Machine learning-guided design of high-performance Mg-based thermoelectrics: insights into thermal expansion effects.

Mg-based thermoelectric materials are becoming ideal candidates for thermoelectric applications, owing to their eco-friendliness and abundant availability. To overcome the limitations of conventional experimental methods and accelerate the development of high-performance thermoelectric materials, this study leverages high-throughput computing and machine learning to perform a comprehensive and systematic evaluation of a vast array of Mg-based thermoelectric materials. Our findings highlight the pivotal role of thermal expansion in modulating the thermoelectric figure of merit (ZT) in Mg-based systems.

Comparable perioperative performance between three robotic system for robot-assisted partial nephrectomy to treat early renal cancer.

This study aimed to compare the safety and efficacy of robot-assisted partial nephrectomy with the two Chinese Robotic systems versus the da Vinci Xi Surgical System. This prospective analytical study included 170 patients who underwent robotic-assisted partial nephrectomy between February 2023 to June 2024. The study included 85 patients who received treatment using two Chinese robotic systems (KangDuo SR 2000: KD-SR-2, EDGE MP1000) and 85 who underwent the da Vinci (DV) surgical system during the same period.

Efficacy of tranexamic acid in reducing perioperative blood transfusions and thrombosis in liver surgery: a systematic review and meta-analysis.

Introduction: Preventing bleeding during the perioperative period is critically important in liver surgery and mismanagement can raise the need for transfusions as well as the rates of morbidity and death. Tranexamic acid (TXA) has been shown to effectively decrease perioperative bleeding in patients with trauma, some studies have also shown that TXA plays the same role in liver surgery. The effectiveness of TXA in hepatectomy and liver transplantation was reassessed in this meta-analysis of randomized controlled trials, which included recently published studies.

Spatial and temporal distribution of mercury contamination in Bombay duck (Harpadon nehereus) from southeastern coastal China.

China's southeastern coast, particularly Zhejiang, Fujian, and Guangdong, is rich in key fishery resources but also faces elevated contamination due to intensive industrial activity. The study investigated the spatial and temporal variations of mercury (Hg) in Bombay duck (Harpadon nehereus) collected from five coastal sites, the Yangtze River estuary, Hangzhou Bay, Wenzhou, Xiamen and Zhanjiang. The Hg levels and MeHg/THg ratios generally increased with decreasing latitude, with the highest Hg concentrations observed in Zhanjiang (THg: 0.

Potential role of gut bacteria in the development of hepatocellular carcinoma.

Liver cancer is the fourth most deadly cancer, and early detection and timely treatment apparently play a crucial role in it. Intestinal bacteria affect the development of liver cancer through various pathways. In this study, the gut bacteria of liver cancer patients are analysed in detail by using metagenomic sequencing technology, and some of the bacterial species and metabolic pathways that may affect the development of liver cancer have been identified.

Menin facilitates the cell proliferation of bladder cancer via modulating the TFAP2C/β-catenin axis.

Bladder cancer (BLCA) is a common malignant tumor of the urinary system, with significant morbidity and mortality rates worldwide. The gene, encoding the menin protein, plays a regulatory role in several cancers. However, the role played by menin in BLCA remains elusive.

Compliant, Tough, Fatigue-Resistant, and Biocompatible PHEMA-Based Hydrogels as a Breast Implant Material.

Breast reconstruction remains hindered by the limitations of conventional implant materials such as silicone, which exhibit hydrophobicity and poor tissue integration, often leading to complications, including capsular contracture. Here, we report the development of a poly-(HEMA-MA)/Fe (PHM/Fe) hydrogel as a next-generation soft implant material. This hydrogel is synthesized via copolymerization of 2-hydroxyethyl methacrylate (HEMA) and maleic acid (MA), followed by immersion in FeCl to induce secondary cross-linking through Fe-carboxyl coordination.

Global research status and trends of compulsive sexual behavior disorder: A comprehensive bibliometric analysis.

Background: Compulsive sexual behavior disorder (CSBD) is a mental health condition that has attracted significant research attention, especially following its inclusion in the eleventh revision of the International Classification of Diseases (ICD-11) by the World Health Organization. Despite this recognition, the field remains fragmented with ongoing debates about its classification and a lack of comprehensive cross-cultural research. In this study, bibliometrics was used to characterize the development status of CSBD over the past 25 years and to identify key research hotspots and future trends.

Data-Driven Design of High-Temperature-Resistant Polyimides Using Hierarchical Gaussian Process Regression.

Accurate prediction of Tg for polyimides (PIs) is essential for assessing material performance in high-temperature applications in aerospace, electronics, microelectronics, and flexible display technology. However, experimental measurements remain critically challenging due to the labor-intensive synthesis, conventional instrument limits, and time-consuming characterization processes. Meanwhile, force field limitations, timescale discrepancy, and validation difficulties exist in the prediction of Tg for PIs using molecular dynamic simulation.

Modulating synaptic glutamate receptors by targeting network nodes of the postsynaptic density condensate.

Biological condensates are assembled through phase separation and play critical roles in diverse cellular processes. Condensates in cells form percolated molecular networks via multi-valent interactions among biomolecules. How the network properties of a condensate are connected to its biological function is poorly understood.

High-performance reverse thermoresponsive hydrogel enabled by one-pot PDMS-enriched domain crosslinking.

Reverse thermoresponsive hydrogels, which exhibit low transparency at ambient temperature and become transparent upon heating, offer distinct advantages in information encryption, thermal display, and emergency signaling. However, integrating such optical responsiveness with mechanical robustness, moisture retention, and interfacial adhesion remains a challenge. Herein, we report a highly stretchable and reverse thermoresponsive hydrogel based on polyacrylamide (PAM) crosslinked by PDMS-enriched microgel-like domains, synthesized an emulsion-assisted one-pot strategy.

Cistanche flavonoids activate the Keap1-Nrf2-ARE signaling pathway in improving cognitive dysfunction in Alzheimer's disease: A review.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder closely associated with oxidative stress, which plays a pivotal role in neuronal damage and disease progression. The Keap1-Nrf2-ARE signaling pathway plays a crucial role in regulating cellular responses to oxidative stress. Keap1 inhibits Nrf2 by maintaining its low expression, thus controlling antioxidant gene expression.

Organocatalytic -C-H Hydroxylation of Azaarene -Oxides.

The chemoselective and site-selective molecular editing of azaarenes presents significant potential, as it allows for the precise construction of complex molecules with diverse applications in pharmaceuticals and materials science. Nevertheless, the most substantial challenge lies in the meticulous control of reaction selectivity, primarily due to the complex electronic properties and multiple reactive sites inherent in azaarenes. In this regard, the development of efficient and practical catalysts, especially organocatalysts for these selective transformations, is of the utmost significance and represents a formidable challenge.

Extracellular Vesicle Protein Panel Enables Early Lung Cancer Detection in a Large Clinical Cohort.

The early detection and diagnosis of lung cancer through extracellular vesicle (EV)-based liquid biopsy show substantial promise for enhancing clinical outcomes. Nonetheless, there is a scarcity of large-scale clinical investigations validating EV-based liquid biopsy. To evaluate the EV membrane protein panel as a diagnostic tool for early-stage cancer detection and validate its efficacy and clinical applicability, a cohort comprised of 302 individuals without cancer and 645 with lung cancer was recruited.

A new strategy to improve the virulence of Bacillus thuringiensis supernatant based on enhancing Vip3A secretion.

Vegetative insecticidal protein (Vip3), which has potent insecticidal activity against lepidopteran insect pests, is a non-classical secreted insecticidal protein produced by Bacillus thuringiensis during vegetative growth. Strains with high levels of Vip3A expression have been developed, but a large amount of Vip3A is retained inside the cell, failing to be secreted. In this study, we found that cell wall hydrolases (CWHs) acting on different sites of peptidoglycan cause differences in the level of Vip3A secretion.

Hydrogel delivery systems in intervertebral disc degeneration: Current status and future perspectives.

Intervertebral disc degeneration (IVDD) is a primary contributor to the development of low back pain, characterized by core pathological features which include extracellular matrix (ECM) degradation, oxidative stress, imbalanced inflammatory microenvironment, and cellular functional exhaustion. Conventional therapies (e.g.

Water-stable MAPbBr@PbBrOH QDs confined by metal-organic framework for photodegradation of wastewater.

While the metal halide perovskite materials are emerging as potentially promising photocatalysts, they still suffer from the intrinsic instability, seriously hampering their further practical applications. In this study, a perovskite-based composite with a sandwich structure is first established to realize the encapsulation of individual octylamine-capped MAPbBr (OM-PE) quantum dots (QDs), and the Zeolitic Imidazolate Framework-67 (ZIF-67) isolates the individual OM-PE@PbBrOH QDs (2 nm) to preserve their unique optoelectronic properties while preventing degradation from environmental factors. The resulting sandwich composite was proved to be a staggered-gap heterostructure with a p-n junction, in which the PbBrOH layer acted as a water-resisting covering and ZIF-67 layer promoted the electron mobility.

Influence of work-family facilitation on work engagement among physical education teachers.

Background: Enhancing work engagement among physical education (PE) teachers is crucial for building a strong sports nation and fostering educational advancement. However, PE teachers frequently experience conflicts between work and family roles, significantly impacting their professional involvement. The concept of work-family facilitation, highlighting mutual facilitation between work and family domains, has considerable theoretical and practical significance but remains underexplored in this context.

Chromosome-level genome assembly of Ampulex clypecomplana Chen & Li (Hymenoptera: Ampulicidae).

Ampulex clypecomplana Chen & Li, 2010 (Hymenoptera: Ampulicidae) is an important predatory insect in Hymenoptera. However, molecular information about this predatory insect is currently limited. In this study, we employed ONT long-read sequencing, MGI-SEQ short-read sequencing, Hi-C sequencing and transcriptomic data to assemble the high-quality genome of A.

PDE4D Regulates Mitochondrial Homeostasis and Adult Hippocampal Neurogenesis via the cAMP/CREB Signaling Pathway in Chronic Stress-Induced Depressive-Like Behavior.

Phosphodiesterase 4D (PDE4D), a major enzyme responsible for cAMP degradation in the hippocampus, has been implicated in mood regulation. Although PDE4D inhibition exerts antidepressant effects, the underlying mechanisms remain poorly understood. Here, we explored the role of PDE4D in chronic stress-induced depressive-like behaviors, mitochondrial dysfunction, and impaired adult hippocampal neurogenesis (AHN).

Regulating Reversible Zn Deposition via a 2D Metal-Organic Framework-Laden Hydrogel Electrolyte.

The practical deployment of aqueous Zn-ion batteries (AZIBs) is impeded by dendritic growth and parasitic side reactions of Zn anodes, which severely compromise reversibility and cycle stability. Herein, a hydrogel electrolyte (HE) is reported integrated with a 2D porphyrin-based metal-organic framework (MOF) as a multifunctional filler to address these issues. The incorporation of the 2D MOF not only reinforces the mechanical integrity and enhances the ionic conductivity (14.

Perioperative Outcomes of Robot-Assisted Partial Nephrectomy with MP1000 Surgical System da Vinci Xi Surgical System and Evaluation of the MP1000 Learning Curve.

To compare the perioperative outcomes between the MP1000 and da Vinci Xi surgical systems in robot-assisted partial nephrectomy (RAPN) and examine the MP1000 learning curve. In this prospective single-center study, 90 patients undergoing RAPN were equally allocated to the MP1000 ( = 45) or da Vinci Xi ( = 45) groups. Perioperative outcomes were analyzed, and the learning curve was assessed for MP1000 group operative times.

Internalized polystyrene nanoplastics trigger testicular damage and promote ferroptosis via CISD1 downregulation in mouse spermatocyte.

Background: There is a growing body of research regarding the potential reproductive toxicity of microplastics and nanoplastics. However, the underlying mechanisms by which nanoplastics exposure adversely affects the testes remain poorly understood. Our study aims to clarify the relationship between ferritinophagy and mitochondrial dysfunction based on polystyrene nanoplastics (PS-NPs)-caused testicular damage in mice.

Gold-Enhanced Lanthanide Nanomedicine for Near-Infrared Photodynamic Therapy.

Cancer remains a major global health challenge due to its high morbidity and mortality rates. Traditional treatments, such as surgery, radiotherapy, and chemotherapy, have some clear limitations, which is why there is a growing need for innovative therapeutic modalities. One precise targeting of tumors with few side effects can be achieved through a promising modality called photodynamic therapy (PDT).