Development and validation of models based on clinical and CT features: multivariate analysis for predicting vascular invasion in non-small cell lung cancer.

Background: Lymphovascular invasion (LVI) is a high-risk pathological marker for the evaluation of metastasis and prognosis of non-small cell lung cancer (NSCLC). Preoperative computed tomography (CT) prediction of vascular invasion in NSCLC is essential for clinical identification of high-risk patients and development of treatment strategies. This study aimed to develop and validate a model for predicting LVI in NSCLC based on clinical and CT features.

Teaching styles and sports engagement: mediation by satisfaction and resilience in Chinese adolescents.

Purpose: This study examined the associations between perceived PE teacher teaching styles on Chinese middle school students' sports learning engagement, and the mediating roles of classroom satisfaction and psychological resilience.

Methods: A cross-sectional survey assessed 1,629 junior and senior high school students in Chengdu and Chongqing, Validated scales measured perceived teaching styles, psychological resilience, sports learning engagement, and PE class satisfaction. SPSS 26.

Development of a nomogram for predicting the risk of lymph node metastasis in non-small cell lung cancer.

Background: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related death worldwide. The accurate preoperative prediction of lymph node (LN) status is crucial for reducing NSCLC mortality rates and formulating treatment strategies. This study aimed to develop and validate a nomogram for the individualized prediction of lymph node metastasis (LNM) risk in NSCLC patients, thereby guiding therapeutic decision making.

Development, deployment, and feature interpretability of a three-class prediction model for pulmonary diseases.

Purpose: To develop a high-performance machine learning model for predicting and interpreting features of pulmonary diseases.

Patients And Methods: This retrospective study analyzed clinical and imaging data from patients with non-small cell lung cancer (NSCLC), granulomatous inflammation, and benign tumors, collected across multiple centers from January 2015 to October 2023. Data from two hospitals in Anhui Province were split into a development set (n = 1696) and a test set (n = 424) in an 8:2 ratio, with an external validation set (n = 909) from Zhejiang Province.

VirNucPro: an identifier for the identification of viral short sequences using six-frame translation and large language models.

Viruses are ubiquitous in nature, yet our understanding of them remains limited. High-throughput sequencing technology facilitates the unbiased revelation of genetic composition in samples; however, viral sequences typically make up a small proportion of the entire sequencing data, making it challenging to accurately identify the few or fragmented viral sequences present in a sample. The limited features and information provided by short sequences result in insufficient resolution of viral sequences by existing models.

A novel tobamo-like mycovirus with filamentous particles replicates in plant cells.

Parasitic and symbiotic plant-fungus relationships have existed for millions of years, and phylogenetic analyses of certain virus families indicate transmission between plants and fungi. A group of tobamo-like viruses from various fungi has recently been identified. Tobamo-like viruses are homologous to plant viruses of the genus in the family, but it was unknown whether they form typical virus particles and can replicate and exhibit cell-to-cell movement in plants.

Some complex probabilistic hesitant fuzzy aggregation operators and their applications to multi-attribute decision making.

As a generalization of complex fuzzy set (CFS), complex hesitation fuzzy set (CHFS) is a powerful tool to express two-dimensional fuzzy information, but it ignores the randomness that exists widely in real life. Considering the randomness and ambiguity often simultaneously occur in real-world problems, we come up with an innovative fuzzy set called complex probabilistic hesitant fuzzy set (CPHFS) in this article, which is a joint extension of CFS and probabilistic hesitant fuzzy set (PHFS). Moreover, we establish four basic operations for complex probabilistic hesitant fuzzy element(CPHFE) and a series of useful operational laws are also developed.

A model for prediction of recurrence of non-small cell lung cancer based on clinical data and CT imaging characteristics.

Objectives: To establish a model for prediction of recurrence of non-small cell lung cancer (NSCLC) based on clinical data and computed tomography (CT) imaging characteristics.

Methods: A total of 695 patients with surgically resected NSCLC confirmed by pathology at three centers were retrospectively investigated. 626 patients from center 1 were randomly divided into two sets in a ratio of 7:3 (training set, n = 438; testing set, n = 188), 69 patients from center 2 and 3 were assigned in the external validation set.

Diversity analysis of tick-associated viruses in northeast China.

• This study identified eleven tick-borne viruses in Liaoning Province and Inner Mongolia. • Tacheng tick virus 2 is for the first time detected outside Xinjiang and in a novel tick species • The Alongshan virus and Tacheng tick virus 2 identified in this study can be considered as novel species.

Genomic characterization of the novel bacteriophage IME183, infecting Klebsiella pneumoniae of capsular type K2.

Klebsiella pneumoniae causes a wide range of serious and life-threatening infections. Klebsiella phage IME183, isolated from hospital sewage, exhibited lytic activity against K. pneumoniae of capsular type K2.

Analysis of the diversity of tick-borne viruses at the border areas in Liaoning Province, China.

Ticks play a significant role in transmitting arboviruses, which pose a risk to human and animal health. The region of Liaoning Province, China, with abundant plant resources with multiple tick populations, has reported several tick-borne diseases. However, there remains a scarcity of research on the composition and evolution of the tick virome.

Survey of mosquito species and mosquito-borne viruses in residential areas along the Sino-Vietnam border in Yunnan Province in China.

Mosquitoes are capable of carrying complex pathogens, and their feeding habits on the mammalian blood can easily mediate the spread of viruses. Surveillance of mosquito-based arbovirus enables the early prevention and control of mosquito-borne arboviral diseases. The climate and geography of Yunnan Province in China are ideal for mosquitoes.

The diagnosis and treatment for a patient with cancer of unknown primary: A case report.

Cancer of unknown primary (CUP) is a class of metastatic malignant tumors whose primary location cannot be determined. The diagnosis and treatment of CUP are a considerable challenge for clinicians. Herein, we report a CUP case whose corresponding primary tumor sites were successfully identified, and the patient received proper treatment.

A SARS-CoV-2-Related Virus from Malayan Pangolin Causes Lung Infection without Severe Disease in Human ACE2-Transgenic Mice.

Coronavirus disease 2019 (COVID-19), which is caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the most severe emerging infectious disease in the current century. The discovery of SARS-CoV-2-related coronaviruses (SARSr-CoV-2) in bats and pangolins in South Asian countries indicates that SARS-CoV-2 likely originated from wildlife. To date, two SARSr-CoV-2 strains have been isolated from pangolins seized in Guangxi and Guangdong by the customs agency of China, respectively.

Characterization of the novel temperate Staphylococcus haemolyticus phage IME1365_01.

The presence of a novel functional prophage, IME1365_01, was predicted from bacterial high-throughput sequencing data and then successfully induced from Staphylococcus haemolyticus by mitomycin C treatment. Transmission electron microscopy showed that phage IME1365_01 has an icosahedral head (43 nm in diameter) and a long tail (172 nm long). This phage possesses a double-stranded DNA genome of 44,875 bp with a G+C content of 35.

Virome in healthy pangolins reveals compatibility with multiple potentially zoonotic viruses.

Previous studies have identified multiple viruses in dead or severely diseased pangolins, but descriptions of the virome in healthy pangolins are lacking. This poses a greater risk of cross-species transmission due to poor preventive awareness and frequent interactions with breeders. In this study, we investigated the viral composition of 34 pangolins with no signs of disease at the time of sampling and characterized a large number of arthropod-associated viruses belonging to 11 families and vertebrate viruses belonging to eight families, including those with pathogenic potential in humans and animals.

N-glycoproteomic profiling revealing novel coronavirus therapeutic targets potentially involved in Cepharanthine's intervention.

The Coronavirus disease 2019 (COVID-19) has posed a serious threat to global health and the world economy. Antiviral therapies targeting coronavirus are urgently required. The Cepharanthine (CEP) is a traditional Chinese herbal extract.

Isolation and genomic characterization of a novel Autographiviridae bacteriophage IME184 with lytic activity against Klebsiella pneumoniae.

Klebsiella pneumoniae, a multidrug resistant bacterium that causes nosocomial infections including septicemia, pneumonia etc. Bacteriophages are potential antimicrobial agents for the treatment of antibiotic resistant bacteria. In this study, a novel bacteriophage IME184, was isolated from hospital sewage against clinical multi-drug resistant Klebsiella pneumoniae.

Molecular dissection of the first Staphylococcus cohnii temperate phage IME1354_01.

In staphylococcal phage research, studies specific to coagulase-negative staphylococci (CoNS) remain severely under-represented, and the number of temperate bacteriophages is limited. This investigation identifies a novel temperate phage IME1354_01 from the strain Staphylococcus cohnii IME1354, which was isolated from the skin of a patient with foot ulcer disease. The phage IME1354_01 is the first isolated temperate phage of S.

Evaluation of Modified Calcium Removal Algorithm in dual energy CT of Internal Carotid Artery.

Purpose: To evaluate the performance of a dual-energy (DE) calcium removal software based on a modified three-material decomposition algorithm in assessing the stenosis of the internal carotid artery (ICA) in comparison with mixed images using digital subtraction angiography (DSA) as the reference standard.

Methods: Forty-six patients (38 men; 67±8 years old), including 154 calcified ICA segments C1-C2 (59), C3-C5 (63), C6 (24), and C7 (8), were recruited in this retrospective study. Mixed images and virtual non-calcium (VNCa) images using the modified dual-energy computed tomography (DECT) algorithm were reconstructed.

Characteristics and genome analysis of a novel bacteriophage IME1323_01, the first temperate bacteriophage induced from Staphylococcus caprae.

Temperate phages play an important role in the evolution of bacteria. So far, lytic phages have been wildly reported, but there is still limited knowledge regarding temperate phages in the genome of pathogenic Staphylococcus caprae. Here we present the characteristics and genome analysis of a novel bacteriophage IME1323_01, which is the first isolated bacteriophage of S.