Assessment of clinical efficacy and safety of sublingual immunotherapy for house dust mite-induced allergic pharyngitis with rhinitis.

Background: Sublingual immunotherapy (SLIT) has been widely established as a disease-modifying treatment for allergic airway diseases. However, its efficacy and safety in allergic pharyngitis (AP) remain insufficiently investigated and require further clinical validation.

Methods: In this retrospective study, 100 patients diagnosed with house dust mite (HDM)-induced AP concomitant with allergic rhinitis (AR) were enrolled.

Manipulating Synergetic Effect of Atomic-Level Chemical and Structural Fluctuations on Magnetism in High-Entropy Oxides.

High-entropy oxides, which incorporate five or more distinct cations into a single crystallographic site, are attracting significant attention, owing to their often unexpected physical and chemical properties. However, understanding and manipulation of local chemical compositions and structures and their dominance on material performance remain a significant challenge. Here, we investigate a prototype antiferromagnetic high-entropy oxide (MgCoNiCuZn)O with rocksalt-type structure, and directly visualize local fluctuating lattice distortions and short-range ordering using advanced scanning transmission electron microscopy imaging.

Electric Double-Layer Structured Grain Boundaries in Medium-Entropy Perovskite Enable Robust Electromagnetic Interference Shielding after 1200 °C Oxidation.

High-temperature electromagnetic interference (EMI) shielding materials are essential for aerospace applications, but achieving both efficiency and stability above 1000 °C remains challenging. To address this challenge, it is proposed to develop electric double-layer (EDL) structured grain boundaries (GBs) within oxide ceramics by point defect segregation at GBs. As a proof of concept, the highly deficient medium-entropy (ME) perovskite is selected with the nominal composition (SrBaLa)TiO, which contains a high concentration of Ti and O vacancies.

One-dimensional nanosonosensitizer boosted multiple branches of immune responses against MHC-deficient immune-evasive urologic tumor.

Cancer immunotherapies rely on CD8 cytolytic T lymphocytes (CTLs) in recognition and eradication of tumor cells via antigens presented on major histocompatibility complex class I (MHC-I) molecules. However, we observe MHC-I deficiency in human and murine urologic tumors, posing daunting challenges for successful immunotherapy. We herein report an unprecedented nanosonosensitizer of one-dimensional bamboo-like multisegmented manganese dioxide@manganese-bismuth vanadate (BMMBV) to boost multiple branches of immune responses targeting MHC-I-deficient tumors.

An efficient hydrogen evolution catalyst constructed using Pt-modified NiS/MoS with optimized kinetics across the full pH range.

Electrocatalyst materials play a crucial role in determining the efficiency of the hydrogen evolution reaction (HER), directly influencing the overall effectiveness of energy conversion technologies. NiS/MoS heterostructures hold substantial promise as bifunctional catalysts, owing to their synergistic electronic characteristics and plentiful active sites. However, their catalytic efficacy is impeded by the relatively elevated chemisorption energy of hydrogen-containing intermediates, which constrains their functionality in different pH environments.

Superconducting Boride NbIrB with Variable and Tunable Stacking Behaviors of Two-Dimensional [Nb-Ir-Nb] Triangular Lattices.

In structures with special geometry lattices, variations in stacking sequences are ubiquitous, yielding many novel structures and functionalities. Despite a wealth of intriguing properties and wide-ranging applications, there remains a considerable gap in understanding the correlation between special geometry lattices and functionalities in borides. Here, we design and synthesize a new superconducting boride NbIrB, with a body-centered orthorhombic structure, consisting of alternating two-dimensional [Nb-Ir-Nb] triple-triangular-lattice-layers and B fragment layers.