Probiotics Prevent Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt: A Randomised Controlled Trial.

Background And Aims: Hepatic encephalopathy (HE) is the most common complication of cirrhosis after transjugular intrahepatic portosystemic shunt (TIPS) and is closely related to intestinal dysbiosis. The efficacy of probiotics in improving minimal HE (MHE) has been well studied, while the role of probiotics for the primary prophylaxis of overt HE (OHE) after TIPS has not been established. We aimed to determine whether Live Combined Bifidobacterium and Lactobacillus Tablets, a commonly used probiotic preparation in China, reduced the risk of post-TIPS HE.

Case Report: transjugular intrahepatic portosystemic shunt combined with hemodialysis for refractory ascites treatment in a patient with idiopathic non-cirrhotic portal hypertension and uremia.

Transjugular intrahepatic portosystemic shunt is a standard treatment for refractory ascites (RA) in patients with cirrhosis. Idiopathic non-cirrhotic portal hypertension (INPH) is a disorder of unknown etiology, clinically characterized by features of portal hypertension. The current therapy is limited to managing portal hypertension and is recommended to be referred to as cirrhosis.

Erratum: Pulsed magnetic field promotes proliferation and neurotrophic genes expression in Schwann cells .

[This corrects the article on p. 2343 in vol. 8, PMID: 26045741.

Association between infection of Helicobacter pylori and the risk of reflux oesophagitis occurrence or recurrence: a systematic review and meta-analysis.

Background: To investigate the correlation between infection of ) and the risk of reflux oesophagitis (RE) occurrence or recurrence.

Methods: Literature was retrieved from PubMed, Embase, Web of Science and Cochrane Library databases, and the search period ranged from the time of database establishment to December 2024. Prospective cohort studies and randomised controlled trials were included for data analysis to assess the association of infection of with the risk of RE occurrence and recurrence, and subgroup analyses were performed.

Erratum: Oxygen carrier in core-shell fibers synthesized by coaxial electrospinning enhances Schwann cell survival and nerve regeneration: Erratum.

[This corrects the article DOI: 10.7150/thno.45035.

Tribological performance and lubrication mechanism of polyacrylamide as a high-efficiency water-based lubricant additive for titanium alloys.

Titanium alloys present challenges in terms of lubrication due to their difficult-to-machine nature, which necessitates the development of sustainable and environmentally friendly lubricants. Water-based lubricants are commonly used for titanium alloys because of their effective cooling properties, despite encountering challenges such as poor lubrication performance and complex mechanisms. This study first demonstrates that polyacrylamide (PAM) is an excellent water-based lubricant additive for the Ti6Al4V (TC4)/GCr15 interface.

Downregulation of SENP1 impairs nuclear condensation of MEF2C and deteriorates ischemic cardiomyopathy.

Ischemic cardiomyopathy (ICM) is characterised by the insufficient capacity of the heart to effectively pump blood, which ultimately contributes to heart failure (HF). In this study, the down regulation of SENP1 is identified in the cardiomyocyte of ICM mouse models and in patients. The depletion of SENP1 exacerbates hypoxia-induced apoptosis of cardiomyocytes in vitro and deteriorated cardiomyocyte injury of ICM mice in vivo.

A two-step self-pollination mechanism maximizes fertility in Brassicaceae.

Self-pollination in self-compatible plant species often occurs prior to flower opening. By tracking the temporal progress of pollination in Arabidopsis, we observed that pollen predominantly targets the lateral region of the stigma in unopened flowers. Notably, approximately 7 h after flower opening, flowers close, thereby pressing anthers toward the central region of the stigma for a second self-pollination.

Self-assembled colloidal glass with 100% lanthanide nanocrystal loading for high-resolution X-ray imaging.

Solution-processable colloidal scintillators are emerging as a promising alternative to traditional bulky scintillators, addressing critical limitations in X-ray imaging technologies. Existing X-ray screens fabricated with colloidal powders in polymer matrices suffer from low spatial resolution at elevated particle concentrations due to severe optical losses induced by nanoparticle aggregation, fundamentally constraining high-resolution imaging capabilities. To resolve these challenges, we developed a novel class of bright, transparent colloidal glasses achieving 100% particle loading through self-assembly of sub-5 nm lanthanide-doped CaMoO nanocrystals.

Glimepiride/hydroxypropyl-β-cyclodextrin inclusion compound: preparation, characterization, and evaluation.

Objective: To enhance solubility and bioavailability of GM, an inclusion compound of glimepiride/hydroxypropyl-β-cyclodextrin (GM/HP-β-CD) was prepared using mechanical ball milling.

Significance: Based on response surface optimization for the ball milling preparation of the inclusion compound, this study investigates its and release and pharmacokinetics.

Methods: GM/HP-β-CD inclusion compound was prepared by optimized ball milling based on response surface methodology and characterized using powder x-ray diffraction, differential scanning calorimetry, scanning electron microscopy, and Fourier transform infrared spectroscopy, and the stability of the compound was studied.

Genetic Diversity Assessment and Core Germplasm Screening of Blackcurrant () in China via Expressed Sequence Tag-Simple Sequence Repeat Markers.

Blackcurrant ( L.) has high nutritional value for human health due to its abundant vitamin C, flavonoids, and organic acids. However, its breeding and genetic research have been severely hindered by the lack of scientific tools such as molecular markers.

Damage and repair in retinal degenerative diseases: Molecular basis through clinical translation.

Retinal ganglion cells are the bridging neurons between the eye and the central nervous system, transmitting visual signals to the brain. The injury and loss of retinal ganglion cells are the primary pathological changes in several retinal degenerative diseases, including glaucoma, ischemic optic neuropathy, diabetic neuropathy, and optic neuritis. In mammals, injured retinal ganglion cells lack regenerative capacity and undergo apoptotic cell death within a few days of injury.

Tidal-driven NO emission is a stronger resister than CH to offset annual carbon sequestration in mangrove ecosystems.

The mangrove ecosystems store a significant amount of "blue carbon" to mitigate global climate change, but also serve as hotspots for greenhouse gases (GHGs: CO, CH and NO) production. The CH and NO emissions offset mangrove carbon benefits, however, the extent of this effect remains inadequately quantified. By applying the 36 h time-series observations and mapping cruises, here we investigated the spatial and temporal distribution of GHGs and their fluxes in Dongzhaigang (DZG) bay, the largest mangrove ecosystem in China, at tidal and monthly scales.

The gut-brain axis underlying hepatic encephalopathy in liver cirrhosis.

Up to 50-70% of patients with liver cirrhosis develop hepatic encephalopathy (HE), which is closely related to gut microbiota dysbiosis, with an unclear mechanism. Here, by constructing gut-brain modules to assess bacterial neurotoxins from metagenomic datasets, we found that phenylalanine decarboxylase (PDC) genes, mainly from Ruminococcus gnavus, increased approximately tenfold in patients with cirrhosis and higher in patients with HE. Cirrhotic, not healthy, mice colonized with R.

Inferring gene regulatory networks with graph convolutional network based on causal feature reconstruction.

Inferring gene regulatory networks through deep learning and causal inference methods is a crucial task in the field of computational biology and bioinformatics. This study presents a novel approach that uses a Graph Convolutional Network (GCN) guided by causal information to infer Gene Regulatory Networks (GRN). The transfer entropy and reconstruction layer are utilized to achieve causal feature reconstruction, mitigating the information loss problem caused by multiple rounds of neighbor aggregation in GCN, resulting in a causal and integrated representation of node features.

Causal association between 731 immunocyte phenotypes and liver cirrhosis: A bidirectional two-sample mendelian randomization analysis.

Background: Liver cirrhosis is a progressive hepatic disease whose immunological basis has attracted increasing attention. However, it remains unclear whether a concrete causal association exists between immunocyte phenotypes and liver cirrhosis.

Aim: To explore the concrete causal relationships between immunocyte phenotypes and liver cirrhosis through a mendelian randomization (MR) study.

Septal Extension Spreader Graft Combined With Warped Alar Batten Graft for Improvement of Nasal Tip and Alar Asymmetry in Adult Cleft Lip Nasal Deformity.

This paper presents the findings of an observational study involving 38 patients to evaluate the application of a surgical technique utilizing an autologous costal cartilage scaffold for correcting nasal tip and alar asymmetry in unilateral cleft lip-nasal deformity. Nasal septum extension spreader grafts (SEG) and warped alar batten grafts, both made from autologous costal cartilage, were utilized in open rhinoplasty procedures. The warped alar batten graft was fixed to the caudal end of the SEG, with the lower lateral cartilage on the cleft side suspended to the free part of the newly created warped alar batten graft to lift the collapsed nasal alar further.

Prevalence, treatment efficacy, and risk factors of vascular complications in acute pancreatitis: A case-control study.

Objective: We aimed to investigate the prevalence of vascular complications in acute pancreatitis (AP), to compare patient outcomes using various treatments, and to explore the related risk factors.

Methods: Consecutive AP patients admitted from January 2010 to July 2017 were retrospectively included. Demographics, vascular complications, laboratory indices, and imaging findings were collected.

Reverse diversity-biomass patterns in grasslands are constrained by climates and stoichiometry along an elevational gradient.

Diversity and biomass play an important role in grassland ecosystem functions. However, diversity and biomass are variable because of their high sensitivity to environmental change in natural ecosystems. How plant diversity, biomass, and driving factors (climates, soils, and plants) in grasslands vary with environmental change remains unclear.

Regulation of tumor metastasis and CD8 T cells infiltration by circRNF216/miR-576-5p/ZC3H12C axis in colorectal cancer.

Background: The tumor immune microenvironment (TIME) is an important regulator of tumor progression, growth and metastasis. In addition, tumor metastasis is one of the principal obstacles to the treatment of colorectal cancer (CRC). Circular RNAs (circRNAs) have been recognized as important regulators in the development of malignancies.

Involved in Anthocyanin Regulation of 'Hongyang' Kiwifruit Induced via Fruit Bagging and High-Postharvest-Temperature Treatments.

Light and temperature are key factors influencing the accumulation of anthocyanin in fruit crops. To assess the effects of fruit bagging during development and high post-ripening temperature on 'Hongyang' kiwifruit, we compared the pigmentation phenotypes and expression levels of anthocyanin-related genes between bagged and unbagged treatments, and between 25 °C and 37 °C postharvest storage temperatures. Both the bagging and 25 °C treatments showed better pigmentation phenotypes with higher anthocyanin concentrations.