Mechanisms of Thickness-Dependent Nonlinear Optical Processes and Ultrafast Dynamics in NbOCl.

NbOCl has garnered interest owing to its second-order nonlinear optical properties, but the influence of thickness on its third-harmonic generation (THG) and excited-state dynamics has not been fully investigated. Here, mechanically exfoliated NbOCl flakes were found to produce THG and second-harmonic generation (SHG), simultaneously, and to show a nonmonotonic dependence on sample thickness. The increase in thickness leads to a decrease in the bandgap.

Tumor Microenvironment-Activated Fe-Doped Dendritic Mesoporous Organosilica Nanocomposites as Ferroptosis Inducers for Enhanced Immunotherapy.

Dendritic mesoporous organosilica (DMOS) nanoparticles are widely used to transport therapeutic agents to cancer sites and rapidly release them owing to their rapid biodegradability in the tumor microenvironment (TME). However, the role of these DMOS nanoparticles as nanocarriers is limited, and their applications remain relatively simple. In this study, Fe-doped dendritic mesoporous organosilica (Fe-DMOS) nanoparticles are designed as a new type of ferroptosis inducer and are combined with sodium hyaluronate-modified calcium peroxide to form TME-responsive nanocomposites.

Integrative machine learning models predict prostate cancer diagnosis and biochemical recurrence risk: Advancing precision oncology.

Prostate cancer (PCa) ranks among the most prevalent cancers in men worldwide. Biochemical recurrence (BCR) presents a major clinical challenge in PCa management, with significant prognostic heterogeneity observed among patients post-recurrence. This study aimed to develop machine learning models for predicting both the diagnosis and prognosis of PCa patients.

Resolving Nanoscale Phases Purity and Lattice Strain in Multi-Cationic Perovskite Solar Cells for Enhanced Stability.

A-site cations in organic-inorganic lead halide perovskites (OLHPs) critically stabilize phases, inhibit ion migration, and reinforce interfaces, ensuring device operational stability. However, the mechanistic links between A-cation engineering and phase purity, and lattice strain in determining perovskite solar cell stability remain elusive. Here, optimized hybrid perovskite A-site cation ratios (FA:70-90%, MA:5-15%, Cs:5-25%) are achieved using an orthogonal L (3^) array, reducing experimental permutations by 66.

Localized surface plasmon resonance induced spatial self-phase modulation of CuS in the near-infrared region.

Generating controllable spatial self-phase modulation (SSPM), such as self-diffraction, is a challenge in the near-infrared (NIR) band. CuS nanoplates (NPs) and their heterojunction nanoplates (HNPs) were confirmed to enable enhancement SSPM between 800 nm and 1550 nm, as p-type semiconductors with localized surface plasmon resonance (LSPR). CuS NPs with particle sizes of 36 nm and 53 nm both exhibit this enhancement, dominated by LSPR-induced hole interband transitions, proofed by the results of open aperture (OA) Z-scan and transient absorption (TA) spectroscopy.

Study of the Herbicidal Potential and Infestation Mechanism of JZ-5 on Six Broadleaved Weeds.

Weeds compete with crops for resources, posing multiple negative impacts for agricultural production systems and triggering degradation of ecosystem services (e.g., alterations in the soil microbial community structure).

Correlation of senescence-related gene FEN1 on neuroblastoma progression and cisplatin chemotherapy sensitivity.

Objective: Neuroblastoma (NB) is frequently associated with high-risk pediatric cases that demonstrate limited response to cisplatin, contributing to a poor prognosis. Recent studies have explored the role of tumor cell senescence in increasing sensitivity to this chemotherapy agent. This study aims to identify genes related to cell senescence in children diagnosed with NB, evaluate their influence on cisplatin sensitivity, and investigate potential strategies to enhance the efficacy of chemotherapy.

Integrative analyses of metabolome and transcriptome identifies the potential mechanism of Aureobasidium pullulans PA-2 inhibiting Chenopodium album L. growth.

Background: Chenopodium album L. is one of the most important threat weeds affecting crops productivity in the fields. Control of this weed is complex and currently, lies in the use of chemical methods, although this method has not proven to be fully effective.

Mutagenesis and transcriptomic analysis of a highly pathogenic Alternaria alternata DT-DYLC against Chenopodium album L.

The development of bioherbicides is often limited by low herbicidal activity. To address this challenge, we enhanced the virulence of Alternaria alternata DT-DYLC, a biocontrol strain against Chenopodium album L., through combined UV and nitrite mutagenesis.

Risk assessment for the bladder carcinogenesis of 4-aminobiphenyl in smokers: A source-to-outcome study.

4-aminobiphenyl (4-ABP) is widely distributed in the environment and is implicated in the pathogenesis of cancer. This study aims to clarify the environmental and toxicological science of 4-ABP, which are currently unexplored. By searching articles from PubMed, Web of Science, and MEDLINE, we established an aggregate exposure pathway (AEP) framework that demonstrated the presence of 4-ABP in the cigarette smoke.

Contrasting sulfur isotope signatures in two arid basins separated by the Qilian mountains.

Global climate variations have intensified the transformation of salt lakes and saline-alkali playas in arid regions into major sources of saline-alkali dust storms, actively influencing atmospheric circulation and climate dynamics. This study focuses on two geographically close but environmentally distinct regions, the Qaidam Basin and the Alxa Plateau, situated on opposite sides of the Qilian Mountains. Surface salts were collected from both areas and analyzed for ion composition and sulfur isotope characteristics.

ALDOC promotes neuroblastoma progression and modulates sensitivity to chemotherapy drugs by enhancing aerobic glycolysis.

Introduction: Neuroblastoma (NB), a malignant extracranial solid tumor originating from the sympathetic nervous system, exhibits poor prognosis in high-risk cases, with a 5-year overall survival rate below 50%. Glycolysis has been implicated in NB pathogenesis, and targeting glycolysis-related pathways shows therapeutic potential. This study investigates the role of the glycolysis-associated gene ALDOC in NB pathogenesis and its impact on chemotherapy sensitivity.

Mapping the knowledge domains of literature on hepatocellular carcinoma and liver failure: a bibliometric approach.

Background: Hepatocellular carcinoma (HCC) accounts for 75-85% of primary liver cancers, with its incidence continually rising, posing a threat to socio-economic development. Currently, liver resection is the standard treatment for HCC. However, post-hepatectomy liver failure (PHLF) is a severe and formidable postoperative complication that increases patients' medical expenses and mortality risk.

Selection and validation of stable reference genes in potato infected by Pectobacterium atrosepticum using real-time quantitative PCR.

Potato blackleg disease is caused by Pectobacterium atrosepticum, can seriously destroy potatoes' growth and development. To accurately evaluate the expression levels of genes involved in potato (Solanum tuberosum) responses to P. atrosepticum infection, seven candidate reference genes (EF1α, eIF5A3, Tubulin, Ubiquitin, GAPDH, Actin, and CYP3) were systematically assessed for their expression stability at 1, 3, and 5 days after inoculation (dai) using the geNorm, NormFinder, BestKeeper, ∆Ct, and RefFinder algorithms.

Orientation-Related Giant Third Harmonics Generation in Quasi-One-Dimensional ZrS Crystals.

Exploring strong nonlinear optical (NLO) response and high NLO anisotropy materials is crucial for nonlinear nanophotonic devices with a polarization function. Here, we report a quasi-one-dimensional (quasi-1D) ZrS nanobelt exhibiting ultrastrong third harmonics generation (THG) with a maximum third-order susceptibility (χ) of 67.9 × 10 m/V for a 24.

New use of an old drug: mechanism of oseltamivir phosphate inhibiting liver cancer through regulation of lipophagy via NEU1.

Background: Neuraminidase-1 (NEU1) is an enzyme that breaks down sialic acids on glycoproteins and glycolipids. Aberrant expression of NEU1 has been linked to the progression of numerous malignancies, including liver cancer. Oseltamivir phosphate (OP) is a drug used to treat and prevent influenza, which specifically inhibits NEU1.

Understanding the relationship between cuproptosis and the development of hepatocellular carcinoma: implications for targeted therapies.

Hepatocellular carcinoma (HCC) presents a significant global health challenge, particularly in developing countries where its incidence is markedly elevated. Despite advancements in treatment modalities, the high malignancy, metastatic potential, and drug resistance associated with HCC contribute to poor clinical outcomes, underscoring the necessity for a more profound understanding of its pathogenesis. This review meticulously examines the role of copper apoptosis, a novel form of programmed cell death linked to dysregulated copper metabolism, in the development and progression of HCC.

Herbicidal activity and crop safety of Alternaria alternata DT-XRKA and Fusarium avenaceum DT-QKBD004A.

Elsholtzia densa and Avena fatua are known as two of the most aggressive weeds, causing severe economic, environmental, human and animal health problems in China and around the world. In this study, seven strains of pathogenic fungi (i.e.

SIGLEC1 has the potential to be an immune-related prognostic indicator in colon adenocarcinoma: a study based on transcriptomic data and Mendelian randomization analysis.

Background: Colonic adenocarcinoma (COAD) is the most common pathological type of colon cancer. Tumor microenvironment (TME) plays an important role in the occurrence and development of COAD. There are currently no specific studies indicating the mechanism of action of TME in COPD patients.

Insights on Degradation, Processing Factors, and Risk Assessment of Pesticide Pymetrozine, Spirotetramat, and Its Four Metabolites on Goji Berry: "Third Pole" Medicine and Food Homologous Crop.

Pesticides are widely used in agriculture, and agricultural commodities are generally consumed as processed foods. How effective these processing procedures are at removing pesticide residues is not well understood. We report initial concentrations of one pesticide that is used extensively on crops of Goji berries, spirotetramat (and its four metabolites: spirotetramat-enol, spirotetramat-enol-glucoside, spirotetramat-monohydroxy, and spirotetramat-keto-hydroxy), and pymetrozine, to be 231.

Inhibitors of the ubiquitin‑proteasome system rescue cellular levels and ion transport function of pathogenic pendrin (SLC26A4) protein variants.

Pendrin (SLC26A4) is an anion exchanger abundantly expressed in the inner ear, kidney and thyroid, and its malfunction resulting from genetic mutation leads to Pendred syndrome and non‑syndromic deafness DFNB4. Pathogenic variants of the pendrin protein are less expressed than the wild‑type, but the mechanism underlying this phenomenon is unknown. In the present study, the hypothesis that reduced protein expression stems from increased protein degradation was explored.

Complete genome sequence of Alteromonas marina OM2201, a marine bacterium degrading Ulva prolifera polysaccharides isolated from surface of the Yellow Sea.

As a consequence of marine eutrophication, there has been an exponential growth of Ulva prolifera, culminating in the yearly emergence of a massive green tide along the shores of Qingdao. This phenomenon exerts a detrimental impact on the marine ecosystem. As reported, the expression level of Alteromonas enzymes involved in U.

Pediatric bacterial meningitis in southern China: analysis of 838 cases.

Objective: This work aims to study the clinical features and risk factors of children with bacterial meningitis (BM) in southern China.

Methods: Clinical data of children with BM between 2012 and 2018 from one national center were analyzed retrospectively.

Results: A total of 838 patients (male/female = 1.

Exploring the Biocontrol Potential of Fungus GD-011 in the Tibetan Plateau.

In screening for biocontrol strains with broad-spectrum and efficient herbicidal activity, strain GD-011 isolated from naturally susceptible ( L.) roots was selected as a promising candidate. The control effects of strain GD-011 on nine weeds of Qinghai farmland were evaluated in vitro and in vivo, and its safety to five local crops was tested.

Complete genome sequence of Vreelandella sp. SM1641, a marine exopolysaccharide-producing bacterium isolated from deep-sea hydrothermal sediment of the Southwest Indian Ocean.

Vreelandella sp. SM1641 was isolated from the hydrothermal vent sediment of the southwest Indian Ocean at a water depth of 2519 m. The complete genome sequence of strain SM1641 was analyzed to understand its metabolic capacities and biosynthesis potential of natural products in this study.