FGF9-FGFR2 Signaling via Osteocytes-Preosteoblasts Crosstalks to Mediate Mechanotransduction-Driven Intramembranous Osteogenesis in the Underdeveloped Maxilla.

Maxillary underdevelopment is a critical component of skeletal Class III malocclusion, closely linked to altered biomechanical signaling. Mechanical stimulation through early facemask protraction can effectively promote maxillary growth, yet the underlying mechanotransduction mechanisms remain unclear. In this study, fibroblast growth factor 9 (FGF9) is identified as a key biomechanical responder in maxillary development.

Risk Assessment of Surgical Site Infections After Cesarean Delivery in Patients with Gestational Diabetes Cases.

BACKGROUND Cesarean sections in patients with gestational diabetes mellitus (GDM) carry a heightened risk of surgical site infections. Understanding the risk factors associated with these infections can inform preventive strategies and improve patient outcomes. MATERIAL AND METHODS A comprehensive retrospective analysis was conducted from January 2020 to December 2023 to identify risk factors for surgical site infections following cesarean sections in GDM patients.

A case report of thyroid myofibroblastic sarcoma.

Rationale: High-grade myofibroblastic sarcoma (HGMS) is a rare mesenchymal tumor with a high recurrence and metastatic rate. Few cases of high-grade myofibroblastic sarcomas have been reported. Herein, we report the first case of HGMS originating from the thyroid.

Preliminary study on SIRI dynamic changes for the efficacy prediction and prognosis evaluation of advanced cancer patients treated with immunotherapy.

Objective: To investigate the values of systemic inflammatory response index (SIRI) and its dynamic changes in predicting the efficacy and evaluating the prognosis of immunotherapy for advanced cancers.

Methods: A retrospective analysis was conducted on the clinical data of 245 patients with locally advanced and advanced cancers who received immune checkpoint inhibitors (ICI) treatment at the 940 Hospital of the Joint Logistics Support Force from June 2020 to June 2023.The χ2-test was used to compare the clinical pathological characteristics of patients in the disease control group and the no-control group, and Kruskal-Wallis test was used to compare the differences in SIRI pre-treatment, disease remission, and disease progression.

Tumor organoids targeted by receptor-engineered immune cells: A promising approach for advancing cancer immunotherapy.

Patient-derived tumor organoids, often referred to as tumor organoids, serve as in vitro tumor models for tumor-related research, such as living biobanks, identification of biomarkers, drug screening and personalized precision medicine. Despite great success of chimeric antigen receptor (CAR)-engineered T cell therapy of B cell malignancies, the efficacy of receptor-engineered immune cell therapy of solid tumors remains suboptimal due to the molecular heterogeneity and immunosuppressive tumor microenvironment. Moreover, direct and extensive clinical studies are limited because of the toxicity of drugs or adoptively transferred immune cells.

Activation of local and systemic calcium and stomatal closure responses by flg22 is regulated by eATP receptor DORN1.

Perception of pathogen-associated molecular patterns (PAMPs) by plants can trigger local and systemic responses in plants. DORN1 (Does not Respond to Nucleotides 1, the lectin receptor kinase I.9) is known as the receptor of extracellular ATP (eATP) of plants and plays important roles in the regulation of the responses of plants to environmental stimulation.

Type D personality and fear of progression among patients with first-ever stroke: the serial mediation role of perceived social support and intolerance of uncertainty.

Objective: Fear of progression (FoP) significantly impacts multidimensional health outcomes in stroke patients. Although Type D personality predicts FoP, mechanisms underlying the association between Type D personality and FoP remain poorly understood. This study aimed to investigate the impact of Type D personality on FoP in first-ever stroke patients and the serial mediation role of perceived social support (PSS) and intolerance of uncertainty (IU).

Association between uric acid to high-density lipoprotein cholesterol ratio and moderate-to-severe perivascular spaces burden: a retrospective cross-sectional study.

Background: Perivascular spaces (PVS) are critical for waste clearance in the central nervous system and are implicated in various neurological disorders. The uric acid to high-density lipoprotein cholesterol ratio (UHR) is a novel inflammatory-metabolic marker, but its association with PVS burden remains unexplored. This study investigated the association between UHR and moderate-to-severe PVS burden.

Association between age-related macular degeneration and osteoporosis in US.

It has been hypothesized that there could be a potential link between low bone mineral density (BMD) and age-related macular degeneration (AMD). This hypothesis has prompted us to conduct a more in-depth exploration of whether an intrinsic association exists between the two. As a result, we undertook a cross-sectional study using the NHANES database to investigate the potential associations between osteoporosis and AMD.

Sludge reflux promotes biofilm formation in upflow membrane aerated biofilm reactor for partial nitritation: insight from computational fluid dynamics stimulation and experiments.

Achieving partial nitritation (PN) process using membrane aerated biofilm reactor (MABR) is a novel approach to provide nitrite for mainstream anammox, gained increasing interests. However, insufficient microbial-membrane attachment raises a challenge for biofilm formation in MABR-PN. This study employed computational fluid dynamics modeling to evaluate sludge volume fraction in biofilm formation zones, using liquid reflux and sludge reflux as comparative strategies for enhancing biomass attachment.

C/EBP β/AEP pathway mediates hippocampal mitochondrial damage in a mouse model of sepsis encephalopathy.

Septic encephalopathy (SE), a neurocritical complication with alarmingly high mortality rates, represents a major diagnostic and therapeutic challenge in intensive care units (ICUs). Current diagnostic protocols rely predominantly on nonspecific clinical symptom assessment, while conventional laboratory biomarkers exhibit insufficient sensitivity for early detection. This diagnostic ambiguity contributes to delayed interventions and unfavorable patient prognoses.

4f-modified Ru-O polarity as a descriptor for efficient electrocatalytic acidic oxygen evolution.

The development of non-iridium-based oxygen evolution reaction (OER) catalysts is crucial for proton exchange membrane water electrolysis (PEMWE), but hydrogen production remains a great challenge because of sluggish OER kinetics and severe catalyst dissolution. Here, we present a 4f-induced covalent polarity modulation strategy for the construction of 4f-orbital-modified RuO (4f-RuO) nanocatalysts with tunable Ru-O polarity. We find that the OER activity of 4f-RuO shows a volcano shape as a function of the polarity of Ru-O bond.

Advanced omics approaches in liver transplant settings: current applications and future prospectives.

Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST), as advanced omics technologies, have addressed critical challenges in liver transplantation (LT), the most effective treatment for end-stage liver disease. This review aims to summarize the applications and future directions of scRNA-seq and ST in the context of LT. We highlight their role in uncovering immune cell heterogeneity and related injury mechanisms post-transplantation.

Efficacy and safety of IBI351 (fulzerasib) monotherapy in KRAS inhibitor-naïve Chinese patients with KRAS-mutated metastatic colorectal cancer: a pooled analysis from phase I part of two studies.

IBI351 (also known as fulzerasib or GFH925), an irreversible covalent inhibitor of KRAS, has demonstrated promising anti-tumour activity in patients with solid tumours. In this study, data were pooled from the phase I part of two clinical studies (NCT05005234 and NCT05497336), aiming to evaluate the efficacy and safety of IBI351 monotherapy in KRAS inhibitor-naïve Chinese patients with KRAS-mutated metastatic colorectal cancer (CRC). The objective response rate (ORR) was the primary endpoint.

Alleviative Effect of Vaginal Lactobacilli with Probiotic Potential from Healthy Chinese Women on Bacterial Vaginosis Caused by Gardnerella vaginalis in Mice.

The main treatment strategy for bacterial vaginosis (BV) is antibiotic therapy, but they are not effective in restoring the vaginal microecology, which can lead to recurrence. This study aimed to isolate the dominant lactobacilli strains from the vagina of healthy Chinese women, evaluate their potential probiotic properties and explore their alleviative effect on BV infected mice. Our study isolated 43 strains of vaginal-dominant Lactobacillus.

Itaconate suppresses neonatal intestinal inflammation via metabolic reprogramming of M1 macrophage.

Background: Necrotizing enterocolitis (NEC) is a rapidly progressive and severe gastrointestinal disorder in neonates that is marked by an inflammatory cascade initiated by mechanisms that remain incompletely understood, resulting in intestinal necrosis and systemic infections. This study demonstrated that itaconate (ITA) exerts a protective effect in NEC by regulating macrophage reprogramming.

Methods: Changes in ITA expression were investigated using immunofluorescence staining and liquid chromatography-mass spectrometry, and their effect on immune cell differentiation was verified through single-cell sequencing.

Research on the indicator system of scholarship of teaching and learning ability for medical teachers in the context of new medical science-based on the grounded theory method.

Background: The Scholarship of teaching and learning (SoTL) is one of the four types of scholarship proposed by Boyer, who emphasized that universities should approach teaching as scholarly work. Studies show that SoTL is an effective tool to improve teaching effectiveness and safeguard educational quality. Enhancing medical teachers' SoTL ability is crucial for improving medical education quality and cultivating innovative medical talents, which directly support New Medical Science construction and ensures the smooth implementation of the Healthy China strategy.

Sub-Nano Ir-Based Alloy Clusters by Hierarchical Confinement Effect for Water Splitting.

The synthesis of sub-nanoscale noble metal catalysts is pivotal for enhancing electrocatalytic performance, yet achieving precise control over particle size at this scale remains a critical challenge. In this work, we propose a hierarchical confinement strategy which combines spatial confinement at nanoscale and anchoring confinement at atomic scale, to overcome the size limitations imposed by high-temperature sintering. Using this strategy, a series of uniformly sized (∼1 nm) Ir-based alloy clusters, including IrMn, IrFe, IrCo and IrNi, are successfully fabricated.

Targeting interferon-stimulated gene of 20 kDa protein (Isg20) inhibits ribosome biogenesis to ameliorate the progression of renal fibrosis.

Chronic kidney disease (CKD) is a global health issue that significantly threatens human health, with its incidence increasing annually. Renal fibrosis is characterized by the progressive loss of kidney function, leading to significant morbidity and mortality. Although ribosome biogenesis has been reported to be increased in several kidney diseases, its role in renal fibrosis remains unclear.

CH02 peptide-stimulated periodontal ligament cells enhance periodontal defect repair in rats.

Objectives: Periodontal ligament cells (PDLCs) are considered ideal seed cells for periodontal tissue engineering and regeneration, and optimizing their efficacy is a pressing challenge. Although basic fibroblast growth factor (bFGF) has been extensively studied for promoting periodontal regeneration, its instability limits its application. This study introduces a smaller, less degradable peptide, CH02, to address this issue.

Association between cerebral small vessel disease and malnutrition risk: a retrospective cross-sectional study.

Introduction: Malnutrition is associated with increased morbidity and mortality from multiple diseases. However, the relationship between cerebral small vessel disease (CSVD) and malnutrition or malnutrition risk remains underexplored. This retrospective study investigated the association between malnutrition risk and CSVD, along with its common imaging markers.

Comparative analysis of Da Vinci robotic surgery and laparoscopic surgery for congenital choledochal cyst in neonates.

Objective: This study aims to compare and analyze the clinical efficacy and safety of Da Vinci robotic surgery (RS) versus traditional laparoscopic surgery (LS) for the treatment of congenital choledochal cyst (CCC) in neonates.

Methods: We retrospectively analyzed sixty-seven neonatal cases of CCC admitted to our hospital between December 2018 and December 2024. The cases were categorized into the robotic group (n = 32) and the laparoscopic group (n = 35) based on the surgical technique employed.

Preferable single-atom catalysts enabled by natural language processing for high energy density Na-S batteries.

Employing appropriate single-atom (SA) catalysts in room-temperature sodium-sulfur (Na-S) batteries is propitious to promote the performance, whereas a universal designing strategy for the highly-efficient single-atom catalysts is absent. In this work, we adopt natural language processing techniques to screen the potential single-atom catalysts, then a binary descriptor is constructed to optimize the catalyst candidates. Atomically dispersed cobalt anchored to both nitrogen and sulfur atoms (SA Co-N/S) is selected as an ideal catalyst to significantly facilitate sulfur reduction reaction.

Advantages of the Da Vinci robotic system in choledochal cyst surgery: a multi-dimensional comparative study with traditional laparoscopic techniques.

The Da Vinci robot-assisted surgical technology signifies a substantial advancement in pediatric surgery for the treatment of congenital structural malformations. This research endeavor aims to perform a comprehensive comparative analysis of the therapeutic efficacy and assess the clinical applicability and value of the Da Vinci robot-assisted surgical method in relation to the conventional laparoscopic surgical technique, particularly in the management of congenital choledochal cysts. A retrospective cohort study was conducted involving 117 pediatric patients diagnosed with congenital choledochal cysts, who were admitted to the Affiliated Hospital of Zunyi Medical University between January 2019 and October 2024.

Effect of Second Sigmoid Colon Intubation During Colonoscopy on Adenoma Detection Rate in Overweight and Obese Patients: A Prospective Randomized Controlled Trial.

Introduction: The sigmoid colon is the most tortuous part of the large intestine and is often the most easily compressed during intubation and more easily missed during withdrawal observation. This study aimed to ascertain whether a second sigmoid colon intubation could enhance the adenoma detection rate (ADR).

Methods: We conducted a randomized controlled trial of patients 45 years and older with a body mass index over 24 who underwent colonoscopy.