Constructing a pancancer ubiquitination regulatory network to determine tumor characteristics, immunotherapy response, and prognosis.

Background: Ubiquitination-a pivotal post-translational modification that orchestrates cellular homeostasis and oncogenic pathways-remains underexplored as a pancancer regulatory hub. Although ubiquitination dysregulation is linked to tumor progression, a comprehensive, multicancer framework integrating prognostic, molecular, and microenvironmental landscapes is lacking.

Methods: This study integrated data of 4,709 patients from 26 cohorts across five solid tumor types (lung cancer, esophageal cancer, cervical cancer, urothelial cancer, and melanoma) and mapped the molecular profiles to the interaction network.

One potent sponge based on plant-protein-polyphenol assemblies for coagulopathic hemostasis.

Commercially available gelatin sponges are widely used in coagulation-dependent bleeding wounds due to its porous structure that concentrates blood cells, and coagulation factors. However, effective hemostasis cannot currently be achieved under coagulopathic conditions. In this study, we designed a procoagulant zein-polyphenol conjugate (ZC) nanoassemblies prepared using an anti-solvent strategy, were directly applied to the surface functionalization of commercially available gelatin sponges.

Tumor deposits in the impact of esophageal squamous cell carcinoma prognosis and recurrence: A multicenter retrospective cohort study.

Purposes: Tumor deposits (TDs) are considered poor prognostic factors in esophageal squamous cell carcinoma (ESCC). However, the impact of tumor deposits-positivity (TDP) on ESCC prognosis and recurrence remains unclear. This multicenter retrospective cohort study aimed to investigate the influence of TDP on recurrence and the potential benefit of adjuvant therapy in ESCC.

Ablation combined with video-assisted thoracic surgery hybrid technique for multiple primary lung cancer.

Increased public health awareness and expanded low-dose computed tomography (CT) utilization, accelerated by the COVID-19 pandemic, have elevated detection rates of pulmonary ground-glass nodules (GGNs). Patients with multiple primary lung cancer (MPLC) often present with multiple GGNs, posing challenges for precise treatment and prognostic assessment. Current therapies including stereotactic body radiation therapy (SBRT), chemotherapy, and immunotherapy face efficacy and safety limitations.

Identification of an individualized immune-related miRNA pair signature for survival prediction of neoadjuvant chemoradiotherapy in esophageal squamous cell cancer.

Background: Immune-related microRNAs (ImiRNAs) have emerged as potential biomarkers owing to their universality and tissue-specificity. Although neoadjuvant chemoradiotherapy (NCRT) has been incorporated into standardized guidelines for esophageal squamous cell carcinoma (ESCC), its efficacy is hindered by tumor and individual heterogeneity. This study aimed to develop a specific ImiRNA pair signature to predict the long-term survival benefits of NCRT for ESCCs.

Optimal lymph node dissection thresholds for early-stage esophageal squamous cell carcinoma: a retrospective multicenter study.

Background: Esophageal cancer (EC), especially esophageal squamous cell carcinoma (ESCC) in China, is a major cause of cancer-related mortality. While lymph node (LN) dissection is crucial for staging and prognosis in early-stage EC, the optimal extent of dissection based on tumor location remains undefined. This study aimed to establish location-specific LN dissection thresholds to improve outcomes in clinical T1-2N0M0 ESCC.

The causal effects of primary biliary cholangitis on irritable bowel syndrome: a mendelian randomization study.

Background: The gut-liver axis indicates a potential relationship between the primary biliary cholangitis (PBC) and irritable bowel syndrome (IBS). Nonetheless, the causality of this association remains unclear. This study performed a two-sample Mendelian randomization (MR) approach to investigate the causal relationship between the PBC and IBS.

Recent advances in biomarkers for predicting the efficacy of immunotherapy in non-small cell lung cancer.

Lung cancer continues to be the primary cause of cancer-related deaths globally, with non-small cell lung cancer (NSCLC) accounting for approximately 85% of all instances. Recently, immune checkpoint inhibitors (ICIs) have transformed the treatment approach for NSCLC, however, only a subset of patients experiences significant benefits. Therefore, identifying reliable biomarkers to forecast the efficacy of ICIs is crucial for ensuring the safety and effectiveness of treatments, becoming a major focus of current research efforts.

Clathrin-mediated trafficking regulates copper tolerance by modulating the localization of HEAVY METAL ATPase 5 in Arabidopsis root cells.

Plant clathrin and its adaptor protein complexes-adaptor protein complex-1 (AP-1) at the trans-Golgi network/early endosome (TGN/EE) and the adaptor protein complex-2 (AP-2) at the plasma membrane (PM)-function in clathrin-mediated trafficking (CMT). This study reports the role of CMT in regulating copper (Cu) tolerance in plants. We found that high concentrations of exogenous Cu treatment increase the abundance of clathrin and adaptor protein complexes at the TGN/EE and/or the PM.

A thermosensitive poloxamer hydrogel with ofloxacin and cationic microparticles for antibacterial and hemostatic applications.

Traditional hemostatic materials often fall short of meeting clinical demands in terms of both hemostasis and antibacterial efficiency. The use of cationic materials in the antibacterial and hemostatic fields has garnered significant attention. However, designing materials that effectively balance these two properties remains a critical challenge in the development of hemostatic materials.

Efficacy and safety of anti-PD-1 versus anti-PD-L1 in perioperative immunotherapy: A comprehensive reanalysis of randomized controlled trials.

Background: Perioperative anti-programmed cell death 1 (PD-1)/PD ligand 1 (PD-L1) immune checkpoint inhibitors improve outcomes, but optimal selection between agents remains debated. We compared the efficacy and safety of anti-PD-1 versus anti-PD-L1 in neoadjuvant/adjuvant settings.

Methods: PubMed, Embase, Cochrane CENTRAL, and major oncology conferences (up to May 20, 2024) were systematically searched for randomized trials comparing anti-PD-1/PD-L1 with standard perioperative therapy.

The effects of different work: Rest durations on physiological, neuromuscular, and ratings of perceived exertion responses during taekwondo-specific high-intensity interval training.

Purpose: To investigate the effect of different work: rest durations on physiological, neuromuscular, and perceived exertion responses during taekwondo-specific high-intensity interval training (HIIT).

Methods: Thirteen moderate-trained taekwondo athletes (age: 21.7 ± 2.

Revisiting lymph node guidelines: limited lymph node examination might be sufficient for elderly gastric cancer patients.

Background: Whether limited examined lymph node (ELN) number is comparable to recommended ELN number for long-term outcomes remains controversial in elderly gastric cancer (GC) patients. The purpose of this study was to assess the long-term survival between limited ELN number and recommended ELN number in elderly GC patients.

Methods: Elderly GC patients over 75 years old from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively reviewed.

Lipidomic signatures as predictive biomarkers for early-onset lung cancer: Identification and development of a risk prediction model.

Introduction: Lung cancer is the leading cause of cancer-related mortality worldwide. While traditionally associated with older adults, early-onset lung cancer (EOLC) is rising, particularly in Asia, which accounts for 75.9% of global cases.

Electroacupuncture for acute postoperative pain during coughing after video-assisted thoracoscopic surgery: study protocol for a pilot randomized controlled trial.

Background: Despite the use of multimodal analgesia regimens following video-assisted thoracoscopic surgery (VATS), acute postoperative pain persists. Electroacupuncture (EA) may alleviate acute postoperative pain following VATS; however, current evidence remains insufficient.

Objectives: This trial will assess the feasibility and efficacy of EA as an adjunctive treatment compared with sham electroacupuncture (SA) for managing acute postoperative pain during coughing after VATS.

Lysine acetyltransferase 5 contributes to diabetic retinopathy by modulating autophagy through epigenetically regulating autophagy-related gene 7.

Objective: Diabetic retinopathy (DR) is a prevalent and serious complication among individuals with diabetes, significantly compromising their visual acuity and overall quality of life. Lysine acetyltransferase 5 (KAT5), an essential catalytic subunit of the nucleosome acetyltransferase of the H4 complex, is implicated in the development of various diseases, including neurological disorders, breast cancer, and lung cancer. However, the function of KAT5 in DR remains poorly understood.

Computed Tomography-Guided Radiofrequency Ablation Combined With Video-Assisted Thoracoscopic Surgery for Multiple Pulmonary Nodules: A Retrospective Study From the National Cancer Center in China.

Background: Recently, the incidence of multiple pulmonary nodules (MPNs) is gradually rising. Therefore, this study aims to evaluate the safety and efficacy of computed tomography (CT)-guided radiofrequency ablation (RFA) combined with video-assisted thoracoscopic surgery (VATS) for patients with MPNs.

Material And Methods: The clinicopathological data and perioperative results of the patients with MPNs who underwent RFA combined with VATS at our center from October 2022 to September 2024 were reviewed.

Shifting landscapes of gender equity in oncology journals: a decade of authorship trends.

Background: Gender disparities persist in academic oncology, particularly in authorship and senior academic roles. This study evaluates trends in authorship gender representation over the past decade across top oncology journals, focusing on regional, journal-specific, and citation-based disparities.

Methods: A cross-sectional analysis was conducted on 29,005 articles published between 2014 and 2023 in the top 20 oncology journals, identified through the Web of Science database.

Co-infections exacerbate inflammatory responses in COVID-19 patients, promoting coagulopathy and myocardial injury, leading to increased disease severity.

Objectives: Severe COVID-19 infection is characterized by excessive inflammatory responses, hypercoagulation, and microvascular dysfunction. However, limited research has investigated the effects of co-infections on these characteristics in COVID-19 patients. This study aims to explore how co-infections influence inflammation, hypercoagulability, and microvascular dysfunction in hospitalized COVID-19 patients, and to assess their impact on disease progression.

Confounder adjustment in observational studies investigating multiple risk factors: a methodological study.

Background: Confounder adjustment is critical for accurate causal inference in observational studies. However, the appropriateness of methods for confounder adjustment in studies investigating multiple risk factors, where the factors are not simply mutually confounded, is often overlooked. This study aims to summarise the methods for confounder adjustment and the related issues in studies investigating multiple risk factors.

Patient-reported outcomes in the early postoperative period following resection of unilateral multiple pulmonary nodules: implications for surgical decision-making.

Background: With increased early lung cancer screening, synchronous multiple pulmonary nodules are more frequently detected. However, due to the lack of standardized treatment strategies, their management remains contentious. This study utilizes patient-reported outcomes (PROs) to assess early postoperative symptoms and functionality, aiming to determine the optimal resection extent for unilateral multiple pulmonary nodules.

One hydrophobic coating enables macro- and micro-scale blood contact activation.

Efforts to develop hemostatic materials/devices have focused solely on enhanced liquid adsorption for concentrating blood components and/or new material forms for covering/sealing injured blood vessels. Considering the increasing coagulopathy conditions and versatile material forms, it is assumed to be valuable but inaccessible for creating universal hemostatic surfaces regardless of liquid-absorption property and coagulation component deficiency. Herein, we illustrate a facile polyphenol/alkyl (ATA) coating for macro-to-micro scale hemostatic materials that can integrate the virtues of contact-activation hemostatic property, low liquid-absorption property and applicability for healthy/coagulopathy conditions.

Clinical effects of phospholipase D2 in attenuating acute pancreatitis.

Background: The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2 (PLD2) exerted a regulatory effect on neutrophil migration, thereby alleviating the progression of acute pancreatitis.

Aim: To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration, thereby alleviating the progression of acute pancreatitis.

Methods: The study involved 90 patients diagnosed with acute pancreatitis, admitted to our hospital between March 2020 and November 2022.