Injectable and self-healing fucoidan hydrogel: A natural anti-inflammatory biomaterial.

Fucoidan, a natural sulfated polysaccharide, offers immense potential as a natural immune-modulatory bioactive polymer to develop hydrogels for tissue engineering. Yet, systematically tunable hydrogels composed primarily of fucoidan, that can also be injected into target tissues to reduce inflammation are still lacking. To address this, we have developed a highly tunable, hydrazone crosslinked fucoidan (hcFu) hydrogel that is injectable and can be utilized for various tissue engineering applications.

Genomic characterization and serotype distribution of dengue virus circulating in Pakistan during 2024.

Dengue virus (DENV) remains a significant public health concern in Pakistan, with recurrent outbreaks necessitating continuous genomic surveillance. The 2024 dengue outbreak prompted an investigation into circulating serotypes and genomic diversity. The National Institute of Health (NIH), Pakistan, received 524 NS-1 confirmed dengue samples across multiple districts in 2024.

Repurposing fluoroquinolones as cancer chemosensitizers: a way to overcome cancer therapeutic bottleneck.

Drug repurposing (DR) is a strategy to develop novel drugs from pre-approved drugs. To overcome the limitations of conventional drug development pathways, DR is a novel method that is cost-effective, with minimal side effects, and less time-consuming. Contrary to de novo drug discovery, DR eliminates the need for FDA approval.

Evaluating gender-based disparities in the outcomes of impella use in acute myocardial infarction patients with cardiogenic shock; insights from real-world global data.

Introduction: Mechanical circulatory support (MCS) devices, such as the Impella, have become critical tools in managing cardiogenic shock (CS), offering temporary hemodynamic support to improve cardiac output and stabilize patients. This study aimed to evaluate gender-based differences in clinical outcomes following Impella implantation for CS secondary to myocardial infarction (MI).

Methods: Using real-world data from the TriNetX database, all patients with CS secondary to MI who underwent Impella implantation were identified and then divided into two cohorts based on gender.

Serological Evidence of Bluetongue Virus Serotypes Circulating in Pakistan.

Introduction: Bluetongue is an arthropod-borne viral disease of ruminants, which is caused by bluetongue virus (BTV) that exists in more than 30 different serotypes. The disease is endemic in Pakistan. However, little is known about circulating BTV serotypes in the country.

Comparison of Success Rate of Direct Versus Indirect Sinus Lifting Techniques for Vertical Bone Augmentation in Patients with Maxillary Dental Implants.

Objective: To compare direct and indirect sinus lifting techniques in patients getting implants in the maxillary molar region for parameters such as postoperative pain, swelling, gingival inflammation, implant stability, and patient comfort.

Study Design: Analytical study. Place and Duration of the Study: Department of Oral and Maxillofacial Surgery, The Armed Forces Institute of Dentistry, Rawalpindi, Pakistan, from 1st February to 1st November 2023.

Serological evidence of epizootic hemorrhagic disease and serotypes of epizootic hemorrhagic disease virus in Pakistan.

This study investigated seroprevalence and serotypes of Epizootic hemorrhagic disease virus (EHDV) in ruminants in North-Western Pakistan. A total of 616 serum samples were tested for the presence of antibodies against EHDV and neutralizing antibodies against 7 EHDV serotypes (EHDV-1, 2, 4, 5, 6, 7 and 8) using competitive ELISA and VNT, respectively. The overall seroprevalence of EHDV was found to be 35.

Exploring age-related changes in gut bacterial community composition of yak: insights from different age groups.

Background: The Qinghai-Tibetan Plateau (QTP) offers one of the most extreme environments for yaks (Bos grunniens). The yak is an indigenous species, and the wild yak was domesticated on the QTP. The gut microbiota plays a vital role in health and animal performance.

Highest Solar-to-Hydrogen Conversion Efficiency in CuZnSnS Photocathodes and Its Directly Unbiased Solar Seawater Splitting.

Despite being an excellent candidate for a photocathode, CuZnSnS (CZTS) performance is limited by suboptimal bulk and interfacial charge carrier dynamics. In this work, we introduce a facile and versatile CZTS precursor seed layer engineering technique, which significantly enhances crystal growth and mitigates detrimental defects in the post-sulfurized CZTS light-absorbing films. This effective optimization of defects and charge carrier dynamics results in a highly efficient CZTS/CdS/TiO/Pt thin-film photocathode, achieving a record half-cell solar-to-hydrogen (HC-STH) conversion efficiency of 9.

Charge Carrier Separation Enhancement Mechanism in Eco-Friendly CZTSSe/(Zn, Sn)O Thin-Film Photocathodes for Highly Efficient Solar-To-Hydrogen Evolution.

Kesterite CuZnSn(S,Se) (CZTSSe)-based photocathodes present promising solutions for solar hydrogen evolution, owing to their non-toxic, cost-effective nature and exceptional photoelectrochemical (PEC) properties. Traditionally, the development of CZTSSe-based photocathodes for PEC water splitting have utilized CdS as the electron transport layer (ETL) owing to its favorable band alignment with the CZTSSe light-absorbing thin film. However, its environmental concerns pose a significant challenge.

Pt-free MoS co-catalyst enables record photocurrent density in SbSe photocathodes for highly efficient solar hydrogen production.

Antimony selenide (SbSe) emerges as a potential light-absorbing material for thin film photovoltaics and photoelectrochemical (PEC) water-splitting devices, due to its earth-abundant constituents and excellent photoelectric properties. However, losses caused by corrosion and sluggish charge transfer at the semiconductor/electrolyte interface require a co-catalyst to enhance these kinetic factors. In this study, MoS is employed as a cost-effective, noble-metal-free catalyst to enhance the photocurrent density ( ), half-cell solar-to-hydrogen (HC-STH) conversion efficiency and stability of SbSe-based photocathodes.

An improved sulfur iodine cycle for sour gas purification and hydrogen fuel production for better environment.

The conventional sulfur-iodine (S-I) thermochemical cycle developed for sour gas purification and hydrogen production from HS stoichiometrically produces 2 moles of H. The present work aims to develop an improved sulfur-iodine cycle, here called the five-step sulfur-iodine cycle, that replaces direct sulfur oxidation with a reaction between metallic oxygen carrier (OC) and elemental S to produce hydrogen. This new cycle does not only produce more H, but also produces extra HSO.

Amid conflict and crisis: addressing the mental health challenges of pregnant women in gaza through integrated humanitarian and healthcare interventions.

This manuscript highlights the mental health challenges faced by pregnant women in Gaza amidst ongoing conflict and a collapsing healthcare system. Limited access to prenatal care and psychological support and the destruction of healthcare infrastructure has worsened mental health issues like anxiety and depression. Pregnant women in Gaza are at higher risk of miscarriage, stillbirth, and birth defects, further impacting their mental well-being.

Bio-Engineered Silver Nanoparticles, Characterization, and Time-Dependent Toxicity against Common Carp (Cyprinus carpio).

Bio-engineered silver nanoparticles (BE-AgNPs) are receiving discernible attention due to their diverse application history; however, the interaction of silver nanoparticles (Ag-NPs) with the environment and their toxicity in aquatic organisms is a matter of concern debate. Therefore, the current study aims to evaluate the bio-fabrication of Ag-NPs using Bellis perennis (B. perennis) plant flower extract and to assess their toxicity against Cyprinus carpio as an aquatic model organism.

Leveraging YOLO deep learning models to enhance plant disease identification.

Early automation in identifying plant diseases is crucial for the precise protection of crops. Plant diseases pose substantial risks to agriculture-dependent nations, often leading to notable crop losses and financial challenges, particularly in developing countries. Symptoms such as chlorosis, structural deformities, and wilting, characterize these diseases.

Gender disparity in living organ donation: a qualitative analysis of experiences and perceptions of female donors in Pakistan.

Objectives: This study aims to explore and analyse the interplay of sociocultural, psychological and institutional factors, gender roles and power dynamics in shaping the decision-making processes and experiences of living kidney and liver donors in Punjab, specifically focusing on women.

Design: This study employed a qualitative approach, using in-depth interviews to delve into the narratives and experiences of living kidney and liver donors in Punjab.

Setting: Punjab Human Organ Transplantation Authority (PHOTA), Lahore, Punjab, Pakistan.

Algebraic invariants of the edge ideals of whisker graphs of cubic circulant graphs.

Let be a polynomial ring over a field and be an edge ideal associated with the whisker graph of a cubic circulant graph. We discuss the regularity, depth, Stanley depth, and projective dimension of .

Determinant factors and coping strategies for depression among pregnant women: an intervention-based qualitative study in Lahore, Pakistan.

Background: The present study is an intervention-based qualitative study that explores the factors causing depression among antenatal women and analyses coping strategies based on the modified version of the Thinking Healthy Programme (THP) intervention in the urban setting of Lahore, Pakistan.

Methods: An exploratory qualitative evaluation approach was used in the present study. The study comprises four phases, i.

Exploring the lived experiences of deep vein thrombosis patients in Lahore, Pakistan: a qualitative phenomenological study on healthcare challenges, resilience and social support.

Objective: This study aimed to explore and describe the lived psychological and emotional experiences of sufferers of deep vein thrombosis (DVT) and to narrate the effect of those experiences on their daily lives.

Design, Setting And Participants: For data collection, a phenomenological qualitative design was used using semistructured, in-depth interviews of patients with DVT aged 18-70 years. Data were transcribed and analysed using the interpretative inductive approach to identify emergent themes.

Effects of adverse childhood experiences on university students' ability to lead healthy lives: an exploratory qualitative study in Lahore, Pakistan.

Background: Adverse Childhood Experiences are a significant global public health concern as these experiences have adverse effects on all the health determinants.

Methods: The interpretive phenomenological research design was used to explore the implications of adverse childhood experiences on the adult life of university students. An interpretive thematic analysis method was employed to analyze this study.

Do collaterals to infarct bed in STE-ACS patients undergoing emergent percutaneous coronary revascularization matter? An assessment of a prospective pool for in-hospital course.

Background: Limited data exist on the role of coronary collaterals circulation (CCC) in patients with ST-elevation acute coronary syndrome (STE-ACS). This study aimed to assess CCC and the in-hospital course of patients with CCC undergoing primary percutaneous coronary intervention (pPCI).

Methods: The study included consecutive STE-ACS patients undergoing pPCI.