Cu-Mn Bimetallic Mesoporous Silica Nanosonosensitizers Enable Oxeiptosis-Mediated Sonodynamic Therapy for Ultra-Minimally Invasive Treatment of Benign Prostatic Hyperplasia.

Benign prostatic hyperplasia (BPH) presents a significant clinical challenge, with conventional therapies carrying substantial risks, including urinary retention, sexual dysfunction, and prolonged recovery. To address the urgent need for safer, ultra-minimally invasive alternatives, we developed a sonosensitizing nanoplatform using copper-manganese-doped mesoporous silica nanoparticles (Cu-Mn@SiO) for ultrasound-induced sonodynamic therapy (SDT). Here, we demonstrate that this innovative strategy provides highly effective and precisely targeted therapy for BPH.

One-Step Preparation of Magnetic Co/N-Containing Carbon for Efficient Chromium Removal: Performance and Mechanism.

Magnetic nitrogen-containing carbon (Co/NC) is prepared by one-step carbonization of ZIF-67, reducing the pore blockage caused by the extra addition of magnetic particles and element doping. Co/NC-800-2 has a relatively high specific surface area, abundant nitrogen-containing functional groups, and sufficient magnetization intensity, achieving a Cr(VI) adsorption capacity of 85.46 mg·g at 30 °C.

SFB flagellin mediates cell adhesion, endocytosis and immune regulation in germ-free mice.

Introduction: Segmented filamentous bacteria (SFB) colonization dynamics are crucial for host immune regulation. Given this, the present study specifically examined the functions of SFB flagellin in bacterial adhesion, cellular internalization, and immune modulation.

Methods: and were engineered to express murine and rat SFB flagellin genes.

Quantitative histopathologic profiling of arterial dissection-related thrombi in acute ischemic stroke: etiological comparisons.

Introduction: Arterial dissection is an important etiology of stroke in young adults and may demonstrate distinct thrombus characteristics. While most studies have focused on compositional differences between cardioembolic (CE) and non-cardioembolic thrombi, systematic analyses of dissection-related thrombi remain scarce. This study characterized the compositions of dissection thrombi, compared them with those of non-dissection thrombi, and explored compositional variations among stroke etiologies.

Targeting YES1 enhances the efficacy of chemotherapy, targeted therapy and Onco-immunotherapy.

YES1 (Yamaguchi sarcoma virus homolog 1), a non-receptor tyrosine kinase of the SRC family (SFK), has been abnormally amplified or mutated in several types of solid tumors. The alteration of YES1 impacted multiple biological processes, including promoting tumor progression and metastasis, especially, producing cancer therapy resistance via bypass pathways. Thus, YES1 can serve as a druggable target to overcome drug resistance and suppress tumor growth.

Mechanisms of Thickness-Dependent Nonlinear Optical Processes and Ultrafast Dynamics in NbOCl.

NbOCl has garnered interest owing to its second-order nonlinear optical properties, but the influence of thickness on its third-harmonic generation (THG) and excited-state dynamics has not been fully investigated. Here, mechanically exfoliated NbOCl flakes were found to produce THG and second-harmonic generation (SHG), simultaneously, and to show a nonmonotonic dependence on sample thickness. The increase in thickness leads to a decrease in the bandgap.

Assessing the Potential Distribution of the Traditional Chinese Medicinal Plant in China Under Climate Change: A Biomod2 Ensemble Model-Based Study.

, a valuable Chinese medicinal plant, faces habitat shifts under climate change. In order to better utilize the medicinal properties of and conduct further investigations, this study utilized the Biomod2 ensemble model to predict and analyze the potential expansion and contraction of suitable habitat areas for in China under changing climatic and environmental conditions. The results showed that, compared to the pre-screened models, the ensemble model significantly improved the prediction accuracy.

Assessment of Fish Community Structure and Invasion Risk in Xinglin Bay, China.

A total of 32 fish species were detected in Xinglin Bay using a combination of environmental DNA metabarcoding (eDNA) and traditional morphological survey methods (TSM), covering eight orders, fifteen families, and twenty-six genera. The dominant order was Perciformes, accounting for 43.75% of the total species.

33 Unresolved Questions in Nanoscience and Nanotechnology.

Significant advances in science and engineering often emerge at the intersections of disciplines. Nanoscience and nanotechnology are inherently interdisciplinary, uniting researchers from chemistry, physics, biology, medicine, materials science, and engineering. This convergence has fostered novel ways of thinking and enabled the development of materials, tools, and technologies that have transformed both basic and applied research, as well as how we address critical societal challenges.

[Three new chalcone C-glycosides from Carthami Flos].

The chemical components of Carthami Flos were investigated by using macroporous resin, silica gel column chromatography, reversed-phase octadecylsilane(ODS) column chromatography, Sephadex LH-20, and semi-preparative high-performance liquid chromatography(HPLC). The planar structures of the compounds were established based on their physicochemical properties and ultraviolet-visible(UV-Vis), infrared(IR), high-resolution electrospray ionization mass spectrometry(HR-ESI-MS), and nuclear magnetic resonance(NMR) spectroscopic technology. The absolute configurations were determined by comparing the calculated and experimental electronic circular dichroism(ECD).

["Kidney deficiency-vessel impairment" as core pathogenesis of panvascular diseases: theoretical and clinical perspectives].

Panvascular disease is a complex systemic disorder. Research by our team has established "kidney deficiency-vascular impairment" as its core pathogenesis. Consequently, we developed a three-tiered progressive prevention and treatment strategy: early prevention phase: focuses on tonifying the kidney and reducing turbidity; mid-term control phase: focuses on tonifying the kidney and stabilizing plaque; late recovery phase: focuses on tonifying the kidney and unblocking collaterals.

A magnetic flower-like hollow vinyl-functionalized covalent organic framework nanocomposite for efficient enrichment of fifteen organophosphate tri-esters in environmental water samples.

Background: Organophosphate tri-esters (tri-OPEs), widely used flame retardants, include alkyl-, halogenated-, and aryl-substituted types with distinct physicochemical properties. They may readily enter the ambient environment through volatilization, mechanical abrasion, and dissolution mechanisms occurring throughout the product lifecycle. To date, a range of monitoring methodologies incorporating sample pretreatment techniques have been developed to characterize the environmental distribution of tri-OPEs.

The impact of school empowerment on the mental health of left-behind children in china: exploring the mediating role of psychological empowerment.

Background: The mental health of left-behind children in China has become a core societal concern. This study examines the impact of school empowerment on the mental health of left-behind children through the internal pathway of psychological empowerment, aiming to address the gap in existing research on the "environment-psychology" interaction mechanism.

Methods: A questionnaire survey was conducted among 317 left-behind children in Yunnan Province, China.

Machine learning analysis reveals tumor heterogeneity and stromal-immune niches in breast cancer.

Breast cancer is a leading cause of cancer-related mortality, with tumor heterogeneity and drug resistance posing significant challenges to treatment. We integrated single-cell RNA sequencing, spatial transcriptomics, and bulk RNA-seq deconvolution to analyze BRCA samples. Our analysis identified 15 major cell clusters, including neoplastic epithelial, immune, stromal, and endothelial populations.

A copper-based single-atom material effectively controls plant diseases with nearly zero soil residue and low phytotoxicity.

A growing population necessitates the development of sustainable agriculture, which requires achieving atom economy in pesticide delivery, fertilization, and so on. To this end, we focus on single-atom materials (SAMs) to enhance atom utilization within agricultural systems. In this study, we report a novel pesticide for plants, a single-atom copper (Cu) formulation, by employing a precipitation-equilibrium-driven (K-driven) method to anchor Cu onto a calcium carbonate (CaCO) carrier.

Diagnostic performance of shear wave elastography and contrast-enhanced ultrasound in evaluating the pathological response of breast cancer patients to neoadjuvant chemotherapy: a meta-analysis.

Background: Neoadjuvant chemotherapy (NAC) is administered to specific subgroups of breast cancer patients to improve clinical outcomes. Achieving a pathological complete response (pCR) is strongly associated with improved survival. This meta-analysis systematically evaluated the diagnostic performance of shear wave elastography (SWE) and contrast-enhanced ultrasound (CEUS) in predicting the pathological response of breast cancer patients to NAC.

Movable Oil Saturation Quantitation Evaluation in Shale Oil: Novel Insights from Distribution.

The quantification of movable shale oil is crucial for the effective exploration and development of shale oil resources. Nuclear magnetic resonance (NMR), a nondestructive and noninvasive technique, has become an indispensable tool for evaluating movable oil saturation. However, the small core sizes, high-frequency instrumentation, costly measurements, and significant losses of light hydrocarbons pose substantial challenges in accurately assessing movable oil.

Multimodal MRI characterization of brain injury in heatstroke: integrating gray matter morphometry and advanced diffusion tractometry.

Objective: To investigate gray-white matter injury in heatstroke using multimodal MRI, and precisely localize damaged white matter segments via automated fiber quantification (AFQ) with clinical correlation.

Results: Compared with the healthy control group, VBM revealed reduced volume in bilateral cerebellar anterior lobes and left fusiform gyrus. TBSS showed widespread white matter abnormalities.

Aquilaria sinensis MYB-Like Transcription Factor AsMYB1 Promotes 2-(2-Phenylethyl)Chromone Biosynthesis Through Interacting With 14-3-3 Family Protein AsGRF1.

2-(2-Phenylethyl)chromones (PECs) are the primary constituents of agarwood, a valuable aromatic resin widely used in traditional oriental medicine and incense production, exhibiting diverse pharmacological activities. While we have previously reported a polyketide synthase (AsPECPS) playing a crucial role in the biosynthesis of PECs in agarwood, the intrinsic regulatory mechanisms underlying PEC biosynthesis remain largely elusive. Here, we successfully characterised a new 1R-subtype myeloblastosis (MYB) transcription factor (AsMYB1) from Aquilaria sinensis whose expression is significantly induced under salt treatment.

cAMP-induced Sporidiobolus pararoseus Y16 alleviates postharvest sour rot of grapes and the potential action mechanisms.

Sour rot caused by Aspergillus carbonarius is a common postharvest disease of grapes, which leads to the declined fruit quality and serious economic losses of grape industry. In this study, we investigated the control effectiveness of Sporidiobolus pararoseus Y16 induced by cyclic adenosine monophosphate (cAMP) against postharvest sour rot of grapes, and explored the potential action mechanisms. The outcomes presented that S.

AUPRC: a metric for evaluating the performance of in-silico perturbation methods in identifying differentially expressed genes.

In silico perturbation models, computational methods that can predict cellular responses to perturbations, present an opportunity to reduce the need for costly and time-intensive in vitro experiments. Many recently proposed models predict high-dimensional cellular responses, such as gene or protein expression to perturbations such as gene knockout or drugs. However, evaluating in silico performance has largely relied on metrics such as $R^{2}$, which assess overall prediction accuracy but fail to capture biologically significant outcomes like the identification of differentially expressed (DE) genes.

11-Methoxytabersonine Induces Ferroptosis in Triple-Negative Breast Cancer via YY1-CDKL1-GPX4 Axis.

The 11-Methoxytabersonine (11-MT), a monoterpenoid-indole alkaloid isolated from the leaves of Melodinus henryi, has shown promising therapeutic potential against triple-negative breast cancer (TNBC). This study aimed to evaluate the anti-tumor efficacy of 11-MT and to elucidate its underlying molecular mechanisms in the context of TNBC. The in vitro anti-cancer effects of 11-MT were assessed using Cell Counting Kit-8 (CCK-8), colony formation assays, and flow cytometry.

Reduced Fracture Anisotropy yet Enhanced Deformability of Multilayer MoS Straps.

The mechanical properties of two-dimensional transition metal dichalcogenides (2D TMDs), molybdenum disulfide (MoS) in particular, are crucial for their reliable applications in advanced flexible electronics and phototransistors. This study systematically investigated the influence of geometrical factors on MoS's mechanical property and fracture behavior by performing in situ tensile tests on submicroscale strap specimens with different thicknesses ranging from 7 to 95 nm inside SEM and TEM. Results demonstrated a strong correlation between the apparent fracture strength and Young's modulus of MoS and the specimen thickness, where thinner samples exhibited a significantly elevated fracture strength and Young's modulus.