Sialic acid serves as a functional receptor for grass carp reovirus.

Grass carp reovirus (GCRV) causes hemorrhagic disease and substantial economic losses in the aquaculture of grass carp (Ctenopharyngodon idella), a commercially important fish species in China. Although viral entry depends on interactions between viral proteins and host receptors, the specific host molecules mediating this process have not been fully elucidated. Here, we identify cell surface sialic acid (SA) as a critical functional receptor for GCRV.

Weight loss practices in Chinese national and international-level Sanda athletes.

Background: Sanda is an unarmed combat sport (CS) comprises punching, kicking, throwing, wrestling, and defensive techniques that has increased in popularity. To ensure athletes compete against opponents of similar body size and weight for fairness, Sanda competition is classified according to weight classes. Previous studies revealed that CS athletes tend to intentionally lose weight to gain a competitive advantage over their opponents.

Reduced Dietary Protein Levels Improved Growth Performance, Promoted Efficient Nutrient Utilization, Increased Fecal , and Reduced Fecal Malodorous Compounds in Late-Fattening Barrows.

The objective of this study was to evaluate the effect of reducing dietary protein levels on barrows during the late fattening period. Fifty Duroc × Landrace × Yorkshire barrows with body weights averaging 76.30 ± 6.

Reevaluating the definition of rapid weight loss in sports: a call for change.

Background: Pre-competition weight loss (WL) is a widely adopted strategy in weight-sensitive sports, particularly among combat sport. This strategy enables athletes to compete at a weight or weight classes below their habitual body mass (BM). Although research on WL for weight-sensitive sports has steadily grown, it mostly employs the term "RWL".

deteriorates autism spectrum disorders by disturbing the gut and oral microbiota.

Autism spectrum disorder (ASD) significantly impairs socialization and communication, posing a major societal challenge due to limited understanding of its pathogenesis and lack of effective treatments. Recent studies have shown an imbalance in the oral and intestinal microbiota of individuals with ASD, which may exacerbate ASD symptoms. In this study, we successfully established an ASD mouse model induced by () solution.

Neutrophil extracellular traps aggravate periodontitis by disturbing regulatory T-cell differentiation.

Excessive neutrophil extracellular traps (NETs) induce an intense inflammatory response in periodontitis. Recently, Tregs were shown to be essential for attenuating inflammation-driven bone resorption. However, the regulation of Tregs differentiation by NETs in periodontitis is still unclear and needs further investigation.

Repurposing fluoroquinolones as cancer chemosensitizers: a way to overcome cancer therapeutic bottleneck.

Drug repurposing (DR) is a strategy to develop novel drugs from pre-approved drugs. To overcome the limitations of conventional drug development pathways, DR is a novel method that is cost-effective, with minimal side effects, and less time-consuming. Contrary to de novo drug discovery, DR eliminates the need for FDA approval.

Metabolomics and proteomics reveal blocking argininosuccinate synthetase 1 alleviates colitis in mice.

To date, treating ulcerative colitis (UC) remains a significant challenge due to its complex etiology. In this study, metabolomics and proteomics analysis for multi-center cohorts reveal that both serum arginine levels and the rate-limiting enzyme argininosuccinate synthetase 1 (ASS1) are significantly elevated in UC patients. Exogenous arginine infusion and ASS1 overexpression exacerbate the pathological features of colitis in mice, while inhibiting or silencing ASS1 offers protection against experimental colitis.

DILC-ESAE: Data-Info envelope stacked autoencoder on correlation among samples rather than themselves.

Stacked autoencoders (SAEs) are a powerful and popular tool for structured classification. However, the existing AEs have a common shortcoming: they only focus on the original sample individual without considering the correlation information between similar samples. In fact, the information can significantly enhance the separability, thereby further improving the classification performance.

Impact of training volume settings between unilateral training and bilateral training on athletic performance: A systematic review and meta-analysis.

Background: The unilateral/bilateral dimension refers to whether an action is performed by one side of the body alone or involves both sides simultaneously. Unilateral training (UT) and bilateral training (BT) have been shown to enhance athletic performance. However, there are differences in training volume settings between unilateral and bilateral training, making it essential to understand their characteristics for optimizing training protocols and improving competitive level.

Breviscapine injection and its main component scutellarin prevents lethal enterovirus infection by inhibiting neuroinflammation and oxidative stress in newborn mice.

Background: Enterovirus 71 (EV71) is the primary cause of severe neurological infections associated with Hand, Foot and Mouth Disease (HFMD) in children, and no specific therapeutic agent is available. Breviscapine injection (BRE Injection) is widely used in China for its neuroprotective properties in ischemic stroke.

Objective: To investigate the therapeutic impact and mechanisms of BRE Injection and its main component scutellarin in preventing fatal infection of EV71 in newborn mice.

Niuhuang Jiedu Tablet's compatibility alleviates realgar-induced intestinal toxicity by activating aryl hydrocarbon receptor pathway via Akkermansia and indole-3-lactate.

Ethnopharmacological Relevance: Realgar is a traditional Chinese medicine rich in arsenic, and long-term use may lead to arsenic poisoning. The toxicity of realgar has primarily focused on the liver and kidney, with limited studies on its intestinal toxicity. Niuhuang Jiedu Tablet (NHJDT) is a renowned realgar-containing formula for clearing heat and detoxifying.

Integrated analysis of WGCNA and machine learning identified diagnostic biomarkers in trauma-induced coagulopathy.

Despite advancements in trauma care, uncontrolled hemorrhage and trauma-induced coagulopathy (TIC) remain the leading causes of preventable deaths after trauma. Understanding the genetic underpinnings and molecular mechanisms of TIC is crucial for developing effective diagnostic and therapeutic strategies. This study employed a comprehensive bioinformatics approach to elucidate the genetic landscape associated with TIC.

Tensile stress promotes the chondrogenic ability of condylar cartilage stem/progenitor cells in the temporomandibular joint via the Piezo1-Ca-Prkca pathway.

Background: Tensile force is a key regulator for condylar cartilage remodeling in the temporomandibular joint (TMJ), and this biomechanical characteristic underlies the mechanisms of mandibular growth modification in orthodontic practice. Cartilage stem/progenitor cells (CSPCs) in the superficial layer of condylar cartilage play an essential part in the development and remodeling of condylar cartilage. However, the regulatory role of tensile force on condylar CSPCs remains unclear.

PTH Promotes Chondrogenesis of Fibrocartilage Stem Cells and Alleviates Temporomandibular Joint Osteoarthritis.

Background: Parathyroid hormone (PTH) can promote subchondral bone formation and alleviate temporomandibular joint (TMJ) osteoarthritis (OA), but the effects of PTH on fibrocartilage stem cells (FCSCs) in cartilage surfaces have yet to be studied.

Methods: We established the TMJOA model in rats and administered PTH to treat them. Rat condyles were analyzed using micro-computed tomography, histological, and immunohistochemical staining.

Bioaccessibility and Health Risk Assessment of Arsenic in Realgar-Containing Traditional Chinese Medicines.

As a traditional Chinese medicine (TCM) composed of AsS, realgar has been widely used for treating various diseases. However, its safety has raised significant concerns due to the well-documented toxicity of arsenic. The Chinese Pharmacopoeia has imposed strict controls on the dosage of realgar, but the bioaccessibility and health risks associated with arsenic in realgar-containing TCMs remain poorly understood.

Characteristics of polyclonal anti-interferon-gamma autoantibodies and novel diagnostic strategies: A prospective cohort study of new biomarkers.

Background: -γ interferon autoantibody (AIGA) syndrome is a widespread and grossly underestimated immunodeficiency disorder characterized by high mortality rates and a lack of standardized diagnostic methods. A highly accurate AIGA biomarker that meets the requirements of absolute quantification is urgently needed to enable the early diagnosis and treatment monitoring of the disease. In our study, we aimed to identify the primary components of AIGAs, determine their function, and develop a novel diagnostic method.

Asymmetry of the Single Leg Jump and Lateral Shuffle Performance in Pre-Juvenile Basketball Players.

The aims of this study were to: 1) assess and compare the performance of lateral shuffles and lower limb jumps among pre-juvenile basketball players; and 2) calculate the asymmetry scores of these assessment methods and examine the association between their performance and existing inter-limb differences. Thirty-nine pre-juvenile basketball athletes (23 boys and 16 girls) performed the countermovement jump, the single leg countermovement jump, the single leg lateral jump, the single leg broad jump, and four shuffle tests (2 distances of 2.5 and 5 m × 2 in each direction) on separate days.

A DEAD-box RNA helicase encoded by DEK223 is essential for maize kernel development by affecting pre-rRNA processing.

The ribosomes play a crucial role in gene expression across all organisms. In eukaryotes, the 80S monosome consists of the 40S small subunit and the 60S large subunit. Ribosome biogenesis is a meticulously coordinated process that encompasses multiple ribosome biogenesis factors.

Study on mine pressure law and support resistance of working face under shallow buried gully terrain.

Because of the control problems caused by the non-uniform load of the roof of the working face when the shallow coal seam is mined under the condition of gully terrain. In this study, theoretical analysis, similar simulation, and field measurement methods are comprehensively used to incorporate gully topographic factors into the study of roof structure control, and a mechanical model of roof structure under non-uniform load is constructed. The interaction relationship between "powered roof support-rock mass" during the period of periodic pressure is analyzed, the corresponding model is established, and then the calculation equation of support resistance for controlling the sliding instability of the roof structure passing through the gully is derived.

The effects of different work: Rest durations on physiological, neuromuscular, and ratings of perceived exertion responses during taekwondo-specific high-intensity interval training.

Purpose: To investigate the effect of different work: rest durations on physiological, neuromuscular, and perceived exertion responses during taekwondo-specific high-intensity interval training (HIIT).

Methods: Thirteen moderate-trained taekwondo athletes (age: 21.7 ± 2.

The Impact of Valproic Acid on Microbiota in a Mouse Model of Autism Spectrum Disorder.

Background: Autism spectrum disorder (ASD) is a complex neuropsychiatric condition with a multifactorial etiology, involving both genetic predisposition and environmental factors. Valproic acid (VPA), a commonly used antiepileptic drug, has been shown to induce ASD-like behaviors in rodent models, making it a valuable tool for studying the pathophysiology of ASD. This study aims to explore the effects of VPA on behavior and the microbiota in a mouse model of ASD.

Training-Intensity Distribution, Volume, Periodization, and Performance in Elite Rowers: A Systematic Review.

Purpose: This study systematically reviewed the literature on elite rowers' training-intensity distribution (TID), volume, periodization, physiological determinants, and performance characteristics.

Methods: Three electronic databases (Scopus, PubMed, and Web of Science) were searched using relevant terms. Studies investigating and detailing training load (TID, volume, and periodization) and reporting data of physiological determinants or performance in elite rowers were included.

Type II grass carp reovirus utilizes autophagosomes for viroplasm formation and subclinical persistent infection.

Grass carp reovirus (GCRV) is the most virulent pathogen within the genus , belonging to the family . GCRV is categorized into three genotypes, with type II (GCRV-II) being the predominant strain circulating in China. Reoviruses are known to replicate and assemble in cytoplasmic inclusion bodies termed viroplasms; however, information regarding the formation of GCRV-II viroplasms and their specific roles in virus infection remains largely unknown.