Hydrological regime mediates stoichiometry regime and source-sink alternation in shallow lakes.

Shallow lakes are increasingly subjected to pronounced alterations in hydrological regimes and exacerbated nutrient stoichiometric imbalances due to climate change and anthropogenic factors. Understanding the interactions between watershed eco-hydrological processes and lake systems, particularly their impact on nutrient balance dynamics deserves further investigation. Employing seasonal-trend decomposition (STL), Copula modeling, and the Lindeman-Merenda-Gold (LMG) algorithm, this study systematically analyzed eco-hydrological processes in Poyang Lake basin and identified hydrological regime as the key factor governing lake nutrient balance.

U-FISH: a fluorescent spot detector for imaging-based spatial-omics analysis and AI-assisted FISH diagnosis.

Imaging-based spatial-omics advances biomedical discoveries with subcellular resolution and high sensitivity, but accurately identifying signal spots from diverse images remains challenging. We develop U-FISH, a deep learning method that enhances images for consistent spot detection across various spatial-omics data. We establish a comprehensive FISH image dataset from seven spatial-omics methods.

Image based subcellular mapping of the protein landscape of SARS-CoV-2 infected cells for target-centric drug repurposing.

The COVID-19 pandemic has resulted in millions of deaths and affected socioeconomic structure worldwide and the search for new antivirals and treatments are still ongoing. In the search for new drug targets and to increase our understanding of the disease, we applied large-scale immunofluorescence profiling to explore host cell response to SARS-CoV-2 infection. Among the 602 host proteins studied in this host response profiling, changes in abundance and subcellular localization were observed for 97 proteins, with 45 proteins showing increased abundance and 10 reduced abundance.

A rare pediatric case of Li-Fraumeni syndrome presenting with virilization symptoms and dual primary malignancies on magnetic resonance imaging and [F]-fluorodeoxyglucose positron emission tomography/computed tomography.

This case report describes a 19-month-old boy presenting with macropenis, increased stature, and deep voice, who was diagnosed with concurrent choroid plexus carcinoma in the right lateral ventricle and left adrenocortical carcinoma. Subsequent germline testing revealed pathogenic TP53 mutations, confirming a diagnosis of Li-Fraumeni syndrome. Li-Fraumeni syndrome with primary manifestations of macropenis and accelerated linear growth has rarely been documented in the medical literature.

New molecular diagnostic targets for Avibacterium paragallinarum and a set of single-plex and multiplex qPCR methods for the rapid differential diagnosis of Mycoplasma gallisepticum, Mycoplasma synoviae, and Avibacterium paragallinarum.

Mycoplasma gallisepticum (MG), Mycoplasma synoviae (MS), and Avibacterium paragallinarum (APG) are respiratory-borne bacterial pathogens that severely harm the poultry industry. The clinical symptoms caused by them share many similarities, such as respiratory disease, growth retardation, and decreased egg production. They are not suitable for rapid diagnosis through isolation and culture and often need to detect nucleic acids or antibodies for differential diagnosis.

Spatiotemporal variations and risk assessment of fungicides in the Dongjiang River Basin: Tributaries as contamination hotspots.

Although considerable research has explored fungicide patterns in major rivers, the role of tributaries remains overlooked. This study investigated the spatiotemporal distribution, and ecological risks of seven target fungicides in the Dongjiang River Basin of southeastern China, focusing on both the main stream and tributaries. All fungicides were detected in 100 % of water samples, with total concentrations ranging from 7.

Self-Healing Triboelectric Sensors with Enhanced Durability for Gesture Recognition and Human-Machine Interaction.

The emergence of triboelectric nanogenerators (TENGs) has significantly developed the landscape of wearable electronics. However, the durability and self-healing capabilities of TENGs remain challenging. Herein, a self-healing triboelectric nanogenerator (SH-TENG) is proposed, utilizing a flexible and biocompatible glycerin and hydroxyethyl cellulose (GHEC), which is synthesized via a one-pot method.

Post-COVID-19 severe pneumonia in a non-HIV and immunocompetent patient: A case report and literature review.

is a ubiquitous opportunistic fungus that can cause life-threatening pneumonia. The clinical manifestations of pneumonia caused by severe acute respiratory syndrome coronavirus 2 and are similar, posing a significant challenge in the diagnosis of pneumonia or coronavirus disease 2019. Herein, we report a case of pneumonia diagnosed through bronchoalveolar lavage and sputum smear analyses.

RhTSH in aiding dynamic assessment in patients with differentiated thyroid Cancer.

Purpose: To evaluate the efficacy of a novel recombinant human thyroid-stimulating hormone (ZGrhTSH) as an alternative to thyroid hormone withdrawal (THW) in dynamic assessment of DTC patients.

Methods: This phase 3, open-label, multicenter trial, conducted across 27 sites in China, employed a self-controlled design to enroll patients. Eligible patients had previously undergone total or near-total thyroidectomy, with or without RAI therapy.

Mechanochemical degradation of UV-328 by solid oxidative reagents: Peroxydisulfate vs. peroxymonosulfate.

Peroxydisulfate (PDS) and peroxymonosulfate (PMS) are crucial oxidative additives for mechanochemical (MC) treatment of persistent organic pollutants and contaminated soils. However, their differences between solid-phase mechanisms remain unclear. This study found that both PDS and PMS achieved comparable 2-(2H-Benzotriazol-2-yl)-4,6-bis(2-methyl-2-butanyl)phenol (UV-328) degradation (91.

Erratum: Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion.

This corrects the article 10.3791/66440.

Cell shapes decode molecular phenotypes in image-based spatial proteomics.

The diversity of cellular and tissue structures can arise from a few basic cell shapes, which undergo various transformations based on biophysical constraints on cytoskeletal organization. While cellular geometry has been linked with selected biological processes such as polarity, signaling or morphogenesis, the orchestration of the whole proteome in association to cell shape is still poorly understood. In this study, using more than 1 million images of single cells stained for 11,998 proteins across 10 cell lines in the Human Protein Atlas database, we performed an integrated analysis of organelle, pathway and single protein levels in association to a 2D cellular shapespace.

The predictive value of perirenal fat thickness in systemic inflammatory response syndrome after percutaneous nephrolithotomy.

Objective: It was hypothesized that perirenal fat (PRF) might be associated with systemic inflammatory response syndrome (SIRS) after percutaneous nephrolithotomy (PCNL). The aim of this study was to investigate risk factors, including perirenal fat thickness (PRFT), that may contribute to SIRS after PCNL.

Methods: 169 patients with unilateral renal stones who underwent PCNL at our institution between January 2020 and December 2023 were retrospectively included.

Plantar Biomechanic Characteristics After High-Intensity Exercise in Young Runners With High-Arched Feet.

This study aimed to evaluate the plantar biomechanics in high-arched (HA) young runners after they performed a high-intensity (HI) ergometer exercise. Eighteen collegiate runners with HA feet (age = 19.9 ± 0.

Family consent to deceased organ donation in China: a participatory qualitative study.

Background: Organ donation improves patient survival and quality of life, yet family refusal is a major barrier. This study aimed to explore the role of family discussions in shaping attitudes and decisions about organ donation in China, while also examining the influencing factors at the individual, family, community and societal levels.

Method: Participatory interviews with family members were conducted based on the social-ecological model (SEM).

Crucial role of the Pht1;4 Gene in Sb(V) tolerance and uptake in Arabidopsis thaliana.

There has been increasing awareness of the risks of antimony (Sb) in the environment, but the process of Sb(V) absorption by plants and its effects on plants remain unclear. This study focused on four independent T-DNA insertion mutant strains of Arabidopsis thaliana and wild-type (WT) plants to investigate their tolerance, uptake, and response to Sb(V). Compared with those of the WT, the Pht1;4 knockout mutant M-P4 presented greater tolerance to Sb(V) and lower absorption levels.

The neglected role of forest eco-hydrological process representation in regulating watershed nitrogen loss.

Forest eco-hydrological functions are relevant to multiple water and ecosystem services essential for watershed management. However, these have received limited attention compared to pollution sources such as farming and fossil fuel power plants. In this study, we systematically analyzed the characteristics, pathways, and sources of nitrogen (N) loss in a forested watershed using a combination of field sampling, remote sensing, and a modified Soil and Water Assessment Tool (SWAT) model with enhanced forest eco-hydrological representation.

Millimetre-scale bioresorbable optoelectronic systems for electrotherapy.

Temporary pacemakers are essential for the care of patients with short-lived bradycardia in post-operative and other settings. Conventional devices require invasive open-heart surgery or less invasive endovascular surgery, both of which are challenging for paediatric and adult patients. Other complications include risks of infections, lacerations and perforations of the myocardium, and of displacements of external power supplies and control systems.

Seasonal dynamics, sources, and ecological risk of estrogens in a freeze-thaw basin: Implications for aquatic ecosystems.

Estrogens have attracted extensive attention because of their harmful effects on organisms such as endocrine disturbance and reproductive toxicity. This study investigated the spatial and temporal distribution and ecological risk assessment of 7 targeted estrogens in surface water in a seasonal freeze-thaw basin. It mainly includes three natural estrogens, estrone (E1), 17β-estradiol (E2) and estriol (E3), two synthetic estrogens, 17α-ethinylestradiol (EE2) and diethylstilbestrol (DES), and two phenolic environmental estrogens, bisphenol-A (BPA) and nonylphenol (NP).

Key mechanisms of angiogenesis in the infarct core: association of macrophage infiltration with venogenesis.

Angiogenesis in the ischemic penumbra compensates for microcirculatory dysfunction and promotes neuronal plasticity after stroke. However, the current understanding may be highly biased because the contribution of veins to angiogenesis has been overlooked. This study revealed that the remodeling processes of veins differ from those of arteries after ischemia.

Seasonal variations and intercorrelations of polycyclic aromatic hydrocarbons, heavy metals and environmentally persistent free radicals in PM in Ulaanbaatar, Mongolia.

Simulated combustion experiments have identified polycyclic aromatic hydrocarbons (PAHs) and metal oxides as critical species in the formation of environmental persistent free radicals (EPFRs). However, little evidence exists regarding the interactions among PAHs, metals, and EPFRs in the real atmosphere. In this study, we collected PM samples in downtown Ulaanbaatar in four seasons from 2020 to 2021, and analyzed the seasonal variations of 16 PAHs, 14 heavy metals and EPFRs in PM.

Advancement Opportunities and Endeavor of Innovative Targeted Therapies for Small Cell Lung Cancer.

Small cell lung cancer (SCLC) is an intractable disease with rapid progression and high mortality, presenting a persistent obstacle impeding clinical management. Although recent advancements in immunotherapy have enhanced the response rates of platinum-based chemotherapy regimens, the emergence of acquired resistance invariably leads to recurrence and metastasis. Consequently, there is an urgent necessity to explore novel therapeutic targets and optimize existing treatment strategies.

The influence of baseline platelet on mortality risk in stroke and cancer patients: a cross-sectional analysis of the NHANES database.

Background: Platelet count and function may be closely related to survival and prognosis of stroke and cancer. However, little is known on the impact of platelet count on the patients with a history of stroke and cancer. This study aimed to examine the association between baseline platelet level and all-cause mortality in this population using a cross-sectional analysis.

Involving degradation products provides a new perspective of diffuse pollution assessment of atrazine with a modified mass balance approach.

Atrazine (ATR) is an endocrine disruptor known for its persistence and mobility. While the diffuse characteristics and potential risks of ATR have been extensively studied, its transregional migration and degradation characteristics have received less attention. In this study, a modified mass balance approach considering the diffuse source (DS), tributaries, water resource usage, degradation, adsorption, and evaporation was developed based on the traditional mass balance framework and field sampling to estimate the DS fluxes of ATR in a large river basin.

Bridging the gap: Integrating cutting-edge techniques into biological imaging with deepImageJ.

This manuscript showcases the latest advancements in deepImageJ, a pivotal Fiji/ImageJ plugin for bioimage analysis in life sciences. The plugin, known for its user-friendly interface, facilitates the application of diverse pre-trained convolutional neural networks to custom data. The manuscript demonstrates several deepImageJ capabilities, particularly in deploying complex pipelines, three-dimensional (3D) image analysis, and processing large images.