Publications by authors named "Kaiyi Fu"
Background: Glutamine synthetase (GS, encoded by Glul) is a well-known ammonia-detoxifying enzyme, but its function in acute liver injury (ALI) remains unclear.
Methods: Lipopolysaccharide (LPS) and D-galactosamine (D-GalN) were utilised to construct the murine ALI model. C57BL/6J-Glul mice (Glul) and B6.
Article Synopsis
- The study investigates the role of 5-hydroxymethylcytosines (5hmC) in the progression of gastric premalignant lesions to gastric adenocarcinoma (GAC) in a large cohort of Chinese patients, with data collected over 12.2 years.
- Researchers conducted a genome-wide mapping of 5hmC that revealed 213 differentially modified gene bodies tied to important biological pathways like cell division, metabolism, and tumorigenesis.
- A predictive model based on 5hmC demonstrated strong potential for assessing cancer progression risk, achieving an 87.5% accuracy in validation samples, marking a significant advance in understanding gastric cancer development.
RNF214 is an understudied ubiquitin ligase with little knowledge of its biological functions or protein substrates. Here we show that the TEAD transcription factors in the Hippo pathway are substrates of RNF214. RNF214 induces non-proteolytic ubiquitylation at a conserved lysine residue of TEADs, enhances interactions between TEADs and YAP, and promotes transactivation of the downstream genes of the Hippo signaling.
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