Diagnostic performance of shear wave elastography and contrast-enhanced ultrasound in evaluating the pathological response of breast cancer patients to neoadjuvant chemotherapy: a meta-analysis.

Background: Neoadjuvant chemotherapy (NAC) is administered to specific subgroups of breast cancer patients to improve clinical outcomes. Achieving a pathological complete response (pCR) is strongly associated with improved survival. This meta-analysis systematically evaluated the diagnostic performance of shear wave elastography (SWE) and contrast-enhanced ultrasound (CEUS) in predicting the pathological response of breast cancer patients to NAC.

Development and validation of a non-invasive prediction model for identifying high-risk children with metabolic dysfunction-associated fatty liver disease.

Objective: This study aims to investigate the prevalence and risk factors of Metabolic dysfunction-associated fatty liver disease (MAFLD) in pediatric populations and establish a novel health index scoring system derived from key risk parameters for early identification of high-risk children with MAFLD.

Method: In this cross-sectional study, a systematic random sampling method was employed to recruit children (6-18 years) with MAFLD. Data collection involved standardized questionnaires and comprehensive anthropometric measurements.

Fatty acid-binding protein 4 as a biomarker for colon adenocarcinoma risk and prognosis: Challenges and future directions.

In this letter, we have commented on the study by Zhang , which utilized bioinformatics and immunohistochemistry to assess the value of fatty acid-binding protein 4 (FABP4) as a biomarker for colon adenocarcinoma (COAD). Their findings improve our understanding of FABP4 in cancer cell adhesion and immune cell infiltration. However, differential expression analysis was insufficient to demonstrate a direct association between FABP4 expression and the occurrence and progression of COAD.

Reliability of Ultrasonic Hepatorenal Indices in Assessing Hepatic Steatosis: A Systematic Review and Meta-Analysis.

The accuracy of the ultrasound hepatorenal index (HRI) in diagnosing hepatic steatosis has varied significantly in different clinical trials. Therefore, we conducted a meta-analysis aimed at exploring the diagnostic accuracy of ultrasound HRI in the quantitative assessment of hepatic steatosis. Thirteen eligible studies published up to May 3, 2025, were obtained through a comprehensive search.

Baseline glutamate-glutamine complex levels modulate antidepressant response to rTMS in major depressive disorder: Insights from magnetic resonance spectroscopy.

Background: Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depressive disorder (MDD), but its neurometabolic effects remain unknown. This study examined whether rTMS outcomes depend on baseline medial prefrontal cortex (mPFC) glutamate-glutamine complex (Glx) levels and aimed to identify clinically translatable imaging biomarkers.

Methods: Seventy-six MDD patients and 44 healthy controls (HC) were enrolled.

Reversal of neurodevelopmental toxicity induced by combined exposure to the neonicotinoid insecticides acetamiprid and imidacloprid in zebrafish through targeting DRP-1: insights into mitophagy and apoptosis mechanisms.

Neonicotinoid pesticides, including acetamiprid (ACE) and imidacloprid (IMI), are widely used due to their high efficacy and broad-spectrum activity. Despite IMI prohibition in certain countries by 2023, its residual effects, particularly in conjunction with ACE, which is frequently detected at elevated concentrations in rivers and surface waters, remain inadequately explored. In this study, the combined neurodevelopmental toxicity of ACE and IMI in zebrafish was investigated, with emphasis on mitochondrial dynamics and potential intervention strategies.

Characterization of key aroma components of jasmine tea with diverse aroma types: Focus on jasmine tea scented with multipetal jasmine.

In this study, the aroma characteristics of jasmine tea (JT) scented by three kinds of multipetal jasmine, Xiangfei 2, 4 and 11 were investigated with common double-petal jasmine as control. Compared with the strong floral aroma of double-petal jasmine tea (TS), the JT scented with Xiangfei 2 (TC) showed fresher aroma, the JT scented with Xiangfei 11 (TB) exhibited sweeter aroma, while the overall aroma of JT scented by Xiangfei 4 (TA) was overall lower. Among them, Benzoic acid, 2-hydroxyl-, ethyl ester contributed to TB's sweet note, 3-Hexen-1-ol, benzoate, (Z) - and Methyl salicylate were related to the fresh aroma of TC, Linalool, Methyl anthranilate, 4-Hexen-1-ol, acetate and Benzyl alcohol were linked to TS's floral aroma.

Chinese Jasmine Tea: The Harmonious Intertwining of Tea and Jasmine Fragrance.

Jasmine tea (JT) is a scented tea that utilizes the adsorption properties of processed tea to adsorb the aroma released by jasmine flowers. JT boasts a long history of production and consumption, stands out in the competitive tea market for its distinctive blend of tea and jasmine aromas, and has gained increasing prominence among consumers and researchers worldwide. In recent decades, more research has been conducted on JT, including the chemical basis for the formation of the characteristic flavor, the improvement of the process, and the potential health benefits.

Diagnostic value of different contrast-enhanced ultrasound (CEUS) methods for sentinel lymph node metastasis in patients with breast neoplasms: a meta-analysis and indirect comparison.

Background: Breast cancer is the most common malignant tumor in female patients. It is important to evaluate axillary lymph node metastasis before surgery to select the most appropriate treatment and evaluate the prognosis of breast cancer patients. In breast cancer, the sentinel lymph node (SLN) is the first lymph node to which tumor cells metastasize, and thus can indicate the status of the axillary lymph nodes.

Comparing efficacies of different transcranial magnetic stimulation targeting methods for depression: A meta-analysis.

Background: Transcranial magnetic stimulation over the left dorsolateral prefrontal cortex is widely used to treat patients with major depressive disorder. The left dorsolateral prefrontal cortex is located using the "5 cm", F3, or neuro-navigational methods. However, whether treatment efficacy differs according to the method used remains unclear.

Diagnostic performance of point shear wave elastography and vibration-controlled transient elastography in paediatric metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis.

Objective: This study aimed to comprehensively assess the diagnostic accuracy of point shear wave elastography (pSWE) and vibration-controlled transient elastography (VCTE) in paediatric metabolic dysfunction-associated steatotic liver disease (MASLD).

Design: Systematic review and meta-analysis of diagnostic test accuracy using the Grading of Recommendations Assessment, Development and Evaluation approach with random-effects models.

Data Sources: PubMed, Embase, Web of Science, Ovid (Medline), Cochrane, China National Knowledge Infrastructure, Wan Fang and OpenGrey were searched for publications from April 1989 to July 2024.

Ultrasound-Triggered Nanocomposite "Lever" Hydrogels with a Full Repair System Accelerates Diabetic Foot Ulcer Repair.

Diabetic foot ulcers (DFUs) are a complex mixture of neuropathy, peripheral arterial disease, and infection, where excessive reactive oxygen species (ROS) exacerbates inflammation and impairs healing. Therefore, there is an urgent need to design a hydrogel dressing with a 'lever' function to balance ROS levels in the wound to achieve both antimicrobial and anti-inflammatory effects on DFUs. In this study, we synthesised ROS-responsive diselenide liposomes loaded with a pro-skin healing factor (ergothioneine (ET)), thrombin, and a sonosensitizer (HMME) and constructed nanocomposite 'lever' hydrogels modulated by ultrasound (US).

Functional identification of Annexin B1 and Annexin B2 from Cysticercus cellulosae and their mechanism in plasma membrane repair.

Background: Cysticercosis is a severe foodborne zoonotic parasitosis infected by the metacestode larvae of Taenia solium. However, its invasion mechanism is still not clear, which might provide the important evidence for treatment or vaccine. It was reported the annexin involved in the physiological and pathological functions of Cysticercus cellulosae.

Enhancing prediction of cervical lymph node metastasis in papillary thyroid carcinoma through nodule-oriented quantification: combined S-Detect and ultrasound elastography.

Background: Papillary thyroid carcinoma (PTC) frequently metastasizes to cervical lymph nodes (LNs), with metastasis rates of 20-90%, significantly impacting patient prognosis. Although ultrasound (US) is the primary preoperative assessment tool, its accuracy (Acc) in detecting LN metastasis (LNM) remains insufficient, with conventional US detecting only 50% of confirmed cases. This study aimed to improve the prediction of cervical LNM in PTC by combining quantitative nodule orientation parameters with multi-modal US techniques.

Prediction of outpatient visits for allergic rhinitis using an artificial intelligence LSTM model - a study in Eastern China.

Background: Allergic rhinitis is a common disease that can affect the health of patients and bring huge social and economic burdens. In this study, we developed a model to predict the incidence rate of allergic rhinitis so as to provide accurate information for the treatment, prevention, and control of allergic rhinitis.

Methods: We developed a Long Short-Term Memory model for effectively predicting the daily outpatient visits of allergic rhinitis patients based on air pollution and meteorological data.

Differentiated fatty acid allocation of helped to maintain their population under food quality deterioration.

Polyunsaturated fatty acids (PUFAs) are vital to the physiological functioning of crustacean zooplankton. However, cyanobacteria blooms frequently lead to PUFA deficiencies, which poses a substantial challenge to population fitness. Therefore, we hypothesize that adapt to PUFA-deficient conditions by prioritizing PUFA allocation to somatic growth, and then to offspring during reproduction to ensure population persistence.

Machine learning-driven ultrasound radiomics for assessing axillary lymph node burden in breast cancer.

Objective: This study explores the value of combining intratumoral and peritumoral radiomics features from ultrasound imaging with clinical characteristics to assess axillary lymph node burden in breast cancer patients.

Methods: A total of 131 breast cancer patients with axillary lymph node metastasis (ALNM) were enrolled between June 2019 and September 2024. Patients were divided into low (n=79) and high (n=52) axillary lymph node burden (ALNB) groups.

The role of lactylation in virology.

Lactylation, a novel post-translational protein modification, is increasingly recognized for its widespread occurrence on lysine residues in both histone and non-histone proteins. Recent research has primarily focused on its implications in specific human diseases, particularly cancer progression, metabolic disorders, neurodegenerative diseases, and immune responses. However, it is crucial to acknowledge the significant roles played by viruses as pathogens in both clinical and veterinary medicine, as well as in zoological and phytopathological studies.

Ultrasound-based radiogenomics: status, applications, and future direction.

Radiogenomics, an extension of radiomics, explores the relationship between imaging features and underlying gene expression patterns. This field is instrumental in providing reliable imaging surrogates, thus potentially representing an alternative to genetic testing. The rapidly growing area of radiogenomics that utilizes ultrasound (US) imaging seeks to elucidate the connections between US image characteristics and genomic data.

Application value of different imaging methods in the early diagnosis of small hepatocellular carcinoma: a network meta-analysis.

Objective: To determine the diagnostic value of ultrasound, multi-phase enhanced computed tomography, and magnetic resonance imaging of small hepatocellular carcinoma.

Methods: Experimental studies on diagnosing small hepatocellular carcinoma in four databases: PubMed, Cochrane Library, Web of Science, and Embase, were comprehensively searched from October 2007 to October 2024. Relevant diagnostic accuracy data were extracted and a Bayesian model that combined direct and indirect evidence was used for analysis.

Global Burden of Otitis Media Attributable to Secondhand Smoke in 204 Countries and Territories from 1990 to 2019: The Analysis of the Global Burden of Disease Study.

Objective: Secondhand smoke (SHS) is a major public health concern. In this study, we evaluated the global burden of otitis media (OM) due to SHS exposure during 1990-2019 and explored the impact of socioeconomic factors on it.

Methods: With reference to the 2019 Global Burden of Disease (GBD) data, we assessed the OM burden linked to SHS during 1990-2019, stratified by gender, GBD region, and country.

[Research progress in mastoparans].

Mastoparans (MP), a class of α-helix cationic insect-derived antimicrobial peptides, have a broad spectrum of biological activities including inhibiting bacteria, fungi, viruses, and parasites. Amino acid substitution, peptide modification, peptide chain cyclization, and dosage form modification can enhance the biological activities and target and reduce the toxicity of mastoparans. In this review, we summarize the structure, biological function and modification methods of mastoparans, and prospect the development of antibacterial drugs based on mastoparans, so as to provide reference for the research of mastoparans as a new antibacterial drug.

A systematic analysis of the burden of disease attributable to occupational noise-induced hearing loss in China based on the 2019 global burden of disease study.

Background: Occupational noise has long been recognized as a significant risk factor for hearing loss, particularly among workers. This study aimed to assess the disease burden of hearing loss caused by occupational noise in China from 1990 to 2019, with a focus on differences across sex and age groups, so as to address the existing gaps in the Global Burden of Disease Study (GBD) reports. By analyzing changes in years lived with disability (YLDs) among different sex and age groups over the past 30 years, this study provides valuable insights for the development of occupational noise safety measures in China.

Using the GoogLeNet deep-learning model to distinguish between benign and malignant breast masses based on conventional ultrasound: a systematic review and meta-analysis.

Background: Breast cancer is one of the most common malignancies in women worldwide, and early and accurate diagnosis is crucial for improving treatment outcomes. Conventional ultrasound (CUS) is a widely used screening method for breast cancer; however, the subjective nature of interpreting the results can lead to diagnostic errors. The current study sought to estimate the effectiveness of using a GoogLeNet deep-learning convolutional neural network (CNN) model to identify benign and malignant breast masses based on CUS.

LD-CSNet: A latent diffusion-based architecture for perceptual Compressed Sensing.

Compressed Sensing (CS) is a groundbreaking paradigm in image acquisition, challenging the constraints of the Nyquist-Shannon sampling theorem. This enables high-quality image reconstruction using a minimal number of measurements. Neural Networks' potent feature induction capabilities enable advanced data-driven CS methods to achieve high-fidelity image reconstruction.