The impact of marital status on hypertension: SEM analysis of a Chinese general population cohort.

Background: Hypertension, a chronic non-communicable disease, has multifaceted and complex etiologies influenced by various risk factors. This study examines the role of marital status among the factors influencing blood pressure levels and assesses its potential indirect effects through other variables.

Methods: This study involved 1852 individuals from the Baoding area in the Beijing-Tianjin-Hebei region, China.

Biomarker profile of a Chinese ALS cohort: A comprehensive clinical-biomarkers-imaging analysis.

Background: Amyotrophic lateral sclerosis (ALS) is a fatal central nervous system neurodegenerative disease, but the relationships among genetic mutations, plasma biomarkers, glymphatic system and clinical variables remain unclear.

Methods: This study retrospectively collected data from April 2015 to November 2024 from the Department of Neurology of First Affiliated Hospital, Fujian Medical University, China. ALS patients (including genetic ALS (gALS) and sporadic ALS (sALS)), Alzheimer's disease (AD) patients, and healthy controls (HC) were included.

EFHD1: A Potential Prognostic Biomarker Related to Mitochondrial Function and Aging in Atherosclerosis Plaque.

Introduction: Atherosclerosis (AS) is prevalent among the elderly population and poses a significant global health burden. However, the precise underlying mechanisms linking aging and mitochondrial dysfunction in AS remain unclear.

Methods: Through comprehensive utilization of databases including the Gene Expression Omnibus (GEO), MitoCarta, Molecular Signatures Database (MSigDB), and Human Aging Genomic Resources (HAGR), we employed various bioinformatics methods to explore the possible function of EF-hand domain family member D1 (EFHD1).

Impact of training volume settings between unilateral training and bilateral training on athletic performance: A systematic review and meta-analysis.

Background: The unilateral/bilateral dimension refers to whether an action is performed by one side of the body alone or involves both sides simultaneously. Unilateral training (UT) and bilateral training (BT) have been shown to enhance athletic performance. However, there are differences in training volume settings between unilateral and bilateral training, making it essential to understand their characteristics for optimizing training protocols and improving competitive level.

Revolutionizing gastroenterology and hepatology with artificial intelligence: From precision diagnosis to equitable healthcare through interdisciplinary practice.

Artificial intelligence (AI) is driving a paradigm shift in gastroenterology and hepatology by delivering cutting-edge tools for disease screening, diagnosis, treatment, and prognostic management. Through deep learning, radiomics, and multimodal data integration, AI has achieved diagnostic parity with expert clinicians in endoscopic image analysis (, early gastric cancer detection, colorectal polyp identification) and non-invasive assessment of liver pathologies (, fibrosis staging, fatty liver typing) while demonstrating utility in personalized care scenarios such as predicting hepatocellular carcinoma recurrence and optimizing inflammatory bowel disease treatment responses. Despite these advancements challenges persist including limited model generalization due to fragmented datasets, algorithmic limitations in rare conditions (, pediatric liver diseases) caused by insufficient training data, and unresolved ethical issues related to bias, accountability, and patient privacy.

Fully non-fused electron acceptor solar cells with 18% efficiency via a synergistic peripheral substituent strategy.

Toward commercialization of organic solar cells (OSCs), photoactive materials that enable high efficiency yet possess low cost should be developed. Fully non-fused ring electron acceptors (FNEAs) that extend the conjugated skeleton with carbon-carbon (C-C) single bonds solely have lower synthetic costs than their fused-ring counterparts. However, the power conversion efficiencies (PCEs) of FNEAs are lagging due to low acceptor crystallinity and difficulty in the formation of fibrillary bi-continuous interpenetrating network morphology.

Targeting CD38 to alleviate brain endothelial cell dysfunction and cognitive impairment in vascular dementia.

Vascular dementia (VaD) is a leading cause of cognitive decline, closely associated with cerebrovascular endothelial cell (CEC) dysfunction, blood-brain barrier (BBB) disruption, and neuroinflammation. CD38, an enzyme implicated in neuroinflammation and cellular senescence, has emerged as a potential regulator of these pathological processes, yet its role in CEC dysfunction within the context of VaD remains unclear. In this study, we investigated the impact of CD38 on CEC dysfunction using a mouse model of VaD induced by bilateral common carotid artery stenosis (BCAS).

The Effect of Adding Different Elements (Mg, Fe, Cu, and Ce) on the Properties of NiCoO for CO-Catalyzed Oxidation.

In this experiment, NiCoO catalysts, with different elements added (Mg, Fe, Cu, and Ce), were prepared using the co-precipitation method to investigate their catalytic performance for carbon monoxide, as well as their water resistance and sulfur resistance. Combined with the sintering flue gas environment of Baosteel Zhanjiang Iron and Steel Co., Ltd.

A linear non-halogenated polymer donor Suzuki-Miyaura coupling for organic solar cells.

A novel linear non-halogenated polymer donor, PTTzP, with a simple structure was synthesized Suzuki-Miyaura coupling. PTTzP exhibits comparable device performance (>12%) in organic solar cells (OSCs) when processed with halogenated and non-halogenated solvents, respectively. This achievement highlights the potential of PTTzP as an efficient and environmentally friendly polymer donor, enabling high-performance OSCs through entirely green synthesis and processing methods.

Asymmetry of the Single Leg Jump and Lateral Shuffle Performance in Pre-Juvenile Basketball Players.

The aims of this study were to: 1) assess and compare the performance of lateral shuffles and lower limb jumps among pre-juvenile basketball players; and 2) calculate the asymmetry scores of these assessment methods and examine the association between their performance and existing inter-limb differences. Thirty-nine pre-juvenile basketball athletes (23 boys and 16 girls) performed the countermovement jump, the single leg countermovement jump, the single leg lateral jump, the single leg broad jump, and four shuffle tests (2 distances of 2.5 and 5 m × 2 in each direction) on separate days.

Parents' knowledge, attitude and practice regarding childhood circumcision: a cross-sectional study in the central region of Sichuan, China.

Introduction: This cross-sectional study aimed to explore parents' knowledge, attitudes, and practices (KAP) regarding male circumcision (MC) for their children.

Methods: A cross-sectional study was conducted among parents of male children under 18 years old in the central region of Sichuan, China, between September 2023 and January 2024 Questionnaires were distributed to collect demographic information and KAP scores.

Results: A total of 497 valid questionnaires were collected.

Enhancement of aluminum doping on removal of norfloxacin by iron-loaded biochar: efficacy and mechanism.

The capacity of aluminum/iron-loaded biochar (AFBC) and iron-loaded biochar (FBC) for removal of norfloxacin (NOR) was investigated by batch experiments, while enhancement efficacy and mechanism was explored by kinetic, isothermal, and thermodynamic analyses, as well as by characterization of the AFBCs and FBCs and solution properties. As the initial pH was raised from 2 to 12, the NOR removal capability of AFBC varied within a narrow range (123.6-124.

Recombinant Detoxified Holotoxin as a Potent Candidate Vaccine Against Botulism.

Vaccination may represent a suitable strategy for preventing botulism. The recombinant expression of toxin functional domains can induce effective immune responses against botulism. This study aims to develop a safe and effective recombinant detoxified full-length BoNTA vaccine.

The effects of different work: Rest durations on physiological, neuromuscular, and ratings of perceived exertion responses during taekwondo-specific high-intensity interval training.

Purpose: To investigate the effect of different work: rest durations on physiological, neuromuscular, and perceived exertion responses during taekwondo-specific high-intensity interval training (HIIT).

Methods: Thirteen moderate-trained taekwondo athletes (age: 21.7 ± 2.

Fatigue in the Preataxic and Ataxic Stages of Spinocerebellar Ataxia Type 3.

Objective: Fatigue is a significant symptom in patients with spinocerebellar ataxia type 3 (SCA3). This study explores the role of fatigue in SCA3, examining its impact on quality of life and its potential as an indicator of disease progression.

Methods: We prospectively recruited 128 molecularly confirmed SCA3 patients and 125 sex-, age-, and education-matched healthy controls (HCs).

Clinical value of systemic immunoinflammatory index in predicting recurrence and metastasis in patients with primary liver cancer.

Background: Primary liver cancer is a highly aggressive neoplasm with high incidence and mortality. Due to the high ability to metastasis, the 5-year survival rate of patients with primary liver cancer is poor.

Aim: To investigate the clinical value of systemic immunoinflammatory index (SII) in predicting recurrence and metastasis after interventional therapy in patients with primary liver cancer.

Plasma microRNA-30a expression in patients with chronic hepatitis B and its application value in the assessment of the severity of liver fibrosis.

Objective: The severity of liver fibrosis (LF) in chronic hepatitis B (CHB) affects the outcome and treatment. We probed plasma miR-30a expression in CHB patients and its value in assessing LF severity.

Methods: This retrospective study included 160 CHB patients and another 98 controls.

In-situ silver (Ag) clusters strengthed spatial separation of photogenerated charge-carriers for efficient photocatalytic tetracycline antibiotic purification.

Metal cluster co-catalysts have been widely considered as an effective strategy to address the energy crisis and environmental problems owning to the efficient light absorption and the enhanced separation of electron hole pairs. In this contribution, via a facile in-situ photoreduction technique, the Ag/(BiO)CO composites were synthesized to degrade the antibiotic pollutant tetracycline (TC). The incorporation of silver (Ag) clusters on (BiO)CO surface can form the built-in electric field (IEF) at the Mott-Schottky junction interface and facilitate the migration of photo-generated electrons from (BiO)CO to Ag clusters.

Physiological and Neuromuscular Fatigue after 3-Minute Lateral Shuffle Movement at Different Speeds and Distances.

This study aimed to 1) investigate and compare physiological and neuromuscular fatigue after a 3-min lateral shuffle movement (LSM) at different speeds and distances, and 2) examine the relationship between the number of changes of direction (CODs) during LSM and fatigue-related variables. Twenty male college athletes (age: 20.9 ± 1.

Validity of Three Commercial Devices for Recording Movement Velocity in the Bulgarian Split Squat.

This study aimed to assess the validity of three commercial devices in recording mean velocity (MV) and peak velocity (PV) during a unilateral resistance exercise. Eighteen strength-trained and healthy males performed repetitions of Bulgarian split squats at loads ranging from 40% to 90% of their one-repetition maximum. MV and PV were simultaneously recorded by GymAware, PUSH, My Lift and compared to Vicon for all repetitions.

Test-Retest Reliability and Sensitivity of Kinematic and Kinetic Metrics Measured from Horizontal Deceleration Ability Tests with Different Sprinting Distances.

This study aimed to (1) assess the test-retest reliability and sensitivity of kinematic and kinetic metrics from 5-m, 10-m, and 20-m horizontal deceleration ability (HDA) tests; (2) explore the relationships of those metrics from HDA5m, HDA10m and HDA20m tests. Eighteen college athletes completed one familiarization session and two test sessions separated by 48 hours. Test sessions consisted of three 5-m, 10-m, and two 20-m maximal sprints, along with HDA tests conducted at the same sprinting distances.

Fast Registration Algorithm for Laser Point Cloud Based on 3D-SIFT Features.

In response to the issues of slow convergence and the tendency to fall into local optima in traditional iterative closest point (ICP) point cloud registration algorithms, this study presents a fast registration algorithm for laser point clouds based on 3D scale-invariant feature transform (3D-SIFT) feature extraction. First, feature points are preliminarily extracted using a normal vector threshold; then, more high-quality feature points are extracted using the 3D-SIFT algorithm, effectively reducing the number of point cloud registrations. Based on the extracted feature points, a coarse registration of the point cloud is performed using the fast point feature histogram (FPFH) descriptor combined with the sample consensus initial alignment (SAC-IA) algorithm, followed by fine registration using the point-to-plane ICP algorithm with a symmetric target function.

Elucidating the Mechanism of VVTT Infection Through Machine Learning and Transcriptome Analysis.

The vaccinia virus (VV) is extensively utilized as a vaccine vector in the treatment of various infectious diseases, cardiovascular diseases, immunodeficiencies, and cancers. The vaccinia virus Tiantan strain (VVTT) has been instrumental as an irreplaceable vaccine strain in the eradication of smallpox in China; however, it still presents significant adverse toxic effects. After the WHO recommended that routine smallpox vaccination be discontinued, the Chinese government stopped the national smallpox vaccination program in 1981.