT) cells to concurrently attack OC tumor cells and their TME. Leveraging stem cell gene engineering and a clinically guided culture method, we achieve robust generation of CAR-NKT cells at high yield and purity.

HHAvatar: Gaussian Head Avatar with Dynamic Hairs.

Creating high-fidelity 3D head avatars has always been a research hotspot, but it remains a great challenge under lightweight sparse view setups. In this paper, we propose HHAvatar represented by controllable 3D Gaussians for high-fidelity head avatar with dynamic hair modeling. We first use 3D Gaussians to represent the appearance of the head, and then jointly optimize neutral 3D Gaussians and a fully learned MLP-based deformation field to capture complex expressions.