Correction: Triple therapy revolutionizes treatment paradigms for previously untreatable HCC complicated by high-flow hepatic arteriovenous fistulas.

[This corrects the article DOI: 10.3389/fimmu.2025.

Cardiac light chain amyloidosis secondary to Waldenström's macroglobulinemia: A case report and review.

Cardiac light chain amyloidosis (AL) secondary to Waldenström's macroglobulinemia (WM) presents a complex challenge in medical practice due to its rarity and diagnostic difficulty. A 67-year-old male presented with symptoms of heart failure and was diagnosed with cardiac AL amyloidosis secondary to WM. The diagnosis of WM was confirmed through a combination of immunoglobulin (Ig) profile with abnormal IgM levels, bone marrow morphology, immunofixation electrophoresis, serum protein electrophoresis and gene mutation analysis.

Global burden and trends of stroke attributable to kidney dysfunction from 1990 to 2021.

Background: Accumulating evidence suggests that kidney dysfunction (KD) is a risk factor for stroke and stroke subtypes (SSS). However, comprehensive studies on the global burden of SSS attributable to KD are lacking. This study aimed to compare the long-term trends of KD-related SSS from 1990 to 2021 at the global, regional and national levels, and predict the disease burden until 2045.

Therapeutic outcomes of GnRHa and rhGH in idiopathic central precocious puberty: a focus on psychological and behavioral improvements.

Objective: The psychological issues associated with idiopathic central precocious puberty (ICPP) in girls remain a contentious topic, particularly regarding the necessity and effectiveness of psychological interventions and pharmacological treatments such as gonadotropin-releasing hormone analog (GnRHa) or GnRHa combined with recombinant human growth hormone (rhGH).

Methods: This study aimed to assess the psychological profiles of 95 ICPP girls and their parents, comparing them with 70 healthy controls, and to investigate the potential therapeutic effects of pharmacological interventions. For parents, psychological evaluations were conducted using the Child Behavior Checklist, State Anxiety Inventory, and Positive and Negative Affect Schedule.

Circ_0049472 downregulation relieves Amyloid-β-induced neuronal injury by modulating PDE4A expression via targeting miR-22-3p in Alzheimer's disease.

Neuronal injury is a common event in the development of Alzheimer's disease (AD). Previous studies have suggested that circular RNAs (circRNAs) are involved in neuronal injury in the pathological progression of AD. However, the potential role of circ_0049472 in the AD process is still unclear.

Serum from patients with oral squamous cell carcinoma remodels the tumor immune escape ecological niche by promoting regulatory T‑cell differentiation and T‑cell exhaustion.

Oral squamous cell carcinoma (OSCC) ranks as the sixth most prevalent malignancy worldwide, and is characterized by high morbidity and mortality rates. Elucidating the molecular and cellular mechanisms of tumor‑directed immune escape through ecological niche remodeling is crucial for advancing tumor biotherapy. The serum of patients with cancer contains not only tumor biomarkers but also immune regulators secreted by immune cells and/or cancer cells.

High fructose consumption aggravates inflammation by promoting effector T cell generation via inducing metabolic reprogramming.

The intake of sugars, especially glucose and fructose, has significantly increased with the change of lifestyle. Excessive intake of sugar has been proven to be associated with tumors and inflammatory diseases. Fructose directly mediates innate immune responses; however, whether it can directly regulate T-cell immunity remains unknown.

The Prophylactic Effect of Acupuncture for Migraine Without Aura: A Randomized, Sham-Controlled, Clinical Trial.

Objective: Acupuncture is recognized as an effective migraine treatment, but the comparative long-term efficacy of different acupuncture methods at identical acupoints remains unclear. This study investigates the prophylactic effects of manual acupuncture (manual penetrating acupuncture, MPA) versus sham acupuncture (non-penetrating acupuncture, NPA) at the same acupoints.

Methods: In this multicenter, single-blind randomized controlled trial conducted across four Chinese clinical centers (May 2020 to September 2022), 192 migraineurs without aura (International Classification of Headache Disorders 3rd edition criteria) were randomized 1:1 to 12 sessions of MPA or NPA.

Comparative Molecular Insights into Developmental and Behavioral Toxicity Induced by Octocrylene and Ethylhexyl Salicylate Exposure on Zebrafish.

Octocrylene (OC) and ethylhexyl salicylate (EHS), widely used organic ultraviolet (UV) filters, are persistently detected in natural environments, raising concerns about their ecological toxicity. However, their toxicity at environmentally relevant concentrations remains poorly understood, and a comparative assessment of their aquatic effects is lacking. This study exposed zebrafish embryos (≤4 h post-fertilization, hpf) to OC and EHS (0.

Autologous Osteoperiosteal Transplantation Versus Autologous Osteochondral Transplantation for Large Cystic Osteochondral Lesions of the Medial Talus: 2-Year Results From a Prospective Randomized Controlled Trial.

Background: Both autologous osteochondral transplantation (AOCT) and autologous osteoperiosteal transplantation (AOPT) are available for large cystic osteochondral lesions of the talus (OLTs). However, there is a lack of valid prospective evidence directly comparing the efficacy between AOPT and AOCT.

Purpose/hypothesis: The purpose of this study was to compare the efficacy and safety of AOPT versus AOCT in patients with large cystic OLTs (>8 mm in cystic diameter) at 2 years of follow-up.

LOR Regulated by METTL3 Alleviates Lipopolysaccharides-Induced Periodontitis Injury.

Periodontitis is a chronic inflammatory disease-causing tissue destruction and systemic effects. Despite significant advancements, the molecular mechanisms driving tissue degeneration remain incompletely understood. Emerging evidence suggests that RNA modifications, particularly N6-methyladenosine (mA) methylation, critically regulate inflammatory responses.

Jumping Dot Sign: A New Radiological Sign Predicting Inferior Clinical Outcome and Higher Cyst Recurrence Following Bone Marrow Stimulation for Cystic Osteochondral Lesions of the Talus.

Background: Bone marrow stimulation (BMS) is the most commonly performed surgery for osteochondral lesion of the talus (OLT), but there is a risk of poor outcome when cysts recur. The indications of BMS in the presence of cystic OLT remain controversial.

Purpose: To investigate whether a new "jumping dot (JD) sign," manifesting as speckle-like areas of elevated signals surrounding the subchondral bone cyst (SBC) on preoperative magnetic resonance imaging (MRI) against the background of bone marrow edema (BME), could be a predictor of clinical outcome and recurrence of SBCs following BMS and to further propose a more precise indication regarding BMS surgery for cystic OLT.

Soufeng sanjie formula alleviates bone erosion in CIA mice via inhibiting RANKL/NF-κB signaling pathway and ameliorates the RA symptom in patients.

Aim Of The Study: Soufeng sanjie formula (SF), composed by scolopendra, scorpion, astragali radix and black soybean seed coats, is an in-hospital preparation of traditional Chinese medicine used for the treatment of rheumatoid arthritis (RA). It has been demonstrated to have a prominent effect on relieving the symptoms of collagen-induced arthritis (CIA) mice after 1 month of administration. This study aimed to evaluate the effect and mechanism of SF on ameliorating bone erosion in CIA mice and RA patients.

Triple therapy revolutionizes treatment paradigms for previously untreatable HCC complicated by high-flow hepatic arteriovenous fistulas.

Purpose: To evaluate the short-term efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) combined with immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs) in patients with hepatocellular carcinoma (HCC) complicated by high-flow hepatic arteriovenous fistula (HAVF).

Patients And Methods: We retrospectively analyzed clinical data from 40 patients with unresectable HCC complicated by high-flow HAVF who received FOLFOX regimen HAIC plus ICIs and TKIs between January 2021 and June 2023. The efficacy evaluation included HAVF effective rate, tumor response, progression-free survival (PFS), overall survival (OS) per RECIST 1.

Nestin in multiple myeloma: emerging insights into a potential therapeutic target.

Multiple myeloma (MM) is the second most common hematological malignancy and remains incurable, with high rates of relapses and refractory. One of the root causes is the presence of multiple myeloma stem cells (MMSCs). The deficiency of MMSC treatment lies in the lack of specific targets.

Hydrogel particle-based protein display enabled by particle-templated emulsification.

Protein display technology enables high-throughput screening and plays an important role in protein discovery and engineering. Conventional display methods face challenges such as inefficient gene transformation and complex cell proliferation dynamics, while display methods are often limited to affinity-based selection and suffer from expression bias due to homogeneous reaction conditions. Here, we present a hydrogel particle-based protein display method enabled by particle-templated emulsification.

Clinical Outcomes and Sports Participation After the Modified Broström Procedure in Children and Adolescents With Chronic Lateral Ankle Instability: A 5- to 10-Year Follow-up of 111 Cases.

Background: Chronic lateral ankle instability (CLAI) can severely impair sports performance and functional mobility in children and adolescents, necessitating surgical interventions such as the modified Broström procedure. However, midterm to long-term clinical outcomes and sports participation after this procedure remain inconclusive.

Purpose: To investigate the midterm to long-term clinical outcomes and analyze the reasons and risk factors for failure to participate at preinjury sports levels after the modified Broström procedure in children and adolescents with CLAI.

Diabetes and periodontitis: the role of a high-glucose microenvironment in periodontal tissue cells and corresponding therapeutic strategies.

Background: Periodontitis is a chronic inflammatory disease that leads to the destruction of periodontal tissues and diabetes is a metabolic disease characterized by hyperglycemia. Both of these diseases affect many people worldwide. Epidemiological data have revealed a close relationship between periodontitis and diabetes.

Mechanism-based perspective on metal ion-induced signal instability and development of a robust LC-MS/MS method for trace quantification of hetrombopag in plasma.

Hetrombopag (Hengqu®) is an oral nonpeptide thrombopoietin receptor agonist for the treatment of thrombocytopenia and aplastic anemia. Research on the pharmacokinetic behavior is very important, but accurate quantification of metal-sensitive hetrombopag in biological specimens is a challenging analytical problem. In view of the presence of trace metals from a variety of sources, such as chromatographic system, containers, and the mass spectrometry spray needle, which can contribute to poor peak shape, tailing, and diminished recovery of compound.

Gastrointestinal diffuse large B-cell lymphoma: Clinical characteristics and prognostic analysis from SEER database.

This study systematically analyzed the clinicopathological characteristics and prognostic factors of gastrointestinal diffuse large B-cell lymphoma (GI-DLBCL) patients using the SEER database. The Kaplan-Meier method was used to survival analysis, while LASSO regression analysis was utilized to further filter variables. The Pi for interaction was applied to verify the interactions in the multivariate analysis, and total survival risks were distinguished using hierarchical survival curves.

IGF2BP3 Modulates mRNA Splicing and Stability to Promote Trophoblast Progression via Interaction with PDE3A and Suppression by miR-196a-5p in Preeclampsia.

Preeclampsia (PE) is a pregnancy-specific disorder and a leading cause of maternal and fetal morbidity and mortality. Impaired trophoblast invasion is a hallmark of PE, and alternative splicing (AS) is crucial for trophoblast differentiation and placental development. However, the exact mechanisms of AS in PE remain poorly understood.

Arthroscopic Characteristics and Risk Factors for Syndesmosis Widening in Chronic Lateral Ankle Instability: A Cross-sectional Study of 521 Patients.

Background: To report the measured characteristics of inferior tibiofibular syndesmosis (iTFS) widening-a condition involving abnormal separation of the distal tibia and fibula in patients with chronic lateral ankle instability (CLAI)-and to investigate its associated risk factors.

Methods: Consecutive CLAI patients undergoing arthroscopy and Broström surgery between June 2020 and August 2023 were included. The anterior, middle, and posterior parts of the transverse iTFS space was measured by using the customized probe under arthroscopy to explore the characteristics of iTFS widening.

Three Birds with One Stone: AMT-Embedded PCL Microspheres Synergize with MXene to Achieve Triple-Healing Multifunctional Anticorrosion Coatings under Photothermal Conversion.

In this paper, a multifunctional intelligent self-healing anticorrosion coating with the ability to realize triple healing in photothermal response as well as pH response was prepared. The composite coating matrix was shape memory polymer (SMP), and the filler was composed of PCL (polycaprolactone) microspheres that encapsulated the corrosion inhibitor AMT (2-amino-5-mercapto-1,3,4-thiadiazole), which was then loaded with MXene (TiCT). Under light exposure, the PTM (PCL@AMT@MXene) composite microspheres achieved a photothermal effect; the temperature increase triggers the shape memory effect of SMP to achieve healing, and the PTM composite microspheres melted to further fill the scratches.

Effects and Neuroimaging Findings of Acupuncture for Amnestic Mild Cognitive Impairment: A Randomized Controlled Trial.

Aim: Due to the limited evidence, the effects and neuroimaging mechanisms of acupuncture for amnestic mild cognitive impairment (aMCI) are still needed to investigate. Our objectives were to assess the effects and investigate its therapy-driven modification in functional neural response.

Methods: Right-handed aMCI patients were enrolled and randomly assigned to an acupuncture group (AG) or a waitlist control group (WG) in the randomized clinical trial using computer-generated randomization sequence method.

Direct scavenging of ROS by S-PPE NP reduces oxidative stress-induced stimulation of the SESN2/AMPK/KIM-1 pathway in acute kidney injury.

Background: Previous research demonstrated that treatment of acute kidney injury (AKI) with the antioxidant S-PPE NP reduced the levels of the oxidative stress-responsive protein Sestrin2 (SESN2), and suggested that kidney injury molecule 1 (KIM-1) could serve as a biomarker for early tubular injury. A comprehensive elucidation of the regulatory effects of S-PPE NP on SESN2 and KIM-1 expression in ischemia-reperfusion injury-AKI (IRI-AKI) could enhance therapeutic approaches for AKI.

Materials And Methods: An human kidney-2 (HK-2) cell hypoxia/reoxygenation (H/R) model and a mouse IRI model were utilized at various time points to assess the expression of SESN2 and KIM-1 and to evaluate the impact of S-PPE NP treatment.