Assessment of clinical efficacy and safety of sublingual immunotherapy for house dust mite-induced allergic pharyngitis with rhinitis.

Background: Sublingual immunotherapy (SLIT) has been widely established as a disease-modifying treatment for allergic airway diseases. However, its efficacy and safety in allergic pharyngitis (AP) remain insufficiently investigated and require further clinical validation.

Methods: In this retrospective study, 100 patients diagnosed with house dust mite (HDM)-induced AP concomitant with allergic rhinitis (AR) were enrolled.

Gut Microbiota and Metabolites: Biomarkers and Therapeutic Targets for Diabetes Mellitus and Its Complications.

Diabetes mellitus (DM) is a complex metabolic disease characterized by significantly elevated blood glucose levels as a result of dysfunctional or impaired pancreatic β-cells, leading to insulin deficiency. This condition can result in severe complications, including cardiovascular diseases, kidney failure, vision impairment, and nerve damage. Currently available anti-diabetic drugs do not fully prevent the progression of these complications.

Ga-doped coenzyme-based adhesives for periodontitis treatment.

Chronic periodontitis is a long-standing thorny issue for oral health, characterized primarily by the excessive production and accumulation of reactive oxygen species, pathogenic bacterial infection, and the continuous loss of alveolar bone. In the present study, a poly(lipoic acid) (PolyLA) coenzyme-based tissue adhesive (PolyLA/Arg/Ga) was developed for the treatment of periodontitis. It functions by combining the non-antibiotic antimicrobial gallium ion (Ga) with PolyLA/Arg to resist pathogenic bacteria and promote osteogenesis.

Influencing Factors of Treatment Response to Rituximab in Refractory Membranous Nephropathy.

Objective: This study aims to identify influencing factors associated with the efficacy of rituximab in treating refractory membranous nephropathy (MN), characterized by persistent proteinuria and unresponsive to conventional immunosuppressive therapies. We sought to determine clinical and biochemical predictors for positive therapeutic outcomes and optimize patient selection criteria.

Methods: A total of 160 patients with biopsy-confirmed refractory MN (meeting criteria of eGFR > 30 mL/min/1.

Effects of combined auricular pressure bean and group guidance on sleep disorders in patients undergoing maintenance hemodialysis.

Background And Purpose: Sleep disorders are highly prevalent and significantly impair quality of life in patients undergoing maintenance hemodialysis. This study aimed to explore the combined effect of auricular pressure bean and group guidance on sleep disorders in patients undergoing maintenance hemodialysis and its potential role in alleviating anxiety and depression.

Materials And Methods: This study included 120 patients with sleep disorders undergoing maintenance hemodialysis at a blood purification center in Guangdong Province, China.

Synergistic Effects of Walnut Oil and Nervonic Acid on Antioxidant Activity and Cognitive Impairment.

Cognitive impairment (CI) poses a significant public health challenge, where oxidative stress plays a crucial role in its initiation and advancement. Previous research has emphasized that walnut oil (WO) and nervonic acid (NA) are potential therapeutic foods for CI. This study aimed to investigate the synergistic effects of WO and NA on antioxidant activity and CI improvement.

SIRT3 promotes mitophagy to attenuate fumonisin B1-induced chicken hepatocyte senescence and antagonism of lycopene.

Fumonisins are a class of mycotoxins produced by molds of the genus Fusarium, and fumonisin B1 (FB1) is the most toxic and common fumonisins. As a carotenoid with natural powerful antioxidant capacity found in plants, lycopene (LYC) can enhance immunity, modulate blood lipids, and prevent liver diseases. Sirtuin 3 (SIRT3) is a versatile molecule in modulating mitochondrial function with the significance in mitophagy and cellular senescence.

Non-target screening and priority assessment of organic pollutants in tropical island watershed water.

Numerous organic chemicals are present in aquatic environments, yet systematically identifying and prioritizing these compounds remains a major challenge, particularly in tropical island watersheds where data are scarce. In this study, we applied high-resolution mass spectrometry (HRMS)-based non-target screening to comprehensively characterize emerging organic pollutants in three major rivers of Hainan Province-Changhua, Wanquan, and Nandu. A total of 177 high-confidence compounds were identified, spanning pharmaceuticals, industrial additives, pesticides, and natural products.

Sumoylation-dependent control of Pmk1 phosphorylation during Magnaporthe oryzae infection.

Rice blast disease, caused by Magnaporthe oryzae, significantly threatens global rice yields. The Pmk1-MAPK signaling pathway is crucial for the infection process, but the precise regulatory mechanisms of Pmk1 remain unclear. Our research reveals that sumoylation of Pmk1 is vital for its infectious function.

Effects of Mytilus edulis derived plasmalogens against atherosclerosis via lipid metabolism and MAPK signaling pathway.

Mytilus edulis-derived plasmalogens (Pls) are rich in polyunsaturated fatty acids, which are reportedly effective in ameliorating cardiovascular disease. The purpose of this study was to clarify the underlying mechanisms of Pls against atherosclerosis (AS) in ApoE mice induced by a high-fat diet (HFD), through a comprehensive analysis of hepatic metabolomics and aortic transcriptomics data. The results demonstrated a significant reduction in pathological indicators associated with AS following Pls treatment.

Jiao-Tai-Wan Improves Cognitive Impairment by Regulating Nrf2/ARE/HO-1 Signaling Pathway in APP/PS1 Mice.

Alzheimer's disease (AD) is a chronic, progressive, and destructive neurodegenerative disorder that severely affects human memory, intelligence, and behavioral abilities. Jiao Tai Wan (JTW) is a classic formula composed of two traditional Chinese medicines, coptis chinensis (CC) and cinnamon (CIN), the ratio of CC and CIN is 10:1. JTW has the effects of promoting cognitive function, and improving learning and memory function.

Determinants of chronic disease patients' intention to use Internet diagnosis and treatment services: based on the UTAUT2 model.

Background: Chronic diseases are a significant public health concern. Internet diagnosis and treatment services can effectively monitor chronic diseases and are vital for alleviating the healthcare system burden caused by these conditions. Distinguishing itself from prior investigations, this study focuses on the critical cohort of chronic disease patients and, building upon the UTAUT2 framework, introduces additional constructs such as trust and medical habits.

Hierarchical FeO@C@MnO nanozymes: bridging structural engineering to on-site biosensing of tannic acid.

Manganese dioxide (MnO)-based heterogeneous catalysts have gained significant attention in nanozyme research due to their exceptional oxidase-mimicking capabilities. This work reports the rational design of MnO functionalized magnetic carbon nanotubes (FeO@C@MnO) through a multistep synthesis strategy. The magnetic N-doped hollow carbon substrate (FeO@C) was first synthesized via controlled pyrolysis of FeOOH-coated polydopamine precursors.

Regulating the cell differentiation trajectory of progenitor cells in adipose tissue fibrosis.

Objective: Adipose fibrosis signifies pathological remodeling of white adipose tissue (WAT) associated with insulin resistance, diabetes, and cardiovascular disease. Matrix Gla protein (MGP) balances bone morphogenetic protein (BMP) and transforming growth factor β (TGFβ) signaling but has an unclear role in WAT.

Methods: To study the role of MGP in WAT, we used mice with global or platelet-derived growth factor receptor α (Pdgfra)-Cre-mediated Mgp deletion in adipose progenitor cells (APCs) together with single cell RNA sequencing (scRNA-seq), characterization on adipose and fibrotic phenotypes, and BMP and TGFβ signaling studies.

Low adipose tissue infiltration in skeletal muscle is a protective phenotype of all-cause death in patients undergoing dialysis.

Background & Aims: A newly developed low-attenuation muscle index (LAMI) reflects the relationship of the degree of adipose tissue infiltration in low-attenuation muscle and the skeletal muscle quality on computed tomography (CT) images. We investigated the relationship between CT-derived LAMI and ratio of low-attenuation muscle area to skeletal muscle area (LAMA/SMA) at transverse process of the first lumbar vertebra (L1) and all-cause death in dialysis patients.

Methods: This retrospective cohort study of initial-dialysis patients enrolled from January 1, 2014, to June 30, 2020.

Advances in Multicompartment Synthetic Protocells: from Design Strategies to Biomedical Application.

Multicompartment synthetic protocells offer significant advantages over traditional single-compartment systems by replicating the compartmentalized organization of natural cells. This advanced design enables effective synergy and precise control over complex biochemical reactions through modular and hierarchical structures. The construction strategies primarily encompass self-assembly methods, microfluidic technology, and double emulsion techniques, which facilitate precise and reproducible formation of interconnected compartments separated by physical or chemical barriers.

Quality of life and its associated factors in patients with severe aortic stenosis undergoing transapical transcatheter aortic valve replacement: a cross-sectional study.

Background: Severe aortic stenosis (AS) significantly impacts patients' quality of life (QoL). Although transcatheter aortic valve replacement (TAVR) has emerged as a less invasive treatment option, its effects on QoL and associated factors remain inadequately explored. To evaluate QoL and its associated factors in patients with AS following TAVR.

Undercarboxylated OCN Inhibits Chondrocyte Hypertrophy and Osteoarthritis Development through GPRC6A/HIF-1α Cascade.

Initial investigations established osteocalcin (OCN) as a pivotal factor in bone formation. Fully carboxylated osteocalcin (cOCN) exhibits a high affinity for hydroxyapatite within the bone matrix, yet under specific physiological conditions, it may undergo decarboxylation, thereby acquiring endocrine regulatory capabilities. Recent findings suggest a potential protective role for undercarboxylated osteocalcin (ucOCN) beyond bone, influencing various systems, including the brain, pancreas, muscle, and gonads, where its effects are well established.

Isolation and preliminary pathogenicity of a recent feline astrovirus strain in China.

Feline astroviruses (FeAstVs) have been increasingly detected in cats in recent years, yet their isolation and pathogenicity remain poorly characterized. In this study, we screened 86 feline diarrheal samples and identified FeAstV in 9.3% (8/86) of the cases, most of which were co-infected with feline parvovirus (FPV).

The Association Between Thromboembolic Events and ALK, ROS1, RET Rearrangements or EGFR Mutations in Patients With Advanced Lung Adenocarcinoma: A Retrospective Cohort Study.

Introduction: Previous studies have reported inconsistent findings regarding the associationbetween ALK and ROS1 rearrangements in lung cancer and thromboembolic risk. This retrospective study aimed to investigate this association in advanced lung adenocarcinoma patients with ALK, ROS1, RET rearrangements, and EGFR mutations.

Materials And Methods: We retrospectively collected information on patients with advanced lung adenocarcinoma in the First Affiliated Hospital of Zhejiang University School of Medicine from January 2013 to March 2021.

Analysis of camrelizumab in neoadjuvant chemotherapy for esophageal cancer: A retrospective cohort study.

Neoadjuvant therapy has the potential to enhance the prognosis of esophageal squamous cell carcinoma (ESCC). Camrelizumab, a domestically developed programmed cell death protein 1 inhibitor in China, offers a convenient treatment option for Chinese patients with ESCC. The NIC-ESCC2019 trial has demonstrated that the combination of camrelizumab and neoadjuvant chemotherapy has favorable efficacy and tolerable toxicity for resectable ESCC.

Small fish making a big difference: beloved star of environmental toxicology research in the current era.

The zebrafish has emerged as a powerful model organism in life science owing to its remarkable biological characteristics and wide-ranging applications. This review provides a comprehensive overview of the recent advancements in research on zebrafish within the field of environmental toxicology, highlighting specific studies where this species was used to investigate various pollutants to elucidate their impacts and underlying mechanisms. The findings of these studies underscore the significant potential of zebrafish as a model to gain crucial insights into the ecological consequences of environmental contamination and toxicity pathways.

Efficacy of probiotics pretreatment in eradication therapy: a systematic review and meta-analysis of clinical outcomes.

Background: Probiotics inhibit growth and alter gut microbiome, in addition to alleviating the side effects of eradication. It has also been reported that be eradicated after fecal microbiota transplantation in some cases. However, whether probiotics used before eradication improves the eradication rate remains unclear.

Association of circulating immuno-oncology biomarkers with breast cancer risk: insights from two prospective cohorts.

Immuno-oncology biomarkers are promising tools for cancer risk assessment and early detection. To identify and validate their associations with breast cancer, nested case-control studies within the Taizhou Longitudinal Study (TZL) cohort and the UK biobank Pharma Proteomics Project (UKB-PPP) were conducted, comprising 195 and 881 incident breast cancer patients, together with their matched controls. Among the 92 plasma proteins tested by the Olink Immuno-oncology panel, 11 proteins were associated with breast cancer risk in the TZL cohort after multiple testing correction.