Association between exposure to polycyclic aromatic hydrocarbons and infections with human papillomavirus and herpes simplex virus type 2.

The study aimed to investigate the association between co-exposure to polycyclic aromatic hydrocarbons (PAHs) and infection with human papillomavirus (HPV) or herpes simplex virus type 2 (HSV-2) in a representative sample of the adult female population in the United States. A cross-sectional analysis was conducted using data from 4,284 participants in the National Health and Nutrition Examination Survey (NHANES). Logistic regression and stratified analyses were used to assess associations between individual PAH exposures and the prevalence of HPV and HSV-2 infection.

Aspartic acid residues in BBE-like enzymes from promote a function shift from oxidative cyclization to dehydrogenation.

Berberine bridge enzyme (BBE)-like enzymes catalyze various oxidative cyclization and dehydrogenation reactions in natural product biosynthesis, but the molecular mechanism underlying the selectivity remains unknown. Here, we elucidated the catalytic mechanism of BBE-like oxidases from involved in the oxidative cyclization and dehydrogenation of moracin C. X-ray crystal structures of a functionally promiscuous flavin adenine dinucleotide (FAD)-bound oxidase, MaDS1, with and without an oxidative dehydrogenation product were determined at 2.

Functional potential and applications of Ureibacillus massiliensis based on whole-genome sequencing analysis.

Background: Ureibacillus massiliensis (U. massiliensis), a Gram-positive bacterium belonging to the phylum Bacillota, has undergone two significant taxonomic revisions before being classified under the Ureibacillus. Although previous studies have highlighted its promising applications in industrial production and environmental remediation, the lack of genomic information has limited the research on its functional mechanisms and industrial development.

Enhancing magnetic dipole emission with a hollow hybrid metal-dielectric-metal nanostructure.

We propose hollow metal-dielectric-metal hybridized nanodisks to enhance both the magnetic dipole (MD) and electric dipole (ED) emissions. By employing a hollow hole in the center of the hybridized nanodisks, the maximum magnetic field intensity is obtained in the hole and can be used to fully improve MD emitter emission. This indicates that the radiative decay rate () of the MD emitter is 965-fold enhanced in the hole and has been achieved with a large quantum efficiency of over 80%.

Tianlong kechuanling ameliorated COPD-PH through DNMT3A-GSDMD axis-dependent regulation of endothelial cell pyroptosis.

Ethnopharmacological Relevance: COPD-PH is a common and severe complication of COPD, posing significant challenges to patient survival and quality of life due to its poor prognosis. However, current treatment options remain clinically unsatisfactory. Tianlong kechuanling (TL), a traditional Chinese medicine compound hospital preparation, has been clinically employed for treating cor pulmonale, although its underlying mechanisms remain elusive.

Acute Myeloid Leukemia With Extramedullary Infiltration-Gastric Myeloid Sarcoma: A Case Report and Literature Review.

Gastric myeloid sarcoma (MS) is a rare disease with numerous endoscopic manifestations and is typically diagnosed on the basis of immunohistochemistry. However, the epidemiology, treatment, and prognosis of gastric MS remain controversial. The goal of this study is to preliminarily analyze these controversial aspects of gastric MS.

Decoding 4-vinylanisole biosynthesis and pivotal enzymes in locusts.

Aggregation pheromone, 4-vinylanisole (4VA), is specifically released by gregarious migratory locusts, and is crucial in forming locust swarms that cause destructive plagues. Control of locust plagues relies heavily on the extensive application of chemical pesticides, which has led to severe environmental and health issues. As pheromones are primary mediators of insect communication and behaviour, exploring their biosynthesis can provide important cues to develop innovative behavioural regulators, potentially reducing the reliance on chemical pesticides.

MiR-155-5p facilitates acute lung injury progression via Th17 cells through the ETS-1/STAT3 pathway.

Acute lung injury (ALI) results from diverse intrapulmonary (direct) or extrapulmonary (indirect) factors, triggering a severe inflammatory response and resulting in varying degrees of damage to the intrapulmonary structures. Clinically, ALI often manifests as progressive hypoxic respiratory insufficiency with imaging changes in bilateral pulmonary infiltrates. ALI has a high mortality rate and poor prognosis among patients in the intensive care unit.

Chromosomal instability by low-coverage whole-genome sequencing assay predicts prognosis in bladder cancer patients underwent radical cystectomy.

Purpose: To investigate chromosomal instability (CIN) in tumor tissue from radical bladder resection and to evaluate whether it can be used as a biomarker for the molecular typing of (BC).

Methods: DNA was extracted from formalin-fixed paraffin-embedded samples of 50 BC patients who were followed up to March 23 2023 using the Qiagen nucleic acid kits. We analyzed CIN in tumor of bladder by low-coverage whole genome sequencing (LC-WGS).

Tribological performance and lubrication mechanism of polyacrylamide as a high-efficiency water-based lubricant additive for titanium alloys.

Titanium alloys present challenges in terms of lubrication due to their difficult-to-machine nature, which necessitates the development of sustainable and environmentally friendly lubricants. Water-based lubricants are commonly used for titanium alloys because of their effective cooling properties, despite encountering challenges such as poor lubrication performance and complex mechanisms. This study first demonstrates that polyacrylamide (PAM) is an excellent water-based lubricant additive for the Ti6Al4V (TC4)/GCr15 interface.

Electric Double-Layer Structured Grain Boundaries in Medium-Entropy Perovskite Enable Robust Electromagnetic Interference Shielding after 1200 °C Oxidation.

High-temperature electromagnetic interference (EMI) shielding materials are essential for aerospace applications, but achieving both efficiency and stability above 1000 °C remains challenging. To address this challenge, it is proposed to develop electric double-layer (EDL) structured grain boundaries (GBs) within oxide ceramics by point defect segregation at GBs. As a proof of concept, the highly deficient medium-entropy (ME) perovskite is selected with the nominal composition (SrBaLa)TiO, which contains a high concentration of Ti and O vacancies.

Association Between Fluoride Exposure and BMI, WWI in Children and Adolescents: A Cross-Sectional Study.

This research aimed to investigate the relationship of fluoride exposure to body mass index (BMI), weight-adjusted waist index (WWI) in children and adolescents. The study used the 2015-2016 Nutrition Examination Survey database and screened a total of 2004 participants aged 6 to 19 years. Multiple linear regression and logistic regression were used to analyze the relationship between blood fluoride, urine fluoride, and water fluoride and BMI, WWI, overweight/obesity, and WWI category.

USP31 confers radio-resistance in cervical cancer cells via ferroptosis pathway by deubiquitinating and stabilizing GPX4.

Ubiquitin-specific peptidase 31 (USP31), a member of the deubiquitinating enzyme family, linked to the pathogenesis of cervical cancer (CC). Despite this association, the precise mechanisms underlying its role remain inadequately understood. Recent studies have identified ferroptosis as a potential mechanism contributing to radiotherapy-mediated tumor suppression and the development of radioresistance.

Cardiomyocyte specific CD38 deletion protects heart from acute myocardial infarction by activating Sirt3 signaling pathway.

Acute myocardial infarction (AMI) is serious disease with high morbidity and mortality worldwide. CD38 is an important metabolic enzyme and plays an important role in a variety of diseases. Our previous studies demonstrated that CD38 deficiency significantly reduced Ang-II-induced ventricular hypertrophy and cardiac ischemia-reperfusion injury.

Qingfei Litan decoction alleviated Klebsiella pneumoniae-induced pneumonia by targeting the TLR4/MyD88/NF-κB axis via miR-146a-5p.

Ethnopharmacological Relevance: Klebsiella pneumoniae (Kp) is a significant pathogen responsible for various clinical bacterial infections, including pneumonia, sepsis, and even death. However, effective treatment options remain limited due to the rising prevalence of antimicrobial resistance. Traditional Chinese medicine (TCM) has shown potential in the treatment of bacterial pneumonia.

Baihe Gujin decoction attenuates idiopathic pulmonary fibrosis via regulating proline metabolism.

Ethnopharmacological Relevance: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease. Baihe Gujin decoction (BHGJ), a traditional Chinese medicine consisting of ten medicine food homology herbs, has shown therapeutic effects in various lung diseases; however, its efficacy in ameliorating IPF and the underlying mechanisms remain unclear.

Aim Of The Study: This study aimed to evaluate the effects of BHGJ on IPF and investigate its potential mechanisms.

Nanoemulsification of PTX and BEZ235 inhibits colon cancer growth.

Colorectal cancer is one of the most common malignant tumors, and its drug resistance poses a huge challenge and a serious threat to people's health. In previous studies, we have found that the combination of paclitaxel and BEZ235 has synergistic anti-colon cancer effects, particularly in drug-resistant colorectal cancer, demonstrating excellent anti-tumor effects. Therefore, this study aims to investigate the preparation of the nanoemulsification of paclitaxel and BEZ235 (NEs-PTX-BEZ235) and to explore the potential key parameters for its clinical translation.

Myeloid but not hepatocytic CD38 is a key driver for hepatic ischemia/reperfusion injury.

Hepatic ischemia-reperfusion injury (HIRI) is a critical condition that often occurs during liver transplantation and surgical liver resection. However, its mechanism has not been fully elucidated. Nicotinamide adenine dinucleotide (NAD), functioning as a coenzyme or cofactor, is crucial for both redox and non-redox processes.

Unraveling the genetic traits and functional diversity of the pan-genome in Pantoea dispersa.

Background: Medical devices are crucial in modern healthcare, but commonly used clinical tools such as cotton swabs can be easily contaminated by microorganisms (such as Pantoea), becoming vectors for pathogens and leading to patient infections or more severe outcomes. Despite the dual nature of the Pantoea that has garnered significant attention, research investigating Pantoea dispersa (P. dispersa) remains limited.

Endoscopic ultrasound-guided ethanol vs ethanol combined with paclitaxel for the ablation of pancreatic cystic lesions: a systematic review and meta-analysis.

Background: Some pancreatic cystic lesions (PCLs) have the risk of malignant transformation, but the complications of pancreatic surgery are high, and minimally invasive treatment is imperative. Endoscopic ultrasound (EUS) -guided ablation has been utilized to treat pancreatic cysts. We undertook the meta-analysis and systematic review to assess the efficacy and safety of this technique in PCLs.

Quality Assessment of Chinese TikTok as a Source of Information About Esophageal Cancer.

Esophageal cancer is a prevalent cancer worldwide, with incidence rates rising significantly in recent years, particularly in high-risk regions where case numbers continue to escalate. As one of the most visited social media platforms globally, TikTok has emerged as a key source for health information. This study aims to evaluate Chinese TikTok videos on esophageal cancer, focusing on content integrity, informational quality, source credibility, usefulness, and reliability.

Association between dietary index of gut microbiota and constipation in a female population: a cross-sectional study.

Objective: To examine the potential association between dietary index of gut microbiota (DI-GM) scores and constipation in adult women in the United States.

Methods: This cross-sectional study used data from adult participants in the 2005-2010 US National Health Survey (NHANES). The missing values in the covariables were filled by multiple interpolation.

Transcriptomic analysis of regulating the growth and development of tomato seedlings by the crosstalk between JA and TOR signaling.

Transcription factors MYB, WRKY, bHLH, bZIP and NAC were identified as key candidate genes for JA and TOR regulation of tomato seedling growth and development. Jasmonic acid (JA) and Target of Rapamycin (TOR) signaling pathways interact to regulate plant growth, development, and stress responses. In this study, transcriptomic and weighted gene co-expression network analysis (WGCNA) were conducted on tomato wild-type (WT) and spr2 mutant lines treated with the TOR inhibitor RAP and activator MHY1485.

Recent development in friction of supramolecular gel lubricant: from mechanisms to applications.

Due to the unique self-assembling structure and rheological properties, supramolecular gel lubricants have become the third major type of liquid lubricating materials to supplement the lubricating oils and greases. The molecular structures of gelators applicable to oil-based, water-based and extreme conditions base oils were summarized firstly. Furthermore, this review aims at exploring the relationships between the molecular structures of gelators and the gel-forming, rheological and tribological properties of gel lubricants.

Low-dose natural clay Kaolin promotes the growth of submerged macrophytes and alters the rhizosphere microorganism community: Implications for lake restoration.

Sediment properties have a crucial effect on the growth and recovery of aquatic plants in lakes. Addition of various chemical substances has been proposed to reinforce the recovery of plants after a nutrient loading reduction. However, the effects of such sediment amendments on plant growth, especially those from rhizosphere microorganisms, is limited.