Accelerating iron redox cycling via acetate modification: a ligand engineering for sustainable fenton-like oxidation.

Accelerating the rate-limiting surface Fe(III)/Fe(II) redox cycling is pivotal for efficient iron-mediated Fenton-like decontamination, yet conventional reductants (e.g., toxic hydroxylamine, thiosulfate) suffer from secondary toxicity, self-quenching, and heavy metal leaching.

Development and validation of a nomogram for predicting 30-day outcomes in patients with unruptured vertebrobasilar dissecting aneurysms undergoing endovascular treatment: a multicenter cohort study.

Background: Endovascular treatment (EVT) of vertebrobasilar dissecting aneurysms (VBDAs) is associated with high morbidity and mortality, significantly influencing patient prognosis. This study aimed to develop and validate a nomogram for predicting 30-day outcomes in patients with unruptured VBDAs undergoing EVT.

Methods: This retrospective study included 606 patients with unruptured VBDAs who underwent EVT at 10 institutions between January 2015 and April 2025, with 491 in the training cohort and 115 in the validation cohort.

Seq2Karyotype (S2K): A Method for Karyotyping Using Single-Sample Whole-Genome Sequencing Data.

DNA abnormalities characterized by cytogenetic imaging at the single cell resolution, i.e. karyotyping, have long served as cancer diagnostic and prognostic biomarkers.

MSG: Stealing data from pruned neural networks via malicious sparsity guidance.

With the widespread adoption of machine learning cloud platforms, concerns over potential privacy risks in model training algorithms have grown. Attackers can exploit these platforms by deploying malicious algorithms to execute correlation value encoding attacks (CVEA). This attack mainly leverages the model's huge capacity for memorization, covertly embedding training data into the model's parameters.

An MRI Atlas of the Human Fetal Brain: Reference and Segmentation Tools for Fetal Brain MRI Analysis.

Accurate characterization of in-utero brain development is essential for understanding typical and atypical neurodevelopment. Building upon previous efforts to construct spatiotemporal fetal brain MRI atlases, we present the CRL-2025 fetal brain atlas, which is a spatiotemporal (4D) atlas of the developing fetal brain between 21 and 37 gestational weeks. This atlas is constructed from carefully processed MRI scans of 160 fetuses with typically-developing brains using a diffeomorphic deformable registration framework integrated with kernel regression on age.

Interfacial Li Diffusion Booster Accelerated by Enhanced Metal-Organic Framework Sieving and Wettability for High-Voltage Solid-State Lithium Metal Batteries.

Solid-state lithium metal batteries (SSLMBs) are promising for realizing higher energy density. However, the poor interfacial Li transport kinetics and Li dendrite growth inhibit SSLMBs, leading to sluggish interfacial ion diffusion and depressive lifespan, which is attributed to high barriers blocked by anions or interface space in solid-state electrolytes. Herein, a flexible solid-state polymer skeleton employed with ionic liquid and metal-organic frameworks (PIM) electrolyte is proposed to strengthen interfacial Li ion exchange by improving the Li sieving effect and interfacial wettability.

The association between body roundness index and lumbar bone mineral density in U.S. adults: Result of a nationwide survey.

A growing body of evidence has established a close association between obesity and bone metabolism. The body roundness index (BRI), a novel anthropometric parameter, has demonstrated superior predictive capability for estimating both visceral fat percentage and total body fat percentage when compared with traditional measures such as Body Mass Index (BMI) and waist circumference. However, there is a paucity of research exploring the relationship between BRI and bone mineral density (BMD).

Case Report: A case of epithelioid hemangioendothelioma of the right femoral artery misdiagnosed as arterial occlusion.

Epithelioid hemangioendothelioma (EHE) is a rare and locally aggressive tumour of vascular endothelial origin, with an estimated prevalence of less than 1 in a million. EHE can arise in any part of the body, most commonly in the liver, lungs, and skeleton, while occurrence in the blood vessels of the extremities is rare. This article reports a rare case of primary epithelioid hemangioendothelioma (EHE) of the right femoral artery.

Development and validation of models based on clinical and CT features: multivariate analysis for predicting vascular invasion in non-small cell lung cancer.

Background: Lymphovascular invasion (LVI) is a high-risk pathological marker for the evaluation of metastasis and prognosis of non-small cell lung cancer (NSCLC). Preoperative computed tomography (CT) prediction of vascular invasion in NSCLC is essential for clinical identification of high-risk patients and development of treatment strategies. This study aimed to develop and validate a model for predicting LVI in NSCLC based on clinical and CT features.

Microstructure Design of Metal Selenides for Sodium-Ion Battery Anodes.

The advancement of sodium-ion batteries (SIBs) as next-generation energy storage systems is critically dependent on developing high-performance anode materials. Metal selenides have garnered significant attention as promising anode candidates due to their high theoretical capacities, yet their practical application is hampered by intrinsic issues such as large volume expansion, poor electrical conductivity, and structural pulverization during cycling. Engineering the microstructure of metal selenides offers a powerful avenue to overcome these limitations and unlock their full electrochemical potential.

NeuroD1 drives a KAT2A-FDFT1 signaling axis to promote cholesterol biosynthesis and hepatocellular carcinoma progression via histone H3K27 acetylation.

Abnormal lipid metabolism is one of the hallmarks of cancer. Lipid metabolic reprogramming, which has been observed in various tumors, could participate in tumor occurrence, invasion, and metastasis of tumors by regulating various carcinogenic signaling pathways. However, the molecular mechanism that regulates tumor cell lipid metabolic reprogramming has not been fully elucidated.

Microenvironmental TFPI2 in Hirschsprung Disease: Mechanisms in ENCC Development.

Background: Hirschsprung disease (HSCR) is a relatively common disorder in pediatric surgery, characterized by the absence of enteric ganglion cells due to defective colonization of enteric neural crest cells (ENCCs) in the intestine. This study aims to investigate alterations in the intestinal microenvironment, focusing on the tissue factor pathway inhibitor 2 (TFPI2) as a potential pathogenic factor.

Methods: Transcriptomic datasets from HSCR patients and fetal mouse intestines were analyzed to identify candidate genes.

Establishing the Minimal Clinically Important Difference, Substantial Clinical Benefit, and Patient Acceptable Symptomatic State for Patient-Reported Outcome Measures After Primary Posterior Cruciate Ligament Reconstruction With a Minimum 5-Year Follow-up.

Background: Improvements in patient-reported outcome measure (PROM) scores have been widely documented after posterior cruciate ligament reconstruction (PCLR). Establishing clinically significant outcome (CSO) benchmarks for PROMs can enhance their clinical applicability.

Purpose: To establish the minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient acceptable symptomatic state (PASS) for PROMs after primary PCLR and identify the predictors of achieving them.

Cold Inducible RNA-Binding Protein: A Novel Therapeutic Target for Ventricular Arrhythmia Control.

Ventricular arrhythmias following myocardial infarction (MI) remain a leading cause of sudden cardiac death, yet therapeutic options are limited by incomplete understanding of the molecular mechanisms governing post-infarction arrhythmogenesis. While RNA-binding proteins have emerged as critical regulators of cardiovascular pathophysiology, their role in cardiac electrophysiology remains largely unexplored. Here, we demonstrate that cold- inducible RNA-binding protein (CIRP) functions as a critical regulator of ventricular arrhythmia susceptibility through post-transcriptional control of cardiac ion channels.

Effects of dual-task mode brain-computer interface based on motor imagery and virtual reality on balance and attention in patients with stroke: a randomized controlled pilot trial.

Background: Brain-computer interface (BCI) has been shown to be beneficial in improving lower limb motility in stroke, but their effectiveness on balance and attention is unclear. In addition, current BCIs are mostly in single-task mode. The BCI system used in this study was based on a dual-task model of motor imagery (MI) and virtual reality (VR).

Design, synthesis and evaluation of clickable photoaffinity probes for nuclear lamins.

Nuclear lamins are type V intermediate filament proteins to support the mechanical stability of mammalian cell nucleus. They also participate in various signaling activities in the cells. We recently discovered substituted pyrroloquinazoline LBL1 as the first small molecule to directly target nuclear lamins despite their poor druggability.

Different graphene derivatives/MXene hybrid fillers reinforce gelatin composite films in food packaging applications.

In order to extend the shelf life of food especially under sunlight, a synergistic dual-component reinforcement strategy of graphene (graphene oxide, reduced graphene oxide aerogel microspheres) and TiCT MXene was applied as fillers in gelatin (GL) matrix. After simultaneous mechanical stirring and ultrasonication, followed by an ultrasonic cell grinding treatment process, the uniform dispersion and full exfoliation of both kinds of fillers in the GL matrix were ensured through the green synthesis method, which effectively enhanced the antibacterial, mechanical, ultraviolet-visible light barrier, and antioxidant properties of GL. Among these fillers, graphene (GE)/TiCT showed the best enhancing effect because GE had more complete graphene rings with greater extent of sp2-hybridized carbons as well as more edges.

GLP-1 receptor agonist semaglutide ameliorates motor deficits and tau pathology in the rTg4510s mouse model.

Background: Tauopathies, including Alzheimer's disease, are characterized by progressive neurodegeneration manifesting as motor and cognitive impairments. This study evaluated the therapeutic potential of semaglutide, a clinically approved glucagon-like peptide-1 receptor agonist, in the rTg4510 mouse model of tauopathy.

Methods: Starting at three months of age, rTg4510 mice and wild-type littermates received semaglutide (0.

Transfer learning with graph neural networks for pressure estimation in monitoring-limited water distribution networks.

Water distribution networks (WDNs) constitute essential urban infrastructure, yet their monitoring is hindered by limited monitoring conditions. Soft sensing methods have been applied to estimate pressure at unmonitored nodes using the latest deep learning models, however, they rely on large datasets from the same WDNs for training. There is a critical gap in pressure estimation of WDNs under realistic monitoring limitations.

Analysis of non-volatile organic acids based on silanization combined with gas chromatography-mass spectrometry and chemometrics: A robust strategy to discriminate geographical origin of sauce-flavor Baijiu.

The quality and aroma of sauce-flavor Baijiu exhibited significant regional characteristics, and the authenticity of its provenance served as the foundation of market value and consumer trust. Non-volatile organic acids (NVOAs) were the principal taste-modifying substances in liquors. Traditional identification methods, such as liquid chromatography-mass spectrometry (LC-MS), have limitations such as fewer compounds and higher detection limits in the analysis of NVOAs.

Damage Diagnosis Framework for Composite Structures Based on Multi-Dimensional Signal Feature Space and Neural Network.

It is particularly important to ensure the safety of engineering structures, such as aerospace vehicles and wind turbines, most of which are made of composite materials. A sudden failure of the structure may happen following the accumulation of structural damage. Since they are sensitive to tiny damage and can propagate through engineering structures over a long distance, Lamb waves have been widely explored to develop highly efficient damage detection theories and methodologies.

Ginseng Nanosizing: The Second Spring of Ginseng Therapeutic Applications.

Plant-derived vesicles offer several advantages, including high yield, low cost, ethical compatibility, safety, and potential health benefits. These advantages enable them to overcome technological limitations associated with vesicles of mammalian origin. Ginseng, a prominent example of a natural botanical plant, is known for its abundant bioactive components.

Shoreline wave breaking strongly enhances the coastal sea spray aerosol population: Climate and air quality implications.

Sea spray aerosol (SSA) emission is a major source of atmospheric aerosols, influencing global climate and coastal air quality. Much of our knowledge about SSA derives from coastal observations near shorelines, but whether and when these observations accurately represent open oceans remain unclear. Here, we show that strong nearshore SSA production during high-wave periods greatly enhances downwind cloud condensation nuclei (CCN) and aerosol mass concentrations.

TiRobot-assisted percutaneous vertebroplasty in the management of middle and upper thoracic osteoporotic vertebral compression fracture.

Purpose: This study aimed to evaluate the clinical efficacy and safety of TiRobot-assisted PVP surgery in the treatment of middle and upper thoracic OVCF. We also aimed to determine (1) changes in Visual Analog Scale (VAS) and Oswestry Disability Index (ODI) before and after treatment, (2) imaging changes of the fractured vertebra, (3) operation time and intraoperative blood loss, (4) frequency of puncture and fluoroscopy, hospital stay, radiation exposure of patient and surgeon, and (5) bone cement leakage and distribution and operation-related complications.

Methods: A retrospective analysis was performed on 62 patients with OVCF of the middle and upper thoracic vertebrae (T1-T8) who underwent PVP surgery in Shenzhen Traditional Chinese Medicine Hospital from January 2017 to January 2023.