Common network related to hyperkinetic seizures revealed by functional lesion network mapping.

Objective: This study aims to determine whether the anatomically heterogeneous lesions that cause hyperkinetic seizures (HKS) are connected to a common functional network.

Methods: We identified patients from the Beijing Tiantan-Fengtai Epilepsy Center with HKs as the primary ictal semiology. These included patients had focal seizure-onset zone, here referred to as a "lesion.

Fatigue characteristics and mechanism of phosphogypsum stabilised red clay under dry and wet cycles.

Phosphogypsum is an acidic solid waste mainly composed of CaSO₄-2H₂O by-products of the wet process phosphoric acid industry, which has the characteristics of high impurity content, poor stability of stockpiling, but can be utilized in a resourceful way. Phosphogypsum waste utilization can reduce environmental pollution, save resources and create economic value. In order to investigate the fatigue characteristics and the mechanism of dynamic strength change of cement-phosphogypsum-red clay under wet and dry cycles, the cumulative deformation characteristics and the rule of change of critical dynamic stress of the mixed materials were investigated by dynamic triaxial fatigue test, SEM and XRD test, and the mechanism of dynamic strength change was analyzed according to the microstructure and the chemical mineral composition of the mixed materials.

Editing a gibberellin receptor gene improves yield and nitrogen fixation in soybean.

Soybean is an important source of oil, protein, and feed. However, its yield is far below that of major cereal crops. The green revolution increased the yield of cereal crops partially through high-density planting of lodging-resistant semi-dwarf varieties, but required more nitrogen fertilizers, posing an environmental threat.

Ultrabroadband Photosensitivity and Frequency-Mixing in Anisotropic Weyl Semimetal NbNiTe.

Broadband anisotropic photodetectors show great promise for polarization-sensitive imaging and multispectral optoelectronic systems yet face critical challenges in material anisotropy modulation and broadband sensitivity. Weyl semimetals exhibit giant optical anisotropy and tunable heterojunction band alignment, enabling high-performance anisotropic photodetection. Herein, ultrabroadband PDs based on the NbNiTe (niobium nickel telluride), enabled by antenna integration and heterostructure engineering, achieve high sensitivity from visible to Terahertz (THz).

Optimization of Enzymatic Parameters for Enhancing Branch Density and Flow Properties of Sweet Potato Starch.

Enhancing the branch density of starch through enzymatic modification is critical for improving its functional properties in various industrial applications. This study optimized the sequential enzymatic treatment of sweet potato starch using α-amylase (AA), β-amylase (BA), and transglucosidase (TG) to maximize the degree of branching (DB). Response Surface Methodology (RSM) was employed to evaluate the synergistic effects of enzyme concentrations and hydrolysis durations, identifying optimal conditions: AA (20.

Association of Ambient Particulate Matter and Nitrogen Dioxide with Hospital Admissions for Parkinson's Disease: A Nationwide Case-Crossover Study in China.

Ambient particulate matter (PM) and nitrogen dioxide (NO) are both major air pollutants with potential neurotoxic effects. Beyond fine PM (PM), large population-based evidence on the associations of coarse PM (PM) and NO, especially co-exposure to high-concentration PM and NO, with hospital admissions for Parkinson's disease (PD) is crucial for PD risk management. In this time-stratified case-crossover study, patients with a principal discharge diagnosis coded of PD (G20) were identified.

Functional Connectivity Predicting Transdiagnostic Treatment Outcomes in Internalizing Psychopathologies.

Importance: Predicting treatment outcomes for internalizing psychopathologies (IPs), such as depression and anxiety, holds promise for advancing precision medicine. The extent to which whole-brain functional connectivity (FC) can predict treatment responses for patients with IPs across different therapeutic modalities remains unclear.

Objective: To examine whether pretreatment FC patterns predict multidimensional treatment outcomes in patients with IPs and whether predictive performance generalizes across diagnoses and treatment modalities.

Carotid Artery Stenting Versus Carotid Endarterectomy for Carotid Artery Stenosis: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: Carotid artery stenosis is a significant risk factor for ischemic stroke. Two primary interventions, carotid artery stenting (CAS) and carotid endarterectomy (CEA), are commonly used to prevent stroke.

Aims: This study systematically reviews and compares the efficacy and safety of CAS versus CEA in preventing stroke and other related outcomes.

Feasibility of fully automatic assessment of cervical canal stenosis using MRI via deep learning.

Background: Currently, there is no fully automated tool available for evaluating the degree of cervical spinal stenosis. The aim of this study was to develop and validate the use of artificial intelligence (AI) algorithms for the assessment of cervical spinal stenosis.

Methods: In this retrospective multi-center study, cervical spine magnetic resonance imaging (MRI) scans obtained from July 2020 to June 2023 were included.

A hydrogel-based nanoparticles sustained-release system selectively targeting pro-inflammatory microglia for spinal cord injury repair.

Spinal cord injury (SCI) often results in irreversible neurological deficits, primarily due to chronic neuroinflammation driven by activated proinflammatory microglia. Effective therapeutic interventions require both precise targeting of pathological immune cells and sustained modulation of the inflammatory microenvironment. Here, we present a cell specific, hydrogel-based nanoparticle system (MG1-MM@Candesartan-Gel) designed for the selective and prolonged delivery of the angiotensin II type 1 receptor (AT1R) antagonist Candesartan to proinflammatory microglia.

Long-term efficacy and predictors of vagus nerve stimulation in drug-resistant epilepsy: a multicenter cohort study.

Background: At present, a number of indicators have been analyzed for the relationship with the efficacy of vagus nerve stimulation (VNS) in drug-resistant epilepsy (DRE) patients, but there is still no definite predictor of efficacy. This study is to assess the long-term effectiveness and predictors of VNS in DRE patients.

Methods: We analyzed DRE patients monitored for over a year post-surgery (2016-2019) to evaluate VNS outcomes.

N-Heterocyclic Carbene (NHC) Catalyzed Annulations of δ-Acetoxy Allenoates and Enaminones: A Time-Controlled Regiodivergent Synthesis of Hexahydroquinolines.

An NHC (N-heterocyclic carbene) catalyzed [3 + 3] annulation of δ-acetoxy allenoates and enaminones has been developed. This strategy provides a facile and convenient approach for the synthesis of 1,4-dihydropyridine and 3,4-dihydropyridine-based hexahydroquinoline derivatives (51 examples, up to 77% yield). This protocol features a broad substrate scope, good functional group tolerance, and mild reaction conditions.

Exploring the causal relationships between spondyloarthritis/ankylosing spondylitis and intervertebral disc degeneration: a bidirectional Mendelian randomization study.

Background: In this study, we investigated the bidirectional causal relationship between spondyloarthritis (SpA)/ankylosing spondylitis (AS) and intervertebral disc degeneration (IVDD).

Methods: Genome-wide association study (GWAS) statistics for SpA, AS, and IVDD were obtained exclusively from the FinnGen consortium. The instrumental variables (IVs) were identified under genome-wide significance thresholds (P < 5 × 10) with linkage disequilibrium clumping removed.

Significant correlation between ferroptosis-associated genes and ulcerative colitis: implications for diagnosis and treatment.

Background: Ulcerative colitis (UC) is a significant type of inflammatory bowel disease (IBD). Ferroptosis is a type of procedural death that is associated with different types of diseases to various degrees. This study aimed to explore the key ferroptosis-associated genes in UC and assess their potential implications for biological therapy.

Molecular characterization and prognostic modeling associated with M2-like tumor-associated macrophages in breast cancer: revealing the immunosuppressive role of DLG3.

Background: M2-like tumor-associated macrophages (TAMs) promote an immunosuppressive microenvironment and contribute to tumor progression and metastasis. However, their molecular characterization and prognostic value have not been fully explored in the field of breast cancer.

Methods: Weighted gene co-expression network analysis (WGCNA) was used to identify modules significantly associated with M2-like TAMs.

Target-aware 3D molecular generation based on guided equivariant diffusion.

Recent molecular generation models for structure-based drug design (SBDD) often produce unrealistic 3D molecules due to the neglect of structural feasibility and drug-like properties. In this paper, we introduce DiffGui, a target-conditioned E(3)-equivariant diffusion model that integrates bond diffusion and property guidance, to address the above challenges. The combination of atom diffusion and bond diffusion guarantees the concurrent generation of both atoms and bonds by explicitly modeling their interdependencies.

Siloxane-Tethered Halogenated Thiophene Additives Enable Excellent Fibrillar Morphology and Air Processing for High-Performing Polymer Solar Cells.

For organic solar cells (OSCs), morphological optimization and high-performance air-processing of the photoactive layer are important concerns. Herein, three siloxane-tethered halogenated thiophene additives Cl-Th-SiO, Br-Th-SiO, and I-Th-SiO, with chlorine, bromine, and iodine substitutions on the thiophene, are designed and synthesized, respectively. With the three additives, fibrillar active layer networks based on polymer donor D18 and nonfullerene acceptor L8-BO can be achieved.

Dynamic Calibration of Quartz Flexure Accelerometers.

The dynamic behavior of quartz flexure accelerometers remains a subject of ongoing investigation, particularly in areas such as theoretical modeling, standardization, calibration methodology, and performance evaluation. To address the limitation of conventional static calibration models in accurately representing accelerometer responses under dynamic acceleration excitation, a dynamic calibration model is proposed. A mathematical model is first developed based on the physical mechanism of the accelerometer, characterizing its intrinsic dynamic response.

Comparative Omics Analysis of Four Grape Varieties and Exploration of Their Anthocyanin Synthesis Mechanisms.

: L. exhibits diverse varietal traits influencing fruit quality and stress tolerance. The summer black grape (Xiahei), known for its superior tolerance to abiotic stress and intense pigmentation, was hypothesized to possess distinct metabolic and genetic profiles, particularly in flavonoid and anthocyanin biosynthesis.

Transcriptomics Analysis of the Adipogenic Differentiation Mechanism of Bovine Adipose-Derived Neural Crest Stem Cells.

The aim of the present study was to investigate the expression of related genes during the differentiation process of baNCSCs into adipocytes using transcriptomics technique, thereby clarifying the potential mechanism underlying baNCSCs differentiation into adipocytes and providing insights into lipid metabolism and regulation of lipid deposition in ruminants. Transcriptomic analysis was conducted on the adipocytes of baNCSCs on days 0 (CON0), 3 (DIF3), and 9 (DIF9) of differentiation. The results showed that in the early stage of adipocyte differentiation of baNCSCs, differentially expressed genes (DEGs) are mainly involved in metabolic pathways such as chromosome modification, cell cycle progression, and regulation of stem cell pluripotency.

Correction: tRF-1:28-Val-CAC-2 promotes the development of nasopharyngeal cancer by targeting EPHB2.

[This corrects the article DOI: 10.3389/fonc.2025.

The impact of trait mindfulness on work engagement among primary and secondary school teachers: a moderated mediation model.

Work engagement not only improves teachers' job performance but also contributes to enhancing their students' academic outcomes and thereby promoting the latter's physical and mental development. Teacher mindfulness can affect work engagement. To clarify the relationship between trait mindfulness and work engagement and its underlying mechanisms, this study constructed a moderated mediation model based on the Conservation of Resources Theory (COR), specifically examining the mediating role of job satisfaction and the moderating role of perceived organizational support.

Applications of Tissue-Inducing Biomaterials in Nonosseous Tissues: Evidence Map of Animal Studies.

Tissue-inducing biomaterials, which promote tissue regeneration without the addition of exogenous cells and/or bioactive factors, have recently attracted increasing interest in the repair of nonosseous tissues. As a key strategy for transforming data into actionable evidence, evidence-based biomaterials research plays a critical role in guiding material development. In this study, evidence mapping method was employed to systematically analyze and visualize animal study designs, material characteristics, outcome indicators, and evaluation methods, aiming to identify current research trends and emerging focal areas.