Proportion and related factors of depression and anxiety for patients with pulmonary nodules in China: a outpatient-based cross-sectional study.

Investigating the proportion of depression and anxiety in patients with pulmonary nodules (PNs) and exploring the factors influencing them may help to optimize PNs management protocols and guide clinical decision-making. This study employed a cross-sectional design and included 260 patients attending the hospital's outpatient clinic. The assessment of depression and anxiety in patients with PNs was conducted using the Hamilton Depression Scale (HAMD) and the Hamilton Anxiety Scale (HAMA), respectively.

Incidence rate and risk factors of pulmonary conditions three years post COVID-19 in Bronx, New York: a retrospective cohort study.

This retrospective cohort study used propensity-matched cohorts with a 3-year follow-up (March 2020-July 2023) to determine incidence rates, relative risks, and risk factors for incident pulmonary conditions after COVID-19 exposure. Data were drawn from a multi-center health system in New York City. Participants had at least 30 days of follow-up and included patients with or without COVID-19 confirmed by PCR, diagnosed with lower respiratory tract infection (LRTI), or without COVID-19/LRTI testing.

Effectiveness of the sleep apnea-specific hypoxic burden and sleep breathing impairment index in assessing cognitive impairment in children with obstructive sleep apnea.

Purpose: This study investigated cognitive impairment in children with obstructive sleep apnea (OSA) by evaluating the utility of sleep apnea-specific hypoxic burden (SASHB) and sleep breathing impairment index (SBII) compared to the obstructive apnea-hypopnea index (OAHI).

Methods: A retrospective analysis included 141 children with suspected OSA from Xi'an Jiaotong University Second Affiliated Hospital (October 2021-October 2024), categorized into OSA ( = 104) and non-OSA ( = 37) groups based on OAHI. Demographic, polysomnography (PSG), and event-related potential (ERP) data were collected.

Sporadic Human Infections With in Yichang, China, 2021-2023.

Japanese spotted fever (JSF) is an easily neglected infectious disease, where misdiagnosis and delayed treatment significantly contribute to poor prognoses in affected patients. Our prospective observational study (2021-2023) systematically characterized 56 JSF cases in Yichang through tripartite analysis encompassing epidemiological distributions, clinical phenotyping, and phylogenetic relationship analysis of (). Our study delineated distinct clinical presentations of JSF, and identified five laboratory indexes demonstrating significant associations with disease severity.

Memantine for the Treatment of Primary Negative Symptoms in Schizophrenia: A Meta-analysis of Randomized Controlled Trials.

Background: Memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist with favorable safety and side effect profiles. There is a growing body of evidence for memantine as an adjunctive therapy for the positive, negative, and cognitive symptoms of schizophrenia.

Objective: This meta-analysis examined the efficacy of memantine as an add-on to treatment with antipsychotic(s) for the primary negative symptoms (PNS) of schizophrenia.

Phloroglucinol Oligomers from as Novel Anti-Hantavirus Replication Agents.

Zoonotic viral diseases have continued to threaten global public health in recent decades, with rodent-borne viruses being significant contributors. Infection by rodent-carried hantaviruses (HV) can result in hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) in humans, with varying degrees of morbidity and mortality. However, no Food and Drug Administration (FDA) vaccines or therapeutics have been approved for the treatment of these diseases.

Gold-Enhanced Lanthanide Nanomedicine for Near-Infrared Photodynamic Therapy.

Cancer remains a major global health challenge due to its high morbidity and mortality rates. Traditional treatments, such as surgery, radiotherapy, and chemotherapy, have some clear limitations, which is why there is a growing need for innovative therapeutic modalities. One precise targeting of tumors with few side effects can be achieved through a promising modality called photodynamic therapy (PDT).

Aglycone Polyether Ionophores Affecting Actin Filaments as Broad-Spectrum Antiviral Agents.

RNA viruses have high mutation rates and constitute an increasing global risk. As the viral target approach to develop antiviral drugs is inadequate for responding to an increasing diversity of viruses, an urgent need exists for the development of new antivirals to prevent future outbreaks. Here, we show that aglycone ionophores maduramycin (Mad) and endusamycin (End) from are broadly virucidal against cytoplasmic replicated viruses, including Japanese encephalitis virus (JEV), rabies virus, hepatitis C virus, vesicular stomatitis virus, hantavirus, dengue virus, Zika virus, chikungunya virus, and SARS-CoV-2 in vitro.

Characterization of Novel WFS1 Variants in Three Diabetes Pedigrees.

Background: Mutations in the WFS1 gene are implicated in Wolfram syndrome (WS), Wolfram-like syndrome (WFLS), and maturity-onset diabetes of the young (MODY). Wolfram syndrome 1 (WFS1) is a diabetes-related gene encoding wolframin, a glycoprotein with nine transmembrane domains localized in the endoplasmic reticulum. However, the relationship between WFS1 mutations and their associated phenotypes remains incompletely understood, requiring additional patient data collection for further investigation.

Independent Association of Sleep Apnea-Specific Hypoxic Burden and Sleep Breathing Impairment Index with Thyroid Function in Obstructive Sleep Apnea: A Retrospective Study.

Purpose: This study aimed to explore thyroid function changes in patients with obstructive sleep apnea (OSA) and analyze the relationships among the sleep apnea-specific hypoxic burden (SASHB), the sleep breathing impairment index (SBII), and the function during different sleep stages.

Methods: This retrospective study included 452 patients with OSA who visited the Second Affiliated Hospital of Xi'an Jiaotong University between August 2017 and March 2024. The severity of OSA was evaluated, grouping patients by their apnea-hypopnea index (AHI), SASHB, SBII, and both SASHB and SBII during non-rapid eye movement (NREM) and rapid eye movement (REM) sleep.

Characterization of radiation electrophysiological properties of U87 cells induced by ionizing radiation and STAT3 inhibitors under microelectrode matrix sensor.

Background: Cellular impedance-sensing technology has not been widely used to determine ionizing radiation- induced apoptosis.

Method: A cellular electrical impedance-sensing system, including host software and a hardware system consisting of 29 microelectrode arrays, was constructed by us. After group processing, U87 cells were inoculated onto the electrode chips, and changes in the electrical impedance of each group of cells were monitored in real-time.

Quantification and clustering of immune states in hepatitis B Cirrhosis.

Background: Hepatitis B Cirrhosis, a severe progression of chronic Hepatitis B infection, requires a comprehensive understanding of the interplay among lymphocyte populations. This study aims to quantify and visualize the relationships among T cells, NK cells, and B cells to aid in assessing immune status, diagnosing the condition, and optimizing treatment strategies.

Methods: Peripheral blood samples were collected from 500 patients diagnosed with Hepatitis B Cirrhosis and 500 healthy controls.

Piezo1: the Potential Novel Target for Radiation-induced Liver Fibrosis by Regulating FAP + fibroblasts.

Radiation-induced liver fibrosis is a serious complication of radiotherapy in patients with liver cancer and is characterized by excessive deposition of the extracellular matrix (ECM). The activation of cancer-associated fibroblasts (CAFs) is central to this event. Piezo1 is a mechanoreceptor that is highly expressed in liver tissue and is closely related to the fibrotic process.

Long-gauge ultra-weak FBG strain sensor insensitive to structural defects: numerical simulation and experimental verification.

Strain monitoring of concrete structures with surface defects and material inhomogeneity is a challenge in the field of structural monitoring. In this paper, based on the characteristics of long-gauge structure and ultra-weak fiber Bragg grating (UWFBG) array, a strain sensor array with long distance and low requirement for structural surface flatness is proposed. The main measurement principle of the sensor is to convert the continuous strain of the measured structure into the average strain of each UWFBG, which can suppress the strain mutation phenomenon caused by structural defects.

PED-TRFIA: PEDV early on-site detection based on the time-resolved fluorescence ImmunoAssay.

Background: Porcine epidemic diarrhea virus (PEDV) infections have a significant impact on the global pig industry. To address the need for on-site detection of PEDV, the paper-based lateral flow immunoassay offers a promising approach, characterized by its simplicity of operation, rapid detection capabilities, and the elimination of expensive instrumentation. However, commonly used signal labels, such as colloidal gold nanoparticles and quantum dots have limitations in sensitivity.

An ultra-sensitive and point-of-care time-resolved fluorescence immunochromatographic platform for trace-level brucellosis antibody rapid on-site detection.

Brucellosis, a significant zoonotic disease, poses a threat to the animal husbandry industry as well as human health. To facilitate rapid and highly sensitive on-site brucellosis diagnostics, we have devised a time-resolved fluorescence immunochromatographic test strip (TRFICTS). TRFICTS employs time-resolved fluorescent microspheres (TRFMs) as both signal amplifiers and label reporters, achieving a sensitivity that is at least 12,800 times greater than the rose Bengal plate test (RBT) recommended by the World Organization for Animal Health (WOAH).

LncRNA MALAT1 Facilitates HIV-1 Replication by Upregulation of CHCHD2 and Downregulation of IFN-I Expression.

Long noncoding RNAs (lncRNAs) are effective regulators of both RNA and protein functions throughout cell biology, including viral replication. Emerging studies have shown that lncRNAs activate or inhibit the replication and latency of HIV-1 by regulating different cellular mechanisms. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is an oncogenic lncRNA required for paraspeckle integrity and has been proven to be linked to viral infection.

Analysis of the Disease Spectrum Characteristics of Inherited Metabolic Liver Diseases in Two Hepatology Specialist Hospitals in Beijing over the Past 20 Years.

Background And Aims: Inherited metabolic liver diseases (IMLDs) have complex etiologies and vary widely in clinical presentation, with a significant overall incidence. With the advancements in diagnostic and treatment technologies, an increasing number of children with inherited metabolic diseases are surviving into adolescence and adulthood. These advancements have improved our understanding of the IMLD disease spectrum and clinical outcomes.

Standing versus supine pelvic incidence in adult lumbar spondylolisthesis.

Background: Pelvic incidence (PI) has been considered a morphological spinopelvic parameter, but this has been questioned by some experts in recent years. There is little research on whether PI changes with posture in patients with spondylolisthesis. This study thus examined the variation of PI in patients with lumbar spondylolisthesis under different postures.

Development and Validation of Ultrasound Hemodynamic-based Prediction Models for Acute Kidney Injury After Renal Transplantation.

Rationale And Objectives: Acute kidney injury (AKI) post-renal transplantation often has a poor prognosis. This study aimed to identify patients with elevated risks of AKI after kidney transplantation.

Materials And Methods: A retrospective analysis was conducted on 422 patients who underwent kidney transplants from January 2020 to April 2023.