Editing a gibberellin receptor gene improves yield and nitrogen fixation in soybean.

Soybean is an important source of oil, protein, and feed. However, its yield is far below that of major cereal crops. The green revolution increased the yield of cereal crops partially through high-density planting of lodging-resistant semi-dwarf varieties, but required more nitrogen fertilizers, posing an environmental threat.

Persistent cough due to cough variant asthma following upper respiratory tract infection treated by traditional Chinese medicine: A case report.

Rationale: Cough variant asthma (CVA) is one of the primary causes of chronic cough, significantly impacting quality of life. Although inhaled corticosteroids-long-acting beta agonists are the first-line treatment, their limitations-such as prolonged treatment duration, high relapse rates after discontinuation, and suboptimal efficacy in some patients-highlight the need to explore alternative treatment options. Traditional Chinese medicine (TCM), with its holistic framework, syndrome differentiation-based treatment, and emphasis on preventing relapse, offers a promising strategy for complementary therapy.

Zika virus infection in neonatal mice disrupts connexin 43 and induces cardiac inflammation, implicating viral myocarditis in neonatal pathogenesis.

Zika virus (ZIKV) is primarily transmitted through mosquito bites and, occasionally, via breast milk, making postnatal ZIKV infections common among newborns and infants, particularly in tropical regions. Previous studies, including ours, have demonstrated that neonatal ZIKV infection can be fatal, highlighting a severe health issue of ZIKV in newborns. However, the pathogenesis and functional outcomes of postnatal ZIKV infection remain largely unexplored.

Ionic liquid modified MOF-808 for efficient adsorption and stable capture of radioactive iodine.

Radioactive iodine (I) is a potential risk to environmental safety and human health. The design of efficient and stable functional materials for I capture remains a challenge. In this work, a simple in-situ impregnation method is used to load Ionic Liquid (IL)-[Cmim][TfN] into the pores of MOF-808, named IL@MOF.

High-Calorie Diets Exacerbate Lipopolysaccharide-Induced Pneumonia by Promoting Propionate-Mediated Neutrophil Extracellular Traps.

: High-calorie diets are linked to increased risks of chronic inflammation and immune dysfunction, yet their role in modulating pneumonia severity remains unclear. Focusing on the interactions among gut-originating short-chain fatty acids (SCFAs), neutrophil function, and histone deacetylases (HDACs), this research examined the exacerbating effects of a high-calorie diet on pneumonia in rats. : Male Sprague-Dawley rats (3 weeks old, 110 ± 10 g) were allocated among four groups: normal diet (N), high-calorie diet (G), LPS-induced pneumonia (P), and high-calorie diet combined with lipopolysaccharide (LPS)-induced pneumonia (GP).

Prevalence and genomic insights into Yersinia enterocolitica in Southeastern China (2008-2022).

Yersinia enterocolitica is a significant foodborne pathogen causing gastrointestinal illnesses worldwide. This study investigates the prevalence and genomic characteristics of Y. enterocolitica to assess potential health risks in southeastern China, a region lacking mandatory yersiniosis monitoring.

Force-Driven In Situ Growth of Nanostructured Silica Fillers in Polyetherimide Nanocomposites.

Inorganic nanofillers have been extensively employed to tailor or enhance the properties of polymer nanocomposites, wherein the morphology of the nanofillers plays a pivotal role. Here, the use of a directional force is demonstrated to drive the in situ growth of inorganic silica nanofillers with controllable morphologies, including silica spherical nanoparticles, nanofibers, and nanosheets, within the polyetherimide (PEI) nanocomposites. The in situ grown nanofillers exhibit exceptional interfacial compatibility and uniform dispersion in the PEI matrix.

The application progress of cell membrane biomimetic nanoparticles in cancer diagnosis and treatment.

Cancer diagnosis and treatment remains challenging, with unresolved issues such as low targeting, drug resistance, and numerous adverse reactions from chemotherapy. Cell membrane biomimetic modified nanoparticles(CMBMNPs), wrapping cell membrane on nanoparticles can achieve homologous cell mimicry, so that it can obtain the functions and properties of the type of cell, with strong targeting ability, strong immune evasion ability, long in vivo circulation time, etc., which is getting more and more attention.

Genome mining and characterization of bifunctional Clerodane Diterpene synthase from a fungus Myrothecium sp.

Clerodane diterpenoids are a promising group of pharmacological molecules and are rarely discovered in fungi. The clerodane diterpene synthase has not yet been characterized in fungi. Herein, we discovered a gene, mterA, encoding chimeric protein with the bifunction of class II and class I synthases from a fungus Myrothecium sp.

Traditional Chinese medicine as a promising choice for future control of PEDV.

Porcine epidemic diarrhea virus (PEDV) is the major agent of the recent outbreaks of diarrhea in piglets, which has caused huge economic losses to the global swine industry. Since traditional vaccine strategies cannot provide complete protection for piglets, the development of safe, effective, and economical antiviral drugs is urgently needed. For many years, traditional Chinese medicines (TCMs) have been broadly applied for viral infectious diseases, exhibiting advantages such as abundant resources, lower toxicity, and minimal drug resistance.

Monitoring dust retention variations in different functional zones based on leaf magnetism and the influence of green belt spatial layouts on leaf dust retention.

Atmospheric particulate pollution generated by traffic activities poses a threat to human health. Due to their unique structure and function, plant leaves efficiently capture and accumulate atmospheric particulate matter, acting as natural particulate collectors. This study focuses on leaf samples from different functional zones in Jinhua City, Zhejiang Province, employing environmental magnetism methods to explore dust retention differences among zones and the impact of green belt spatial layouts on dust retention.

The effects of coagulation factors on the risk of autoimmune diseases: A Mendelian randomization study.

The objective of this study was to investigate the potential causal relationship between coagulation factors and autoimmune diseases (ADs). We employed Mendelian randomization to investigate the associations between selected 7 coagulation factors and 10 ADs, leveraging genetic variants as instrumental variables to assess causal relationships between exposures of interest and outcomes. Within the scope of this investigation, coagulation factors were designated as the exposure source, while ADs were observed to manifest as the consequent outcome.

Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies.

Introduction: Alopecia is a systemic disease with multiple contributing factors. Effective treatment is challenging when only hair growth mechanisms are targeted while ignoring the role of maintaining hair follicle microenvironment homeostasis, which is crucial for cell growth and angiogenesis. Oxidative stress and inflammation are major disruptors of this microenvironment, leading to inhibited cell proliferation and compromised hair follicle circulation.

Knowledge of and attitude towards depression among urban and rural residents in Beijing: a cross-sectional study.

Objectives: To compare the level of knowledge of depression, recognition ability and attitudes towards depression among urban and rural residents in Beijing.

Design: A cross-sectional study.

Setting: Six districts in Beijing, China, 2021.

Differential effects of inosine monophosphate dehydrogenase (IMPDH/GuaB) inhibition in and .

Inosine 5'-monophosphate dehydrogenase (IMPDH), known as GuaB in bacteria, catalyzes the rate-limiting step in guanine biosynthesis and is conserved from humans to bacteria. We developed a series of potent inhibitors that selectively target GuaB over its human homolog. Here, we show that these GuaB inhibitors are bactericidal, generate phenotypic signatures that are distinct from other antibiotics, and elicit different time-kill kinetics and regulatory responses in two important Gram-negative pathogens: and .

Novel pyridazinone derivatives bind to KSRP: Synthesis, anti-tumor biological evaluations and modelling insights.

Pyridazinone derivatives have been extensively used as anticancer agents. IMB5036 is a structure specific pyridazinone compound with potential antitumor activity via targeting KSRP protein which controls gene expression at multiple levels. In this study, fifteen IMB5036 analogues were synthesized and preliminary structure-activity relationships were explored.

The emerging role of oxidative stress in inflammatory bowel disease.

Inflammatory bowel disease (IBD) is a chronic immune-mediated condition that affects the digestive system and includes Crohn's disease (CD) and ulcerative colitis (UC). Although the exact etiology of IBD remains uncertain, dysfunctional immunoregulation of the gut is believed to be the main culprit. Amongst the immunoregulatory factors, reactive oxygen species (ROS) and reactive nitrogen species (RNS), components of the oxidative stress event, are produced at abnormally high levels in IBD.

Magnetic-assisted alignment of nanofibers in a polymer nanocomposite for high-temperature capacitive energy storage applications.

Flexible polymer-based dielectrics with high energy storage characteristics over a wide temperature range are crucial for advanced electrical and electronic systems. However, the intrinsic low dielectric constant and drastically degraded breakdown strength hinder the development of polymer-based dielectrics at elevated temperatures. Here, we propose a magnetic-assisted approach for fabricating a polyethyleneimine (PEI)-based nanocomposite with precisely aligned nanofibers within the polymer matrix, and with AlO deposition layers applied on the surface.

Sulfur vacancy-rich bismuth sulfide nanowire derived from CAU-17 for radioactive iodine capture in complex environments: Performance and intrinsic mechanisms.

Effective capture and immobilization of volatile radioiodine from the off-gas of post-treatment plants is crucial for nuclear safety and public health, considering its long half-life, high toxicity, and environmental mobility. Herein, sulfur vacancy-rich Vs-BiS@C nanocomposites were systematically synthesized via a one-step solvothermal vulcanization of CAU-17 precursor. Batch adsorption experiments demonstrated that the as-synthesized materials exhibited superior iodine adsorption capacity (1505.

Flexible and Simply Degradable MXene-Methylcellulose Piezoresistive Sensor for Human Motion Detection.

Flexible pressure sensors are intensively demanded in various fields such as electronic skin, medical and health detection, wearable electronics, etc. MXene is considered an excellent sensing material due to its benign metal conductivity and adjustable interlayer distance. Exhibiting both high sensitivity and long-term stability is currently an urgent pursuit in MXene-based flexible pressure sensors.

The effect of childhood trauma on depression in college students: A moderated mediation model.

Objective: Childhood trauma is considered as a critical risk factor for depression. Although many studies have investigated the pathway of Childhood trauma to depression, especially the mediating or moderating effects of cognitive emotion regulation strategies or neuroticism or stress perception, the results were inconsistent and the underlying psychological mechanisms of depression remain unclear. This study aims to explore the influence and mechanism of childhood trauma on depression in college students, and establish a full model among these interactive factors.

Exploring the effects of epigallocatechin gallate on lipid metabolism in the rat steatotic liver during normothermic machine perfusion: Insights from lipidomics and RNA sequencing.

Background: Hepatic steatosis is the leading cause of discarded liver grafts. Defatting steatotic liver grafts using drug combinations during ex vivo normothermic machine perfusion (NMP) has been reported. However, the effectiveness of NMP in reducing fat content using epigallocatechin gallate (EGCG) as a single defatting agent and its effect on lipid metabolism are poorly investigated.