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Background: Chronic lateral ankle instability (CLAI) can severely impair sports performance and functional mobility in children and adolescents, necessitating surgical interventions such as the modified Broström procedure. However, midterm to long-term clinical outcomes and sports participation after this procedure remain inconclusive.
Purpose: To investigate the midterm to long-term clinical outcomes and analyze the reasons and risk factors for failure to participate at preinjury sports levels after the modified Broström procedure in children and adolescents with CLAI.
Study Design: Case series study; Level of evidence, 4.
Methods: A total of 144 consecutive patients younger than 18 years with CLAI underwent the modified Broström procedure from August 2014 to July 2019, of whom 126 meeting the inclusion criteria were contacted via telephone to complete a survey. Clinical outcomes were assessed using the visual analog scale (VAS) for pain, Karlsson-Peterson score, Tegner score, and Foot and Ankle Outcome Score (FAOS). A structured questionnaire evaluated the outcomes of sports participation, ankle recurrent sprains, subjective satisfaction, and surgical complications. Univariate and multivariate logistic regression analyses were conducted to identify factors influencing return to preinjury sports levels at final follow-up.
Results: There were 107 patients (111 ankles; 84.9% follow-up rate) included for analysis, with a mean age at the time of surgery of 15.2 ± 2.0 years and a follow-up period of 5 to 10 years (mean, 86.4 ± 17.7 months). Postoperative clinical scores showed significant improvements compared with preoperative scores, with VAS pain scores decreasing from 4.0 ± 2.1 to 0.8 ± 1.1, the Karlsson-Peterson score increasing from 55.8 ± 20.8 to 91.4 ± 7.9, the Tegner score increasing from 3.6 ± 2.0 to 5.5 ± 1.5, and the total FAOS score increasing from 64.4 ± 18.7 to 93.0 ± 6.2 ( < .001 for all). All cases returned to daily activities and recreational sports levels at a mean time of 5.1 ± 3.6 months after surgery. Among them, 55.0% were able to participate at their preinjury level of sports at final follow-up, while the other 45.0% were not, citing reasons such as ankle-related events (46.0%), health problems (10.0%), life-related events (18.0%), and personal preferences (24.0%). Recurrent sprains occurred in 27.0% of cases, with an overall complication rate of 5.4% (all cases with skin numbness; no infections) and a high patient satisfaction rate of 97.3%. Multivariate analysis identified that being an athlete ( = .035) or having a calcaneofibular ligament injury ( = .040) was negatively related to the success of returning to preinjury sports levels at 5- to 10-year follow-up.
Conclusion: Over a 5- to 10-year follow-up period, the modified Broström procedure provided satisfactory clinical outcomes in children and adolescents with CLAI, enabling them to resume daily activities and recreational sports. However, approximately one-quarter experienced recurrent sprains, and nearly half of the cohort was not able to achieve their previous sports performance, particularly athletes and those with calcaneofibular ligament injuries.
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http://dx.doi.org/10.1177/03635465251354961 | DOI Listing |
Turk Kardiyol Dern Ars
September 2025
Department of Cardiology, Necmettin Erbakan University, School of Medicine, Konya, Turkiye.
Cardiac resynchronization therapy (CRT) improves outcomes in heart failure, but prior interventions like percutaneous mitral annuloplasty may hinder lead placement. We present a 70-year-old male with ischemic cardiomyopathy and severe functional mitral regurgitation who previously received a Carillon device. Due to coronary sinus inaccessibility, left bundle branch area pacing optimized cardiac resynchronization therapy (LOT-CRT) was performed.
View Article and Find Full Text PDFStroke
September 2025
Department of Medicine, University of Melbourne, Parkville, Victoria, Australia. (V.Y., B.C.V.C., L.C., L.O., M.W.P.).
Background: To assess the efficacy and safety of tenecteplase in patients presenting within 24 hours of symptom onset with a large vessel occlusion and target mismatch on perfusion computed tomography.
Methods: ETERNAL-LVO was a prospective, randomized, open-label, blinded end point, phase 3, superiority trial where adult participants with a large vessel occlusion, presenting within 24 hours of onset with salvageable tissue on computed tomography perfusion, were randomized to tenecteplase 0.25 mg/kg or standard care across 11 primary and comprehensive stroke centers in Australia.
Curr Med Imaging
September 2025
Department of Pharmacy, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Unlabelled: Leptomeningeal metastasis (LM) is a severe complication of solid malignancies, including lung adenocarcinoma, characterized by poor prognosis and diagnostic challenges. This study assesses whether curvilinear peri-brainstem hyperintense signals on MRI are a characteristic feature of LM in lung adenocarcinoma patients.
Methods: This retrospective study analyzed data from multiple centers, encompassing lung adenocarcinoma patients with peri-brainstem curvilinear hyperintense signals on MRI between January 2016 and March 2022.
Circulation
September 2025
Division of Cardiology, Columbia University Irving Medical Center, New York, NY (S.A.P.).
Background: Limited treatment options exist for infrapopliteal disease in patients with chronic limb-threatening ischemia (CLTI), a condition associated with a high risk of limb loss. Interventional management of diseased infrapopliteal vessels with percutaneous transluminal angioplasty (PTA) is associated with high rates of restenosis and reintervention. In the LIFE-BTK trial, the drug-eluting resorbable scaffold (DRS) demonstrated superior 12-month efficacy compared with PTA in a selected CLTI population with predominantly noncomplex, mildly to moderately calcified lesions.
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