The long noncoding RNA SNHG12 defines KEAP1 stability and ferroptosis susceptibility by targeting E3 ligase TRIM25.

Ferroptosis is a novel type of programmed cell death caused by iron-dependent lipid peroxidation. Targeted induction of ferroptosis holds great promise for cancer treatment. SNHG, a newly recognized lncRNA family, has been reported to implicate in the proliferation, invasion, migration or drug resistance of cancer cells.

Gut microbial production of imidazole propionate drives Parkinson's pathologies.

Parkinson's disease (PD) is characterized by the selective degeneration of midbrain dopaminergic neurons and aggregation of α-synuclein. Emerging evidence implicates the gut microbiome in PD, with microbial metabolites proposed as potential pathological mediators. However, the specific microbes and metabolites involved, and whether gut-derived metabolites can reach the brain to directly induce neurodegeneration, remain unclear.

Dynamic changes of the S wave in lead V6: A novel visual indicator for left bundle branch capture.

Background: During the electrode screwing process in left bundle branch pacing (LBBP), the significance of the S wave in lead V6 remains elusive. Our study analyzes the change of the S wave in lead V6 under different patterns of capture and explores its mechanisms.

Methods: This study included 243 cases with criterion of selective LBBP (SLBBP), we performed continuous pacing technique and classified the electrophysiological characteristics observed during the screwing process into four patterns: left ventricular septal pacing (LVSP), non-selective LBBP (NSLBBP) in low output and in the lower output, selective LBBP.

Diffusion Model-based Medical Image Generation as a Potential Data Augmentation Strategy for AI Applications.

Introduction: This study explored a generative image synthesis method based on diffusion models, potentially providing a low-cost and high-efficiency training data augmentation strategy for medical artificial intelligence (AI) applications.

Methods: The MedMNIST v2 dataset was utilized as a small-volume training dataset under low-performance computing conditions. Based on the characteristics of existing samples, new medical images were synthesized using the proposed annotated diffusion model.

Accurate prediction of toxicity peptide and its function using multi-view tensor learning and latent semantic learning framework.

Motivation: Therapeutic peptide is an important ingredient in the treatment of various diseases and drug discovery. The toxicity of peptides is one of the major challenges in peptide drug therapy. With the abundance of therapeutic peptides generated in the post-genomics era, it is a challenge to promptly identify toxicity peptides using computational methods.

Efficient catalytic sulfur conversion in aqueous zinc-sulfur batteries mediated by iodide-coupled ether groups.

A novel aqueous electrolyte incorporating tetraethylene glycol dimethyl ether (G4) and trace amounts of ZnI (HSG-I) is presented to enhance the sulfur conversion reversibility. G4 improves kinetics, stabilizes the interfaces, and enables uniform zinc deposition. Crucially, G4's ether groups coordinate I, mediating reversible I/I transformation to ensure efficient sulfur redox chemistry.

[Common detoxification mechanisms in processing of toxic medicinal herbs of the same genus: a case study of Euphorbia pekinensis, E. ebracteolata, and E. fischeriana].

Traditional Chinese medicine(TCM) processing is a specialized pharmaceutical technique with the primary objective of reducing the toxicity of medicinal substances. Euphorbia pekinensis, E. ebracteolata, and E.

Hypoxia and TTR dysregulation in astrocytes from Parkinson's disease with a specific mitochondrial haplogroup: A single-cell analysis.

Mitochondrial DNA variants have been linked to cognitive progression in Parkinson's disease; however, the mechanisms by which mitochondrial DNA variants or haplogroups contribute to this process remain unclear. In the present study, we analyzed single-nucleus RNA sequencing data from 241 post-mortem brain samples across five regions to investigate the dysregulatory mechanisms associated with mitochondrial DNA haplogroup H and haplogroups J, T, and U#. Our findings revealed significant alterations in the proportions of astrocyte subtypes CHI3L1 and GRM3 in the neocortical regions of haplogroup H.

mediates the sensitivity to irinotecan toxicity via tryptophan catabolites.

Background: Late-onset diarrhoea remains a poorly managed concern for clinical irinotecan therapy. Although bacterial β-glucuronidases (β-GUS) mediated SN-38 production is prevailingly thought to mediate intestinal toxicity, β-GUS inhibitors confer limited benefits in the clinic.

Objective: This study aimed to explore the role and mechanism of endogenous bacterial metabolites in susceptibility to irinotecan toxicity.

Uncovering internal water-flux and surface-potential dominance in hydrogel-based moisture-enabled power generation: mechanistic insights and performance enhancement.

Ambient humidity is an abundant yet underexploited energy reservoir, and its sustained conversion mechanisms remain elusive. This study employs single-layer, bilayer and ion-selective designs, in combination with Kelvin-probe force microscopy and molecular dynamics simulations, to delineate the fundamental physics of hydrogel-based moisture-enabled generators (MEGs). We demonstrate that continuous, directional water flux-rather than ion migration-governs electricity generation: the transport of 1 g of HO through the hydrogel network yields ≈9.

[Clinical efficacy of demineralized dentin matrix particles in immediate implantation for bone defects in posterior region: a 1 to 5-year follow-up study].

Objectives: This study aims to evaluate the short- to medium-term clinical efficacy of demineralized dentin matrix (DDM) particles applied during the immediate implantation of alveolar bone defects in the posterior region.

Methods: A total of 76 patients with 110 simple taper retentive implants were included in the conducted study and divided into Groups A and B in accordance with the bone grafting materials. Cone beam computed tomography and panoramic radiographs were taken immediately after implant surgery, immediate crown repair, and final follow-up time.

Differential lipid metabolism in beef cattle: A comparative study of high and low residual feed intake bulls.

This study investigated lipid metabolism differences between low and high residual feed intake (LRFI and HRFI) bulls. Fifty-five Simmental bulls (449.84 ± 8.

Inspiratory Muscle Training Improves Respiratory Muscle Strength and Cardiovascular Autonomic Regulation in Obese Young Men.

Objective: To investigate the effect of an 8-week inspiratory muscle training (IMT) intervention on respiratory muscle strength and cardiovascular autonomic regulation in obese young men.

Methods: The study included 36 obese young men who met the inclusion and exclusion criteria. Participants were randomly divided into two groups: the IG (inspiratory muscle training group, n = 17), which underwent high-intensity IMT intervention for 8 weeks, 5 times a week, and the CG (control group, n = 18), which was not given any additional intervention.

The gut-retina axis: association of dietary index for gut microbiota with diabetic retinopathy in diabetic patients-a cross-sectional study from NHANES 2009-2018.

Background: The gut-retina axis, an emerging area of research, has uncovered the bidirectional link between the intestines and retina, offering new insights into ophthalmic disease management. Diabetic retinopathy (DR), a common diabetes complication with a digestive-related connection, lacks large-sample retrospective studies on the impact of gut microbiota-related diets. The association between the Dietary Index for Gut Microbiota (DI-GM) and DR requires further investigation.

Convergent and Divergent Mitochondrial Pathways as Causal Drivers and Therapeutic Targets in Neurological Disorders.

Mitochondrial dysfunction is implicated across a spectrum of neurological diseases, yet its causal role and mechanistic specificity remain unclear. This study employed a multi-modal integrative analysis of mitochondrial gene expression in Alzheimer's Disease (AD), Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), and Parkinson's Disease (PD) to address these gaps. We combined machine learning for predictive modeling with genetic causal inference methods (Mendelian Randomization, colocalization, PheWAS), followed by drug enrichment analysis and molecular docking.

Harnessing cellular immunity for next-generation vaccines against respiratory viruses: mechanisms, platforms, and optimization strategies.

Respiratory tract infections, such as influenza, respiratory syncytial virus (RSV) infection, and COVID-19, remain a persistent threat to global public health due to their high transmissibility and disease burden. Vaccination, as a key preventive strategy, not only reduces the risk of infection but also blocks transmission by activating adaptive immunity. While traditional vaccine evaluations have primarily focused on humoral immunity, growing evidence highlights the critical role of T lymphocyte-mediated cellular immunity in clearing virus-infected cells, establishing long-term immune memory, and responding to viral mutations.

Shifts in Diversity Along the Spine Surgery Training Pathway: Racial, Ethnic, and Gender Representation from Medical School to Fellowship.

Background Context: Racial and ethnic minorities are underrepresented among healthcare providers in the United States (US).

Purpose: This study analyzed the training pathway of underrepresented groups in spine surgery relative to earlier stages of training and the US population.

Study Design/setting: This was a cross-sectional analysis of medical students, orthopaedic surgery residents, and spine surgery fellows at accredited training programs (2014 to 2024).

Da Vinci Xi robot -assisted subxiphoid resection of thymoma and reconstruction of the left brachiocephalic vein: A case report.

Background: Thymomas are the most common anterior mediastinal malignancies, typically requiring surgical resection. While median sternotomy has been the traditional approach, robotic-assisted thymectomy using the Da Vinci Xi system is reshaping minimally invasive surgery. Its 12× magnification, 3D visualization, and articulating instruments with tremor suppression allow precise dissection in anatomically constrained areas, particularly in tumors with vascular invasion, compared with the more aggressive classical approach.

Targeting FXR in Hepatocytes: A Promising Approach to Enhance Fibrinolysis and Reduce Deep Vein Thrombosis Risk.

Obesity is a major health issue and a risk factor for venous thromboembolic disease (VTE). Plasminogen activator inhibitor 1 (PAI-1), encoded by the gene SERPINE1, is a negative regulator of fibrinolysis and has been associated with obesity. The liver, which senses obesity-induced metabolic stress, is a key determinant of circulating PAI-1 levels.

Inflammation in Ossification of the Posterior Longitudinal Ligament of the Cervical Spine: Monocytes and Proinflammatory Cytokines Increased Significantly.

Study Design: A retrospective cohort study.

Objective: The study aimed to explore the expression difference of inflammatory cells in patients with ossification of the posterior longitudinal ligament (OPLL) of the cervical spine and investigate the expression level of IL-6, IL-1β, MCP-1, TNF-α, RANTES, and IL-10 in patients with OPLL.

Background: Ossification of the posterior longitudinal ligament (OPLL) is a disease that can seriously affect spinal cord and nerve function.

Exploration of the relationship between apoptosis related characteristic genes and the prognosis of HCC.

The acquisition of resistance to anoikis is a critical driver of metastasis in various tumor types. However, the combined role of anoikis apoptosis in the progression and prognosis of hepatocellular carcinoma (HCC) remains largely unexplored. This study integrates known anoikis genes with single-cell datasets to identify differentially expressed Anoikis (DE-Anoikis) through unsupervised clustering, enabling the classification of samples from The Cancer Genome Atlas (TCGA).

Chinese herbal medicine for chronic pain: a bibliometric analysis based on integrated databases (2011-2024).

Background: Chronic pain has become an increasingly prevalent issue in primary care. Current management in modern medicine for chronic pain often remains unsatisfactory. Chinese herbal medicine has gained growing recognition as a complementary approach.

Jianpi Lishi Jiedu Decoction (JLJD) Inhibit Th17 Cell Differentiation via the Jak/Stat3/RORγt Pathway in Colorectal Adenomas.

Background: Jianpi Lishi Jiedu Decoction (JLJD) are used in China to prevent colorectal adenoma recurrence, but their molecular mechanism is unclear.

Objective: Evaluate JLJD's preventive and therapeutic effects on colorectal adenomas and elucidate its molecular mechanisms.

Methods: JLJD components were identified via HPLC.

Apoptosis-Related Non-Coding RNAs in Cardiac Fibrosis and Heart Failure: Implications for Pathogenesis and Therapy.

Heart failure (HF) and cardiac fibrosis constitute a substantial portion of the global cardiovascular disease (CVD) burden and are significant contributors to morbidity and mortality. Several mechanisms are involved in the pathogenesis of HF and cardiac fibrosis, with many studies recognizing apoptosis as a central player in their progression. Apoptosis is a conserved biological process directly regulated by extrinsic and intrinsic stimuli.