Zinc ions coordinated carboxymethyl chitosan hydrogel doped with ellagic acid for accelerative diabetic wound healing.

Diabetic wound healing remains a critical clinical challenge due to persistent inflammation derived from long-term hyperglycemia. To address this challenge, we reported a zinc ion coordinated CMCS hydrogel for pH responsive delivery of ellagic acid to fulfill diabetic wound management. The incorporation of zinc ions and EA reinforce the hydrogel network via coordination and hydrogen bonding, and confer a pH-responsive release of EA under simulative wound microenvironment.

Geometric-Driven Cross-Modal Registration Framework for Optical Scanning and CBCT Models in AR-Based Maxillofacial Surgical Navigation.

Objective: Accurate preoperative planning for dental implants, especially in edentulous or partially edentulous patients, relies on precise localization of radiographic templates that guide implant positioning. By wearing a patientspecific radiographic template, clinicians can better assess anatomical constraints and plan optimal implant paths. However, due to the low radiopacity of such templates, their spatial position is difficult to determine directly from cone-beam computed tomography (CBCT) scans.

Serum trimethylamine N-oxide and long-term mortality risk in rural Northern China: A family-based cohort study.

The current study aims to assess associations between trimethylamine N-oxide (TMAO) levels and mortality, and to investigate modification effects of genetics. A total of 500 participants from a family-based cohort study were enrolled from 2005 to 2017 and followed up until 2020 in Fangshan District, Beijing, China. Serum TMAO levels were measured using the enzyme-linked immunosorbent assay (ELISA) kit.

Impact of comprehensive tobacco control policies on stroke and acute myocardial infarction among patients with hypertension and type 2 diabetes in Beijing, China: An interrupted time-series analysis.

Background And Aims: Tobacco control policies enhance cardiovascular health at the population level, but their effects on high-risk individuals, such as those with type 2 diabetes mellitus (T2DM) or hypertension, remain unclear. This study evaluated the association between a tobacco control policy and hospital admissions for stroke and acute myocardial infarction (AMI) in hypertensive and T2DM individuals.

Design: Interrupted time series study.

[A retrospective study on clinical outcomes of implant-supported rehabilitations in patients with alveolar cleft].

Purpose: To retrospectively evaluate the clinical outcomes of implant-supported prosthesis in alveolar cleft patients.

Methods: A total of 14 patients with alveolar cleft underwent implant restoration in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from January 2015 to January 2023 were collected. Among them, 9 were male and 5 were female.

Accuracy of robot-assisted dental implant surgery and its clinical influencing factors: a retrospective case series of 100 patients.

Background: This retrospective study aimed to investigate the accuracy of robot-assisted implant surgery and identify the factors influencing it.

Methods: Patients with single or multiple missing teeth were enrolled in the robot-assisted implant surgery. The patients underwent cone-beam computed tomography (CBCT) using a marker.

Application of artificial intelligence in bone quality and quantity assessment for dental implant planning: A scoping review.

Objectives: To assess how artificial intelligence (AI) models perform in evaluating bone quality and quantity in the preoperative planning process for dental implants.

Data: This review included studies that utilized AI-based assessments of bone quality and/or quantity based on radiographic images in the preoperative phase.

Sources: Studies published in English before April 2025 were used in this review, which were obtained from searches in PubMed/MEDLINE, Embase, Web of Science, Scopus, and the Cochrane Library, as well as from manual searches.

Design, Synthesis, and Evaluation of N'-Phenylisonicotinohydrazides With Broad-Spectrum Antifungal Activity Against Phytopathogenic Fungi.

Developments of novel antifungal agents with unique scaffolds are crucial for sustainable plant protection. In this study, a series of N'-phenylisonicotinohydrazides were designed and synthesized, and their antifungal activity against eight phytopathogenic fungi was evaluated. The results found that most of the target compounds showed excellent antifungal activity with more than 80% inhibition rates against most or all of the tested fungi at 20 µg/mL.

Antihypertensive medications and cancer risk: Evidence from 0.27 million patients with newly diagnosed hypertension.

Background: Whether specific antihypertensive treatments increase cancer risk in patients with hypertension is still controversial. We aimed to estimate the associations of different antihypertensive treatments with cancer risk in real-world settings.

Methods: A longitudinal cohort study was designed in a population of 1.

Glossary of Computer-Assisted Implant Surgery and Related Terms. First Edition.

The rapid development of computer-assisted implant surgery (CAIS) and the respective research and clinical applications have necessitated a standardization of the terminology related not only to different devices, but also the different steps involved, surgical and presurgical procedures. The present glossary was introduced at the 1st International Team for Implantology Symposium on Computer-assisted Implant Surgery, based on the collective work of clinicians and researchers with deep understanding and experience in these technologies. The glossary was further refined and revised through the structured input of a large group of global experts within clinical application, research, and education of CAIS.

X-ray stimulates NQO1-dependent cascade reactions to induce strong immunogenicity for MRI-guided cancer radio-chemodynamic-immunotherapy.

Immunogenicity activation is vital for radioimmunotherapy, but the short-term oxidative damage caused by precise radiation planning limits this effect. Chemodynamic therapy (CDT) with prolonged generation of hydroxyl radical (•OH) can initiate immunogenicity in combination with X-rays, however, its performance is constrained by tumor insufficient H2O2. Here, we propose to construct β-lapachone-based nanoparticles (β-Lap/Fe NPs) which initiate cascade reactions to generate high levels •OH for an extended period in tumor following X-ray irradiation.

Diet-Gene Interaction Between Fruit Intake and rs2925979 Polymorphism in Relation to Type 2 Diabetes: A Family-Based Study in Northern China.

: This study aimed to investigate the association between dietary intake and the risk of type 2 diabetes mellitus (T2DM) in a rural northern Chinese population, and to explore potential gene-diet interactions that may influence T2DM susceptibility. : A total of 1747 participants (1138 with T2DM and 609 without) were included, using baseline data from a family-based cohort study in rural northern China. Demographic characteristics, lifestyle factors, and medical history were collected via standardized questionnaires.

Comparison of marker-based and marker-free registration techniques in dynamic navigation-guided implant surgery for fully and partially edentulous patients: A systematic review and meta-analysis.

Objectives: To compare the accuracy of marker-based and marker-free registration methods in the context of dynamic navigation guided implant surgery for patients with partial or complete tooth loss.

Methodology: The review includes research articles written in English and Mandarin Chinese published between January 2013 and May 2025, from databases such as MEDLINE/PubMed, Scopus, Cochrane, Embase, China National Knowledge Infrastructure (CNKI) and Web of Science. Both laboratory-based and clinical investigations were taken into account.

Quantitative Characterization and Influencing Factors for Electrode-Molecule-Electrode Junction Stability.

Molecular electronics has made considerable progress in recent decades. The construction of a stable "electrode-molecule-electrode" junction is critical for the study of molecular electronics, as the stability can promote the exploration of the electrical properties of individual molecules and enable the prolonged observation of physical and chemical phenomena at the single-molecule scale. However, dispersed discussions and conflated concepts hinder our understanding of molecular junction stability.

Parental Transmission of Type 2 Diabetes Risk in Offspring: A Prospective Family-Based Cohort Study in Northern China.

While parental type 2 diabetes (T2D) is a known risk factor for offspring T2D, the differential impact of maternal versus paternal transmission remains debated. This prospective family-based cohort study enrolled 4508 diabetes-free adults from Northern China with a median 7.32-year follow-up.

Long-Term Comprehensive Results of Four-Implant-Supported Overdentures and Fixed Complete Dentures: A Systematic Review and Meta-Analysis.

Purpose This systematic review aims to integrate the medium-term outcomes of four-implant supported overdentures (IODs) and full arch fixed restorations (IFRs) in the maxilla. Materials and Methods The search was performed in PubMed, Embase, and Cochrane databases, complemented by manual search. The inclusion criteria were at least 10 maxillary edentulous patients restored by IOD or IFR and at least five years of follow up.

Daily Parenting and Adolescent Maladjustment: A Two-Wave Multi-Informant Daily Diary Study Before and During the COVID-19 Pandemic.

Introduction: The COVID-19 pandemic posed major challenges to parent-adolescent relationships under global stressors. Scant research has examined changes in the daily links between parenting behaviors and adolescent maladjustment before and after the onset of the pandemic. This study investigated the within-day associations between two parenting behaviors-positive parenting and psychological control-and three adolescent maladjustments-conduct problems, emotional problems, and negative affect-before and during COVID-19 through a two-wave multi-informant month-long daily diary study.

The accuracy of different macrogeometry of dental implant in dynamic navigation guided immediate implant placement in the maxillary aesthetic zone: an in vitro study.

Purpose: This study aimed to compare the accuracy of immediate implant placement (IIP) with different implant macrogeometry using a dynamic navigation in the maxillary aesthetic zone.

Methods: Seventy-six extraction sockets in the maxillary aesthetic zone from nineteen partially edentulous models were randomly divided into four implant system groups with different macrogeometry: non-progressive and trapezoidal (NP-T), progressive and trapezoidal (P-T), progressive and V-shaped (P-V), progressive and spiral (P-S). The coronal, apical, and angular deviations of the fully guided implants with navigation were measured and compared among different groups.

Automatic Segmentation of Bone Graft in Maxillary Sinus via Distance Constrained Network Guided by Prior Anatomical Knowledge.

Maxillary Sinus Lifting is a crucial surgical procedure for addressing insufficient alveolar bone mass andsevere resorption in dental implant therapy. To accurately analyze the geometry changesof the bone graft (BG) in the maxillary sinus (MS), it is essential to perform quantitative analysis. However, automated BG segmentation remains a major challenge due to the complex local appearance, including blurred boundaries, lesion interference, implant and artifact interference, and BG exceeding the MS.

Genetic Nurture Effects on Type 2 Diabetes Among Chinese Han Adults: A Family-Based Design.

: Genes and environments were transmitted across generations. Parents' genetics influence the environments of their offspring; these two modes of inheritance can produce a genetic nurture effect, also known as indirect genetic effects. Such indirect effects may partly account for estimated genetic variance in T2D.

Dental Implant Rehabilitation in Patients Carrying WNT10A Mutations With Different Molecular Statuses and Phenotypes: A Retrospective Cohort Study.

Objectives: WNT10A mutations are associated with tooth agenesis. This study aimed to assess the clinical outcomes of dental implants in patients carrying WNT10A mutations with different molecular statuses and phenotypes over a long-term follow-up period.

Materials And Methods: Patients with tooth agenesis were screened by whole-exome sequencing (WES) from January 2010 to September 2023.

Time in Target Range for Blood Pressure and Adverse Health Outcomes: A Systematic Review.

Background: Blood pressure (BP) time in target range (TTR) reflects the proportion of time that BP measurement is within a specified target range. We aim to summarize the evidence for relationships between TTR and adverse health outcomes.

Methods: Seven databases were searched.

NURBS curve shape prior-guided multiscale attention network for automatic segmentation of the inferior alveolar nerve.

Accurate segmentation of the inferior alveolar nerve (IAN) within Cone-Beam Computed Tomography (CBCT) images is critical for the precise planning of oral and maxillofacial surgeries, especially to avoid IAN damage. Existing methods often fail due to the low contrast of the IAN and the presence of artifacts, which can cause segmentation discontinuities. To address these challenges, this paper proposes a novel approach that employs Non-Uniform Rational B-Spline (NURBS) curve shape priors into a multiscale attention network for the automatic segmentation of the IAN.

Identification of shared genetic etiology of cardiovascular and cerebrovascular diseases through common cardiometabolic risk factors.

Cardiovascular diseases (CVDs) and cerebrovascular diseases (CeVDs) are closely related vascular diseases, sharing common cardiometabolic risk factors (RFs). Although pleiotropic genetic variants of these two diseases have been reported, their underlying pathological mechanisms are still unclear. Leveraging GWAS summary data and using genetic correlation, pleiotropic variants identification, and colocalization analyses, we identified 11 colocalized loci for CVDs-CeVDs-BP (blood pressure), CVDs-CeVDs-LIP (lipid traits), and CVDs-CeVDs-cIMT (carotid intima-media thickness) triplets.