Fucoidan enhances stability of gelatin/anthocyanin-based oleogels via hydrogen-bonded crosslinking.

Polyphenols and edible polysaccharides have emerged as promising crosslinking agents to enhance structural stabilities of protein emulsions and their templated oleogels. To enhance stabilities of gelatin (G) emulsion-based oleogels, three edible polysaccharides and two typical polyphenols were employed to oleogel preparation. Fucoidan (FUC) and flaxseed gum (FG) formed more compact network than sodium alginate, improving three-phase contact of gelatin.

Density and Maturity of Tertiary Lymphoid Structures Predict Clinical Outcome in Invasive Lung Adenocarcinoma.

IntroductionTertiary lymphoid structures (TLSs) have been associated with the prognosis of various solid tumors. However, the association between TLSs and the prognosis of invasive lung adenocarcinoma (IAC) remains unclear in terms of location, density, and maturity.MethodsWe retrospectively reviewed the clinicopathological characteristics of 750 patients with IAC.

Manipulated photocatalytic air-concentration CO into CHOH by dual hetero-metal atom pair sites.

Carbon dioxide (CO) reduction encompasses intricate protonation steps, frequently leading to unpredictable products. To achieve target product selectivity, it is essential to strategically manipulate the reaction pathway. Herein, we build Cu-Ag dual hetero-metal atom pair sites for photoreduction of 0.

Effect of a single low-dose esketamine administration during surgical abortion on postoperative sleep disturbance: a randomized controlled trial.

Women with pre-existing sleep disturbance frequently experience postoperative sleep disturbance after surgery. This randomized, double-blind, placebo-controlled, parallel-group trial was conducted to investigate the efficacy of intraoperative adjunctive esketamine administration in the reduction of postoperative sleep disturbance following surgical abortion for women with pre-existing sleep disturbance. 204 women who had sleep disturbance and were scheduled for elective surgical abortion were randomized in a one-to-one allocation ratio to receive either a single intravenous injection of 0.

Survival outcomes and risk factors after lung transplantation in patients with pre-transplant malignancy: a national cohort study.

Background: Pre-transplant malignancy (PTM) is a relative contraindication for lung transplantation (LTx). The proportion of patients with PTM in LTx is increasing annually. We sought to identify modifiable risk factors affecting patient survival and evaluate the prognosis of different types of PTM.

Red emission from strain-relaxed bulk InGaN active region.

High-In-content InGaN quantum wells (QWs) in red light-emitting diodes (LEDs) are typically grown at low temperatures to ensure effective In incorporation. In this study, red LEDs based on bulk InGaN active region were demonstrated. The growth temperature of bulk InGaN was ∼800℃, which is over 100℃ higher than the typical growth temperature of red QWs.

Development of direct infusion quadrupole mass spectrometry database and intelligent identification system for 100 root herbs.

Background: Counterfeiting is widespread in the herbal medicine market, especially for roots and rhizomes. Current authentication methods for these herbs remain limited and subjective, posing challenges to quality assurance and authenticity verification.

Purpose: To overcome the limitations of low efficiency and high subjectivity in traditional identification methods for root and rhizome traditional Chinese medicine (RRTCM), this study aims to develop a high-throughput intelligent identification system based on direct infusion QDa mass spectrometry (DI-QDa-MS) for the rapid and objective identification of 100 RRTCM, including 88 herbal medicines and 12 processed products.

Climate-resilient city pilot and green economy: A study of local and peer effects.

Under the dual pressures of rapid global climate change and the transition to a green economy, the policy effects of Climate-Resilient City Pilot (CRCP), launched in 2017, urgently require a systematic quantitative assessment. Based on this, this study utilizes panel data from 282 prefecture-level cities in China from 2010 to 2022 to construct a difference-in-differences (DID) model, analyzing the impact effects and pathways of the CRCP on green economic efficiency (GEE) from a "local-neighborhood" dual-dimensional perspective. The research findings reveal that: (1) CRCP significantly enhances the GEE of pilot cities and passes multiple robustness tests.

Unraveling the Role of Sulfonic Acid Group-Containing Organic Additive in Regulating Zinc Ions Solvation and Zn Deposition Chemistry for Reversible Zn Metal Anodes.

Sluggish desolvation of the hydrated zinc ions and disordered zinc deposition are two main challenges for hindering the practical application of Zn anodes. Here, camphor sulfonic acid (CSA) is employed as a sulfonic acid group-containing organic molecule additive in the ZnSO electrolyte for simultaneous regulation of the zinc ions solvation and deposition chemistry. The CSA reshapes the zinc ions solvation structure and reconstructs the hydrogen bonding network among free water molecules, thus effectively suppressing the hydrogen evolution reaction and maintaining stable pH microenvironment.

Acupuncture vs. Chinese Medicine for Knee Osteoarthritis: Systematic Review and Meta-Analysis.

Background: This study aimed to systematically evaluate the clinical efficacy of acupuncture and external traditional Chinese medicine therapy, each combined with massage, for treating knee osteoarthritis.

Methods: The meta-analysis followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines and was registered with PROSPERO (CRD42024600977). A comprehensive search was conducted in databases including PubMed and Chinese Knowledge Infrastructure until September 2024.

Plasma metabolomic profiling for hepatocellular carcinoma diagnosis and microvascular invasion prediction.

Altered metabolites are pivotal in hepatocellular carcinoma (HCC) development. This study employed untargeted metabolomic analysis to identify novel biomarkers for early HCC detection and explore their functions. Plasma samples were collected from 138 HCC patients, 69 patients with benign hepatic lesions, and 35 healthy donors.

Analysis of regional characteristics in mortality trends of three chronic infectious diseases among the elderly in China, 2004-2021.

Background: HIV/AIDS, hepatitis B, and tuberculosis (TB) are chronic infectious diseases prioritized by the United Nations Sustainable Development Goals (SDGs) and China's "Healthy China Initiative (2019-2030)," posing persistent challenges to global and Chinese public health systems. This study analyzed mortality trends and regional/urban-rural disparities of these three diseases among Chinese elderly individuals aged 60 years and older from 2004 to 2021 to identify priority areas for targeted prevention strategies.

Methods: Data were sourced from the "China Cause-of-Death Surveillance Dataset (2004-2021)" published by the Chinese Center for Disease Control and Prevention.

First-trimester triglyceride-glucose index and birth weight: a retrospective cohort mediation analysis of preterm birth and gestational complications.

Background: Insulin resistance during pregnancy, while physiologically adaptive to enhance fetal nutrient supply, becomes pathological when excessive, contributing to low birth weight (LBW). The triglyceride-glucose (TyG) index, a biomarker of insulin resistance, predicts gestational complications, but its pathways to birth weight disparities remain unclear. This study investigates whether and to what extent first-trimester TyG index influences birth weight through preterm birth and gestational complications.

High-Throughput Viral Integration Detection Reveals Baseline Breakpoints Burden Associated With HBsAg Seroclearance.

Background: The profiles of hepatitis B virus (HBV) integration related to hepatitis B surface antigen (HBsAg) loss remain largely unknown.

Aims: We aimed to delineate the patterns of HBV integration in virally suppressed chronic hepatitis B (CHB) patients and their association with HBsAg loss following antiviral therapy.

Methods: Forty-five patients with paired liver biopsies were randomly selected from the Anchor study for high-throughput viral integration detection.

Effects of online and offline social participation on depression among older adults living alone vs. not.

This study explored how online and offline social participation affects depression symptoms in older adults through social networks, basic psychological needs, and cognitive reactivity. Conducted as a cross-sectional survey among 700 urban and rural older adults in Ningde City, Fujian Province, data on social participation, social networks, psychological needs, cognitive reactivity, and depression symptoms were analyzed using partial least squares structural equation modeling and multi-group structural equation modeling. Results indicated that offline social participation directly reduced depression symptoms, whereas online participation did not.

Molecular Characterization and Antibiograms of Nontuberculous Mycobacterium Infections in Kashgar, China.

To investigate the prevalent characteristic of nontuberculous mycobacteria (NTM) isolates in Kashgar. A total of 52 NTM culture-positive isolates were collected in 2020 from Kashgar, China. All strains were confirmed to be NTM species by whole genome sequencing (WGS).

Chinese Patent Medicine Nei-Xiao-Pian Shrinks Thyroid Nodules by Regulating Proliferation and Apoptosis of Cells Inhibiting the IL-6/JAK2/STAT3 Signaling Pathway.

Background: Thyroid nodules (TN) are distinct lesions within the thyroid gland that can cause compression symptoms, disrupt thyroid function, and impact aesthetics and daily life. Nei-Xiao-Pian (NXP), a traditional Chinese patent medicine developed by Suzhou Hospital of Traditional Chinese Medicine, has been effectively used in clinical treatment for TN. Due to the complex nature of traditional Chinese medicine (TCM), limited clinical research exists on NXP, and its precise mechanisms of action remain largely unknown.

Bear Bile Powder Alleviates Corticosterone-induced Depression-like Behavior in Female Mice by Protecting Hippocampal Neurons via the BDNF/TrkB/ CREB Pathway.

Introduction: Bear bile powder (BBP) has been traditionally used in Chinese medicine for calming the liver, pacifying the mind, and relieving convulsions, as recorded in Ben Jing Feng Yuan and Yu Qiu Yao Jie. Although the antidepressant effects of BBP have been previously reported, the underlying neurological mechanisms have yet to be fully elucidated. This study aimed to investigate the antidepressant effects of BBP on corticosterone (CORT)-induced depression-like behaviors in female mice and to explore the involvement of the BDNF/TrkB/CREB signaling pathway.

Nicotine and tar-multiple targets synergize to alter the immune micro-environment to induce prostate cancer.

Background: Prostate cancer (PC) is a common urinary system malignancy in men, and smoking is a clear risk factor. Among them, nicotine and tar in cigarettes play a key role in the development of PC, but the specific mechanism is not completely clear.

Objective: To explore the mechanism of PC immune inflammation caused by nicotine and tar, and to provide the theoretical basis and new targets for the prevention and treatment of PC.

Biomimetic Mineralization Nucleation with Polymer Template Enabled High-Performance Perovskite Solar Cells by Anti-Solvent-Free Technology.

Nucleation regulation in the perovskite film-forming process has been widely studied to optimize crystal quality and enable high-efficiency perovskite solar cells (PVSCs) by an anti-solvent-free method. However, the vertical nucleation process is often difficult to control in anti-solvent-free preparation, due to the heterogeneous metal ion distribution and subsequent non-uniform nucleation. Inspired by natural biomineralization mechanisms, this is pioneered that the introduction of a functional biopolymer carboxymethyl chitosan (CMC) at the buried interface of the perovskite layer, which would promote homogeneous vertical nucleation.

Cathepsin H increases the risk of diabetic retinopathy: evidence from Mendelian randomization and bioinformatic analysis.

Background: While lysosomal cathepsins are crucial in cellular homeostasis and may contribute to diabetic chronic complications, their precise causal relationships remain insufficiently characterized.

Methods: This study employed comprehensive multidimensional Mendelian randomization (MR) analyses to investigate potential causal associations between nine cathepsins (B, E, F, G, H, L2, O, S, and Z) and six diabetic chronic complications encompassing both microvascular (nephropathy, retinopathy, proliferative retinopathy, maculopathy, neuropathy) and macrovascular manifestations (peripheral angiopathy). The analytical framework incorporated generalized summary-data-based MR (GSMR), univariable MR, multivariable MR, summary-data-based MR (SMR), and cis-expression quantitative trait locus (cis-eQTL) MR approaches, utilizing data derived from publicly available genome-wide association studies (GWAS).

suppresses colitis-associated colorectal cancer by modulating the gut microbiota-bile acid-FXR axis.

Gut microbiota dysbiosis critically contributes to colitis-associated colorectal cancer (CAC) pathogenesis, positioning microbial modulation as a promising therapeutic strategy. () is an emerging probiotic with potential cancer-inhibiting effects. This study investigates the anti-tumorigenic potential of in an azoxymethane/dextran sulfate sodium-induced CAC murine model.

Fully non-fused electron acceptor solar cells with 18% efficiency via a synergistic peripheral substituent strategy.

Toward commercialization of organic solar cells (OSCs), photoactive materials that enable high efficiency yet possess low cost should be developed. Fully non-fused ring electron acceptors (FNEAs) that extend the conjugated skeleton with carbon-carbon (C-C) single bonds solely have lower synthetic costs than their fused-ring counterparts. However, the power conversion efficiencies (PCEs) of FNEAs are lagging due to low acceptor crystallinity and difficulty in the formation of fibrillary bi-continuous interpenetrating network morphology.

Effects of urbanization on soil heavy metal accumulation and improvement using Glomalin-related soil protein.

Glomalin-related soil protein (GRSP) exhibits strong adsorption and sequestration capacities for heavy metals. However, the contribution rate of GRSP to the sequestration of soil heavy metals under rapid urbanization remains unclear. Therefore, 184 soil samples from the green spaces in a built-up area of Nanchang, China were selected as the research site according to the urbanization intensity levels and the impervious surface area rates.

Berberine Attenuates Pyroptosis in Renal Tubular Epithelial Cells by Activating the FOXO3a/ARC Pathway.

Renal ischemia/reperfusion (I/R) injury is primarily mediated by oxidative stress, inflammation, and pyroptosis. Berberine (BBR), a naturally occurring isoquinoline alkaloid, possesses anti-inflammatory, antipyroptotic, and antioxidant properties. However, the impact of BBR on renal I/R injury remains unclear.