Hydrological regime mediates stoichiometry regime and source-sink alternation in shallow lakes.

Shallow lakes are increasingly subjected to pronounced alterations in hydrological regimes and exacerbated nutrient stoichiometric imbalances due to climate change and anthropogenic factors. Understanding the interactions between watershed eco-hydrological processes and lake systems, particularly their impact on nutrient balance dynamics deserves further investigation. Employing seasonal-trend decomposition (STL), Copula modeling, and the Lindeman-Merenda-Gold (LMG) algorithm, this study systematically analyzed eco-hydrological processes in Poyang Lake basin and identified hydrological regime as the key factor governing lake nutrient balance.

Development and validation of interpretable machine learning models for predicting AKI risk in patients treated with PD-1/PD-L1: a retrospective study.

Background: Anti-programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) immunotherapy has revolutionized cancer treatment. However, it can cause immune-related adverse events, including acute kidney injury (AKI). Such adverse events can interrupt treatment, affecting patient outcomes.

Modulating the Coverage of Adsorbed Hydrogen via Hydrogen Spillover Enables Selective Electrocatalytic Hydrogenation of Phenol to Cyclohexanone.

Selective electrocatalytic hydrogenation (ECH) of phenol is a sustainable route to produce cyclohexanone, an industrially important feedstock for polymer synthesis. However, attaining high selectivity and faradaic efficiency (FE) for cyclohexanone remain challenging, owning to over-hydrogenation of phenol to cyclohexanol and competition of hydrogen evolution reaction (HER). Herein, by employing hydrogen spillover effect, we modulate adsorbed hydrogen species (H) coverage on Pt surface via migration to TiO in an anatase TiO-supported Pt catalyst.

Electro-oxidation of 5-hydroxymethylfurfural in a low-concentrated alkaline electrolyte by enhancing hydroxyl adsorption over a single-atom supported catalyst.

Electrocatalytic oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA), a sustainable strategy to produce bio-based plastic monomer, is always conducted in a high-concentration alkaline solution (1.0 mol L KOH) for high activity. However, such high concentration of alkali poses challenges including HMF degradation and high operation costs associated with product separation.

Eco-hydrological processes regulate lake riparian soil organic matter under dryness stress.

As transitional zone between terrestrial and aquatic ecosystems, the soil properties of riparian zones are deeply influenced by the eco-hydrological conditions of lakes. However, with the increasing frequent drought events caused by climate change, the response of riparian soil organic matter (SOM) dynamics to the eco-hydrological process of lakes under dryness stress is unclear. In this study, we utilized the field research, indoor experiments, ecoenzymatic stoichiometry model and data analysis to identify whether riparian SOM and enzyme activity were affected by dryness stress and determine the feedback relationship between soil biochemical properties and lake eco-hydrological processes.

Safranal alleviates pentetrazole-induced epileptic seizures in mice by inhibiting the NF-κB signaling pathway and mitochondrial-dependent apoptosis through GSK-3β inactivation.

Ethnopharmacological Relevance: Saffron, a traditional Chinese medicine, is derived from Crocus sativus L. stigmas and has been reported to possess neuroprotective properties and potentially contribute to the inhibition of apoptosis and inflammation. Safranal, a potent monothyral aldehyde, is a main component of saffron that has been reported to have antiepileptic activity.

Steering Selectivity in Electrocatalytic Furfural Reduction via Electrode-Electrolyte Interface Modification.

Electrocatalytic reduction of biomass-derived furfural (FF) represents a sustainable route to produce furfuryl alcohol (FA) and 2-methylfuran (MF) as a value-added chemical and a biofuel, respectively. However, achieving high selectivity for MF as well as tuning the selectivity between FA and MF within one reaction system remain challenging. Herein, we have reported an electrode-electrolyte interface modification strategy, enabling FA and MF selectivity steering under the same reaction conditions.

Transport dynamics of watershed discharged diffuse phosphorus pollution load to the lake in middle of Yangtze River Basin.

Diffuse pollution, including that in the lower and middle reaches of the Yangtze River, is the primary source of pollution in several agricultural watersheds globally. As the largest river basin in China, the Yangtze River Basin has suffered from total phosphorus (TP) pollution in the past decade owing to diffuse pollution and aquatic ecology destruction, especially in the midstream tributaries and mid-lower reaches of the lakes. However, the transport dynamics of diffuse pollutants, such as phosphorus (P) from land to water bodies have not been well evaluated, which is of great significance for quantifying nutrient loss and its impact on water bodies.

Electrochemical carbon-carbon coupling with enhanced activity and racemate stereoselectivity by microenvironment regulation.

Enzymes are characteristic of catalytic efficiency and specificity by maneuvering multiple components in concert at a confined nanoscale space. However, achieving such a configuration in artificial catalysts remains challenging. Herein, we report a microenvironment regulation strategy by modifying carbon paper with hexadecyltrimethylammonium cations, delivering electrochemical carbon-carbon coupling of benzaldehyde with enhanced activity and racemate stereoselectivity.

Rechargeable Biomass Battery for Electricity Storage/generation and Concurrent Valuable Chemicals Production.

The development of a rechargeable battery that can produce valuable chemicals in both electricity storage and generation processes holds great promise for increasing the electron economy and economic value. However, this battery has yet to be explored. Herein, we report a biomass flow battery that generates electricity while producing furoic acid, and store electricity while yielding furfuryl alcohol.

Comprehensive assessment of nine target prediction web services: which should we choose for target fishing?

Identification of potential targets for known bioactive compounds and novel synthetic analogs is of considerable significance. In silico target fishing (TF) has become an alternative strategy because of the expensive and laborious wet-lab experiments, explosive growth of bioactivity data and rapid development of high-throughput technologies. However, these TF methods are based on different algorithms, molecular representations and training datasets, which may lead to different results when predicting the same query molecules.

Phytoplankton biomass dynamics with diffuse terrestrial nutrients pollution discharge into bay.

Diffuse terrestrial pollution in bay area has important ecological impacts on coastal ecosystems. This study investigated spatiotemporal changes in N, P, and chlorophyll a (Chla) in the Jiaozhou Bay (JZB) and phytoplankton biomass dynamics under terrestrial nutrients loading. The results from SWAT (Soil and Water Assessment Tool) model demonstrated that the annual average total N (TN) and total P (TP) loading from main rivers were 3626.

Electrocatalytic synthesis of adipic acid coupled with H production enhanced by a ligand modification strategy.

Adipic acid is an important building block of polymers, and is commercially produced by thermo-catalytic oxidation of ketone-alcohol oil (a mixture of cyclohexanol and cyclohexanone). However, this process heavily relies on the use of corrosive nitric acid while releases nitrous oxide as a potent greenhouse gas. Herein, we report an electrocatalytic strategy for the oxidation of cyclohexanone to adipic acid coupled with H production over a nickel hydroxide (Ni(OH)) catalyst modified with sodium dodecyl sulfonate (SDS).

Electrocatalytic Hydrogenation of 5-Hydroxymethylfurfural Promoted by a Ru Cu Single-Atom Alloy Catalyst.

Electrochemical reduction of biomass-derived 5-hydroxymethylfurfural (HMF) represents an elegant route toward sustainable value-added chemicals production that circumvents the use of fossil fuel and hydrogen. However, the reaction efficiency is hampered by the high voltage and low activity of electrodes (Cu, Bi, Pb). Herein, we report a Ru Cu single-atom alloy (SAA) catalyst with isolated Ru atoms on Cu nanowires that exhibits an electrochemical reduction of HMF to 2,5-dihydroxymethylfuran (DHMF) with promoted productivity (0.

LncRNA PVT1 Promotes Cell Proliferation, Invasion, and Migration and Inhibits Cell Apoptosis by Phosphorylating YAP.

Gastric cancer (GC) as a serious global health problem is a threat to human longevity. Plasmacytoma variant translocation 1 (PVT1) participates in the formation and progression of various cancers, including GC. The aim of this study is to investigate the mechanism underlying the functions of PVT1 and explore a novel target for the diagnosis and treatment of GC.

Oncogenic LINC00857 recruits TFAP2C to elevate FAT1 expression in gastric cancer.

FAT atypical cadherin 1 (FAT1) is a mutant gene frequently found in human cancers and mainly accumulates at the plasma membrane of cancer cells. Emerging evidence has implicated FAT1 in the progression of gastric cancer (GC). This study intended to identify a regulatory network related to FAT1 in GC development.

Selective Electrooxidation of Biomass-Derived Alcohols to Aldehydes in a Neutral Medium: Promoted Water Dissociation over a Nickel-Oxide-Supported Ruthenium Single-Atom Catalyst.

The biomass-derived alcohol oxidation reaction (BDAOR) holds great promise for sustainable production of chemicals. However, selective electrooxidation of alcohols to value-added aldehyde compounds is still challenging. Herein, we report the electrocatalytic BDAORs to selectively produce aldehydes using single-atom ruthenium on nickel oxide (Ru -NiO) as a catalyst in the neutral medium.

Hydrogen production coupled with water and organic oxidation based on layered double hydroxides.

Hydrogen production via electrochemical water splitting is one of the most green and promising ways to produce clean energy and address resource crisis, but still suffers from low efficiency and high cost mainly due to the sluggish oxygen evolution reaction (OER) process. Alternatively, electrochemical hydrogen-evolution coupled with alternative oxidation (EHCO) has been proposed as a considerable strategy to improve hydrogen production efficiency combined with the production of high value-added chemicals. Although with these merits, high-efficient electrocatalysts are always needed in practical operation.

Tandem catalyzing the hydrodeoxygenation of 5-hydroxymethylfurfural over a NiFe intermetallic supported Pt single-atom site catalyst.

Single-atom site catalysts (SACs) have been used in multitudinous reactions delivering ultrahigh atom utilization and enhanced performance, but it is challenging for one single atom site to catalyze an intricate tandem reaction needing different reactive sites. Herein, we report a robust SAC with dual reactive sites of isolated Pt single atoms and the NiFe intermetallic support (Pt/NiFe IMC) for tandem catalyzing the hydrodeoxygenation of 5-hydroxymethylfurfural (5-HMF). It delivers a high catalytic performance with 99.

Selectively Upgrading Lignin Derivatives to Carboxylates through Electrochemical Oxidative C(OH)-C Bond Cleavage by a Mn-Doped Cobalt Oxyhydroxide Catalyst.

Oxidative cleavage of C(OH)-C bonds to afford carboxylates is of significant importance for the petrochemical industry and biomass valorization. Here we report an efficient electrochemical strategy for the selective upgrading of lignin derivatives to carboxylates by a manganese-doped cobalt oxyhydroxide (MnCoOOH) catalyst. A wide range of lignin-derived substrates with C(OH)-C or C(O)-C units undergo efficient cleavage to corresponding carboxylates in excellent yields (80-99 %) and operational stability (200 h).

microRNA-365 inhibits YAP through TLR4-mediated IRF3 phosphorylation and thereby alleviates gastric precancerous lesions.

Background: Gastric carcinoma (GC) is currently one of the most common malignant tumors of the digestive system, and gastric precancerous lesions play a vital role in studying the mechanism of GC. Multiple microRNAs (miRNAs) have been documented to be potential biomarkers to indicate progression of gastric precancerous lesions. In this study, we explained the anti-cancer effect of miR-365 in gastric precancerous lesions via regulation of the TLR4/IRF3/YAP/CDX2 axis.