Front Public Health
August 2025
Introduction: The burden of chronic kidney disease (CKD) varies across regions. This study provides comprehensive global, regional, and national estimates of total CKD and CKD due to four specific etiologies from 1990 to 2021.
Methods: Data were extracted from the 2021 Global Burden of Disease study, categorized by sex, 20 age groups, 204 countries or territories, and 5 sociodemographic index (SDI) regions.
Background: Massive postoperative gastrointestinal bleeding is a severe postoperative complication of Crohn's disease (CD) with a high mortality rate, and deteriorating patients' recovery. However, there are few related studies, and it lacks effective prevention measures. Therefore, we conducted a multicenter study to explore the risk factors for massive postoperative gastrointestinal bleeding in CD patients.
View Article and Find Full Text PDFKeratinases represent a distinct class of proteolytic enzymes capable of depolymerising the highly recalcitrant structure of keratin. In recent years, these enzymes have garnered increasing attention owing to their potential applications in environmental remediation and the circular bioeconomy. This review systematically traces the historical progression of keratinase research, delineates their classification and catalytic mechanisms, and highlights their diverse application spectrum.
View Article and Find Full Text PDFPurpose: To develop a flow pulsatile-resolved pseudo-continuous arterial spin labeling (FPR-pCASL) technique for noninvasively assessing cerebral microvascular pulsatility.
Methods: In FPR-pCASL, a pCASL sequence with single-shot three-dimensional gradient and spin echo acquisition was performed while simultaneously recording cardiac pulse signals using a pulse oximeter, and the pCASL images were retrospectively binned into multiple cardiac phases to resolve pulsatile microvascular blood flow. Both numerical simulations and in vivo experiments were performed to investigate the confounding factors of cardiac-induced variations of labeling efficiency and arterial transit time on pCASL signal fluctuations.
Study Question: Does female or male hepatitis B virus (HBV) infection affect the oocyte and embryo quality, pregnancy outcomes, and neonatal outcomes in infertile couples undergoing ART treatment?
Summary Answer: The female or male HBV infection did not have a statistically significant negative impact on the development of oocytes and embryos, pregnancy outcomes, or neonatal outcomes of ART.
What Is Known Already: Only few studies assessing the effects of HBV infection on the reproductive outcomes among infertile population have been conducted with inconsistent results. There is limited research that focuses on the oocyte and embryo development of HBV-infected females and males.
In this work, we proposed a multiband dual-VENC 2D PC-MRI technique termed MB-DV PC-MRI to simultaneously measure arterial pulsatility across multiple cerebral arterial segments, including both proximal greater and distal smaller arteries. A multiband SINC RF pulse was designed to simultaneously excite multiple slices with varied gaps between adjacent slices in MB-DV PC-MRI. A retrospectively gated MB-DV PC-MRI sequence was performed on 11 young (29.
View Article and Find Full Text PDFThis research pursues a systematic review and meta-analysis concerning the cardiovascular event risk prediction models for maintenance hemodialysis patients. Through systematic literature searching, the titles and abstracts of 23,707 related papers were initially screened, ultimately including 16 papers covering 17 prediction models. The results reveal that among these models, a total of 16 predictive variables were chosen at least twice, with age, diabetes history, and history of cardiovascular disease being the primary predictors.
View Article and Find Full Text PDFStudy Objectives: This study aimed to assess the effectiveness of metabolic and bariatric surgery (MBS) in patients with obesity comorbid with obesity hypoventilation syndrome (OHS) at 1-year follow-up.
Methods: This retrospective study was conducted between January 2020 and June 2023 at an MBS center in a university-affiliated tertiary hospital in China. Clinical data, including body mass index (BMI), arterial blood gas (ABG) values, portable sleep study results, and anthropometric parameters, were recorded pre- and postoperatively.
Ionic liquids (ILs) have been found to be a good type of electrolyte material to fabricate highly sensitive H sensors, accredited to their minimal vapor pressure and array of tunable physicochemical properties. Of the two IL molecules commonly used, [Bmpy][NTf] and [Bmim][NTf], experimental results reveal that [Bmim][NTf] exhibits a higher ionic diffusivity and conductivity than [Bmpy][NTf]. However, recent hydrogen sensing tests demonstrate that [Bmpy][NTf] based sensors are more sensitive instead.
View Article and Find Full Text PDFBackground: The role of concurrent chemoradiotherapy (CCRT) in postoperative head and neck adenoid cystic carcinoma (ACC) remains controversial due to the limited evidence from randomized trials. This study assessed the effectiveness of CCRT by comparing a prospective CCRT group with a retrospective radiation(RT) alone group using propensity score matching (PSM).
Methods And Materials: Postoperative head and neck ACC patients with T3-4/N1-3 M0 disease or after R1/R2 resection were enrolled.
BMC Med Imaging
March 2025
Objectives: This study aims to differentiate Kimura's disease (KD) from Sjogren's syndrome with mucosa-associated lymphoid tissue lymphoma (SS&MALT), neurofibromatosis (NF), and lymphoma in the head and neck by using a stepwise decision tree approach.
Materials And Methods: A retrospective analysis of 202 patients with pathologically confirmed KD, SS&MALT, NF, or lymphoma was conducted. Demographic and magnetic resonance imaging (MRI) data were collected, with qualitative features (e.
: To identify transfusion thresholds and risk factors for acute kidney injury (AKI) in gastrointestinal oncology surgery, enhancing early intervention and improving postoperative outcomes. : From 2018 to 2022, 765 patients with gastric or colorectal cancer who underwent major gastrointestinal surgery were retrospectively enrolled. The primary outcome was AKI development within 7 days postoperatively.
View Article and Find Full Text PDFBackground: Chronic infection with Clonorchis sinensis (C.sinensis) has been associated swith the development of intrahepatic cholangiocarcinoma (ICC); however, the relationship between C.sinensis and hepatocellular carcinoma (HCC) remains uncertain.
View Article and Find Full Text PDFUrinary tract infections (UTIs) are prevalent; however, comprehensive and current epidemiological data remain scarce. This study examined the global, national, and regional burden of UTIs by sex, age, and socio-demographic index (SDI) from 1990 to 2021. The 2021 Global Burden of Disease study included age-standardised incidence rate (ASIR), age-standardised prevalence rate (ASPR), age-standardised death rate (ASDR), and age-standardised disability-adjusted life years rate (ASDAR).
View Article and Find Full Text PDFBackground And Objectives: Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) typically undergo surgery followed by postoperative radiotherapy/chemoradiotherpy. Nutritional issues often arise during treatment, potentially affecting outcomes. This study aimed to investigate whether early initiation of oral nutritional supplements (ONS) would prevent weight loss in HNSCC patients undergoing postoperative radiotherapy/chemoradiotherapy compared to conventional nutritional intervention.
View Article and Find Full Text PDFRenal fibrosis is one of the main pathological features of chronic kidney disease (CKD), and its treatment has been a hot research topic. Recent studies have shown that stem cell therapy can repair renal pathological changes and slow the progression of CKD. In addition, a large number of experiments have confirmed that traditional Chinese medicine (TCM), especially Chinese medicine compound preparations, has the advantage of multitargeting interventions to improve renal fibrosis.
View Article and Find Full Text PDFObjectives: WNT10A mutations are associated with tooth agenesis. This study aimed to assess the clinical outcomes of dental implants in patients carrying WNT10A mutations with different molecular statuses and phenotypes over a long-term follow-up period.
Materials And Methods: Patients with tooth agenesis were screened by whole-exome sequencing (WES) from January 2010 to September 2023.
Background: Between 2020 and 2022, the COVID-19 pandemic spread globally, and the implementation of preventive measures led to reduced outdoor activities for older adults, resulting in a decline in social functioning. This study aims to improve community-based health interventions tailored to older adults experiencing physical and psychological declines following the COVID-19 pandemic.
Methods: This study utilized previous data mining results to estimate the demand for community health services for older adults.
Objective: To explore the association between representative insulin resistance (IR) indices and the risk of kidney stone disease in an American adult population. The representative IR indices referred to metabolic score for IR (METS-IR), triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, triglyceride glucose-body mass index (TyG-BMI), visceral adiposity index (VAI), and homeostatic model assessment of IR (HOMA-IR).
Methods: We investigated adult participants who joined the 2015-2018 National Health and Nutrition Examination Survey (NHANES) and reported kidney stone histories.
Objective: This study aimed to develop and internally validate a prognostic nomogram for predicting nodal recurrence-free survival (NRFS) in patients with early-stage oral squamous cell carcinoma (OSCC) with clinically negative neck lymph nodes.
Materials And Methods: The management of early-stage oral cancer patients with clinically negative neck lymph nodes (cN0) remains controversial, especially concerning the need for elective neck dissection. Data from a single institution spanning 2010 to 2020 were utilized to develop and evaluate the nomogram.
Nat Sci Sleep
September 2024
Wound Repair Regen
November 2024
Globally, a great number of children have been suffering from physical dysfunction and psychological stress due to uncontrollable scar growth and a lack of effective modalities. Despite chemotherapy's established role as a primary treatment for pathological scarring in adults, its efficacy in preventing or minimizing scar formation in paediatric patients remains underexplored. This retrospective cohort study aimed to refine the relevant clinical evidence and investigate the effect of chemotherapy on pathological scars in children.
View Article and Find Full Text PDFIntroduction: This study explored the causal connections between gut microbiota (GM), urinary tract infection (UTI), and potential metabolite mediators using Mendelian randomization (MR).
Methods: We utilized summary statistics from the most comprehensive and extensive genome-wide association studies (GWAS) available to date, including 196 bacterial traits for GM, 1,091 blood metabolites, 309 metabolite ratios, alongside UTI data from ukb-b-8814 and ebi-a-GCST90013890. Bidirectional MR analyses were conducted to investigate the causal links between GM and UTI.