Causal Associations Between Oral Microbiota and Gestational Diabetes Mellitus: A Two-Sample Mendelian Randomization Study.

Background: Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes. The oral microbiota, influenced by genetic factors, may play a role in GDM development, but the causal association remains unclear.

Methods: We employed a two-sample Mendelian randomization (MR) approach using Genome-Wide Association Study (GWAS) data on GDM from FINN cohort data (ID: finngen_R10_GEST_DIABETES) and GWAS data on the Oral microbiota from the Danish ADDITION-PRO cohort.

Establishing a long-term predictive model for aggressive behavior in schizophrenia: a 21-year longitudinal study in rural China.

Background: Although identifying factors contributing to aggressive behavior in individuals with schizophrenia is crucial for developing targeted prevention strategies and intervention, most studies were cross-sectional or short-term, and did not take into account the factor of urbanicity. This study aimed to develop a predictive model of aggressive behavior in individuals with schizophrenia in rural China.

Method: A total of 205 individuals with schizophrenia who were identified in 1994 and followed up in 2015 were included in the study.

HADHB mediates 5-fluorouracil sensitivity in colorectal cancer.

Purpose: 5-Fluorouracil (5FU) is a primary chemotherapy for colorectal cancer (CRC), but resistance reduces its effectiveness. HADHB, important in mitochondrial fatty acid β-oxidation, is linked to tumor metabolism changes in various cancers. Its potential influence on 5FU sensitivity in CRC remains unclear.

Single-Layer High-Efficiency Metasurface for Multi-User Signal Enhancement.

In multi-user wireless communication scenarios, signal degradation caused by channel fading and co-channel interference restricts system capacity, while traditional enhancement schemes face challenges of high coordination complexity and hardware integration. This paper proposes an electromagnetic focusing method using a single-layer transmissive passive metasurface. A high-efficiency metasurface array is fabricated based on PCB technology, which utilizes subwavelength units for wide-range phase modulation to construct a multi-user energy convergence model in the WiFi band.

Using the COM-B model to explore factors influencing influenza vaccination among the elderly: Insights from primary healthcare workers in China.

The influenza vaccination rate among the elderly in China remains suboptimal. As key figures in effective intervention strategies, the perspectives of primary healthcare workers (PHCWs) on this issue have not been explored yet. This study aims to use the capability, opportunity, motivation-behavior (COM-B) model to identify the factors that influence influenza vaccination among the elderly from the perspective of PHCWs in China, analyze the mechanisms, and formulate targeted intervention strategies.

Inhibition of eCIRP attenuates PANoptosis and renal fibrosis.

Extracellular cold-inducible RNA-binding protein (eCIRP) was discovered as a potent damage-associated molecular pattern (DAMP). It has been shown that eCIRP is linked to various types of programmed cell death and acute inflammation. However, the role of eCIRP in chronic inflammation and renal fibrosis has not been elucidated.

Enhancing influenza vaccination uptake: a systematic review and meta-analysis of intervention strategies.

Introduction: Despite extensive efforts, global influenza vaccination rates remain suboptimal, particularly among high-risk populations.

Research Design And Methods: We conducted a comprehensive literature search up to April 2023. Experimental studies assessing the effectiveness of interventions on influenza vaccination uptake were included, expressed as risk ratios (RR) with 95% confidence intervals (CI).

Enhances Thermotolerance in Potato ( L.) by Enhancing Antioxidant Defense and Photosynthetic Efficiency Under Heat Stress.

The functional role of MAPKK genes in potato ( L.) under high-temperature stress remains unexplored, despite their critical importance in stress signaling and yield protection. We characterized StMAPKK1, a novel group D MAPKK localized to plasma membrane/cytoplasm.

Beyond Handrubs: QAC Wipes as a Water-Sparing Alternative for Protein-Contaminated Hand Hygiene with Persistent Dorsum Challenges.

Background: This study compared the effectiveness of quaternary ammonium compound (QAC) wipes, handwashing, and hydrogen peroxide-enhanced alcohol-based hand rubs (ABHRs) in removing microorganisms from hands contaminated with proteinaceous organic matter.

Methods: A self-controlled crossover trial recruited 15 volunteers who received standardized hand hygiene training. Participants underwent three intervention methods: (1) handwashing with non-antimicrobial soap and running water for 60 seconds; (2) hand rubbing with 70% ethanol + 0.

The efficacy and neuroplasticity of Tuina combined with repetitive transcranial magnetic stimulation in the treatment of post-stroke depression: study protocol for a single-center, randomized, controlled trial.

Introduction: Post-stroke depression (PSD), characterized by low mood and low interest, is the most common complication after stroke. The limitations of PSD drug therapy often require multidisciplinary combination therapy in clinical practice. Tuina therapy and repetitive transcranial magnetic stimulation (rTMS) have shown potential in modulating neural plasticity and improving depressive symptoms.

Functional analysis of CBL-interacting protein kinases 15 (StCIPK15) in response to salt and heat stress in potato (Solanum tuberosum L.).

Potato (Solanum tuberosum L.), a staple crop, is highly susceptible to environmental stressors such as high salinity and elevated temperatures. Calcineurin B-like (CBL) proteins and CBL-interacting protein kinases (CIPKs) form sensor-response complexes that regulate plant growth, development, differentiation, and stress responses.

Arachidonic Acid Metabolism Down-Regulation-Mediated Tumor Necrosis Factor Signaling Contributes to Cutaneous Fibrosis and Skull Hyperplasia in Goldfish Hoods.

Goldfish () are renowned as a premier ornamental fish in the world. Especially, the hood, a distinctive cephalic skin protrusion, is a highly sought-after feature for its endearing aesthetics. Despite a longstanding hypothesis that the hood is a type of tumor, the details of their composition, structure, and the mechanism of its formation have remained enigmatic.

The association between solid fuel use and oral health: the mediating effect of depressive symptom.

Objectives: This study aimed to investigate the associations between solid fuel use and oral health and the mediating effects of depressive symptom.

Methods: 64,521 Indian adults were included in this study. Binary logistic regression was performed to evaluate the associations of solid fuel use with tooth loss, dental cavity, and periodontal disease.

stimulates thermotolerance in potato ( L.) through antioxidant and photosynthetic modulation.

Heat stress severely impacts the growth and development of potato plants. However, the molecular mechanisms underlying thermotolerance, particularly the role of WRKY transcription factors (TFs), remain poorly understood. Here, we identified as a heat-responsive gene in potato, demonstrating significant transcriptional upregulation under 30°C and 35°C heat stress conditions.

Predicting depression using serum perfluoroalkyl and polyfluoroalkyl substances levels via interpretable machine learning.

Background: Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals with widespread environmental persistence and human exposure. Currently, no studies have used machine learning (ML) to predict depression based on PFAS exposure. This study aimed to develop an interpretable ML model to predict depression risk based on serum PFAS levels.

The Overlooked Stereoisomers of the Ionizable Lipid ALC315.

Lipid nanoparticles (LNPs) are a powerful delivery platform for nucleic acid therapeutics such as mRNA vaccines and gene therapies. Central to their success are ionizable lipids, which facilitate the cellular uptake and endosomal escape of nucleic acids. However, achieving a high delivery efficiency often comes with the drawback of increased cytotoxicity.

Cross-neutralization of human sera with diverse SARS-CoV-2 omicron exposure histories, 2022-2024: Evidence of immune heterogeneity.

Background: SARS-CoV-2 Omicron lineages continue to evolve, driving recurrent infection waves since 2022 through immune escape in populations with diverse immunological histories. Understanding cross-variant neutralization capacity, especially against emerging variants like JN.1, is critical for optimizing protection strategies.

Comparison of the Therapeutic Effects of Rebamipide and Diquafosol on Apoptotic Damage of the Ocular Surface in Dry Eyes.

Dry eye disease (DED) is characterized by tear film instability and oxidative stress-induced epithelial damage. This study was conducted to compare the therapeutic effects of 2% rebamipide (REB) and 3% diquafosol (DQS) on oxidative stress-related apoptotic damage of the ocular surface in DED. Human corneal epithelial cells (HCECs) were exposed to hyperosmotic stress in vitro and treated with REB or DQS.

Splicing factor 3b subunit 1 mutation patterns and prognostic implications in myelodysplastic syndromes, acute myeloid leukemia, and chronic lymphocytic leukemia: A retrospective study of 1691 cases.

Background: Splicing factor 3b subunit 1 (SF3B1) mutations have been implicated in hematologic malignancies, but the clinical significance of distinct SF3B1 mutation variants remain unclear.

Methods: The objective of this study was to evaluate clinicopathologic features, mutational profiles, and outcomes of 1691 patients with hematologic malignancies, including myelodysplastic syndromes (MDS; n = 402), acute myeloid leukemia (AML; n = 758), and chronic lymphocytic leukemia (CLL; n = 531).

Results: The frequency of SF3B1-mutated (SF3B1) MDS, AML, and CLL was 70 of 402 patients (17.

Optimization of synchronous grout properties and construction parameters for shield tunnels in soft soil.

Improper synchronous grouting materials and construction parameters may cause the shield segments to float, resulting in tunnel dislocation, open joints, uneven deformation, and water leakage. This paper conducts tests on shield synchronous grout performance and presents a multi-objective optimization method for grout performance. This method considers initial setting time, shear yield strength, early compressive strength, and density as optimization performance indicators.

Human papillomavirus vaccination coverage and willingness among women in mainland China: A meta-analysis based on the COM-B model.

Objectives: To estimate human papillomavirus (HPV) vaccination coverage and vaccination willingness among women in mainland China and identify the influencing factors using the Capability, Opportunity, and Motivation model of Behavior (COMB).

Methods: PubMed, Web of Science, Cochrane Library, Embase, and Chinese databases including CNKI, Wanfang Data, VIP, and CBM were searched. Pooled HPV vaccination coverage and willingness were calculated using a random-effects model with 95 % confidence intervals (CIs).

Functional analysis of gene in response to heat stress in potato ( L.).

Heat stress severely restricts potato tuber growth and development, yet the roles of WRKY transcription factors (TFs) in mediating heat responses remain poorly understood. Using quantitative reverse transcription PCR (qRT-PCR), we identified in potato cultivars '' and '' as a heat-inducible gene, showing significant upregulation under 30°C and 35°C treatments. Phylogenetic analysis classified into the WRKY Group II family, with close evolutionary homology to tomato , and subcellular localization confirmed its nuclear targeting.

Evaluating the Tree Drawing Test Depression Assessment Scale for adolescent depression screening.

To assess the effectiveness of the Tree Drawing Test Depression Assessment Scale in screening for depressive disorders among adolescents. This study adopted a case-control design involving 50 adolescents diagnosed with depressive disorders and 54 healthy controls. Participants were administered the Tree Drawing Test (TDT), a subjective projective assessment tool that evaluates psychological states through the analysis of individually drawn tree images.

Population Genomics, Virulence Traits, and Antimicrobial Resistance of Isolated in China.

is a significant zoonotic pathogen of public health importance. In this study, whole-genome sequencing of 177 isolates of , isolated from diseased swine across 15 provinces in China between 2017 and 2019, was performed. A total of 23 serotypes and 28 ST types were identified, with serotypes 2 and 3 comprising 50.

Unraveling allelopathic potential of Medicago ruthenica (L.) Trautv.: insights from allelopathic effects and untargeted metabolomics.

The allelopathic effects of dominant native plants such as grasses and legumes are conducive to restore plant communities and shape ecological patterns in degraded grassland ecosystems. In the present study, plant bioassays combined with untargeted metabolomics were employed to explore the allelopathic activity and potential allelochemicals of plant methanol extract (PM), rhizosphere soil water extract (SW), and rhizosphere soil methanol extract (SM) of M. ruthenica.