Circadian Clock: A Regulator of Immunity in Autoimmune Diseases.

Aim: Autoimmune diseases, characterized by the immune system mistakenly attacking the body's own tissues, are a growing global concern, with increasing prevalence. The circadian clock is a fundamental regulator of physiological processes, critically modulating immune functions. This review explores the intricate connections between circadian rhythms and immune responses in autoimmune pathogenesis and how disruptions exacerbate disease.

The impacts of polypropylene microplastics on carbon and nitrogen cycling in coastal wetlands: Field evidence.

Coastal wetlands are hotspots for carbon and nitrogen cycling and serve as sinks for microplastics (MPs). Although MP effects on these biogeochemical cycles have been investigated under laboratory experiments, field-based evidence is lacking. This study presents the first field investigation of MP impacts, specifically polypropylene (PP), on sediment carbon and nitrogen cycling in intertidal and supratidal zones of a coastal wetland, employing in-situ culture over three months.

Boundary Sampled-Data Synchronization of Delayed Reaction-Diffusion Neural Networks.

We study the synchronization of delayed reaction-diffusion neural networks (RDNNs) with Neumann boundary conditions, considering both distributed and discrete delays. Particularly, boundary sampled-data (SD) control is proposed to synchronize delayed RDNNs. In the proposed synchronization strategy, boundary SD control is based on boundary and distributed SD measurements.

Innovative utilization of argon plasma coagulation combined with endoclips for managing gastrointestinal bleeding attributed to colonic diverticular bleeding: a retrospective study.

Background: Colonic diverticular bleeding is one of the primary causes of lower gastrointestinal bleeding, with endoscopic hemostasis as the first-line treatment. However, the outcomes of endoscopic treatments remain suboptimal. This study utilized an innovative therapeutic method to manage colonic diverticular bleeding and evaluated its feasibility and safety in clinical settings.

The modified mRNA vaccine protects immunocompromised AG129 mice from lethal challenge and multi-tissue infection by Zika virus.

The multiple epidemics of Zika virus (ZIKV) posed a substantial threat to public health. Clinical evidence suggests that ZIKV could break through the blood-brain, blood-placenta, and blood-testis barriers, leading to severe outcomes such as congenital malformations in newborns and Guillain-Barré syndrome in adults. Currently, there are no specific treatments for ZIKV infection.

The value of intellectual structural imbalance in the differentiation of autism spectrum disorder and attention deficit hyperactivity disorder.

Background: The study delves into the intricate task of differentiating intellectual structures among children diagnosed with the high-functioning Autism Spectrum Disorder (HF-ASD), Attention Deficit Hyperactivity Disorder (ADHD), or comorbidity (ASD+ADHD), aiming to assist in their clinical differentiation, with the goal of refining clinical diagnoses and developing targeted therapeutic interventions.

Methods: The study included 200 outpatients aged 6.5-13.

Pericoronary adipose tissue radiomics to improve risk stratification for patients with acute coronary syndrome: a multicenter retrospective cohort study.

Background: Pericoronary adipose tissue (PCAT) radiomics derived from coronary computed tomography angiography (CCTA) for predicting major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS) remains unclear. This study aimed to assess whether PCAT radiomics could further provide complementary predictive value for the risk of MACE during long-term follow-up.

Methods: A multicenter retrospective study enrolled 777 subjects who underwent pre-intervention CCTA at 3 medical centers.

In-ex site selectivity: a novel mechanism for the controlled fabrication of hollow multi-shelled nanostructures.

Site selectivity is fundamental to fabricating complex nanostructures. Herein, we introduce "In-Ex site selectivity," a novel mechanism for regulating deposition on a liquid template containing internal solid particles. The selectivity dictates whether deposition occurs on the interior (In) solid surface or the exterior (Ex) surface of the liquid template.

Initial local treatment strategies on survival outcomes of early-stage breast mucosa-associated lymphoid tissue lymphoma.

To compare survival outcomes among different initial treatment strategies for early-stage (stage I-II) breast mucosa-associated lymphoid tissue (MALT) lymphoma. Using data from the Surveillance, Epidemiology, and End Results program, we analyzed patients diagnosed with early-stage breast MALT lymphoma between 2000 and 2017. Statistical analyses included chi-square tests, Kaplan-Meier survival estimates, and multivariate Cox proportional-hazards models.

Ginsenoside Rd alleviates LPS-induced neuroinflammation and depressive-like behaviors via regulating TLR4-PI3K-NF-κB-JMJD3 signaling.

Background And Purpose: Previous studies have highlighted a strong association between neuroinflammation and depression, and inhibiting neuroinflammation could offer a promising alternative strategy for depression treatment. Ginsenoside Rd (Rd), a major bioactive saponin from Panax ginseng, exhibits potent anti-inflammatory activity. This study aimed to evaluate the antidepressant-like effects of Rd in a lipopolysaccharide (LPS)-induced mouse model of depression and to elucidate its underlying molecular mechanisms.

Self-assembled nanopeptide dendrites with high antifungal activity and protease hydrolytic stability for fungal keratitis treatment.

The excessive use of antibiotics in recent years has contributed to an increase in microbial resistance, thereby compromising the health of both humans and animals and necessitating the development of innovative therapeutic strategies. In this study, we have creatively integrated fatty acids into the previously reported anti-enzymolysis unit (CRKP) in a branched configuration, resulting in the design and fabrication of a series of peptide dendritic with potent antifungal and anti-drug-resistant fungal activities. Notably, peptide dendron C-2 exhibited significantly enhanced antifungal efficacy, favorable in vitro biocompatibility, and remarkable stability in the presence of serum and proteases.

Effects of dietary fishmeal replacement with Periplaneta americana meal on growth, antioxidant activity, and immunity of juvenile largemouth bass, Micropterus salmoides.

At present, the aquaculture industry is experiencing a significant rise in fishmeal (FM) demand due to the growth of breeding scale and factory aquaculture, which seriously impedes the sustainable development of aquaculture. Insect meal has become a key option for partially substituting FM in aquafeed. The study investigated how substituting FM with (Periplaneta americana meal (PAM) impacts the growth performance, body composition, antioxidant activities, digestive enzyme activity, and immunity in juvenile largemouth bass (JLMB).

Neuroactive network tissue based on dual-factor neuroregenerative bioactive coating scaffolds and neural stem cells for spinal cord injury repair.

Spinal cord injury (SCI) results in sensory and motor dysfunction, with neuronal death, circuit disruption, and the inhibitory microenvironment serving as key limitations to effective treatment. In this study, we developed a neuroactive network tissue for SCI repair by immobilizing dual recombinant growth factors based on biomimetic mussel adhesive units onto an oriented electrospun nanofiber scaffold, and seeding neural stem cells (NSCs) onto the scaffold. This dual-factor system continuously stimulates and enhances the paracrine function of NSCs, promoting repair of the injury site.

In-silico Analysis of a Novel MCR-1.1 Variant on an IncX4 Plasmid Attenuating Colistin Resistance in Multidrug-Resistant ST131.

Introduction: The emergence of mcr-1.1-mediated colistin resistance in poses a significant threat to last-resort antibiotic therapy. This study investigates a novel variant of mcr-1.

Novel Compound Heterozygous Missense Variants in RPL3L Gene Associated With Neonatal Dilated Cardiomyopathy.

Dilated cardiomyopathy type 2D (CMD2D) is a rare autosomal recessive disorder characterized by neonatal-onset severe cardiomyopathy, rapid progression to cardiac decompensation, and high mortality, with heart transplantation being the only life-saving intervention. Although mutations in RPL3L, a muscle-specific ribosomal protein gene critical for cardiac and skeletal muscle function, are known to cause CMD2D, this disorder remains genetically and clinically undercharacterized. To date, only 13 patients with RPL3L-related CMD2D have been reported, with nearly all of whom are attributed to compound missense mutations.

Upcycling waste polyimide foam into efficient adsorbent for deep removal of nickel complex from wastewater.

We report a "treating waste with waste" strategy for the removal of high-concentration nickel tartrate (Ni-TA) complexes from electroplating wastewater. Using waste polyimide foam as the raw material, an amine-sulfhydryl dual-functionalized material (PI-ACS) was prepared through chemical modification. At the optimal molar ratio of sulfhydryl to amine groups (1.

Mendelian randomization revealed a one-way causal association between increased Isovalerylcarnitine (C5) levels and the risk of idiopathic pulmonary fibrosis.

There have been multiple observational studies that have established a link between metabolite levels in the body and idiopathic pulmonary fibrosis (IPF), specifically focusing on metabolites derived from fatty acids. However, a complete understanding of the precise molecular and biological factors, as well as the causality between them, remains elusive. The main objective of our study was to evaluate the potential causal relationship between blood metabolites and IPF by using Mendelian randomization (MR).

Identification of green patches prioritized for urban expansion as a supplementary approach to mitigating landscape connectivity loss.

The promotion of landscape connectivity is an important way to address habitat fragmentation, and the limited land resources in high-density urban areas pose greater challenges to protecting or increasing ecological patches and corridors. This study identifies green patches that can be prioritized as land for urbanization, in addition to the supplementation of patches or corridors, and explores a supplementary method to reduce landscape connectivity loss. Beijing, a typical urbanized area, is selected as the research area.

Clinical Trial Eligibility Criteria Decomposition and Parsing with Large Language Models.

Clinical trial eligibility criteria, often presented as complex free text, pose significant challenges for automated processing. This study introduces a Decomposition and Parsing (DP) workflow to address these challenges by systematically breaking down criteria into "study traits"-the smallest meaningful units-and structuring them with components such as entities, modifiers, constraints, and negations. Leveraging advanced large language models (LLMs) like GPT-4o and Llama3.

Engineered Stem Cell Membrane-Coated Nanodrugs for Targeted Therapy of Alzheimer's Disease.

The pathological complexity of Alzheimer's disease (AD) necessitates the development of efficient nanomedicine delivery systems. Nanoparticles are considered promising therapeutic candidates for AD owing to their drug-loading capacity. This study introduces an engineered cell membrane coating strategy to enhance nanoparticle functionality in targeting efficiency and susceptivity to immune clearance.

Integration of homologous vanadium oxide and nitride with adjustable interfacial strain and charge for high performance cathode aqueous zinc-ion batteries.

The poor stability and slow kinetics of VO-based electrodes present significant challenges for their implementation in aqueous zinc-ion batteries (ZIBs). Herein, a homologous 2VO-3VN heterostructure was fabricated through metal-assisted etching and hydrothermal reaction. The metal-assisted etching creates spatial channels that facilitate rapid ion and electron transport.

Zika virus infection in neonatal mice disrupts connexin 43 and induces cardiac inflammation, implicating viral myocarditis in neonatal pathogenesis.

Zika virus (ZIKV) is primarily transmitted through mosquito bites and, occasionally, via breast milk, making postnatal ZIKV infections common among newborns and infants, particularly in tropical regions. Previous studies, including ours, have demonstrated that neonatal ZIKV infection can be fatal, highlighting a severe health issue of ZIKV in newborns. However, the pathogenesis and functional outcomes of postnatal ZIKV infection remain largely unexplored.

Trace Sulfur-Incorporation of Palladium Nanosheets to Boost the Oxygen Reduction Reaction.

With a S: Pd feeding ratio of 1: 100, Pd nanosheets (denoted as S-Pd NSs) with wrinkled nanosheet morphology and polycrystalline structure that are almost indistinguishable with pristine Pd NSs are synthesized via a facile one-pot solvothermal process. Notably, the trace amount of S-incorporation (0.83 atom%) distinctively altered the surface electronic structure of the Pd NSs and boosted the performance of the S-Pd NSs as oxygen reduction reaction (ORR) electrocatalyst.

The effect of microplastic pollution on rice growth, paddy soil properties, and greenhouse gas emissions: A global meta-analysis.

Microplastic (MP) pollution has emerged as a global environmental concern, posing threats to various ecosystems, including agricultural lands. Paddy fields, critical for global food security, are particularly vulnerable. However, the specific effects of MP contamination on rice production, paddy soil properties, and greenhouse gas (GHG) emissions in these systems remain unclear.

Quantum phase transition and chaos of anomalous Dicke model in the thermodynamic limit.

We study the anomalous Dicke model from two different perspectives including the quantum theory and semiclassical approximation method. Due to the competition between both bidirectional couplings in this appealing model, it exhibits three distinct phases, i.e.