Integrated metabolomics and the microbiome reveal the compatibility mechanism of the Suxiao Jiuxin pill in the treatment of stable coronary artery disease.

Background: The Suxiao Jiuxin pill (SJP) is a Chinese patent medicine that is used for the treatment of stable coronary artery disease (SCAD). However, the compatibility mechanism of SJP in treating of SCAD is still unclear. This study aimed to elucidate the serum metabolic profiles of patients with SCAD treated with SJP and to decipher the compatibility mechanism of its effective components, Chuanxiong Rhizoma and borneol.

Prebiotic template-directed peptide formation mediated by polyphosphates and peptide promoters.

Minerals have long been recognized for their role in promoting molecular self-assembly in prebiotic environments by serving as insoluble inorganic scaffolds. However, it remains unclear whether soluble inorganic scaffold molecules, such as polyphosphates, also possess the ability to drive the assembly of small molecules. In this study, carbonyldiimidazole (CDI) was used as a chemical activator in combination with polyphosphates (polyP) to investigate the polymerization behavior of the alkaline amino acid arginine (Arg, R).

Risk factors of axial symptoms after posterior cervical spine surgery: a meta-analysis.

Background: Axial symptoms are a frequent complication after posterior cervical spine surgery.While literature has documented risk factors for these symptoms, they are still debated. This study's objective was to explore the risk elements associated with axial symptoms following posterior cervical spine surgery.

Upcycling shrimp processing by-products into dual-functional peptides: Insights into bioactivity and flavor.

Shrimp processing produces a significant quantity of by-products. They are abundant in proteins, which can serve as excellent precursors of bioactive and taste-active peptides. This review systematically summarizes recent progress in bioactive and taste-active peptides from shrimp by-products, compares main preparation methods including enzymatic hydrolysis and microbial fermentation, reviews bioactive and taste-active activities, and discusses the underlying mechanisms and structure-activity relationships.

Experimental analysis of blast shock wave-induced injuries in rats: Neurobehavioral and tissue damage assessments.

To investigate the dynamic response characteristics of personnel injuries caused by blast shock waves under actual working conditions, experimental studies on blast-induced injuries in rats, behavioral experiments post-injury, and pathological examinations were conducted, followed by injury assessments. The results showed that all rats died when the peak overpressure was 0.427 MPa.

Polymerisation-Induced Self-Assembly on Planar Surfaces: A New Approach for Controlling Surface Topography and Modulating Material-Bio Interactions.

Polymerisation-induced self-assembly (PISA) has emerged as a highly efficient method for synthesising polymeric nanoparticles with diverse and well-defined morphologies for a range of applications. While extensive research has focused on solution-based PISA mediated by conformationally free macro-stabilisers, the process of PISA on planar surfaces using surface-tethered macro-stabilisers with constrained mobility, namely surface PISA, remains largely unexplored. Investigating this process is significant to further advance PISA technology and expand its applications.

Deep Neural-Assisted Flexible MXene-Ag Composite Strain Sensor with Crack Dual Conductive Network for Human Motion Sensing.

Developing stretchable strain sensors that combine both high sensitivity and a wide linear range is a critical requirement for health electronics, yet it remains challenging to meet the practical demands of daily health monitoring. This study proposes a novel heterogeneous surface strategy by in situ silver deposition on modified PDMS followed by MXene spray coating, constructing a multilevel microcrack strain sensor (MAP) using silver nanoparticles and MXene. This innovative multilevel heterogeneous microcrack structure forms a dual conductive network, which demonstrates excellent detection performance within GF = 487.

Low-concentration CNF stabilized Pickering emulsions: The assisted role of low-concentration gelatin.

Pickering stabilizers are usually used in high concentration, especially for polysaccharide particles with relatively poor surface activity, such as nanocellulose. This study investigated the preparation and properties of Pickering emulsions co-stabilized by a low concentration complex system based on the carboxylated cellulose nanofibril (CNF, 0.2 %) and gelatin (G, 0.

Association between thyroid function and thyroid homeostasis parameters and the prevalence and all-cause and cardiovascular mortality of chronic kidney disease: a population-based study.

Background: To evaluate the relationship between thyroid function and thyroid homeostasis parameters with the prevalence of chronic kidney disease (CKD) and furtherly explore the all-cause and cardiovascular mortality among individuals with CKD using data from the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

Methods: This study included 8,526 adults, including 1,625 patients with CKD. Thyroid function included serum free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH).

TRPV1 signaling in skeletal muscle: A mini review of physiological and pathological roles.

Transient receptor potential vanilloid subtype 1 (TRPV1) is a non-selective cation channel that is mainly sensitive to stimuli such as high temperature, acidic environment, and capsaicin. Studies have reported that TRPV1 is expressed in skeletal muscle tissues and is involved in the regulation of a variety of physiological and pathological processes in skeletal muscle, but its regulatory mechanisms have not been analyzed and discussed. For this reason, we summarized the role of TRPV1 in skeletal muscle function and the mechanism of its influence on skeletal muscle-related physiopathological changes, such as myotube formation, inflammation, autophagy, mitochondrial biogenesis, and energy metabolism, which provides a theoretical basis and therapeutic target for understanding TRPV1 regulation of skeletal muscle-related diseases.

Design, Synthesis, and Evaluation of N'-Phenylisonicotinohydrazides With Broad-Spectrum Antifungal Activity Against Phytopathogenic Fungi.

Developments of novel antifungal agents with unique scaffolds are crucial for sustainable plant protection. In this study, a series of N'-phenylisonicotinohydrazides were designed and synthesized, and their antifungal activity against eight phytopathogenic fungi was evaluated. The results found that most of the target compounds showed excellent antifungal activity with more than 80% inhibition rates against most or all of the tested fungi at 20 µg/mL.

A lightweight end to end traffic congestion detection framework using HRTNet on the Qinghai Tibet plateau.

Managing traffic in plateau regions, particularly on critical routes like the Qinghai-Tibet Line, presents significant challenges from extreme climate and terrain. Traditional monitoring methods struggle with image distortion and information loss in rain, compromising congestion detection. To address these issues, we propose HRTNet, a lightweight real-time end-to-end model for congestion monitoring.

4f-modified Ru-O polarity as a descriptor for efficient electrocatalytic acidic oxygen evolution.

The development of non-iridium-based oxygen evolution reaction (OER) catalysts is crucial for proton exchange membrane water electrolysis (PEMWE), but hydrogen production remains a great challenge because of sluggish OER kinetics and severe catalyst dissolution. Here, we present a 4f-induced covalent polarity modulation strategy for the construction of 4f-orbital-modified RuO (4f-RuO) nanocatalysts with tunable Ru-O polarity. We find that the OER activity of 4f-RuO shows a volcano shape as a function of the polarity of Ru-O bond.

ANTP-SmacN7 enhances radiosensitivity in TPC-1 cells through XIAP-mediated activation of apoptotic protein.

A subset of differentiated thyroid cancer still lacks effective treatment options, such as locally advanced or metastatic patients. Some of these patients also need to try radiation therapy. The objective of this study is to investigate the potential of the antennapedia-modified SMAC fragment (ANTP-SmacN7) as a radiation sensitizer to enhance the therapeutic efficacy of radiotherapy in papillary carcinoma of thyroid (PTC), ascertain the contribution of X-linked inhibitor of apoptosis protein (XIAP), and explore its associated mechanisms to the apoptotic response in PTC.

A supramolecular photopyroptosis nanoinducer with acidity-activatable immunomodulation for potentiating cancer immunotherapy.

Photopyroptosis, characterized by releasing tumor-associated antigens (TAAs) and damage-associated molecular patterns (DAMPs), is capable of promoting the maturation of dendritic cells (DCs) and recruitment of T lymphocytes (TLs) to activate antitumor immune responses. However, immunosuppressive regulatory T cells (Tregs) negatively influence T-cell homing and activation, leading to the immunosuppressive tumor microenvironment (ITM). Herein, a supramolecular photopyroptosis nanoplatform with an acidity-activatable immunomodulation is developed aiming to enhance cancer immunotherapy.

Integrated bioinformatics identifies ferroptosis biomarkers and therapeutic targets in idiopathic pulmonary arterial hypertension.

Idiopathic pulmonary arterial hypertension (IPAH), a rare and devastating pulmonary vascular disorder, is characterized by cellular proliferation and vascular remodeling. Although previous studies have underscored that ferroptosis, an iron-dependent cell death process, plays an important regulatory role in pulmonary artery hypertension, its role remains understudied. Gene expression profiles were downloaded from the Gene Expression Omnibus(GEO).

[Retracted] N6‑methyladenosine upregulates miR‑181d‑5p in exosomes derived from cancer‑associated fibroblasts to inhibit 5‑FU sensitivity by targeting NCALD in colorectal cancer.

Subsequently to the publication of the above article, an interested reader drew to the authors' attention that certain of the tumor images shown in Fig. 7B on p. 13 had already appeared in different form in Fig.

Colony Binary Classification Based on Persistent Homology Feature Extraction and Improved EfficientNet.

Classifying newly formed colonies is instrumental in uncovering sources of infection and enabling precision medicine, holding significant clinical value. However, due to the ambiguous features of early-stage colony images in culture dishes, conventional computer vision (CV) classification algorithms are often ineffective. To achieve accurate and efficient colony classification, this paper proposes a high-precision method based on Persistent Homology (PH) and an improved EfficientNet.

Acrylamide Neurotoxicity Studies in Model.

Acrylamide (ACR), utilized as a precursor for producing polyacrylamide for water purification, has demonstrated neurotoxic properties. However, the mechanisms underlying its neurotoxicity remain inadequately understood. In this investigation, were exposed to ACR at concentrations ranging from 250 to 1000 μg/mL and then their locomotor behavior, neuronal development, neurotransmitter concentrations, and gene expression profiles were assessed.

An "On-Off" Electrochemiluminescence Aptasensor for Ochratoxin A Detection Based on CdS-Apt and Ru(bpy).

An "on-off" electrochemiluminescence (ECL) aptasensor was proposed for the highly sensitive and selective detection of ochratoxin A (OTA) in cereals. The substrate nanomaterial employed in the ECL experiments was titanium carbide (TiCT) MXene, while cadmium sulfide quantum dots (CdS QDs) were used as coreactants of the ECL reagent tris (2,2'-bipyridyl) ruthenium(II) (Ru(bpy)). Compared to tripropylamine, a more toxic conventional coreactant, CdS QDs can react efficiently with Ru(bpy) in the ECL reaction, and the reaction principles of both were also investigated.

Traditional Chinese Medicine Improves the Development of Vascular Thrombotic Inflammation: The Key Role of Gut Microbiota and Its Derived Metabolites.

Vascular thrombotic inflammation is the most serious complication of cardiovascular disease, and the platelet and coagulation cascades are effective targets for antithrombotic methods. However, the application of traditional antiplatelet drugs is limited to a certain extent due to their various side effects, such as bleeding risk and drug resistance. New evidence showed that gut microbiota is considerably associated with thrombotic inflammation, and targeted microbial pathways can promote beneficial 'antiplatelet' effects and decrease the promotion of thrombosis, without bleeding complications.

Dynamically Dual-Center Coupled Synergistic Catalysis for Highly Efficient Oxygen Reduction.

The oxygen reduction reaction (ORR) suffers from inherent kinetic limitations arising from the competitive adsorption behavior of *OOH intermediates and their divergent conversion pathways toward either the 4e⁻-dominant route or the 2e⁻-peroxide byproduct. Conventional single-component catalysts fundamentally lack temporal-spatial control to simultaneously accelerate O─O bond cleavage while suppressing *HO desorption. To overcome this kinetic dilemma, herein, we propose a dynamically dual-center coupled synergistic (DCCS) catalytic mechanism enabled by precisely engineered PdRh─Pt nanosheet binary-component interfaces.

The influence of chronic cadmium exposure on the activity of adult Pelophylax nigromaculatus revealed by brain transcriptomics and metabolomics.

Cadmium (Cd), a common environmental pollutant, has potentially negative effects on the behavior of aquatic animals. This study investigated the effects of exposure to Cd (0 mg/L, 1 mg/L and 10 mg/L) on movement behavior, brain metabolites, and brain gene expression of adult Pelophylax nigromaculatus. Treatments with 1 mg/L and 10 mg/L Cd resulted in a significant increase in movement frequency, movement time, average speed of movement, and movement distance.

Machine learning and multi-omics analysis reveal key regulators of proneural-mesenchymal transition in glioblastoma.

Glioblastoma (GBM) is classified into subtypes according to the molecular expression profile; the proneural subtype has a relatively good prognosis, and the mesenchymal type is the most aggressive form with the worst prognosis. GBM undergoes proneural-mesenchymal transition (PMT) during its evolution or in response to changes in the microenvironment or therapeutic interventions. PMT is accompanied by infiltration of non-tumor cells, decreased tumor purity, and immune evasion.