Predictive Accuracy of Magnetocardiography for Diagnosing Myocardial Ischemia in NSTE-ACS Patients With Residual Post-PCI Angina.

Background: Post-percutaneous coronary intervention (PCI) angina affects 20% to 40% of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) survivors but remains a clinical challenge due to its unpredictable course.

Objectives: This study aimed to validate a rapid 90-second optically pumped magnetometer magnetocardiography (OPM-MCG) test for diagnosing post-PCI angina and develop a predictive model using dynamic MCG parameters.

Methods: NSTE-ACS patients who underwent pre- and post-PCI OPM-MCG scans were included.

The efficacy and neuroplasticity of Tuina combined with repetitive transcranial magnetic stimulation in the treatment of post-stroke depression: study protocol for a single-center, randomized, controlled trial.

Introduction: Post-stroke depression (PSD), characterized by low mood and low interest, is the most common complication after stroke. The limitations of PSD drug therapy often require multidisciplinary combination therapy in clinical practice. Tuina therapy and repetitive transcranial magnetic stimulation (rTMS) have shown potential in modulating neural plasticity and improving depressive symptoms.

Magnetocardiography's role in a recurrent angina patient following percutaneous coronary intervention - Case report.

Currently, there is a lack of convenient and effective methods for assessing recurrent angina following percutaneous coronary intervention (PCI). We documented the course of magnetocardiography's (MCG) changes in a 41-year-old man with recurrent angina throughout his visit to the clinic. The MCG suggested myocardial ischemia at the first visit.

Additive interaction of maternal early pregnancy exposure to particulate matter and residential greenness on congenital heart disease in the Offspring: Mediation of DNA methylation in placental tissue.

We aim to assess the interactive effect of greenness with particulate matter(PM) on congenital heart disease(CHD), and estimate the mediation of DNA methylation in PM on CHD. A case-control study of 1540 CHD mother-child pairs and one-to-one, age±2 years and gravidity-matched controls was organized in Tianjin, China during 2018-2021. And we further collected placental tissue(30 CHD mother-child pairs and 30 controls).

Machine learning in diagnosing coronary artery disease via optical pumped magnetometer magnetocardiography: a prospective cohort study.

The potential of optical pumped magnetometer magnetocardiography (OPM-MCG) for diagnosing coronary artery disease (CAD) has been initially shown, yet lacks large-scale prospective research.Using invasive coronary angiography (ICA) as a reference, we constructed three feature sets for the development of machine learning (ML) models: a 'Heart' feature set consisting only of OPM-MCG features, a 'Clinical' feature set, and a 'Heart + Clinical' combined feature set. We assessed the performance of 11 ML models with 10-fold cross-validation and conducted a feature importance analysis.

Microfluidic Fabrication of Hyaluronic Acid-Cysteine-Modified Chitosan Microspheres for CD44-Targeted Probiotic Delivery in Colitis Treatment.

Probiotics play a crucial role in regulating intestinal immune homeostasis and supporting gut health; however, oral administration faces challenges such as nonspecific distribution and low efficacy. To achieve precise and efficient delivery, in this study, a targeted delivery system embedded probiotics to the colonic inflammatory site CD44 was constructed by covalently linking yaluronic acid (HA) to ysteine-modified hitosan (CCH) using microfluidic technology. Two probiotic strains, FL-276.

Integrated Analysis of miRNA and mRNA Expression Profiles Associated with Development of Skeletal Muscle of Jiangquan Black Pigs.

Background: Hypertrophy, myogenic differentiation, and mass gain of porcine skeletal muscle are key factors in meat production efficiency, regulated by miRNAs through post-transcriptional mechanisms. This study aims to identify miRNA-mRNA pairs linked to growth and muscle development in Jiangquan Black pigs with differing average daily gains (ADGs), providing a foundation for molecular breeding in this breed.

Methods: This study divided eight pigs into two groups and analyzed the skeletal muscle characteristics of Jiangquan Black pigs with different average daily weight gains using HE staining.

The value of plasma immunoproteasome for predicting coronary collateral circulation in ST-elevation myocardial infarction.

Objective: The immunoproteasome is linked to endothelial function and may act as a proangiogenic factor. This study explored its predictive value for coronary collateral circulation (CCC) in ST-elevation myocardial infarction (STEMI) patients.

Methods: We enrolled 252 STEMI patients from April 2021 to April 2024.

Integrated Analysis of DNA Methylome and Transcriptome Reveals Regulatory Mechanism in the Longissimus Dorsi of Duroc Pigs.

DNA methylation plays a pivotal role in the epigenetic regulation of gene expression and holds promise for enhancing livestock meat production. In this study, we analyzed the DNA methylome and transcriptome of the longissimus dorsi muscle (LDM) in Duroc pigs with varying growth rates. Our results reveal that DNA methylation suppressed the expression of key muscle development markers (, , ) and proliferation markers (, ), as well as the protein expression and phosphorylation of PI3K and AKT ( < 0.

Development and characterization of endolysosomal trafficking targeting chimera degraders of α-adrenergic receptor.

Introduction: Despite the booming targeted protein degradation technologies, degrading cell membrane proteins remains an enormous challenge. In particular, only a limited approach is appropriate for the degradation of the G protein-coupled receptor (GPCR) superfamily. It is encouraging that accelerating GPCRs' endocytosis and switching their post-endocytic fate from recycling to lysosomal degradation would represent a promising strategy for developing chemical degraders of GPCRs.

Programmable Self-Sorting within a Library of Metal-Organic Cages.

Self-sorting exerts a pivotal role in biological self-assembly processes, enabling the hierarchical organization of biomacromolecules with exquisite selectivity. Inspired by nature, we present a programmable supramolecular coordination system where two types of ligands undergo sequential narcissistic and social self-sorting events to assemble either homoleptic or heteroleptic metal-organic cages. Homoleptic cage formation proceeds through the narcissistic self-sorting of either rigid or flexible ligands, depending on their varying sizes, whereas heteroleptic cages emerge through social self-sorting, where flexible ligands undergo adaptive conformational adjustments to achieve geometric complementarity with rigid counterparts.

Achieving Nearly 100% Targeted Conversion of NO to NO through Cooperative Activation of Lattice Oxygen and Molecular Oxygen on Dual-Defect LaMnO.

Inhibiting the deposition of N species on the catalyst surface for the targeted oxidation of NO to NO is still a great challenge. Herein, a La and O dual-defective LaMnO (2U-LMO) perovskite was fabricated using a urea-nonstoichiometric comodulation strategy, which achieved 97.6% NO oxidation efficiency at 210 °C and 300,000 h, and was also capable of nearly 100% targeted oxidation of NO to NO, as well as exhibited excellent stability and recyclability.

MGF505-7R and I267L Deletions Attenuate African Swine Fever Virus and Confer Protection Against the Virulent Pandemic Virus in Pigs.

African swine fever virus (ASFV) poses a serious risk to wild boars and domestic pigs worldwide. Developing live-attenuated vaccines (LAVs) containing specific gene deletions is an effective approach to prevent and control African swine fever (ASF) epidemics. We created a novel ASFV mutant, ASFV-GS-Δ7R/ΔI267L, with deletions of genes MGF505-7R and I267L, using the highly pathogenic parental strain ASFV-GS/2018 (ASFV-GS).

Evaluation of the application value of ultrasound in the diagnosis of community-acquired pneumonia in children: a preliminary study based on large-scale outpatient cases.

Objective: To evaluate the diagnostic value of lung ultrasound (LUS) for childhood community-acquired pneumonia (CAP).

Methods: A case-control study was conducted among pediatric outpatients with suspected CAP who underwent LUS examination. Baseline data such as clinical manifestations were collected.

Effect of an Aerobic Exercise Programme on Bone Density in Middle-Aged and Elderly Patients with Prostate Cancer Undergoing Androgen Deprivation Therapy: A Retrospective Study.

Background: Prostate cancer is a remarkable health concern in men, particularly in middle-aged and elderly men, with androgen deprivation therapy (ADT) being a common treatment approach for this malignancy. However, ADT is associated with adverse effects on bone health, including accelerated bone loss and decreased bone mineral density, leading to increased fracture risk. As a result, exploring interventions to mitigate ADT-induced bone loss is needed.

Feasibility study of synergistic anchoring and supporting in coal entry heading faces with moderately stable surrounding rock.

The support method in coal entry heading faces significantly impacts the stability of surrounding rock and heading efficiency. To enhance heading efficiency while ensuring the stability of surrounding rock, this study takes the 011813 headgate heading face in Jinfeng Mine. Addressing the technical conditions and the demand for rapid heading, an innovative partitioned support approach of "local anchoring + non-repeated temporary support" and "rapid reinforcement anchoring" is proposed.

Tryptophan metabolism and ischemic stroke: An intricate balance.

Ischemic stroke, which is characterized by hypoxia and ischemia, triggers a cascade of injury responses, including neurotoxicity, inflammation, oxidative stress, disruption of the blood-brain barrier, and neuronal death. In this context, tryptophan metabolites and enzymes, which are synthesized through the kynurenine and 5-hydroxytryptamine pathways, play dual roles. The delicate balance between neurotoxic and neuroprotective substances is a crucial factor influencing the progression of ischemic stroke.

Repurposing shared bike frames into rural infrastructure.

While bike-sharing systems have generated significant economic benefits, they have also faced challenges regarding the disposal and recycling of discarded bicycle frames. A potential solution to reuse these difficult-to-recycle frames for essential public service facilities in rural areas has not yet been thoroughly explored. Using shape grammar as a design method, this study examines two typical bicycle frame designs with different geometric properties and successfully repurpose the frames into various public service facilities, such as public tables and chairs, railings, installations, and public restrooms.

Improved evaluation of coronary artery diseases from patients with coronary calcification utilizing FFR: a comparative study against CCTA.

Objective: This multicenter study evaluated the diagnostic accuracy of coronary computed tomography angiography (CCTA) and computed tomography-derived fractional flow reserve (FFR) in diagnosing coronary artery disease (CAD), focusing on the impact of coronary calcification, using invasive coronary angiography (ICA) as the reference.

Methods: The study analyzed 4172 patients from 3 centers who underwent CCTA and FFR between August 2021 and August 2022. Exclusion criteria included the absence of ICA within 90 days after CCTA, left main disease, previous coronary revascularization, or unmeasurable Agatston score (AS).

The mA reader YTHDC2 restrains endometrial cancer progression through suppressing hedgehog signaling pathway.

N6-methyladenosine (mA) is a prevalent RNA modification involved in different physiological and pathological processes. However, little is known about the role of mA modification in endometrial cancer (EC). In this study, we explored the expression and prognosis of mA-related genes in EC using public databases to screen relevantgenes.

The Deletion of the MGF360-10L/505-7R Genes of African Swine Fever Virus Results in High Attenuation but No Protection Against Homologous Challenge in Pigs.

African swine fever virus (ASFV) is the causative agent of African swine fever (ASF), a severe hemorrhagic disease with a mortality rate reaching 100%. Despite extensive research on ASFV mechanisms, no safe and effective vaccines or antiviral treatments have been developed. Live attenuated vaccines generated via gene deletion are considered to be highly promising.

Comparison of magnetocardiography and coronary computed tomographic angiography for detection of coronary artery stenosis and the influence of calcium.

Objectives: This study aimed to compare the diagnostic performance of magnetocardiography (MCG) and coronary computed tomography angiography (CCTA) in detecting coronary artery stenosis in relation to coronary calcification.

Methods: A total of 587 patients who underwent invasive coronary angiography (ICA) with both CCTA and MCG between September 1, 2022, and August 31, 2023, were included. The patients were divided into three subgroups based on their coronary artery calcium score (CACS), namely less than 100, 100-400, and 400 and above, as determined by the Agatston score.

MicroRNAs in vascular smooth muscle cells: Mechanisms, therapeutic potential, and advances in delivery systems.

Vascular smooth muscle cells (VSMCs) are essential players in a wide range of physiological processes, and their phenotypic transitions are critical in the development of vascular diseases such as atherosclerosis (AS), restenosis, aortic dissection/aneurysm (AAD), chronic kidney disease (CKD), and diabetes mellitus (DM). MicroRNAs (miRNAs), a class of short non-coding RNAs, regulates key cellular functions like proliferation, migration, and apoptosis by modulating gene expression. Numerous studies have shown that various miRNAs play pivotal roles in the pathophysiological processes of VSMCs, with VSMC phenotype switching being a key factor.

The effects of integrated traditional Chinese and western medicine rehabilitation programs on post-acute ankle sprain: A randomized controlled trial study protocol.

Background: Ankle sprain is a common clinical disease, which has the highest incidence rate among joint and ligament injuries. And acute ankle sprains can easily develop into chronic ankle instability, thereby increasing the difficulty of treatment. The current clinical guidelines for post-acute ankle sprains are still controversial.