SMARCB1 (INI1)-deficient sinonasal carcinoma with yolk sac differentiation, a case of long-term clinical remission after multiple rounds of radiotherapy-a case report and literature review.

Rationale: SMARCB1 (INI1) deficient sinonasal carcinoma is a subtype of Switch/Sucrose nonfermentable (SWI/SNF) complex deficient sinonasal carcinoma, which is distinct from sinonasal undifferentiated carcinoma (SNUC) in 5th edition of the WHO classification of head and neck tumors. It commonly shows basaloid, eosinophilic, oncocytoid or rhabdoid morphology. However, it can exhibit yolk sac like differentiation in very rare cases, with associated SALL4, GPC-3 and CDX2 and AFP expression, which can lead to the misdiagnosis of primary nasopharyngeal yolk sac tumor (YST).

Relationship between the platelet-to-lymphocyte ratio and in-hospital mortality of ischemic stroke patients in the intensive care unit.

Background: The relationship between the platelet-to-lymphocyte ratio (PLR) and the prognosis of patients with ischemic stroke was unclear.

Objective: This study aimed to explore the correlation between PLR levels and in-hospital mortality in ischemic stroke patients admitted to the intensive care unit (ICU).

Methods: A retrospective cohort study was conducted using data from the MIMIC-IV database.

Patient-derived colorectal microtumors predict response to anti-PD-1 therapy.

Immune checkpoint inhibitors have made remarkable impacts in treating various cancers, including colorectal cancer (CRC). However, CRC still remains a leading cause of cancer-related deaths. While microsatellite instability (MSI) CRC has shown positive responses to anti-PD-1 therapy, this subgroup represents a minority of all CRC patients.

Engineering Gradient D-d Orbital Occupancy to Boost Substrate Adsorption for Efficient Electrocatalytic Biomass Valorization.

Electrocatalysis provides a green and sustainable approach for the upgrading of biomass-derived 5-hydroxymethylfurfural (HMF) to the polymer monomer 2,5-furandicarboxylic acid (FDCA). Precisely tuning the electronic structure, specifically the electron gradient orbitals and spin state of key active sites, is crucial for achieving high catalytic performance, as it directly influences the adsorption strength of the reactive substrate. Herein, by introducing Mn with low 3d filling, the e-e repulsion between bridging O and Ni is weakened due to π-donation function.

Chicoric acid inhibits the initial attachment of IPEC-J2 cells by porcine epidemic diarrhea virus through the suppression of Akt phosphorylation.

Porcine epidemic diarrhea virus (PEDV) poses a formidable threat to global swine production, causing severe post-weaning diarrhea that undermines industry sustainability. Cichoric acid (CA), a bioactive phenolic compound, exhibits broad-spectrum antiviral properties. Using PEDV-infected IPEC-J2 cells, it has been demonstrated that CA concentration-dependently inhibits viral attachment by blocking host cell attachment.

Enhanced tyrosinase inhibitory activity of side chain-modified aromatic-turmerone derived from Curcuma longa for advanced skin whitening formulations.

Tyrosinase (TYR) is a key enzyme in melanin production and a crucial target for skin-whitening agents. Due to challenges in isolating pure human TYR, we constructed a homology model and evaluated the inhibitory effects of Ar-turmerone (A1) and its derivatives (A8 and B18) through in vitro assays and molecular dynamics (MD) simulations. Ar-turmerone reduced TYR activity by 19.

Interplay between Through-Space and Through-Bond Electronic Coupling in Singlet Fission.

Singlet fission (SF) is a spin-allowed photophysical process that generates two triplet excited states for one absorbed photon. It therefore has the potential to boost solar cell efficiencies beyond the 33% detailed balance limit. A better understanding of through-space and through-bond electronic coupling in SF, and their interplay, is essential for practical applications of SF materials.

miR-146a-5p targets IRAK1/TRAF6 to promote bacillus Calmette-Guérin survival by exosome-mediated autocrine actions.

Background: Exosomes carry signaling molecules between cells and play important roles in the interaction between macrophages and Mycobacterium tuberculosis (Mtb). This study aimed to examine the function and content of exosomes secreted by macrophages infected with Bacillus Calmette-Guérin (BCG).

Methods: THP-1 monocytes and HEK293T cells were used.

Efficacy and Safety of Bushen Jiedu Tongluo Decoction in Active Rheumatoid Arthritis: Study Protocol for a Multi-Center, Randomized, Double-Blind, Controlled Trial.

Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease with the primary clinical symptoms of joint swelling and pain. Among the currently available therapeutic agents, methotrexate (MTX) is an internationally recognized first-line disease-modifying antirheumatic drug (DMARD) for RA and is widely used as a basic drug in combination therapies. The Bushen Jiedu Tongluo Decoction (BSJDTL), an herbal formula, has been used for the treatment of RA for more than ten years with a better curative effect.

Effects and the mechanism of pine pollen polysaccharides on diabetic wound healing and .

Introduction: Pine pollen polysaccharides (PPPS) has anti-inflammatory, immunomodulatory, anti-oxidant, hypoglycemic, and anti-bacterial properties. PPPS can accelerate wound healing in mouse cutaneous wounds, yet it is unclear whether PPPS can promote diabetic wound healing.

Methods: Fibroblasts, keratinocytes, and human umbilical vein endothelial cells (HUVECs) were stimulated with high glucose (HG) to mimic hyperglycemic environment.

Evaluation and comparison of large language models' responses to questions related optic neuritis.

Objectives: Large language models (LLMs) show promise as clinical consultation tools and may assist optic neuritis patients, though research on their performance in this area is limited. Our study aims to assess and compare the performance of four commonly used LLM-Chatbots-Claude-2, ChatGPT-3.5, ChatGPT-4.

Efficient perovskite/silicon tandem with asymmetric self-assembly molecule.

Achieving highly ordered and uniformly covered self-assembled monolayers with optimal packing configuration on textured silicon substrates remains a critical challenge for further improving the efficiency of perovskite/silicon tandem solar cells. Here we design an asymmetric self-assembled monolayer (named as HTL201) featuring an anchoring group and a spacer flanking a carbazole core, serving as a hole-selective layer for perovskite/silicon tandem solar cells. When compared with symmetric self-assembled monolayers with a nitrogen-bonded phosphonic acid group, the HTL201 molecule shows minimized steric hindrance and improved coverage on the transparent conductive oxide recombination layer.

Stress granules and cell death: crosstalk and potential therapeutic strategies in infectious diseases.

Pathogens exploit cellular stress responses to drive infection and evade immune responses, posing a persistent global health threat. Stress granules (SGs), dynamic mRNA hubs formed under stress, and regulated cell death (RCD) pathways collectively orchestrate host-pathogen dynamics. While SGs regulate mRNA translation to aid adaptation, RCD mechanisms-including apoptosis, pyroptosis, and necroptosis-eliminate infected cells to curb pathogen spread.

Potential antiviral effects of the marine probiotic on the respiratory syncytial virus.

Probiotics can reduce the incidence of respiratory syncytial virus (RSV) disease in premature infants; this approach is resource-intensive and less expensive than other strategies and easier to implement than most current methods worldwide. Traditional lactic acid-producing bacteria are the main probiotics that have been studied for RSV treatment. Marine probiotics promote the survival, immunity, and disease resistance of aquatic plants and animals.

Reliability and validity of the Chinese version of the nurses' health-related procrastination scale (NHRPS) in Chinese nurses.

Background: The physical and mental health of nurses is closely related to the quality of nursing and patient safety. Nurses face greater health risks, which are closely related to health procrastination. At present, China lacks scientifically effective tools to assess the level of health-related procrastination among clinical nurses.

Effects of Dietary BCAAs Intake on the Blood Pressure in Dahl Salt-Sensitive Rats.

Aim: Circulating branched-chain amino acids (BCAAs) have been widely found to be associated with the risk of hypertension, but mechanisms remain unclear. In this study, we hypothesized that BCAAs could alleviate the development of salt-induced hypertension in Dahl salt-sensitive (SS) rats. The objective was to explore whether long-term high-salt diets (a major dietary risk for high blood pressure) alter BCAAs levels in SS rats and how dietary BCAAs influence salt-induced hypertension.

Alkaloids from the tubers of Pinellia pedatisecta.

Nine undescribed alkaloids (1, 3, 4, 7, 8 and 10-13) and four undescribed natural products (2, 5, 6 and 9), together with eight known components, were isolated from the tubers of Pinellia pedatisecta Schott. Their structures were elucidated based on spectroscopic data, Rh(OCOCF)-induced ECD spectral analysis, DP4+ analysis, ECD analysis and interpretation of their optical rotation data. The protective effects of all compounds against Aβ-induced PC-12 cell injury were tested by MTT method, and the results indicated that compounds 1, 2, 5-10 and 16-20 exhibited obviously protective effects.

Intraindividual Variability in Adolescent Impulsivity: The Predictive Role of Family and Peer Relationships.

Adolescent impulsivity is a robust risk factor for adolescent problem behaviors. Historically, impulsivity has been conceptualized as a trait characteristic; however, recent work conducted with adult samples indicates impulsivity also exhibits state-like qualities, fluctuating within persons from day to day. If this is also true for adolescents, it suggests that there are days of higher and lower risk for problem outcomes.

UNC0638 inhibits SARS-CoV-2 entry by blocking cathepsin L maturation.

Since the outbreak of SARS-CoV-2, viral mutations have posed significant challenges in identifying therapeutic targets and developing broad-spectrum antiviral drugs. Post-translational modifications of genes involved in interferon production and signaling pathways play a crucial role in regulating interferon responses. In this study, we employed CRISPR-Cas9 screening based on adenine base editors to investigate functional amino acids in 1,278 innate immune-related genes.

Water-Hydroxyl Wetting Monolayer Predicted and Realized on a Hydrophobic Metal Surface.

Water adsorption on metal surfaces is ubiquitous in broad natural and technological settings. However, elucidating this phenomenon is often challenging due to difficulties in accurately determining the morphology and understanding the chemistry of adsorbed water networks. Here, we report a significant discovery of the water-hydroxyl (HO-OH) wetting monolayer, which has long been deemed possible only on hydrophilic metal surfaces, now realized on an archetypal hydrophobic metal surface, Ag(111).

UBE2C, Regulated by n6-methyladenosine Methyltransferase METTL3, Is an Oncogene in Retinoblastoma via PI3K-AKT Pathway.

Retinoblastoma (RB) arising from the retina's primitive neural precursor cells is a highly aggressive pediatric ocular malignancy. Ubiquitin-conjugating enzyme E2C (UBE2C) is implicated in carcinogenesis, but its role and mechanism in RB remain unexplored. Here, we aimed to explore the effect of UBE2C and its regulatory mechanism in an N6-methyladenosine (mA) modification method in RB.

Feeding probiotics-fermented distiller's grains diets increases rumen enzyme activities and glycerophospholipid levels in finishing cattle by modulating rumen microbiota.

Background: Distiller's grains (DG), a major by-product of the Chinese Baijiu industry, represent an inexpensive yet high-quality protein raw material. Previous studies have shown that probiotics-fermented distiller's grains (FDG) hold the potential to serve as an effective livestock feed resource. However, the impacts of feeding FDG-based diets on rumen enzyme activities, rumen microbial communities and metabolism in finishing cattle, along with their underlying regulatory mechanisms, remain poorly understood.

High-Throughput Determination of Multiclass Chemical Hazards in Poultry Muscles and Eggs Using UPLC-MS/MS.

A high-throughput method for the determination of a variety of chemical hazards in poultry muscle and egg samples was established via ultra-performance liquid chromatography-tandem triple quadrupole mass spectrometry (UPLC-QqQ-MS). The sample preparation procedure was developed based on this quick, easy, cheap, effective, rugged, and safe (QuEChERS) method and validated for 280 chemical hazards potentially present in poultry products. The target compounds in poultry samples were extracted with a 1% formic acid-acetonitrile solution (15:85, /), and the metal ions in the matrix were chelated by adding ethylenediaminetetraacetic acid disodium salt (NaEDTA).

Whole-Genome Sequence Analysis, Probiotic Potential, and Safety Assessment of the Marine Bacterium CGMCC1.16464.

CGMCC1.16464 () is a novel antiviral probiotic candidate strain. To ensure its safety as a potential probiotic, a safety evaluation was conducted in this study.