Fatal X-linked agammaglobulinemia complicated by septic shock: a case report and comprehensive review of novel BTK mutations.

X-linked agammaglobulinemia (XLA) is a rare primary immunodeficiency disorder caused by mutations in the Bruton tyrosine kinase (BTK) gene. This article presents a fatal case of a 20-year-old male with XLA complicated by septic shock due to infection, highlighting two novel BTK insertion mutations in exon 15 (NM_000061.3 exon15:c.

Development and validation of interpretable machine learning models for predicting AKI risk in patients treated with PD-1/PD-L1: a retrospective study.

Background: Anti-programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) immunotherapy has revolutionized cancer treatment. However, it can cause immune-related adverse events, including acute kidney injury (AKI). Such adverse events can interrupt treatment, affecting patient outcomes.

A new category for understanding the mechanisms of drug-induced kidney injury.

Medications contribute to about a quarter of acute kidney injury (AKI) cases among patients in hospitals. The impact of AKI is substantial on both families and society, and it has become a worldwide public health concern. Recently, a new framework for drug-induced acute kidney injury (DI-AKI) classification has been proposed.

The Regulatory Role of EvfG Through Coordinated Control of Flagellar Biosynthesis and Energy Metabolism in Porcine Extraintestinal Pathogenic (ExPEC).

In this study, we found that the deletion of the gene in the type VI secretion system (T6SS) gene cluster significantly affected the motility of porcine extraintestinal pathogenic (ExPEC) strain PCN033. Furthermore, the bacterial motility assay showed that Δ mutants exhibited reduced motility compared to the parental strain. Transmission electron microscopy (TEM) showed a significant reduction in the number of flagella in the mutant Δ when compared with PCN033.

Piezo1: the Potential Novel Target for Radiation-induced Liver Fibrosis by Regulating FAP + fibroblasts.

Radiation-induced liver fibrosis is a serious complication of radiotherapy in patients with liver cancer and is characterized by excessive deposition of the extracellular matrix (ECM). The activation of cancer-associated fibroblasts (CAFs) is central to this event. Piezo1 is a mechanoreceptor that is highly expressed in liver tissue and is closely related to the fibrotic process.

Reducing proton pump inhibitors overuse with an advisory, risk-based, context-aware electronic alert system: A controlled interrupted time series analysis.

Background: Proton pump inhibitors (PPI) are frequently overprescribed despite guidelines recommending cautious use. Electronic alert systems have shown potential in improving prescribing practices, but their effectiveness varies. This study evaluates a novel electronic alert system designed to reduce perioperative PPI overuse by leveraging real-time, patient-specific clinical data.

Downregulation of MGAT3 Promotes Benzo[]pyrene-Mediated Lung Carcinogenesis by Regulating Cell Invasion and Migration Activity.

Environmental chemical carcinogens are major factors in the induction of lung cancer, with benzo[]pyrene (B[]P) being one of the most widespread and highly carcinogenic among them. Although studies have reported that B[]P exerts its carcinogenic effects by causing mutations, inducing cytotoxicity, and inhibiting DNA synthesis, the early molecular regulatory events and mechanisms involved in B[]P-induced tumor initiation remain unclear. This study found that the MGAT3 gene was significantly downregulated in B[]P-induced mouse lung tumorigenesis, suggesting its important tumor-suppressive function.

Associations of Adverse Childhood Experiences and Lifestyle With Probable Eating Disorders in Chinese Adolescents: A Longitudinal Study.

Background: To examine the independent association of adverse childhood experiences (ACEs) and lifestyle patterns with incident probable eating disorders among adolescents, and to explore whether healthy lifestyle affects incident probable eating disorders that vary by ACEs exposure levels.

Methods: This longitudinal study included 7726 adolescents (mean [SD] age at baseline, 15.89 [0.

Organocatalytic Deoxygenative [3+2] Cycloaddition of -Hydroxyamides with Alkynes to Access Isoxazoles.

Although the transition-metal-catalyzed [3+2] cycloadditions to access isoxazoles have been described well, organocatalytic methods remain underdeveloped. Herein, we report the use of an organophosphine catalyst for the preparation of a series of isoxazoles with exceptional regioselectivity via the [3+2] cycloaddition of -hydroxyamides and alkynes. The scope of this organocatalytic transformation is broad, tolerating numerous functional groups and proceeding uniformly in an environmentally friendly, simple, and efficient manner.

The changes in zoological publication rates and focal subdisciplines between 1960 and 2022.

Since ancient times, zoology, as the branch of biology dealing with animals, has been a cornerstone of natural science and has developed substantially over the last century. We conducted a bibliometric analysis using structural topic modeling (STM) to determine changes in the representation of principal zoological subdisciplines in the literature between 1960 and 2022. We collated a corpus of 217 414 articles from 88 top-ranked zoology journals and identified three main fields: (i) ecology, (ii) evolution, and (iii) applied research.

Identification of PANoptosis-related predictors for prognosis and tumor microenvironment by multiomics analysis in glioma.

PANoptosis is a newly described inflammatory programmed cell death, that highlights coordination between pyroptosis, apoptosis and necroptosis. However, the functions of PANoptosis-related genes in glioma progression still remain to be explored. This study aims to identify PANoptosis-related predictors that may be utilized for prognosis prediction and development of new therapeutic targets.

Serum metabolomic profiles in BALB/c mice induced by infection.

Introduction: The protozoan parasite is the primary cause of human babesiosis. This parasite invades and multiplies inside red blood cells (RBCs), and infections differ significantly based on the age and immune competency of the host. The aim of this study was to investigate the use of serum metabolic profiling to identify systemic metabolic variations between -infected mice and noninfected controls.

Genome sequencing of biocontrol strain Bacillus amyloliquefaciens Bam1 and further analysis of its heavy metal resistance mechanism.

Plant growth-promoting rhizobacteria (PGPR) or Biocontrol strains inevitably encounter heavy metal excess stress during the product's processing and application. Bacillus amyloliquefaciens Bam1 was a potential biocontrol strain with strong heavy metal resistant ability. To understand its heavy metal resistance mechanism, the complete genome of Bam1 had been sequenced, and the comparative genomic analysis of Bam1 and FZB42, an industrialized PGPR and biocontrol strain with relatively lower heavy metal tolerance, was conducted.

Critical pore size for micropore filling in coal samples with different rank coals.

The objectives of this study were to explore the occurrence and migration of coalbed methane in coals of different ranks and reveal the microscopic reservoir space and the mechanism of coalbed methane. To meet these objectives, this study selected six coal samples of different coal ranks for low-pressure N2 adsorption experiments, explored the critical pore filling characteristics of packed N2 molecules in the coals, and analyzed the low-pressure N2 adsorption/desorption experimental isotherms using the DFT method and DA equation based on the micropore filling theory. Finally, the critical filling pressure and pore size range for micropore filling were determined, and the analysis results were verified by combining the Langmuir, DA, and BET equations.

Deltex E3 ubiquitin ligase 3 inhibits colorectal cancer cell growth and regulates cell cycle progression via upregulating E2F transcription factor 1.

Background: The mortality rate of colorectal cancer (CRC) remains high in developing countries. Interventions that can inhibit the proliferation of tumor cells represent promising strategies in CRC treatment. Deltex E3 ubiquitin ligase 3 (DTX3) plays an essential role in tumor development and may predict the outcome of cancer patients.

COVID-19 information overload and generation Z's social media discontinuance intention during the pandemic lockdown.

While previous research highlights the benefits of social media in times of a pandemic, this research focuses on the potential dark side of social media use among Generation Z (Gen Z) in the UK during the COVID-19 pandemic lockdown between March and May 2020. The study reveals that COVID-19 information overload through social media had a negative impact on Gen Z social media users' psychological well-being. Moreover, perceived information overload heightened both social media fatigue and fear of COVID-19, which, in turn, increased users' social media discontinuance intention.

ESM1 promotes triple-negative breast cancer cell proliferation through activating AKT/NF-κB/Cyclin D1 pathway.

Background: Triple-negative breast cancer (TNBC) is a subtype of invasive breast cancer that tests negative for PR, ER and excess HER2 protein. TNBC has a greater progression potential with poorer prognosis, compared with other types of breast cancer. Endothelial cell-specific molecule 1 (ESM1), also known as endocan, is overexpressed in various cancers including breast cancer and may play an important role in cancer progression.

Dirhodium(II)-catalyzed [3 + 2] cycloaddition of -arylaminocyclopropane with alkyne derivatives.

Dirhodium(II) complex-catalyzed [3 + 2] reactions between -arylaminocyclopropanes and alkyne derivatives are described. The cycloaddition products proved to be versatile synthetic intermediates. -Cyclic β-amino acids and derivatives thereof can be conveniently synthesized using this cycloaddition protocol.

New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis.

Background: Bacterial meningitis remains a big threat to the integrity of the central nervous system (CNS), despite the advancements in antimicrobial reagents. Escherichia coli is a bacterial pathogen that can disrupt the CNS function, especially in neonates. E.

Differential transcription profiles of long non-coding RNAs in primary human brain microvascular endothelial cells in response to meningitic Escherichia coli.

Accumulating studies have indicated the influence of long non-coding RNAs (lncRNAs) on various biological processes as well as disease development and progression. However, the lncRNAs involved in bacterial meningitis and their regulatory effects are largely unknown. By RNA-sequencing, the transcriptional profiles of host lncRNAs in primary human brain microvascular endothelial cells (hBMECs) in response to meningitic Escherichia coli were demonstrated.

EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis.

Background: Streptococcus suis serotype 2 (SS2) is an important zoonotic bacterial pathogen in both humans and animals, which can cause high morbidity and mortality. Meningitis is one of the major clinical manifestations of SS2 infection. However, the specific process of SS2 meningitis and its molecular mechanisms remain unclear.

Induction of VEGFA and Snail-1 by meningitic Escherichia coli mediates disruption of the blood-brain barrier.

Escherichia coli is the most common Gram-negative bacterium that possesses the ability to cause neonatal meningitis, which develops as circulating bacteria penetrate the blood-brain barrier (BBB). However, whether meningitic E. coli could induce disruption of the BBB and the underlying mechanisms are poorly understood.

[Evaluation of absolute alcohol treatment for renal cyst with percutaneous puncture and catheterization under ultrasonographic guidance].

Objective: To evaluate the effect of absolute alcohol treatment for renal cyst with percutaneous puncture and catheterization.

Methods: This report presented 64 cases of renal cysts, 34 cases were treated with percutaneous puncture (A group) and 30 cases with percutaneous catheterization (B group). According to the size, the cysts were divided into 2 groups, more than 6 cm in diameter and less than 6 cm in diameter.