Interspecific Associations of Dominant Tree Species at Different Structural Levels and Community Stability in the Habitat of Endangered Plant Merr. & Chun.

The endangered plant serves as both an indicator and keystone species in tropical rainforests, and its survival status is influenced by the interspecific relationships among coexisting tree species within the community. To explore these relationships, species resource utilization patterns, and community succession dynamics within the endangered plant community, this study utilized survey data from the community in the Bawangling and Jianfengling branches of the National Park of Hainan Tropical Rainforest. Various analytical methods were employed, including the Variance Ratio () method, test statistic (), test, Spearman's rank correlation, and M.

Relationship between the platelet-to-lymphocyte ratio and in-hospital mortality of ischemic stroke patients in the intensive care unit.

Background: The relationship between the platelet-to-lymphocyte ratio (PLR) and the prognosis of patients with ischemic stroke was unclear.

Objective: This study aimed to explore the correlation between PLR levels and in-hospital mortality in ischemic stroke patients admitted to the intensive care unit (ICU).

Methods: A retrospective cohort study was conducted using data from the MIMIC-IV database.

Eicosapentaenoic Acid Modulates TGF-β1/Smad3/ILK Pathway to Attenuate Renal Fibrosis: A Biotechnological Approach.

Background: Renal fibrosis is a key pathological process in chronic kidney disease (CKD), characterized by excessive extracellular matrix (ECM) deposition and epithelial-mesenchymal transition (EMT). Current treatment strategies have limited efficacy, necessitating the exploration of novel therapeutic agents. Eicosapentaenoic acid (EPA), a bioactive marine-derived omega-3 polyunsaturated fatty acid, has shown promise in modulating fibrosis-related signaling pathways.

SUCLG1 deficiency-induced histone succinylation impairs oncogene expression in acute myeloid leukemia.

Mitochondria-driven histone lysine succinylation is emerging as a critical signaling system that links cellular metabolism to the pathogenesis of diseases, including cancer. Here, we report that a global increase in protein/histone succinylation is associated with mitochondrial tricarboxylic acid cycle defects in acute myeloid leukemia (AML). Depletion of the succinyl-coenzyme A (CoA) synthetase alpha subunit SUCLG1 causes protein/histone hypersuccinylation in leukemia cells, which impairs cell proliferation and leukemia progression in xenograft models.

High-strength DLP-printed zirconia for ultra-thin dental veneers.

Objectives: To evaluate the feasibility of utilizing Digital Light Processing (DLP) 3D-printing technology to fabricate ultra-thin (0.1-0.7 mm) zirconia dental veneers.

An optimized SPE-UPLC-MS/MS method for simultaneous quantification of 11 tetracyclines in dairy products.

Background: The global rise in antibiotic use, particularly tetracyclines (TCs) in animal husbandry, poses significant risks to food safety and public health due to residual accumulation and bacterial resistance. Existing detection methods for TCs in dairy products often lack efficiency, sensitivity, or the capability for simultaneous multi-residue analysis. Developing a rapid, precise, and cost-effective method to monitor TCs in compliance with international maximum residue limits remains an urgent need.

Preparation of Superhydrophobic P-TiO-SiO/HDTMS Self-Cleaning Coatings with UV-Aging Resistance by Acid Precipitation Method.

The superhydrophobic coatings for outdoor use need to be exposed to sunlight for a long time; therefore, their UV-aging resistances are crucial in practical applications. In this study, the primary product of titanium dioxide (P-TiO) was used as the raw material. Nano-silica (SiO) was coated onto the surface of P-TiO by the acid precipitation method to prepare P-TiO-SiO composite particles.

Clinical Significance of Low-Density Granulocytes in Acute Pancreatitis.

Low-density granulocytes (LDGs), a unique subset of neutrophils, have been shown in previous studies to exhibit distinct biological functions in immune-inflammatory diseases. However, their role in acute pancreatitis (AP) remains unclear. To investigate the association between peripheral blood LDGs levels and clinical severity in patients with AP.

SITA: Predicting site-specific immunogenicity for therapeutic antibodies.

Antibody (Ab) humanization is critical to reduce immunogenicity and enhance efficacy in the preclinical phase of the development of therapeutic Abs originated from animal models. Computational suggestions have long been desired, but available tools focused on immunogenicity calculation of whole Ab sequences and sequence segments, missing the individual residue sites. This study introduces Site-specific Immunogenicity for Therapeutic Antibody (SITA), a novel computational framework that predicts B-cell immunogenicity score for not only the overall antibody, but also individual residues, based on a comprehensive set of amino acid descriptors characterizing physicochemical and spatial features for antibody structures.

Medicinal chemistry approaches to the discovery and development of p300/CBP inhibitors for cancer therapy.

p300 and CBP (CREB-binding protein) are homologous histone acetyltransferases (HATs) that function as transcriptional co-activators, playing pivotal roles in regulating gene expression through acetylation of histones and transcription factors. Their dysregulation has been implicated in various cancers, making them attractive targets for therapeutic intervention. Significant advancements have been made in the discovery and development of small-molecule inhibitors targeting p300/CBP.

A modified QuEChERS method for extracting different classes of emerging contaminants in soil.

Emerging contaminants (ECs) in soil pose concerns due to their potential health risks and toxicities. However, the pretreatment method for simultaneously extracting different classes of ECs was limited in soil. In this study, a rapid and robust pretreatment method based on a "Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS)" technology was developed for simultaneous extraction of 50 ECs, including 28 per- and polyfluoroalkyl substances (PFAS), 17 organophosphate esters (OPEs) and 5 diesters (di-OPEs) in soil.

USPs and non-coding RNAs: Unraveling their interplay within tumor microenvironment for targeted cancer therapy.

Cancer represents a significant global health threat, with the World Health Organization reporting millions of new cases annually. Dysregulation in cellular homestasis leads to the aggressive and heterogeneous nature of cancers. Conventional treatments encounter challenges due to the inhomogeneity of tumor microenvironment (TME).

Impact of different treatment strategies on therapeutic efficacy and biomarkers in children with IVIG-resistant Kawasaki disease: a retrospective cohort study.

Background: Intravenous immunoglobulin (IVIG) is the standard first-line treatment for Kawasaki disease (KD), although 10%-20% of patients are resistant to initial IVIG therapy. This study investigates retreatment strategies and associated biomarkers in IVIG-resistant KD patients.

Methods: This retrospective analysis included 68 IVIG-resistant KD patients from the Children's Hospital Affiliated to Shandong University.

Predictive Nomogram for Acute Kidney Injury Risk with Vancomycin and Piperacillin Tazobactam in Sepsis Treatment.

BACKGROUND The combination of vancomycin (VAN) and piperacillin-tazobactam (TZP) is commonly used to treat sepsis, but it is associated with a high risk of acute kidney injury (AKI). This article describes our development of a nomogram to predict the probability of AKI caused by the combination of the VAN and TZP in the treatment of sepsis. MATERIAL AND METHODS Patients with sepsis treated with VAN and TZP from the MIMIC-IV database were included.

Long-term follow-up of patients with non-ischemic cerebral enhancing lesions following endovascular aneurysm treatment: magnetic resonance imaging findings, clinical course, and treatment.

Background: Non-ischemic cerebral enhancing (NICE) lesions are a rare complication following endovascular therapy (EVT) for cerebral aneurysms. Although first described in 2008, data on long-term outcome and treatment response remain limited.

Objectives: In this study, we investigated the long-term follow-up of patients with NICE lesions, including magnetic resonance imaging (MRI) findings, clinical course, and treatment.

Central Pathophysiology and Brain Network Changes Related to Camptocormia in Parkinson's Disease.

Background: Studies on brain connectivity offer important insights into the changes that occur in central network diseases such as Parkinson's disease (PD). Camptocormia, a condition characterized by abnormal flexion of the trunk, often occurs in advanced PD, but its underlying mechanisms are not yet clear.

Objective: This study aims to investigate the changes in the central motor network, associated with camptocormia.

Gray Matter Volume Abnormalities in Schizophrenia: Comparisons Between P-Value and Effect Size Inference Frameworks Using Mega- and Meta-Analyses.

Background And Hypothesis: Identifying generalizable brain imaging markers from large multi-center datasets remains challenging due to varying statistical aggregation approaches and p-hacking with increasing big data. We hypothesized that effect size (ES) inference surpasses P-value-based inference in reliably identifying core brain damage of schizophrenia, regardless of whether Mega- or Meta-analyses are used.

Study Design: We examined voxel-wise inter-group differences in gray matter volume (GMV) based on individual data from 976 schizophrenia patients and 801 healthy controls across 16 datasets, along with published coordinates data from 103 studies involving 5151 patients and 5438 controls, using Mega-analysis (Mega), Image-Based Meta-analysis (IBMA), and Coordinate-Based Meta-analysis (CBMA) under P-value and ES inference frameworks, respectively.

AP-1-dependent c-Fos activation by TREX1 drives M2 macrophage polarization and mitigates osteoarthritis progression.

Background: Inflammation significantly contributes to the pathogenesis of osteoarthritis (OA). Recent studies have elucidated the critical role of the three-prime repair exonuclease 1 (TREX1) in regulating inflammatory responses and oxidative stress. The aim of the study was to investigate the regulatory function of TREX1 in maintaining joint homeostasis subsequent to the destabilization of the medial meniscus (DMM) in a murine model.

Topological and superconducting properties of two-dimensional MXC [M:X = In:As, Se:As, In:Te and As:Te] by first-principles study.

Topological superconductivity is a fascinating quantum property in the field of condensed matter physics. The exploration of topological superconductivity in two-dimensional (2D) materials has become one of the current hot topics. Based on first-principles calculations, we predict that 2D MXC materials (M:X = In:As, Se:As, In:Te and As:Te) are thermodynamically and dynamically stable.

Co-Intercalation of Sericite by Cationic and Anionic Surfactants and the Mechanical Properties of Sericite/Epoxy Resin Composites.

Although the intercalation of sericite with cationic surfactants has been extensively studied, successful intercalation using anionic surfactants has yet to be achieved. This article aims to partially or fully intercalate sericite with an anionic surfactant, and to develop the corresponding sericite/polymer nanocomposite. To achieve this goal, we modified raw sericite by thermal modification, acid activation, and sodium modification.

FMO2 Prevents Pathological Cardiac Hypertrophy by Maintaining the ER-Mitochondria Association Through Interaction With IP3R2-Grp75-VDAC1.

Background: Cardiac hypertrophy, as an important pathological change, contributes to heart failure. Recent studies indicate that the mitochondria-associated endoplasmic reticulum membranes (MAMs) play key roles in this pathological process. However, the molecular mechanism remains unclear.

Myeloid Glutamine Synthetase Protects Against Acute Liver Injury in Mice Independent of Its Enzyme Activity.

Background: Glutamine synthetase (GS, encoded by Glul) is a well-known ammonia-detoxifying enzyme, but its function in acute liver injury (ALI) remains unclear.

Methods: Lipopolysaccharide (LPS) and D-galactosamine (D-GalN) were utilised to construct the murine ALI model. C57BL/6J-Glul mice (Glul) and B6.

AuNPs@UiO-66-(COOH)-NH/Eu for ratiometric fluorescent and colorimetric sensing of trace inorganic mercury in water samples.

Background: due to the toxicity and widespread distribution of inorganic mercury ions (Hg), it is a crucial task for researchers to develop simple methods for field analysis of water samples for trace Hg.

Result: a colorimetric and ratiometric fluorescent dual-mode assay based on bifunctional UiO-(COOH)-NH/Eu and gold nanocomplexes (AuNPs@UiO-(COOH)-NH/Eu) was constructed for the sensitive, selective and potentially on-site determination of Hg. The incorporation of Hg resulted in the formation of gold amalgam, which enhanced peroxidase-like activity of AuNPs@UiO-(COOH)-NH/Eu, accelerating the oxidization of zymolyte 3,3',5,5'-tetramethylbenzidine (TMB).

A panoramic view of cotton resistance to : From genetic architectures to precision genomic selection.

Investigating the genetic regulatory mechanisms underlying complex traits forms the foundation for crop improvement. Verticillium wilt (VW), caused by e (), is one of the most devastating diseases affecting crop production worldwide. However, the genetic basis underlying crop resistance to remains largely obscure, hindering progress in the genomic selection for VW resistance breeding.

Early versus late pancreatic stent placement for preventing post-ERCP pancreatitis: protocol of a multicenter randomized clinical trial.

Background: Pancreatic stenting has been shown to effectively lower the occurrence of post-ERCP pancreatitis (PEP) and reduce its severity. To date, no evidence exists to determine the optimal timing for pancreatic stent placement in prospective trials. Our aim is to compare early versus late pancreatic stent placement in preventing PEP among patients with naive papilla.